PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TCEAL4	0	RB1CC1	9	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	USP7	14	affinity chromatography technology	Rodriguez J (2016)	1
TCEAL1	3	TCEAL4	0	affinity chromatography technology	Sowa ME (2009)	1
USP11	3	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Sowa ME (2009), Maertens GN (2010), Maertens GN (2010), Ma H (2012), Hein MY (2015)	7
TCEAL4	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Hein MY (2015), Hein MY (2015)	3
USP7	14	HLTF	7	affinity chromatography technology	Sowa ME (2009)	1
USP15	4	USP7	14	enzymatic study	Loch CM (2012)	1
AURKA	1	UBA2	0	genetic interference	Horlbeck MA (2018)	1
TP53	0	TCEAL1	3	affinity chromatography technology	Huttlin EL (2015)	1
TCEAL1	3	USP11	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Sowa ME (2009), Sowa ME (2009), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
TCEAL1	3	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
RB1CC1	9	TP53	0	affinity chromatography technology	Chano T (2010)	1
TCEAL4	0	SPTLC1	1	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	HECTD1	16	affinity chromatography technology	Rodriguez J (2016)	1
TCEAL4	0	USP15	4	affinity chromatography technology	Hein MY (2015)	1
UBA2	0	TCEAL4	0	biochemical	Kristensen AR (2012)	1
EGLN3	0	SPTLC1	1	affinity chromatography technology	Rodriguez J (2016)	1
TCEAL4	0	ATXN2L	4	affinity chromatography technology	Hein MY (2015)	1
PPP2R1A	8	TCEAL4	0	affinity chromatography technology	Fogeron ML (2013)	1
TCEAL4	0	VPS41	3	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	AURKB	2	affinity chromatography technology	Rodriguez J (2016)	1
AURKB	2	AURKA	1	affinity chromatography technology	Fogeron ML (2013)	1
AURKB	2	TCEAL4	0	affinity chromatography technology	Fogeron ML (2013)	1
TP53	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li M (2002), Li M (2002), Li M (2002), Li M (2002), Brooks CL (2007), Brooks CL (2007), Becker K (2007), Hu M (2006), Hu M (2006), Sarkari F (2010), Marchenko ND (2007), Epping MT (2011), Qing P (2011), Tang J (2006), Ma J (2010), Dai C (2011), Holowaty MN (2003), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Yi P (2013), Yi P (2013), Zhang J (2014), Fang Z (2013), Ye M (2015), Lim KH (2015), Lim KH (2015), Reddy BA (2014), Reddy BA (2014)	29
USP11	3	TP53	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Ke JY (2014), Ke JY (2014)	3
EGLN3	0	AURKA	1	affinity chromatography technology	Rodriguez J (2016)	1
TCEAL4	0	CAMSAP3	3	affinity chromatography technology	Hein MY (2015)	1
NEDD1	1	TCEAL4	0	affinity chromatography technology	Fogeron ML (2013)	1
TP53	0	USP15	4	affinity chromatography technology, affinity chromatography technology	Liu WT (2016), Liu WT (2016)	2
TP53	0	HECTD1	16	affinity chromatography technology	Fogeron ML (2013)	1
TP53	0	PPP2R1A	8	imaging technique, affinity chromatography technology	Chen TC (2014), Kikuchi J (2003)	2
TCEAL1	3	TCEAL2	0	affinity chromatography technology	Sowa ME (2009)	1
TCEAL4	0	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	PPP2R1A	8	affinity chromatography technology	Rodriguez J (2016)	1
USP7	14	ACTL8	1	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	USP15	4	affinity chromatography technology	Rodriguez J (2016)	1
USP5	2	TCEAL4	0	biochemical	Kristensen AR (2012)	1
TCEAL4	0	ACTL8	1	affinity chromatography technology	Hein MY (2015)	1
P4HB	1	TCEAL4	0	biochemical	Kristensen AR (2012)	1
TP53	0	TCEAL4	0	affinity chromatography technology	Fogeron ML (2013)	1
UBA2	0	P4HB	1	biochemical	Kristensen AR (2012)	1
TP53	0	AURKA	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, genetic interference, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen SS (2002), Chen SS (2002), Chen SS (2002), Chen SS (2002), Chen SS (2002), Katayama H (2004), Katayama H (2004), Katayama H (2004), Katayama H (2004), Hsueh KW (2013), Huttlin EL (2015), Huttlin EL (2017)	12
USP11	3	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	TCEAL1	3	affinity chromatography technology	Rodriguez J (2016)	1
TCEAL4	0	HECTD1	16	biochemical	Kristensen AR (2012)	1
TRIM27	2	TP53	0	affinity chromatography technology, pull down, enzymatic study	Chu Y (2011), Chu Y (2011), Chu Y (2011)	3
TCEAL4	0	HLTF	7	affinity chromatography technology	Hein MY (2015)	1
USP15	4	USP11	3	affinity chromatography technology	Sowa ME (2009)	1
TCEAL4	0	SLC35F6	0	affinity chromatography technology	Hein MY (2015)	1
USP7	14	TRIM27	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hayes SD (2012), Hein MY (2015), Zaman MM (2013), Zaman MM (2013)	4
EGLN3	0	TCEAL4	0	affinity chromatography technology	Rodriguez J (2016)	1
AURKA	1	TCEAL4	0	affinity chromatography technology	Fogeron ML (2013)	1
USP5	2	P4HB	1	biochemical	Kristensen AR (2012)	1
TCEAL4	0	IFRD1	2	affinity chromatography technology	Hein MY (2015)	1
AURKA	1	TCEAL2	0	affinity chromatography technology, pull down	Fogeron ML (2013), Kamran M (2017)	2
USP11	3	TCEAL2	0	affinity chromatography technology	Sowa ME (2009)	1
TCEAL4	0	TCEAL2	0	affinity chromatography technology	Sowa ME (2009)	1
TP53	0	AURKB	2	affinity chromatography technology	Wu L (2011)	1
TCEAL4	0	USP11	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Sowa ME (2009), Hein MY (2015), Hein MY (2015)	5