PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NTRK1	1	WWP2	7	affinity chromatography technology	Emdal KB (2015)	1
UHRF2	1	FBXL18	5	affinity chromatography technology	Lai M (2016)	1
FBXL18	5	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
HSP90AA1	7	SKP1	0	pull down	Zhang M (2008)	1
CUL1	7	EZH2	4	affinity chromatography technology	Sahasrabuddhe AA (2014)	1
TRAF1	0	SKP1	0	affinity chromatography technology	Greenfeld H (2015)	1
FBXL16	4	FBXL18	5	affinity chromatography technology	Huttlin EL (2017)	1
FBXL18	5	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
SKP1	0	PSMA3	1	affinity chromatography technology	Hauri S (2016)	1
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
NEDD4	2	SKP1	0	affinity chromatography technology	Liu J (2014)	1
FBXL18	5	MDFI	1	two hybrid, two hybrid	Venkatesan K (2009), Rolland T (2014)	2
TRAF4	1	WWP2	7	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CUL1	7	PSMA3	1	affinity chromatography technology	Bennett EJ (2010)	1
FHL3	0	MTUS2	4	two hybrid	Yu H (2011)	1
PLSCR1	0	FBXL18	5	two hybrid	Rual JF (2005)	1
TRAF1	0	CUL1	7	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	COPS5	0	affinity chromatography technology	Emdal KB (2015)	1
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
CHMP1A	3	FBXL18	5	biochemical	Havugimana PC (2012)	1
CUL1	7	HNRNPK	4	affinity chromatography technology	Bennett EJ (2010)	1
TRAF4	1	FBXL18	5	two hybrid	Rolland T (2014)	1
TRIM25	5	SKP2	2	affinity chromatography technology	Choudhury NR (2017)	1
FBXL7	0	FBXL18	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Liu Y (2015), Liu Y (2015), Liu Y (2015), Liu Y (2015)	4
TRAF1	0	FBXL18	5	two hybrid	Rolland T (2014)	1
COPS6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Reitsma JM (2017)	7
WWP2	7	FBXL18	5	two hybrid	Rolland T (2014)	1
COPS5	0	FBXL18	5	affinity chromatography technology	Bennett EJ (2010)	1
PLSCR1	0	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
LYPD4	1	FBXL18	5	affinity chromatography technology	Huttlin EL (2017)	1
SKP2	2	FBXL18	5	affinity chromatography technology	Huttlin EL (2017)	1
FBXL7	0	CUL1	7	affinity chromatography technology	Liu Y (2015)	1
TRAF4	1	CALCOCO2	0	two hybrid	Rozan LM (2006)	1
NTRK1	1	PSMA3	1	affinity chromatography technology	Emdal KB (2015)	1
UHRF2	1	SKP1	0	far western blotting	Mori T (2011)	1
HSP90AA1	7	SKP2	2	affinity chromatography technology	Taipale M (2012)	1
PSTPIP1	3	FBXL18	5	two hybrid	Rolland T (2014)	1
TBL1Y	0	FBXL18	5	affinity chromatography technology	Huttlin EL (2017)	1
EZH2	4	WWP1	3	affinity chromatography technology	Cao Q (2014)	1
EZH2	4	FBXL18	5	affinity chromatography technology	Cao Q (2014)	1
PSMA3	1	FBXL18	5	two hybrid	Rolland T (2014)	1
TRAF4	1	WWP1	3	two hybrid	Rolland T (2014)	1
MID2	1	FBXL18	5	two hybrid	Rolland T (2014)	1
TRIM25	5	PSMA3	1	affinity chromatography technology	Choudhury NR (2017)	1
RBPMS	0	FBXL18	5	two hybrid	Rolland T (2014)	1
SKP2	2	SKP1	0	affinity chromatography technology, pull down, pull down, two hybrid, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Strack P (2000), Ng RW (1998), Ng RW (1998), Schulman BA (2000), Cenciarelli C (1999), Marti A (1999), Sabile A (2006), Ji P (2004), Wang W (2004), Tokarz S (2004), Watanabe N (2004), Lin HK (2009), Lin HK (2009), Lin HK (2009), Price CT (2009), Huang Z (2004), Wu J (2012), Bashir T (2010), Saiga T (2009), Li T (2005), Carrano AC (1999), Wu J (2012), Wu L (2012), Rodier G (2008), Swarnalatha M (2013), Yumimoto K (2013), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Tian X (2015), Liu YQ (2015), Kuchay S (2017), Chan CH (2013), Chan CH (2013), Hauri S (2016), Ma X (2017)	37
COPS6	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
FBXL18	5	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
HNRNPK	4	FBXL18	5	two hybrid	Rolland T (2014)	1
MAGEA1	0	FBXL18	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
FHL3	0	FBXL18	5	two hybrid	Rolland T (2014)	1
IRGC	1	FBXL18	5	affinity chromatography technology	Huttlin EL (2017)	1
CUL1	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
FBXL18	5	GNA11	2	affinity chromatography technology	Huttlin EL (2015)	1
NTRK1	1	CUL1	7	affinity chromatography technology	Emdal KB (2015)	1
FBXL18	5	KRT40	0	two hybrid	Rolland T (2014)	1
COPS6	0	FBXL18	5	affinity chromatography technology	Bennett EJ (2010)	1
NEDD4	2	HNRNPK	4	pull down	Ingham RJ (2005)	1
COPS5	0	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
EZH2	4	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
TRIM25	5	NOTCH2NL	1	affinity chromatography technology	Choudhury NR (2017)	1
CUL1	7	WWP2	7	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	COPS6	0	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	FBXL18	5	affinity chromatography technology	Choudhury NR (2017)	1
WWP2	7	HNRNPK	4	affinity chromatography technology	Chaudhary N (2014)	1
FBXL7	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koyama-Nasu R (2007), Watanabe N (2004), Liu Y (2015), Kuchay S (2017)	4
TRAF4	1	KRT40	0	two hybrid	Rolland T (2014)	1
FBXL18	5	NEDD4	2	affinity chromatography technology	Liu J (2014)	1
PLSCR1	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
EZH2	4	WWP2	7	affinity chromatography technology	Cao Q (2014)	1
COPS5	0	SKP2	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
NTRK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rao R (2010), Taipale M (2012), Emdal KB (2015)	3
GOLGA2	2	FBXL18	5	two hybrid	Rolland T (2014)	1
NEDD4	2	NTRK1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Arevalo JC (2006), Arevalo JC (2006), Arevalo JC (2006), Georgieva MV (2011), Georgieva MV (2011), Persaud A (2009), Persaud A (2009), Emdal KB (2015)	8
COPS5	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Fang L (2008), Sharon M (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Choi HH (2011), Kristensen AR (2012), Birol M (2014), Birol M (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	18
KRTAP10-3	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
NTRK1	1	GOLGA2	2	affinity chromatography technology	Emdal KB (2015)	1
CALCOCO2	0	MID2	1	two hybrid	Rolland T (2014)	1
SKP1	0	FBXL18	5	affinity chromatography technology	Hauri S (2016)	1
HSP90AA1	7	WWP1	3	affinity chromatography technology	Taipale M (2012)	1
PSMA3	1	HSP90AA1	7	affinity chromatography technology	Fedorova OA (2011)	1
WWP1	3	FBXL18	5	two hybrid	Rolland T (2014)	1
HSP90AA1	7	FBXL18	5	affinity chromatography technology	Taipale M (2012)	1
KRTAP4-12	2	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
FBXL18	5	ACSF3	2	affinity chromatography technology	Tan MK (2013)	1
CALCOCO2	0	FBXL18	5	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
CUL1	7	FBXL18	5	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Reitsma JM (2017)	2
GOLGA2	2	MID2	1	two hybrid	Rolland T (2014)	1
COPS5	0	HNRNPK	4	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
PNMA1	0	FBXL18	5	two hybrid	Rolland T (2014)	1
NTRK1	1	FBXL18	5	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	GNA11	2	affinity chromatography technology	Choudhury NR (2017)	1
MTUS2	4	FBXL18	5	two hybrid	Rolland T (2014)	1
NEDD4	2	CUL1	7	affinity chromatography technology	Liu J (2014)	1
TFCP2	1	FBXL18	5	two hybrid	Rolland T (2014)	1
SKP2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2003), Min KW (2003), Lisztwan J (1998), Lisztwan J (1998), Marti A (1999), Zheng N (2002), Menon S (2008), Chew EH (2007), Chew EH (2007), Ji P (2006), Sabile A (2006), Tan P (1999), Lin HK (2009), Nie L (2011), Chua YS (2011), Huang Z (2004), Wu J (2012), Koyama-Nasu R (2007), Bashir T (2010), Saiga T (2009), Choo YY (2011), Jonason JH (2007), Jonason JH (2007), Bennett EJ (2010), Michel JJ (1998), Carrano AC (1999), Lyapina SA (1998), Lyapina SA (1998), Wu J (2012), Yu ZK (1998), Yu ZK (1998), Rodier G (2008), Swarnalatha M (2013), Cordero-Espinoza L (2013), Yumimoto K (2013), Chung FZ (2014), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Zhang S (2016), Zhang S (2016), Huttlin EL (2017), Kuchay S (2017), Reitsma JM (2017), Reitsma JM (2017), Ma X (2017)	46
COPS6	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
MOCS3	0	FBXL18	5	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	HNRNPK	4	affinity chromatography technology	Emdal KB (2015)	1
KRTAP4-12	2	NOTCH2NL	1	two hybrid	Rolland T (2014)	1