PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SUV39H2	3	AP4M1	2	affinity chromatography technology	Huttlin EL (2017)	1
SUV39H2	3	CCT4	2	affinity chromatography technology	Hauri S (2016)	1
TUBA1C	1	CCT6A	1	affinity chromatography technology	Hein MY (2015)	1
EHMT2	4	KLF3	0	two hybrid	Rolland T (2014)	1
SUV39H2	3	CCT6A	1	affinity chromatography technology	Hauri S (2016)	1
KRAS	1	SUV39H2	3	genetic interference	Luo J (2009)	1
EHMT2	4	LNX1	7	two hybrid	Rual JF (2005)	1
SUV39H2	3	RASSF1	3	two hybrid, two hybrid	Vinayagam A (2011), Weimann M (2013)	2
NME4	0	SUV39H2	3	two hybrid	Weimann M (2013)	1
SUV39H2	3	FAM20C	2	two hybrid	Vinayagam A (2011)	1
TUBA1C	1	CCT4	2	affinity chromatography technology	Hein MY (2015)	1
TCP1	0	CCT4	2	affinity chromatography technology, biochemical, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
EHMT2	4	EHMT1	18	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Hauri S (2016)	2
KLF3	0	SUV39H2	3	two hybrid	Weimann M (2013)	1
CCT8	0	CCT6A	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
SUV39H2	3	SPRR2E	0	affinity chromatography technology	Hauri S (2016)	1
EHMT2	4	WIZ	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ueda J (2006), Ueda J (2006), Bantscheff M (2011), Hein MY (2015), Hauri S (2016)	5
SUV39H2	3	CCT8	0	affinity chromatography technology	Hauri S (2016)	1
KCTD17	0	LNX1	7	two hybrid	Rual JF (2005)	1
EWSR1	2	WIZ	2	bioid	Elzi DJ (2014)	1
AKAP9	13	SUV39H2	3	two hybrid	Weimann M (2013)	1
ACTBL2	0	CCT3	1	affinity chromatography technology	Huttlin EL (2017)	1
SUV39H2	3	NARS	3	affinity chromatography technology	Huttlin EL (2015)	1
EHMT2	4	CBX1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Spektor TM (2009), Chin HG (2007), Roopra A (2004), Hauri S (2016)	4
SUV39H2	3	SHC1	0	two hybrid	Vinayagam A (2011)	1
SUV39H2	3	AP4E1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KLHDC4	3	SUV39H2	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
SUV39H2	3	CBX1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SHC1	0	CCT6A	1	affinity chromatography technology	Brehme M (2009)	1
CCT4	2	CCT3	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
CBX5	3	CCT7	2	affinity chromatography technology	Hauri S (2016)	1
PNMA1	0	ACTBL2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KRAS	1	SHC1	0	genetic interference	Hart T (2015)	1
CBX5	3	WIZ	2	affinity chromatography technology	Nozawa RS (2010)	1
CCT5	1	CCT7	2	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
MYL12A	0	SUV39H2	3	two hybrid	Weimann M (2013)	1
SUV39H2	3	CCT5	1	affinity chromatography technology	Hauri S (2016)	1
RAB3IP	0	SUV39H2	3	two hybrid	Weimann M (2013)	1
CCT3	1	CCT8	0	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
WIZ	2	SUV39H2	3	two hybrid	Weimann M (2013)	1
EWSR1	2	BLZF1	0	two hybrid	Ravasi T (2010)	1
CBX1	0	EHMT1	18	affinity chromatography technology	Hauri S (2016)	1
SUV39H2	3	EHMT2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCT5	1	CCT6A	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
SUV39H2	3	RPL39	0	affinity chromatography technology	Hauri S (2016)	1
ACTBL2	0	CCT4	2	affinity chromatography technology	Huttlin EL (2017)	1
ZNF644	6	EHMT2	4	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hauri S (2016)	2
TCP1	0	CCT5	1	affinity chromatography technology, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Wan C (2015)	3
CBX1	0	LRIF1	3	two hybrid, affinity chromatography technology	Stelzl U (2005), Hauri S (2016)	2
CCT5	1	CCT8	0	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
CCT7	2	CCT6A	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
ZNF212	1	SUV39H2	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
AP4E1	4	AP4S1	0	two hybrid, affinity chromatography technology	Hirst J (1999), Hein MY (2015)	2
CDCA4	1	SUV39H2	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
ACTBL2	0	CCT8	0	affinity chromatography technology	Huttlin EL (2017)	1
CCT4	2	CCT5	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TCP1	0	CCT7	2	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Gingras AC (2005), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
EHMT2	4	TCP1	0	affinity chromatography technology	Hauri S (2016)	1
TCP1	0	CCT6A	1	affinity chromatography technology, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Wan C (2015)	3
CCT3	1	CCT7	2	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
WIZ	2	EHMT1	18	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
KCTD17	0	SUV39H2	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
CBX5	3	EHMT1	18	affinity chromatography technology	Nozawa RS (2010)	1
ZNF557	3	CEP70	1	two hybrid	Yu H (2011)	1
SUV39H2	3	ARG1	0	affinity chromatography technology	Hauri S (2016)	1
KRAS	1	POLR3F	1	genetic interference	Luo J (2009)	1
CBX1	0	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Mateos-Langerak J (2007), Rosnoblet C (2011), Nozawa RS (2010), Hauri S (2016), Hauri S (2016)	10
POLR3F	1	LRIF1	3	two hybrid	Stelzl U (2005)	1
CCT7	2	CCT8	0	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
CBX5	3	SUV39H2	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nozawa RS (2010), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
AP4S1	0	AP4M1	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
ZNF644	6	EHMT1	18	affinity chromatography technology	Hein MY (2015)	1
TUBA1C	1	CCT5	1	affinity chromatography technology	Hein MY (2015)	1
CFAP100	3	SUV39H2	3	two hybrid	Weimann M (2013)	1
AR	3	MAGEA11	1	imaging technique, two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Bai S (2005), Bai S (2005), Bai S (2005), Bai S (2005), Bai S (2008), Liu Q (2011), Askew EB (2009), Askew EB (2009), Minges JT (2013), Corominas R (2014)	10
EHMT2	4	CBX5	3	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Chin HG (2007), Chin HG (2007), Nozawa RS (2010), Roopra A (2004)	4
CCT4	2	CCT7	2	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
TUBA1C	1	TCP1	0	affinity chromatography technology	Hein MY (2015)	1
SUV39H2	3	CEP70	1	two hybrid, two hybrid	Vinayagam A (2011), Weimann M (2013)	2
SASH1	8	SUV39H2	3	x-ray crystallography	Wu H (2010)	1
SUV39H2	3	MCM3AP	6	two hybrid	Vinayagam A (2011)	1
LNX1	7	SUV39H2	3	two hybrid	Weimann M (2013)	1
SUV39H2	3	AP4S1	0	affinity chromatography technology	Huttlin EL (2017)	1
ZNF57	0	SUV39H2	3	two hybrid	Weimann M (2013)	1
CBX1	0	WIZ	2	affinity chromatography technology	Hauri S (2016)	1
BLZF1	0	AKAP9	13	two hybrid	Rolland T (2014)	1
EWSR1	2	MAGEA11	1	two hybrid	Rual JF (2005)	1
AR	3	SUV39H2	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Askew EB (2017), Askew EB (2017), Askew EB (2017), Askew EB (2017), Askew EB (2017)	5
CBX1	0	ARG1	0	affinity chromatography technology	Hauri S (2016)	1
CCT3	1	CCT6A	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
CCT5	1	CCT3	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
TUBA1C	1	CCT8	0	affinity chromatography technology	Hein MY (2015)	1
CBX7	1	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
TUBA1C	1	CCT3	1	affinity chromatography technology	Hein MY (2015)	1
C8orf74	0	SUV39H2	3	two hybrid	Weimann M (2013)	1
ACTBL2	0	CCT7	2	affinity chromatography technology	Huttlin EL (2017)	1
CBX1	0	ZNF644	6	affinity chromatography technology	Hauri S (2016)	1
GSTCD	1	SUV39H2	3	two hybrid	Weimann M (2013)	1
ACTBL2	0	CCT6A	1	affinity chromatography technology	Huttlin EL (2017)	1
SUV39H2	3	SMAD5	2	affinity chromatography technology	Frontelo P (2004)	1
MAGEA11	1	SUV39H2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, imaging technique	Askew EB (2017), Askew EB (2017), Askew EB (2017), Askew EB (2017), Askew EB (2017)	5
PHF19	3	ACTBL2	0	affinity chromatography technology	Huttlin EL (2017)	1
SHC1	0	TUBA1C	1	affinity chromatography technology	Brehme M (2009)	1
POLR3F	1	SUV39H2	3	two hybrid	Weimann M (2013)	1
ZNF644	6	WIZ	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
CCDC151	1	SUV39H2	3	two hybrid	Weimann M (2013)	1
TUBA1C	1	CCT7	2	affinity chromatography technology	Hein MY (2015)	1
SNF8	2	SUV39H2	3	two hybrid	Weimann M (2013)	1
ID2	0	SUV39H2	3	two hybrid	Weimann M (2013)	1
CBX5	3	LRIF1	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Nozawa RS (2010), Hauri S (2016)	3
APPL2	4	SUV39H2	3	two hybrid, two hybrid	Weimann M (2013), Rolland T (2014)	2
SUV39H2	3	LRIF1	3	two hybrid	Vinayagam A (2011)	1
AP4M1	2	AP4E1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hirst J (1999), Hein MY (2015), Hein MY (2015)	3
MRFAP1	1	SUV39H2	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
CBX1	0	CCT3	1	affinity chromatography technology	Hauri S (2016)	1
EHMT2	4	CCT3	1	affinity chromatography technology	Hauri S (2016)	1
EWSR1	2	SUV39H2	3	two hybrid	Rual JF (2005)	1
SUV39H2	3	CCT7	2	affinity chromatography technology	Hauri S (2016)	1
PHF19	3	GSTCD	1	affinity chromatography technology	Huttlin EL (2017)	1
SUV39H2	3	CCT3	1	affinity chromatography technology	Hauri S (2016)	1
MTF2	4	SUV39H2	3	two hybrid	Weimann M (2013)	1
PNMA1	0	SUV39H2	3	two hybrid	Rolland T (2014)	1
SUV39H2	3	ACTBL2	0	affinity chromatography technology	Huttlin EL (2017)	1
SUV39H2	3	EHMT1	18	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PHF19	3	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
SUV39H2	3	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
SUV39H2	3	ZNF644	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EHMT2	4	CCT7	2	affinity chromatography technology	Hauri S (2016)	1
SUV39H2	3	TCP1	0	affinity chromatography technology	Hauri S (2016)	1
MAGEA11	1	LNX1	7	two hybrid	Rual JF (2005)	1
CBX7	1	SUV39H2	3	protein complementation assay	Li Q (2010)	1
LCA5L	1	SUV39H2	3	two hybrid	Weimann M (2013)	1
CCT4	2	CCT6A	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
TCP1	0	CCT8	0	affinity chromatography technology, biochemical, biochemical	Gingras AC (2005), Havugimana PC (2012), Wan C (2015)	3
ZNF557	3	SUV39H2	3	two hybrid	Weimann M (2013)	1
PHF19	3	SUV39H2	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
BLZF1	0	SUV39H2	3	two hybrid	Weimann M (2013)	1
KRAS	1	CCT7	2	two hybrid	Vinayagam A (2011)	1
TCP1	0	CCT3	1	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Gingras AC (2005), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
ID2	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
CCT4	2	CCT8	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2