PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NFKB1	2	TNFAIP3	3	affinity chromatography technology	Lapid D (2017)	1
TNIP3	3	KRT40	0	two hybrid	Rolland T (2014)	1
KRTAP10-8	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
NFKB1	2	TNIP3	3	affinity chromatography technology	Bouwmeester T (2004)	1
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
UBC	7	TNIP1	1	affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down	Wagner S (2008), Wagner S (2008), Fenner BJ (2009), Verhelst K (2012), Zhang X (2017), Kliza K (2017)	6
TNIP3	3	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
TNIP1	1	NFKB1	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Cohen S (2009), Cohen S (2009), Wang J (2011), Li X (2015)	4
TAX1BP1	3	DAZAP2	1	two hybrid	Rolland T (2014)	1
TNIP3	3	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
TNIP1	1	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Gao L (2011), Gao L (2011), Rolland T (2014)	3
UBC	7	TAX1BP1	3	pull down, x-ray crystallography, pull down, pull down	Fenner BJ (2009), Tumbarello DA (2015), Tumbarello DA (2015), Zhang X (2017)	4
TAX1BP1	3	TNIP3	3	two hybrid	Rolland T (2014)	1
TNFAIP3	3	TNIP1	1	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid	Heyninck K (1999), Heyninck K (1999), Bohgaki M (2008), Klinkenberg M (2001), Heyninck K (2003), Wang J (2011), Rodriguez MS (2014), Rolland T (2014)	8
UBC	7	DAZAP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TNFAIP3	3	TNIP3	3	affinity chromatography technology, two hybrid	Wullaert A (2007), Rolland T (2014)	2
KRTAP10-3	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
TNIP3	3	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
TNIP3	3	LZTS2	4	two hybrid	Rolland T (2014)	1
TNIP3	3	ZBTB8A	0	two hybrid	Rolland T (2014)	1
TNIP1	1	TNIP3	3	two hybrid	Rolland T (2014)	1
KRTAP10-8	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
UBC	7	TNIP3	3	affinity chromatography technology, two hybrid	Wagner S (2008), Wagner S (2008)	2
DAZAP2	1	TNIP3	3	two hybrid	Rolland T (2014)	1
TNFAIP3	3	TAX1BP1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	De Valck D (1999), De Valck D (1999), Klinkenberg M (2001), Kelly C (2012), Huttlin EL (2017)	5