PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DOK1	2	SRC	2	pull down, unspecified method	van Dijk TB (2000), Liu BA (2012)	2
CBLL1	6	WTAP	0	biochemical	Wan C (2015)	1
SRC	2	CBLL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Swaminathan G (2011), Shen Y (2008), Shrestha H (2017)	3
CBLL1	6	DOK1	2	affinity chromatography technology	Mukherjee M (2012)	1
CDC42	3	CDH1	4	pull down, affinity chromatography technology	Shen Y (2008), Shen Y (2008)	2
ESR1	0	CBLL1	6	two hybrid, affinity chromatography technology	Gong EY (2010), Gong EY (2010)	2
CDC42	3	CBLL1	6	pull down, imaging technique	Shen Y (2008), Shen Y (2008)	2
CDH1	4	CBLL1	6	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Fujita Y (2002), Fujita Y (2002), Hirao T (2006), Swaminathan G (2011), Shen Y (2008), Chen Y (2009), Mukherjee M (2012), Smyth D (2012), Figueiredo J (2013), Shrestha H (2017)	10
CDH1	4	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Genda T (2000), Swaminathan G (2011), Shen Y (2008), Guo Z (2014)	4
ESR1	0	SFPQ	2	pull down	Nalvarte I (2010)	1
CDH1	4	CTTN	1	bioid	Guo Z (2014)	1
YWHAQ	0	WTAP	0	pull down	Meek SE (2004)	1
RNF2	1	CBLL1	6	affinity chromatography technology	Cao Q (2014)	1
DGCR6	0	CBLL1	6	two hybrid	Corominas R (2014)	1
YWHAQ	0	ESR1	0	pull down	Zilliacus J (2001)	1
CBLL1	6	VIRMA	4	biochemical	Wan C (2015)	1
RNF2	1	CDH1	4	affinity chromatography technology	Cao Q (2014)	1
KIF26B	11	CBLL1	6	affinity chromatography technology	Hein MY (2015)	1
SRC	2	ESR1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, imaging technique, imaging technique, imaging technique, pull down, imaging technique, imaging technique, affinity chromatography technology, two hybrid	Migliaccio A (2000), Teo AK (2001), Slentz-Kesler K (2000), Bourdoncle A (2005), Jaber BM (2004), Jaber BM (2004), Ku TK (2007), Cabodi S (2004), Monroe DG (2003), Hitosugi T (2007), Zwart W (2007), Zwart W (2007), Zwart W (2007), Yoshimaru T (2013), Yoshimaru T (2013), Zhang H (2006), Zhang H (2006), Zhang H (2006), Endler A (2012), Endler A (2012)	20
YWHAQ	0	VIRMA	4	pull down	Meek SE (2004)	1
SFPQ	2	CBLL1	6	affinity chromatography technology	Figueroa A (2009)	1
YWHAQ	0	CBLL1	6	pull down	Meek SE (2004)	1
WTAP	0	VIRMA	4	biochemical	Wan C (2015)	1
CBLL1	6	CTTN	1	affinity chromatography technology	Mukherjee M (2012)	1