PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RBPMS	0	WDR54	0	two hybrid	Rolland T (2014)	1
DOK5	0	DOK3	5	two hybrid	Grossmann A (2015)	1
DOK1	2	DOK3	5	two hybrid	Grossmann A (2015)	1
DOK3	5	WDR54	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LRRK1	12	DOK3	5	affinity chromatography technology	Titz B (2010)	1
APPL1	1	APPL2	4	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Nechamen CA (2007), Nechamen CA (2007), Rolland T (2014), Huttlin EL (2017)	5
CRK	0	DOK2	2	two hybrid	Grossmann A (2015)	1
BLNK	2	DOK3	5	affinity chromatography technology, affinity chromatography technology	Oellerich T (2011), Oellerich T (2011)	2
TNS2	3	DOK3	5	two hybrid	Grossmann A (2015)	1
GRB2	2	DOK3	5	affinity chromatography technology	Brehme M (2009)	1
DOK2	2	DOK3	5	two hybrid	Grossmann A (2015)	1
DOK3	5	UHRF1BP1L	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DOK3	5	DPP9	4	affinity chromatography technology	Huttlin EL (2015)	1
APPL1	1	DOK3	5	two hybrid	Grossmann A (2015)	1
DOK4	3	DOK3	5	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
DOK3	5	MIOS	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
RBPMS	0	DOK3	5	two hybrid	Rolland T (2014)	1
TRAF1	0	DOK3	5	two hybrid	Rolland T (2014)	1
APPL1	1	DOK2	2	two hybrid	Grossmann A (2015)	1
LRRK1	12	GRB2	2	affinity chromatography technology, affinity chromatography technology	Titz B (2010), Brehme M (2009)	2
DOK3	5	WDR34	2	affinity chromatography technology	Huttlin EL (2015)	1
GRB2	2	YWHAE	0	affinity chromatography technology	Bisson N (2011)	1
RIN3	2	DOK3	5	two hybrid	Grossmann A (2015)	1
DOK3	5	DPP8	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DOK3	5	AMD1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RIN3	2	CRK	0	two hybrid	Grossmann A (2015)	1
DOK1	2	CRK	0	unspecified method	Liu BA (2012)	1
DOK3	5	TPP2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STAT3	0	DOK3	5	two hybrid	Grossmann A (2015)	1
DOK1	2	DOK2	2	affinity chromatography technology	Dunant NM (2000)	1
YWHAE	0	DOK3	5	affinity chromatography technology	Choudhary C (2009)	1
STAT3	0	DOK2	2	two hybrid	Grossmann A (2015)	1
GRB2	2	DOK1	2	affinity chromatography technology	Kepley CL (2004)	1
ANKS1A	3	DOK3	5	two hybrid	Grossmann A (2015)	1
APPL2	4	DOK3	5	two hybrid	Grossmann A (2015)	1
SHE	2	DOK3	5	two hybrid	Grossmann A (2015)	1
TNS2	3	YWHAE	0	affinity chromatography technology	St-Denis N (2016)	1
CRK	0	DOK3	5	two hybrid	Grossmann A (2015)	1
BLNK	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Fu C (1998), Engels N (2001), Fusaki N (2000), Wienands J (1998), Oellerich T (2011), Oellerich T (2011)	6