PPI network (data source: BioGrid)

Symbol A GeneA coding DNM count Symbol B GeneB coding DNM count Interaction detection method Publication Evidence
BCR 3 GRB2 2 affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Million RP (2000), Million RP (2004), Million RP (2004), Puil L (1994), Puil L (1994), Ma G (1997), Maru Y (1995), Maru Y (1995), Gaston I (2004), Gaston I (2004), Brehme M (2009), Bisson N (2011), Huttlin EL (2017) 13
ABL1 9 PAK4 3 biochemical Wan C (2015) 1
SOS1 5 ABL1 9 affinity chromatography technology Puil L (1994) 1
PAK4 3 PPM1B 2 biochemical Wan C (2015) 1
BRCA1 7 CCT2 1 affinity chromatography technology Ertych N (2016) 1
LRRK1 12 LRRK1 12 enzymatic study, x-ray crystallography, affinity chromatography technology Civiero L (2012), Civiero L (2012), Klein CL (2009) 3
BCR 3 ABL1 9 affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down Ling X (2003), Pendergast AM (1991), Puil L (1994), Puil L (1994), Slupianek A (2011) 5
LRRK1 12 BCR 3 affinity chromatography technology Titz B (2010) 1
CUL3 17 NAP1L1 2 affinity chromatography technology Bennett EJ (2010) 1
PPM1B 2 LRRK1 12 biochemical Wan C (2015) 1
MAP4K1 1 EGFR 5 biochemical, two hybrid, protein complementation assay Anafi M (1997), Kotlyar M (2015), Petschnigg J (2014) 3
LRRK1 12 DOK3 5 affinity chromatography technology Titz B (2010) 1
SOS2 3 EGFR 5 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay Qian X (2000), Tong J (2009), Tong J (2008), Foerster S (2013), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014) 7
EGFR 5 HNRNPK 4 affinity chromatography technology Yao Z (2017) 1
SHC1 0 BCR 3 affinity chromatography technology Brehme M (2009) 1
LRRK1 12 GAB2 3 affinity chromatography technology Titz B (2010) 1
LRRK1 12 DNAJA1 2 affinity chromatography technology Titz B (2010) 1
SHC1 0 CCT2 1 affinity chromatography technology Brehme M (2009) 1
LRRK1 12 RIMS1 6 affinity chromatography technology Ewing RM (2007) 1
LRRK2 5 DAPK1 6 affinity chromatography technology, affinity chromatography technology Klein CL (2009), Klein CL (2009) 2
LRRK1 12 VAPA 1 affinity chromatography technology Titz B (2010) 1
GRB2 2 DOK3 5 affinity chromatography technology Brehme M (2009) 1
SOS1 5 PTPN11 20 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Hadari YR (1998), Chin H (1997), Kapoor GS (2010), Yu WM (2006) 4
EGFR 5 GRB2 2 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009) 51
SOS1 5 BCR 3 affinity chromatography technology, affinity chromatography technology Puil L (1994), Maru Y (1995) 2
INPPL1 6 INPP5D 2 affinity chromatography technology Brehme M (2009) 1
LRRK1 12 INPP5D 2 affinity chromatography technology Titz B (2010) 1
LRRK1 12 SHC1 0 affinity chromatography technology Titz B (2010) 1
LRRK1 12 CCT2 1 affinity chromatography technology Titz B (2010) 1
LRRK1 12 DAPK1 6 affinity chromatography technology, affinity chromatography technology Klein CL (2009), Klein CL (2009) 2
NEDD4 2 ABL1 9 enzymatic study, pull down Persaud A (2009), Persaud A (2009) 2
SHC1 0 ABL1 9 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Wisniewski D (1999), Puil L (1994), Brehme M (2009), Brehme M (2009), Brehme M (2009) 5
DAPK1 6 CUL3 17 affinity chromatography technology Lee YR (2010) 1
LRRK2 5 LRRK1 12 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Klein CL (2009), Dachsel JC (2010), Dachsel JC (2010) 3
PTPN11 20 GAB2 3 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Boudot C (2002), Boudot C (2002), Lynch DK (2002), Zhao C (1999), Crouin C (2001), Crouin C (2001), Schaeper U (2000), Cholay M (2010), van den Akker E (2004), Arnaud M (2004), Arnaud M (2004), Yu WM (2006), Yu WM (2006) 13
GRB2 2 PTPN11 20 affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Ganju RK (2000), Bennett AM (1994), Ward AC (1998), Yin T (1997), Tang J (1997), Tang H (1999), Hadari YR (1998), Zhang S (1999), Wong L (1996), Brehme M (2009), Craddock BL (1997), Bisson N (2011), Blagoev B (2003), Bisson N (2011), Tauchi T (1995), Huttlin EL (2017), Kapoor GS (2010), Kapoor GS (2010), Vogel W (1996), Vogel W (1996), Yu WM (2006) 21
SHC1 0 DNAJA1 2 affinity chromatography technology Brehme M (2009) 1
CUL3 17 CCT2 1 affinity chromatography technology Bennett EJ (2010) 1
EGFR 5 SHC1 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology Schulze WX (2006), Sakaguchi K (1998), Tong J (2009), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Burke P (2001), Katayama H (1999), Tong J (2008), Zhang L (1999), Levkowitz G (1999), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Foerster S (2013), Gotoh N (1994), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Li J (2013), Prigent SA (1996), Prigent SA (1996), Grosse R (2000), Yao Z (2017), Wills MK (2014), Wills MK (2014), Kapoor GS (2010) 29
LRRK1 12 ASAP1 1 affinity chromatography technology Titz B (2010) 1
EGFR 5 VAPA 1 protein complementation assay, affinity chromatography technology Deribe YL (2009), Foerster S (2013) 2
LRRK1 12 MAP4K1 1 affinity chromatography technology Titz B (2010) 1
LRRK1 12 RSU1 2 affinity chromatography technology Titz B (2010) 1
EGFR 5 PAK4 3 affinity chromatography technology Yao Z (2017) 1
LRRK1 12 ABL1 9 affinity chromatography technology Titz B (2010) 1
SOS1 5 SHC1 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Qian X (2000), Foehr ED (2000), Park RK (1999), Chin H (1997), Wang Y (1999), Brehme M (2009), Brizzi MF (1996), Yu WM (2006), Klint P (1995) 9
LRRK1 12 PAK4 3 affinity chromatography technology Ewing RM (2007) 1
EGFR 5 INPPL1 6 affinity chromatography technology, affinity chromatography technology Pesesse X (2001), Sanada F (2009) 2
GRB2 2 SHC1 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995) 57
LRRK1 12 SOS2 3 affinity chromatography technology Titz B (2010) 1
CDC37 0 FKBP5 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014) 4
LRRK1 12 NAP1L1 2 affinity chromatography technology Titz B (2010) 1
BRCA1 7 LRRK1 12 affinity chromatography technology Ertych N (2016) 1
SOS1 5 EGFR 5 affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Qian X (2000), Qian X (1998), Buday L (1994), Tong J (2009), Kurada BR (2009), Tong J (2008), Foerster S (2013), Tong J (2014), Kapoor GS (2010) 9
ABL1 9 EGFR 5 unspecified method, two hybrid, protein complementation assay Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014) 3
ABL1 9 INPPL1 6 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Wisniewski D (1999), Brehme M (2009), Brehme M (2009) 3
LRRK2 5 DNAJA1 2 affinity chromatography technology Sen S (2009) 1
EGFR 5 PTPN11 20 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, affinity chromatography technology, enzymatic study Schulze WX (2006), Tomic S (1995), Crovello CS (1998), Jones RB (2006), Yao Z (2017), Kapoor GS (2010), Vogel W (1996) 7
SHC1 0 S100A8 0 affinity chromatography technology, affinity chromatography technology Brehme M (2009), Li J (2013) 2
GRB2 2 CCT2 1 affinity chromatography technology Brehme M (2009) 1
GRB2 2 S100A8 0 affinity chromatography technology Li J (2013) 1
LRRK1 12 PTPN11 20 affinity chromatography technology Titz B (2010) 1
NEDD4 2 HNRNPK 4 pull down Ingham RJ (2005) 1
PPM1B 2 S100A8 0 affinity chromatography technology Ewing RM (2007) 1
LRRK1 12 GRB2 2 affinity chromatography technology, affinity chromatography technology Titz B (2010), Brehme M (2009) 2
LRRK1 12 FKBP5 0 affinity chromatography technology Titz B (2010) 1
BRCA1 7 CDC37 0 affinity chromatography technology Ertych N (2016) 1
GRB2 2 HNRNPK 4 two hybrid, affinity chromatography technology, two hybrid, two hybrid Bandyopadhyay S (2010), Brehme M (2009), Wang J (2011), Rolland T (2014) 4
CUL3 17 LRRK1 12 affinity chromatography technology Wimuttisuk W (2014) 1
LRRK1 12 NEDD4 2 affinity chromatography technology Titz B (2010) 1
EGFR 5 DNAJA1 2 affinity chromatography technology, affinity chromatography technology Foerster S (2013), Tong J (2014) 2
LRRK1 12 S100A8 0 affinity chromatography technology Ewing RM (2007) 1
DNAJA1 2 CCT2 1 biochemical Wan C (2015) 1
SHC1 0 GAB2 3 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Boudot C (2002), Lynch DK (2002), van den Akker E (2004) 3
INPP5D 2 BCR 3 affinity chromatography technology Ruschmann J (2010) 1
EGFR 5 LRRK1 12 affinity chromatography technology Yao Z (2017) 1
GRB2 2 INPP5D 2 unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Kavanaugh WM (1996), Kavanaugh WM (1996), de Castro RO (2012), Ho JM (2002) 4
BRCA1 7 NAP1L1 2 affinity chromatography technology Ertych N (2016) 1
INPP5D 2 SHC1 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Dunant NM (2000), Dunant NM (2000), Wisniewski D (1999), Leitges M (2002), Damen JE (1996), Damen JE (1996), March ME (2000), Hunter MG (2004), Ho JM (2002) 9
ABL1 9 GRB2 2 affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down Warmuth M (1997), Ren R (1994), Ren R (1994), Patel H (2006), Johnson KJ (2009), Gaston I (2004), Gaston I (2004), Brehme M (2009), Brehme M (2009), Chen R (2013), Feller SM (1994) 11
CUL3 17 GRB2 2 affinity chromatography technology Bennett EJ (2010) 1
EGFR 5 PPM1B 2 two hybrid Yao Z (2017) 1
SHC1 0 INPPL1 6 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Wisniewski D (1999), Wisniewski D (1999), Pesesse X (2001), Habib T (1998), Brehme M (2009), Brehme M (2009) 6
GRB2 2 SOS2 3 affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology Scholler JK (2000), Yang SS (1995), Bandyopadhyay S (2010), Brehme M (2009), Bisson N (2011), Wang J (2011), Huttlin EL (2017) 7
GRB2 2 ASAP1 1 two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology Bandyopadhyay S (2010), Brehme M (2009), Bisson N (2011), Wang J (2011), Huttlin EL (2017) 5
ABL1 9 BRCA1 7 affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, fluorescent resonance energy transfe Foray N (2002), Foray N (2002), Foray N (2002), Foray N (2002), Foray N (2002), Morell M (2007) 6
LRRK1 12 CDC37 0 affinity chromatography technology Titz B (2010) 1
LRRK1 12 INPPL1 6 affinity chromatography technology Titz B (2010) 1
LRRK1 12 LYZ 0 affinity chromatography technology Ewing RM (2007) 1
GRB2 2 GAB2 3 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Million RP (2004), Lynch DK (2002), Zhao C (1999), Zhao C (1999), Bandyopadhyay S (2010), Brehme M (2009), Bisson N (2011), Rolland T (2014), Huttlin EL (2017), Yu WM (2006), Yu WM (2006) 11
BRCA1 7 HNRNPK 4 affinity chromatography technology Ertych N (2016) 1
LRRK1 12 158055 0 affinity chromatography technology Ewing RM (2007) 1
SOS2 3 SHC1 0 affinity chromatography technology, affinity chromatography technology Qian X (2000), Brehme M (2009) 2
EGFR 5 CDC37 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Li J (2013) 4
LRRK1 12 SOS1 5 affinity chromatography technology Titz B (2010) 1
GRB2 2 MAP4K1 1 pull down, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology Oehrl W (1998), Anafi M (1997), Anafi M (1997), Anafi M (1997), Ling P (1999), Ling P (2001) 6
BRCA1 7 DNAJA1 2 two hybrid, affinity chromatography technology, affinity chromatography technology Woods NT (2012), Hill SJ (2014), Ertych N (2016) 3
INPP5D 2 PTPN11 20 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Liu L (1997), Chernock RD (2001), Chernock RD (2001) 3
CUL3 17 HNRNPK 4 affinity chromatography technology Bennett EJ (2010) 1
ABL1 9 PPM1B 2 biochemical Wan C (2015) 1
CUL3 17 DNAJA1 2 affinity chromatography technology Bennett EJ (2010) 1
INPPL1 6 GRB2 2 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Brehme M (2009), Brehme M (2009), Brehme M (2009), Bisson N (2011) 4
LRRK2 5 CDC37 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Nichols RJ (2010), Wang L (2008), Rudenko IN (2012), Gloeckner CJ (2006), Imai Y (2015) 5
NEDD4 2 EGFR 5 enzymatic study, pull down Persaud A (2009), Persaud A (2009) 2
BCR 3 GAB2 3 affinity chromatography technology Million RP (2004) 1
GRB2 2 SOS1 5 affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Blagoev B (2003), Liu SK (1998), Oneyama C (2002), Puil L (1994), Robinson A (1996), Li N (1993), Wong A (2002), Wong A (2002), Reif K (1994), DAngelo G (1999), Nel AE (1995), Pandey P (1995), Buday L (1994), Tong XK (2000), Park RK (1999), Okada S (1996), Okada S (1996), Okada S (1996), Germani A (1999), Park RK (1999), Chin H (1997), Saci A (2002), Sastry L (1997), Spivak-Kroizman T (1994), Ingham RJ (1996), Wang Y (1999), Chu J (1998), Brehme M (2009), Houtman JC (2006), Lao DH (2006), Bisson N (2011), Wang J (2011), Ng MY (2017), Huttlin EL (2017), Kapoor GS (2010), Saito T (2004), Klint P (1995) 37
LRRK1 12 HNRNPK 4 affinity chromatography technology Titz B (2010) 1