PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDC5L	2	AURKB	2	affinity chromatography technology	Lleres D (2010)	1
YWHAQ	0	TSC2	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical	Ewing RM (2007), Pozuelo-Rubio M (2010), Meek SE (2004), Pozuelo-Rubio M (2010), Pozuelo-Rubio M (2010)	5
YWHAQ	0	IQGAP1	1	pull down	Meek SE (2004)	1
UBE3A	4	CALM1	0	affinity chromatography technology, pull down	Jung SY (2005), Kapoor I (2015)	2
EGFR	5	TRPV1	1	affinity chromatography technology, pull down	Bode AM (2009), Bode AM (2009)	2
CALM1	0	GRB7	1	affinity chromatography technology, pull down, fluorescent resonance energy transfe	Li H (2005), Li H (2005), Li H (2005)	3
SLC9A1	10	CALM1	0	far western blotting, affinity chromatography technology	Li X (2003), Garnovskaya MN (2003)	2
NOS3	7	CALM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, unspecified method, x-ray crystallography	Jung SB (2010), Jung SB (2010), Fleming I (2001), Chen PF (2009), Chen PF (2009), Piazza M (2012)	6
CSNK2A1	15	SNCA	0	enzymatic study, enzymatic study	Payton JE (2004), Okochi M (2000)	2
TRIM13	1	CALM1	0	affinity chromatography technology, affinity chromatography technology	Lerner M (2007), Lerner M (2007)	2
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
CALM1	0	AKT1	1	pull down, affinity chromatography technology	Shen X (2005), Shen X (2005)	2
CALM1	0	SNCA	0	pull down, affinity chromatography technology	Lee D (2002), Martinez J (2003)	2
AKT1	1	AR	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin HK (2001), Lin HK (2001), Deep G (2008), Deep G (2008), Steely AM (2017)	5
SYK	3	CALM1	0	enzymatic study, enzymatic study	Brunati AM (1988), Meggio F (1987)	2
SCN5A	9	CALM1	0	two hybrid, unspecified method, x-ray crystallography, two hybrid	Tan HL (2002), Tan HL (2002), Chagot B (2011), Young KA (2005)	4
CALM1	0	AR	3	affinity chromatography technology, pull down, imaging technique	Cifuentes E (2004), Cifuentes E (2004), Cifuentes E (2004)	3
UBE3A	4	YWHAE	0	two hybrid	Vinayagam A (2011)	1
AURKB	2	DDX5	2	affinity chromatography technology	Fogeron ML (2013)	1
CSNK2A1	15	CALM1	0	enzymatic study, pull down, enzymatic study	Meggio F (1987), Benitez MJ (2001), Llorens F (2003)	3
FKBP8	1	CALM1	0	pull down, affinity chromatography technology, pull down, pull down, pull down, x-ray crystallography	Edlich F (2007), Edlich F (2005), Edlich F (2005), Edlich F (2005), Edlich F (2007), Edlich F (2007)	6
YWHAQ	0	AR	3	pull down	Zilliacus J (2001)	1
ARHGEF7	3	CBL	7	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Flanders JA (2003), Flanders JA (2003), Schmidt MH (2006), Schmidt MH (2006), Schmidt MH (2006), Wu WJ (2003), Singh VK (2012), Singh VK (2012), Chang CC (2012)	9
CALM1	0	DDX5	2	pull down, affinity chromatography technology	Shen X (2005), Jang DJ (2007)	2
SNCA	0	AKT1	1	affinity chromatography technology, far western blotting	Chung JY (2011), Chung JY (2011)	2
CALM1	0	AURKB	2	affinity chromatography technology, affinity chromatography technology	Mallampalli RK (2013), Mallampalli RK (2013)	2
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
AKAP9	13	CALM1	0	affinity chromatography technology, pull down	Takahashi M (2002), Takahashi M (2002)	2
CSNK2A1	15	AKT1	1	enzymatic study	Di Maira G (2005)	1
CSNK2B	5	RRAD	2	enzymatic study	Moyers JS (1998)	1
EGFR	5	SNCA	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
EGFR	5	RRAD	2	affinity chromatography technology, pull down, affinity chromatography technology	Yeom SY (2014), Yeom SY (2014), Yao Z (2017)	3
YWHAE	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Subramanian RR (2001), Taipale M (2014), Taipale M (2014)	3
IQGAP1	1	AKT1	1	affinity chromatography technology	Tekletsadik YK (2012)	1
CALM1	0	GEM	1	unspecified method, pull down	Fischer R (1996), Fischer R (1996)	2
EGFR	5	ARHGEF7	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
TRPV1	1	CBL	7	affinity chromatography technology	Bode AM (2009)	1
YWHAQ	0	CBL	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Pedraza-Alva G (2001), Liu YC (1996), Liu YC (1996), Melander F (2004), Subramanian RR (2001), Liu YC (1997), Liu YC (1997), Brehme M (2009)	8
GP6	0	CALM1	0	affinity chromatography technology, affinity chromatography technology	Locke D (2003), Arthur JF (2011)	2
TSC2	17	CALM1	0	far western blotting, pull down, unspecified method, pull down	Noonan DJ (2002), Noonan DJ (2002), Noonan DJ (2002), York B (2005)	4
TSC2	17	AKT1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dan HC (2002), Roux PP (2004), Dan HC (2002), Dan HC (2002)	4
AKT1	1	TRIM13	1	affinity chromatography technology, enzymatic study	Joo HM (2011), Joo HM (2011)	2
RYR1	18	CALM1	0	far western blotting, fluorescent resonance energy transfe	Yamaguchi N (2001), Boschek CB (2008)	2
H2AFX	1	YWHAE	0	affinity chromatography technology	Yang X (2010)	1
NOS2	6	YWHAE	0	affinity chromatography technology	Foster MW (2013)	1
NOS3	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Brouet A (2001), Brouet A (2001), Dimmeler S (1999), Chen TC (2014)	4
CSNK2B	5	CALM1	0	pull down, enzymatic study	Benitez MJ (2001), Llorens F (2003)	2
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
CDC5L	2	YWHAQ	0	two hybrid	Camargo LM (2007)	1
EGFR	5	DDX5	2	affinity chromatography technology	Yao Z (2017)	1
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
HYPK	2	CALM1	0	affinity chromatography technology, affinity chromatography technology	Choudhury KR (2012), Choudhury KR (2012)	2
EGFR	5	YWHAQ	0	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CNN1	1	CALM1	0	pull down, biochemical	Winder SJ (1990), Takahashi K (1988)	2
CSNK2A1	15	H2AFX	1	imaging technique, affinity chromatography technology, enzymatic study	Olsen BB (2012), Basnet H (2014), Basnet H (2014)	3
EGFR	5	SEC61A1	1	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Wang YN (2010)	2
SLC9A1	10	AKT1	1	affinity chromatography technology	Amith SR (2017)	1
CDC5L	2	AKAP9	13	two hybrid	Camargo LM (2007)	1
MYC	2	YWHAQ	0	affinity chromatography technology	Koch HB (2007)	1
CBL	7	SYK	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Lupher ML (1998), Lupher ML (1998), Bertagnolo V (2001), Melander F (2003), Macglashan D (2004), Rao N (2001), Rao N (2001), Yankee TM (1999), Saci A (2000), Moon KD (2005), Lottin-Divoux S (2006), Grossmann AH (2004), Ota S (2000), Ota S (2000), Panchamoorthy G (1996), Marcilla A (1995), Justa-Schuch D (2016)	17
CSNK2A1	15	RRAD	2	enzymatic study	Moyers JS (1998)	1
YWHAE	0	TSC2	17	affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Choudhary C (2009)	2
MYLK	3	CALM1	0	pull down, x-ray crystallography	Toeroek K (1994), Meador WE (1992)	2
TRPV1	1	CALM1	0	affinity chromatography technology, pull down	Numazaki M (2003), Numazaki M (2003)	2
CALM1	0	CDC5L	2	pull down, affinity chromatography technology	Shen X (2005), Shen X (2005)	2
RALA	1	TSC2	17	affinity chromatography technology	Castro AF (2003)	1
KCNN4	0	CALM1	0	two hybrid, pull down, biochemical	Fanger CM (1999), Fanger CM (1999), Fanger CM (1999)	3
DAPK1	6	DDX5	2	affinity chromatography technology	So J (2015)	1
SEC61A1	1	CALM1	0	unspecified method, pull down	Erdmann F (2011), Erdmann F (2011)	2
CALM1	0	RRAD	2	pull down, pull down	Moyers JS (1998), Fischer R (1996)	2
CDC5L	2	DDX5	2	affinity chromatography technology	Lleres D (2010)	1
NOS2	6	YWHAQ	0	affinity chromatography technology	Foster MW (2013)	1
CALM1	0	RALA	1	pull down, two hybrid, pull down	Clough RR (2002), Clough RR (2002), Sidhu RS (2005)	3
DAPK1	6	TSC2	17	affinity chromatography technology	Lin Y (2011)	1
H2AFX	1	CALM1	0	affinity chromatography technology, two hybrid	Du YC (2006), Du YC (2006)	2
CALM1	0	IQGAP1	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Z (2003), Briggs MW (2002), Ren JG (2008), Hein MY (2015), Boldt K (2016)	5
CALD1	2	CSNK2A1	15	biochemical	Kristensen AR (2012)	1
CDC5L	2	IQGAP1	1	affinity chromatography technology	Lleres D (2010)	1
CALD1	2	CALM1	0	pull down, pull down	Graether SP (1997), Graether SP (1997)	2
AKT1	1	YWHAE	0	affinity chromatography technology	Klein JB (2005)	1
CALM1	0	PPEF2	0	pull down, two hybrid	Kutuzov MA (2002), Kutuzov MA (2002)	2
KRAS	1	EGFR	5	genetic interference	Hart T (2015)	1
CALM1	0	RYR2	26	pull down, affinity chromatography technology	Nyegaard M (2012), Vassilakopoulou V (2015)	2
UBE3A	4	TSC2	17	pull down, affinity chromatography technology, pull down	Lu Z (2004), Zheng L (2008), Zheng L (2008)	3
CALM1	0	NOS2	6	unspecified method, affinity chromatography technology, x-ray crystallography	Chen PF (2009), Foster MW (2013), Piazza M (2012)	3
AKT1	1	DDX5	2	affinity chromatography technology, affinity chromatography technology	Zhu QS (2011), Zhu QS (2011)	2
CBL	7	IQGAP1	1	affinity chromatography technology	Brehme M (2009)	1
CALM1	0	PPEF1	1	pull down, two hybrid	Kutuzov MA (2002), Kutuzov MA (2002)	2
MYC	2	YWHAE	0	affinity chromatography technology	Koch HB (2007)	1
H2AFX	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Dittmann K (2011), Yao Z (2017)	2
CDC5L	2	YWHAE	0	affinity chromatography technology	Lleres D (2010)	1
UBE3A	4	AR	3	affinity chromatography technology, enzymatic study	Khan OY (2006), McClurg UL (2016)	2
CALM1	0	CBL	7	affinity chromatography technology, affinity chromatography technology	Singh VK (2012), Singh VK (2012)	2
YWHAQ	0	DAPK1	6	affinity chromatography technology	Henshall DC (2003)	1
YWHAQ	0	H2AFX	1	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
CSNK2A1	15	MYC	2	enzymatic study	Channavajhala P (2002)	1
EGFR	5	CALM1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, pull down	Li H (2004), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Aifa S (2002)	5
CALM1	0	RALB	0	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Clough RR (2002), Clough RR (2002), Clough RR (2002), Clough RR (2002)	4
MYC	2	CALM1	0	affinity chromatography technology, pull down	Agrawal P (2010), Raffeiner P (2017)	2
EGFR	5	SYK	3	unspecified method	Jones RB (2006)	1
MYC	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAQ	0	SNCA	0	affinity chromatography technology	Watabe M (2004)	1
YWHAE	0	CALM1	0	two hybrid, pull down	Luk SC (1999), Luk SC (1999)	2
EGFR	5	AR	3	affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Bonaccorsi L (2004), Bonaccorsi L (2004), Bonaccorsi L (2004), Bonaccorsi L (2004)	4
CALM1	0	KRAS	1	affinity chromatography technology, pull down, pull down, two hybrid	Villalonga P (2001), Villalonga P (2001), Sidhu RS (2003), Sidhu RS (2003)	4
RYR1	18	RYR2	26	affinity chromatography technology	Xiao B (2002)	1
MYC	2	MYLK	3	genetic interference	Toyoshima M (2012)	1
CALM1	0	DAPK1	6	affinity chromatography technology, x-ray crystallography, pull down	Henshall DC (2004), de Diego I (2010), de Diego I (2010)	3
TRPV6	0	CALM1	0	pull down, unspecified method	Niemeyer BA (2001), Niemeyer BA (2001)	2
EGFR	5	FKBP8	1	protein complementation assay	Deribe YL (2009)	1
CCP110	6	CALM1	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tsang WY (2006), Tsang WY (2006), Tsang WY (2006), Tsang WY (2006), Boldt K (2016)	5
EGFR	5	IQGAP1	1	affinity chromatography technology	Casar B (2009)	1
YWHAQ	0	CALM1	0	affinity chromatography technology, pull down, biochemical	Pozuelo-Rubio M (2010), Meek SE (2004), Pozuelo-Rubio M (2010)	3
EGFR	5	CSNK2A1	15	affinity chromatography technology	Tong J (2014)	1
ARHGEF7	3	CALM1	0	affinity chromatography technology, pull down, affinity chromatography technology	Singh VK (2012), Singh VK (2012), Singh VK (2012)	3
CALM1	0	MIP	1	unspecified method, pull down	Peracchia C (1989), Girsch SJ (1991)	2