PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PAICS	0	NUDT18	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
PSME3	0	NUDT18	0	two hybrid	Rual JF (2005)	1
RWDD1	0	NUDT18	0	two hybrid	Rual JF (2005)	1
CUTC	0	NUDT18	0	two hybrid	Rual JF (2005)	1
TRIM37	7	TRAF2	1	pull down	Zapata JM (2001)	1
DHPS	3	NUDT18	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
TRAF2	1	TIFA	4	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
KHDRBS3	0	NUDT18	0	two hybrid	Rual JF (2005)	1
NT5C2	1	NUDT18	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
TRIM37	7	NUDT18	0	two hybrid	Rual JF (2005)	1
RABAC1	0	NUDT18	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
TERF2IP	1	GNMT	0	two hybrid	Lee OH (2011)	1
COIL	1	NUDT18	0	two hybrid	Lim J (2006)	1
NUDT18	0	NAT9	1	two hybrid	Venkatesan K (2009)	1
KCTD17	0	NUDT18	0	two hybrid	Rual JF (2005)	1
GNMT	0	NUDT18	0	two hybrid	Rual JF (2005)	1
SLC33A1	1	NUDT18	0	affinity chromatography technology	Hein MY (2015)	1
PCBD1	0	NUDT18	0	two hybrid	Rual JF (2005)	1
NUDT18	0	RAD54B	3	two hybrid	Venkatesan K (2009)	1
GLUL	2	NUDT18	0	two hybrid	Rual JF (2005)	1
NUDT18	0	EVI5L	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
RAB3IL1	0	NUDT18	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
TRAF2	1	NUDT18	0	two hybrid	Rual JF (2005)	1
NUDT18	0	TARBP2	0	two hybrid	Venkatesan K (2009)	1
ZBED1	0	NUDT18	0	two hybrid	Rual JF (2005)	1
PAPD5	3	NUDT18	0	affinity chromatography technology	Hein MY (2015)	1
KRT15	2	NUDT18	0	two hybrid	Rual JF (2005)	1
NUDT18	0	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
DCTD	0	NUDT18	0	two hybrid	Rual JF (2005)	1
NUDT18	0	KCTD13	1	two hybrid	Rual JF (2005)	1
TERF2IP	1	NUDT18	0	two hybrid	Lee OH (2011)	1
DUT	1	NUDT18	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
CAVIN2	3	NUDT18	0	two hybrid	Rual JF (2005)	1
KXD1	1	NUDT18	0	two hybrid	Rual JF (2005)	1
NUDT18	0	TIFA	4	two hybrid	Rual JF (2005)	1
GSE1	14	NUDT18	0	two hybrid	Rual JF (2005)	1
APIP	0	NUDT18	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
HSD17B14	0	NUDT18	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
NADK	1	NUDT18	0	two hybrid	Rual JF (2005)	1
COIL	1	PSME3	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Huttlin EL (2015), Huttlin EL (2017)	3