PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PDHA1	7	CALD1	2	affinity chromatography technology	Malty RH (2017)	1
PAN2	3	MYH9	19	affinity chromatography technology	Bett JS (2013)	1
SHC1	0	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
FH	0	CALD1	2	biochemical	Kristensen AR (2012)	1
RPA2	0	PRKACA	2	biochemical	Kristensen AR (2012)	1
HSP90AA1	7	TERF1	1	affinity chromatography technology	Hein MY (2015)	1
MYO19	0	CALD1	2	affinity chromatography technology	Hein MY (2015)	1
TP53	0	RPA1	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Romanova LY (2004), Romanova LY (2004), Riva F (2001), Glanzer JG (2013)	4
TP53	0	OBSL1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Hanson D (2014), Hanson D (2014), Li X (2015)	4
RPA2	0	TMPO	0	affinity chromatography technology	Marechal A (2014)	1
TMPO	0	HSP90AA1	7	affinity chromatography technology	Brady GF (2018)	1
RPA3	2	RPA2	0	biochemical, x-ray crystallography, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Havugimana PC (2012), Du Y (2009), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
MYH9	19	LIMA1	4	affinity chromatography technology	Hein MY (2015)	1
HNRNPL	3	ARRB1	2	affinity chromatography technology	Fei T (2017)	1
RPA3	2	TERF2	2	affinity chromatography technology	Marechal A (2014)	1
ARRB1	2	MYH9	19	affinity chromatography technology	Xiao K (2007)	1
MYH9	19	ACTN1	5	affinity chromatography technology	Hein MY (2015)	1
RPA3	2	CALD1	2	affinity chromatography technology	Marechal A (2014)	1
EPB41L2	2	CSNK2A1	15	biochemical	Kristensen AR (2012)	1
NTRK1	1	LRCH3	2	affinity chromatography technology	Emdal KB (2015)	1
SHC1	0	MYH9	19	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
NTRK1	1	LIMA1	4	affinity chromatography technology	Emdal KB (2015)	1
ARRB1	2	CALD1	2	affinity chromatography technology	Xiao K (2007)	1
RPA1	0	RPA2	0	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Kristensen AR (2012), Ghospurkar PL (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Elia AE (2015), Elia AE (2015), Huttlin EL (2017), Feeney L (2017)	13
ACTN1	5	CALD1	2	biochemical	Havugimana PC (2012)	1
SHC1	0	CALD1	2	affinity chromatography technology	Wang Z (1999)	1
CSNK2A1	15	CALM1	0	enzymatic study, pull down, enzymatic study	Meggio F (1987), Benitez MJ (2001), Llorens F (2003)	3
CUL7	4	ACTN1	5	affinity chromatography technology	Hanson D (2014)	1
OBSL1	9	CSNK2A1	15	affinity chromatography technology	Hanson D (2014)	1
ARRB1	2	HSP90AA1	7	affinity chromatography technology	Xiao K (2007)	1
TINF2	1	TERF1	1	affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Stelzl U (2005), Kim SH (1999), Kim SH (1999), Giannone RJ (2010), Zhu Q (2009), Zhu Q (2009), Zhu Q (2009), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Tan R (2017)	18
TES	1	ACTN1	5	affinity chromatography technology	Sala S (2017)	1
RPA1	0	HNRNPL	3	affinity chromatography technology	Marechal A (2014)	1
CALM1	0	HSP90AA1	7	pull down	Ning YM (1995)	1
PRKACA	2	CALD1	2	enzymatic study	Hettasch JM (1991)	1
NTRK1	1	TMPO	0	affinity chromatography technology	Emdal KB (2015)	1
HSP90AA1	7	ACTN1	5	affinity chromatography technology	Falsone SF (2005)	1
TERF2	2	CALD1	2	affinity chromatography technology	Giannone RJ (2010)	1
POT1	2	TINF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Liu D (2004), Loayza D (2003), Loayza D (2003), Giannone RJ (2010), Liu D (2004), Liu D (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	14
NTRK1	1	KIF11	5	affinity chromatography technology	Emdal KB (2015)	1
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
CUL7	4	TMPO	0	affinity chromatography technology	Hanson D (2014)	1
CUL7	4	CSNK2A1	15	affinity chromatography technology	Hanson D (2014)	1
TERF1	1	CALD1	2	two hybrid	Lee OH (2011)	1
TP53	0	RPA2	0	affinity chromatography technology	Li X (2015)	1
PDHA1	7	RPA3	2	affinity chromatography technology	Malty RH (2017)	1
ARRB1	2	TMPO	0	affinity chromatography technology	Xiao K (2007)	1
GPSM2	2	CALD1	2	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	OTUB1	0	affinity chromatography technology	Emdal KB (2015)	1
CDH1	4	LIMA1	4	bioid	Guo Z (2014)	1
CUL7	4	HNRNPL	3	affinity chromatography technology	Hanson D (2014)	1
TACC3	1	CALD1	2	affinity chromatography technology	Hein MY (2015)	1
TERF2	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bhattacharyya S (2009), Bhattacharyya S (2009), Bhattacharyya S (2009)	3
LRCH3	2	CALD1	2	affinity chromatography technology	Couzens AL (2013)	1
PDHA1	7	TP53	0	affinity chromatography technology	Malty RH (2017)	1
NTRK1	1	SHC1	0	two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Qian X (1998), Borrello MG (1994), Nakamura T (2002), Meakin SO (1999), Koch A (2000), Emdal KB (2015), Emdal KB (2015)	7
TERF1	1	MYH9	19	affinity chromatography technology	Giannone RJ (2010)	1
MYO19	0	MYH9	19	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
TP53	0	LIMA1	4	affinity chromatography technology	Horikawa I (2014)	1
RPA1	0	MYH9	19	affinity chromatography technology	Marechal A (2014)	1
TERF2	2	MYH9	19	affinity chromatography technology	Giannone RJ (2010)	1
PAN2	3	CALD1	2	affinity chromatography technology	Bett JS (2013)	1
NTRK1	1	RPA1	0	affinity chromatography technology	Emdal KB (2015)	1
TP53	0	CALD1	2	affinity chromatography technology	Horikawa I (2014)	1
CDH1	4	TES	1	bioid	Guo Z (2014)	1
TMPO	0	MYH9	19	affinity chromatography technology	Brady GF (2018)	1
FIGNL1	2	CALD1	2	affinity chromatography technology	Hein MY (2015)	1
OBSL1	9	HNRNPL	3	affinity chromatography technology	Hanson D (2014)	1
PDHA1	7	LIMA1	4	affinity chromatography technology	Malty RH (2017)	1
LUZP4	2	ACTN1	5	affinity chromatography technology	Viphakone N (2015)	1
ISG15	0	CALD1	2	affinity chromatography technology	Zhao C (2005)	1
LIMA1	4	CALM1	0	affinity chromatography technology	Hein MY (2015)	1
MYO19	0	LIMA1	4	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
PAN2	3	HSP90AA1	7	affinity chromatography technology	Bett JS (2013)	1
PRKACA	2	HSP90AA1	7	affinity chromatography technology	Varjosalo M (2013)	1
HNRNPL	3	LRCH3	2	affinity chromatography technology	Fei T (2017)	1
NTRK1	1	MYH9	19	affinity chromatography technology	Emdal KB (2015)	1
PHAX	0	CALD1	2	biochemical	Kristensen AR (2012)	1
ISG15	0	HNRNPL	3	affinity chromatography technology	Zhao C (2005)	1
HSP90AA1	7	CALD1	2	affinity chromatography technology	Gano JJ (2010)	1
RPA1	0	TMPO	0	affinity chromatography technology	Marechal A (2014)	1
NEFM	0	CALD1	2	affinity chromatography technology	Hein MY (2015)	1
LUZP4	2	CALD1	2	affinity chromatography technology	Viphakone N (2015)	1
NTRK1	1	ACTN1	5	affinity chromatography technology	Emdal KB (2015)	1
CSNK2A1	15	TMPO	0	enzymatic study	Zhang M (2011)	1
ISG15	0	HSP90AA1	7	affinity chromatography technology	Zhao C (2005)	1
LUZP4	2	LIMA1	4	affinity chromatography technology	Viphakone N (2015)	1
POT1	2	ARRB1	2	two hybrid	Lee OH (2011)	1
RPA1	0	TERF2	2	affinity chromatography technology	Marechal A (2014)	1
RPA2	0	MYH9	19	affinity chromatography technology	Marechal A (2014)	1
LIMA1	4	CALD1	2	affinity chromatography technology	Hein MY (2015)	1
HSP90AA1	7	MYH9	19	affinity chromatography technology	Falsone SF (2005)	1
RPA3	2	HNRNPL	3	affinity chromatography technology	Marechal A (2014)	1
PAN2	3	KIF11	5	affinity chromatography technology	Bett JS (2013)	1
RPA2	0	TERF2	2	affinity chromatography technology	Marechal A (2014)	1
ISG15	0	ACTN1	5	affinity chromatography technology	Zhao C (2005)	1
MYH9	19	CALM1	0	affinity chromatography technology	Hein MY (2015)	1
RPA2	0	CALD1	2	affinity chromatography technology	Marechal A (2014)	1
EPB41L2	2	CALD1	2	biochemical	Kristensen AR (2012)	1
CDH1	4	TMPO	0	bioid	Guo Z (2014)	1
CUL7	4	LIMA1	4	affinity chromatography technology	Hanson D (2014)	1
MYO19	0	ACTN1	5	affinity chromatography technology	Hein MY (2015)	1
ISG15	0	CSNK2A1	15	affinity chromatography technology	Zhao C (2005)	1
PAN2	3	RPA1	0	affinity chromatography technology	Bett JS (2013)	1
TP53	0	CUL7	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Andrews P (2006), Andrews P (2006), Andrews P (2006), Dowell JD (2007), Dowell JD (2007), Dowell JD (2007), Skaar JR (2007), Skaar JR (2007), Kim SS (2007), Kim SS (2007), Kim SS (2007), Kaustov L (2007), Kasper JS (2006), Kasper JS (2006), Kasper JS (2006), Fogeron ML (2013), Hanson D (2014), Hanson D (2014), Huttlin EL (2015), Li X (2015), Huttlin EL (2017), Guo H (2014)	22
TACC3	1	KIF11	5	affinity chromatography technology	Hein MY (2015)	1
TERF2	2	ACTN1	5	affinity chromatography technology	Giannone RJ (2010)	1
CUL7	4	RPA1	0	affinity chromatography technology	Hanson D (2014)	1
TM9SF4	2	CALD1	2	affinity chromatography technology	Hein MY (2015)	1
CSNK2A1	15	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study	Uhle S (2003), Fogeron ML (2013), Bhansali M (2014), Chen TC (2014), Walerych D (2004), Walerych D (2004)	6
NTRK1	1	FIGNL1	2	affinity chromatography technology	Emdal KB (2015)	1
LUZP4	2	RPA1	0	affinity chromatography technology	Viphakone N (2015)	1
HNRNPL	3	CALD1	2	affinity chromatography technology	Fei T (2017)	1
CSNK2A1	15	HNRNPL	3	enzymatic study	Zhang M (2011)	1
HNRNPL	3	PDHA1	7	biochemical	Wan C (2015)	1
TES	1	PDHA1	7	affinity chromatography technology	Sala S (2017)	1
TMPO	0	HNRNPL	3	affinity chromatography technology	Brady GF (2018)	1
NTRK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rao R (2010), Taipale M (2012), Emdal KB (2015)	3
PAN2	3	RPA2	0	affinity chromatography technology	Bett JS (2013)	1
OBSL1	9	ACTN1	5	affinity chromatography technology	Hanson D (2014)	1
PAN2	3	TP53	0	affinity chromatography technology	Bett JS (2013)	1
TERF1	1	ACTN1	5	affinity chromatography technology	Giannone RJ (2010)	1
LIMA1	4	TES	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Sala S (2017)	2
ISG15	0	MYH9	19	affinity chromatography technology	Zhao C (2005)	1
CALD1	2	CSNK2A1	15	biochemical	Kristensen AR (2012)	1
TERF2	2	POT1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Giannone RJ (2010), Giannone RJ (2010), Liu D (2004), Liu D (2004), Liu D (2004), Hein MY (2015), Huttlin EL (2017)	7
PAN2	3	LIMA1	4	affinity chromatography technology	Bett JS (2013)	1
OBSL1	9	LIMA1	4	affinity chromatography technology	Hanson D (2014)	1
RPA3	2	RPA1	0	biochemical, x-ray crystallography, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Du Y (2009), Wan C (2015), Hein MY (2015), Elia AE (2015)	8
RPA2	0	LIMA1	4	affinity chromatography technology	Marechal A (2014)	1
LUZP4	2	CALM1	0	affinity chromatography technology	Viphakone N (2015)	1
KIF11	5	CALD1	2	affinity chromatography technology	Hein MY (2015)	1
PDHA1	7	TMPO	0	affinity chromatography technology	Malty RH (2017)	1
CALD1	2	CALM1	0	pull down, pull down	Graether SP (1997), Graether SP (1997)	2
PDHA1	7	RPA1	0	affinity chromatography technology	Malty RH (2017)	1
TES	1	CALD1	2	affinity chromatography technology	Sala S (2017)	1
OBSL1	9	TMPO	0	affinity chromatography technology	Hanson D (2014)	1
NTRK1	1	PDHA1	7	affinity chromatography technology	Emdal KB (2015)	1
POT1	2	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loayza D (2003), Giannone RJ (2010), Giannone RJ (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
HNRNPL	3	TM9SF4	2	affinity chromatography technology	Fei T (2017)	1
CSNK2A1	15	OTUB1	0	enzymatic study	Herhaus L (2015)	1
TINF2	1	TERF2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, far western blotting, imaging technique, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Giannone RJ (2010), Liu D (2004), Liu D (2004), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Her YR (2013), Her YR (2013), Hein MY (2015), Huttlin EL (2017)	15
CDH1	4	ACTN1	5	affinity chromatography technology	Hazan RB (1998)	1
NTRK1	1	CSNK2A1	15	affinity chromatography technology	Emdal KB (2015)	1
OBSL1	9	CALD1	2	affinity chromatography technology	Hanson D (2014)	1
TERF2	2	TERF1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Giannone RJ (2010), Ye JZ (2004), Ye JZ (2004)	3
CDH1	4	HSP90AA1	7	affinity chromatography technology	Catimel B (2005)	1
RPA3	2	TMPO	0	affinity chromatography technology	Marechal A (2014)	1
TP53	0	OTUB1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Sun XX (2011), Sun XX (2011), Sun XX (2011), Li Y (2014), Fernandez-Majada V (2016)	5
ARRB1	2	CSNK2A1	15	affinity chromatography technology	Ewing RM (2007)	1
OTUB1	0	CALD1	2	affinity chromatography technology	Scholz CC (2016)	1
CDH1	4	CALD1	2	bioid	Guo Z (2014)	1
CDH1	4	MYH9	19	bioid	Guo Z (2014)	1
PAN2	3	CALM1	0	affinity chromatography technology	Bett JS (2013)	1
PDHA1	7	CALM1	0	affinity chromatography technology	Malty RH (2017)	1
PDHA1	7	NEFM	0	affinity chromatography technology	Malty RH (2017)	1
LRCH3	2	LIMA1	4	affinity chromatography technology	Couzens AL (2013)	1
RPA2	0	HNRNPL	3	affinity chromatography technology	Marechal A (2014)	1
RPA1	0	CALD1	2	affinity chromatography technology	Marechal A (2014)	1
PAN2	3	LRCH3	2	affinity chromatography technology	Bett JS (2013)	1
HSP90AA1	7	CSNK2A1	15	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Miyata Y (1995), Muller P (2012), Zhang M (2011), Woo SH (2009)	4
RPA1	0	LIMA1	4	affinity chromatography technology	Marechal A (2014)	1
RPA3	2	MYH9	19	affinity chromatography technology	Marechal A (2014)	1
TINF2	1	CALD1	2	two hybrid	Lee OH (2011)	1
OBSL1	9	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litterman N (2011), Litterman N (2011), Hanson D (2011), Hanson D (2011), Nie J (2015)	5
NTRK1	1	CALD1	2	affinity chromatography technology	Emdal KB (2015)	1
MYH9	19	CSNK2A1	15	affinity chromatography technology, enzymatic study	Kohlstedt K (2006), Kohlstedt K (2006)	2
MYH9	19	CALD1	2	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	TACC3	1	affinity chromatography technology	Emdal KB (2015)	1
POT1	2	CALD1	2	affinity chromatography technology, two hybrid	Giannone RJ (2010), Lee OH (2011)	2
LUZP4	2	CSNK2A1	15	affinity chromatography technology	Viphakone N (2015)	1
TMPO	0	CALD1	2	affinity chromatography technology	Brady GF (2018)	1
ARRB1	2	LIMA1	4	affinity chromatography technology	Xiao K (2007)	1
CUL7	4	CALD1	2	affinity chromatography technology	Hanson D (2014)	1
RPA3	2	LIMA1	4	affinity chromatography technology	Marechal A (2014)	1
TP53	0	MYH9	19	affinity chromatography technology	Horikawa I (2014)	1