PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TMED9	0	TMED1	2	biochemical	Dominguez M (1998)	1
CDK5RAP3	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Kwon J (2010), Wu J (2010)	2
SRPRB	0	CDK5RAP3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK5RAP3	0	TMED4	0	affinity chromatography technology	Huttlin EL (2017)	1
TUBG1	2	MRPS7	0	affinity chromatography technology	Fogeron ML (2013)	1
MDM2	2	RPS3	0	pull down, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Yadavilli S (2009), Yadavilli S (2009), Yadavilli S (2009), Yadavilli S (2009)	4
CDK5RAP3	0	ESS2	0	two hybrid	Wang J (2011)	1
CDKN2A	1	HSPA8	4	pull down	Souza-Rodrigues E (2007)	1
CDK5RAP3	0	NPM1	0	affinity chromatography technology	Kwon J (2010)	1
SRPRB	0	TMED4	0	biochemical	Havugimana PC (2012)	1
CDK5RAP3	0	TUBG1	2	affinity chromatography technology, affinity chromatography technology, biochemical	Horejsi B (2012), Horejsi B (2012), Horejsi B (2012)	3
KHK	2	CDK5RAP3	0	affinity chromatography technology	Ewing RM (2007)	1
CDKN2A	1	NPM1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Enomoto T (2006), Enomoto T (2006), Chen D (2005), Chen D (2005), Haindl M (2008), Itahana K (2003), Itahana K (2003), Chio II (2012), Herkert B (2010), Lo D (2014), Wang L (2015), Enomoto T (2006)	12
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
CDK5RAP3	0	RPS3	0	affinity chromatography technology	Kwon J (2010)	1
MME	3	CDK5RAP3	0	affinity chromatography technology	DallEra MA (2007)	1
HUWE1	22	KPNA2	0	affinity chromatography technology	Thompson JW (2014)	1
DISC1	6	CDK5RAP3	0	two hybrid	Camargo LM (2007)	1
NPM1	0	HSPA4	3	affinity chromatography technology	Chen R (2013)	1
ESS2	0	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
CDK5RAP3	0	CDH4	0	affinity chromatography technology, affinity chromatography technology, biochemical	Wu J (2010), Wu J (2010), Wu J (2010)	3
UBC	7	NPM1	0	affinity chromatography technology, pull down	Matsumoto M (2005), Koike A (2010)	2
HSPB1	2	HSPA4	3	two hybrid	Katsogiannou M (2014)	1
TUBG1	2	HSPA4	3	biochemical	Wigley WC (1999)	1
CD274	2	CDK5RAP3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FKBP6	1	CDK5RAP3	0	two hybrid	Rolland T (2014)	1
CDK5RAP3	0	DDRGK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Wu J (2010), Wu J (2010), Huttlin EL (2015), Huttlin EL (2017)	5
RPL10A	0	RPS3	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CDK5RAP3	0	UFL1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Kwon J (2010), Kwon J (2010), Kwon J (2010), Huttlin EL (2017)	5
HUWE1	22	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Bewley MA (2011), Thompson JW (2014)	2
NPM1	0	TAB1	1	affinity chromatography technology	Chen R (2013)	1
TUBG1	2	HSPA8	4	affinity chromatography technology	Fogeron ML (2013)	1
NPM1	0	HSPB1	2	affinity chromatography technology	Chen R (2013)	1
MDM2	2	NPM1	0	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Kurki S (2004), Kurki S (2004), Nicholson J (2012), Nicholson J (2012)	4
CDK5RAP3	0	3514	0	affinity chromatography technology	Ewing RM (2007)	1
HUWE1	22	RPS3	0	affinity chromatography technology	Thompson JW (2014)	1
TUBG1	2	RPS3	0	affinity chromatography technology	Fogeron ML (2013)	1
UBC	7	TAB1	1	pull down	Zhang X (2017)	1
CDK5RAP3	0	HUWE1	22	affinity chromatography technology	Kwon J (2010)	1
CDKN2A	1	CDK5RAP3	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang J (2006), Wang J (2006), Wang J (2006), Han M (2012)	4
TMEM206	5	CDK5RAP3	0	affinity chromatography technology	Huttlin EL (2017)	1
DDRGK1	1	UFL1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSPA8	4	UBC	7	two hybrid	Stelzl U (2005)	1
HUWE1	22	NPM1	0	affinity chromatography technology	Thompson JW (2014)	1
CDK5RAP3	0	HSPA8	4	affinity chromatography technology	Kwon J (2010)	1
TAB1	1	MDM2	2	affinity chromatography technology	Zhu Y (2013)	1
SRPRB	0	DDRGK1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MME	3	HSPA4	3	affinity chromatography technology, affinity chromatography technology	DallEra MA (2007), DallEra MA (2007)	2
UFC1	0	UFM1	0	affinity chromatography technology, biochemical, pull down, biochemical	Komatsu M (2004), Havugimana PC (2012), Gavin JM (2014), Wan C (2015)	4
RPL10A	0	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
UBC	7	SRPRB	0	pull down	Zhang X (2017)	1
TPTE2	3	CDK5RAP3	0	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	MRPS7	0	affinity chromatography technology	Matsumoto M (2005)	1
CDK5RAP3	0	KPNA2	0	two hybrid	Wang J (2011)	1
CRMP1	0	HSPA4	3	biochemical	Kristensen AR (2012)	1
CDK5RAP3	0	PLD2	1	affinity chromatography technology	Huttlin EL (2017)	1
HUWE1	22	RPL10A	0	affinity chromatography technology	Thompson JW (2014)	1
CDK5RAP3	0	CRMP1	0	two hybrid	Stelzl U (2005)	1
RPS3	0	HSPA4	3	affinity chromatography technology	Kim TS (2006)	1
TUBG1	2	RPL10A	0	affinity chromatography technology	Fogeron ML (2013)	1
HSPA4	3	HSPA8	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Hidalgo-de-Quintana J (2008), Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Wan C (2015)	5
CDK5RAP3	0	TMED9	0	affinity chromatography technology	Huttlin EL (2017)	1
CDKN2A	1	HSPA4	3	pull down	Souza-Rodrigues E (2007)	1
MME	3	HSPB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	DallEra MA (2007), DallEra MA (2007), DallEra MA (2007)	3
HUWE1	22	HSPB1	2	affinity chromatography technology, two hybrid, affinity chromatography technology	Thompson JW (2014), Katsogiannou M (2014), Katsogiannou M (2014)	3
MDM2	2	HSPA4	3	affinity chromatography technology	Lu TL (2010)	1
CDK5RAP3	0	ARL1	0	affinity chromatography technology	Ewing RM (2007)	1
CDK5RAP3	0	LYPD6B	0	affinity chromatography technology	Kwon J (2010)	1
UBC	7	HSPB1	2	affinity chromatography technology	Matsumoto M (2005)	1
HSPA8	4	TAB1	1	affinity chromatography technology	Huttlin EL (2017)	1
TMEM206	5	DDRGK1	1	affinity chromatography technology	Huttlin EL (2017)	1
CDK5RAP3	0	CDK5R1	0	pull down	Wang X (2000)	1
MME	3	ARL1	0	affinity chromatography technology	DallEra MA (2007)	1
SMNDC1	1	CDK5RAP3	0	affinity chromatography technology	Ewing RM (2007)	1
UBC	7	CDKN2A	1	pull down, imaging technique	Zhang X (2017), Zhang X (2017)	2
MRPS7	0	CDK5RAP3	0	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	RPS3	0	pull down	Zhang X (2017)	1
CDK5RAP3	0	MDM2	2	affinity chromatography technology, affinity chromatography technology	Wang J (2006), Wang J (2006)	2
CDK5RAP3	0	PIP4P2	0	affinity chromatography technology, affinity chromatography technology	Kwon J (2010), Huttlin EL (2017)	2
TAX1BP3	1	CDK5RAP3	0	two hybrid, pull down, affinity chromatography technology	Han M (2012), Han M (2012), Han M (2012)	3
CDK5RAP3	0	3493	0	affinity chromatography technology	Ewing RM (2007)	1
CDK5RAP3	0	TMED1	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM44	2	CDK5RAP3	0	affinity chromatography technology	Huttlin EL (2017)	1
CDK5RAP3	0	UFM1	0	affinity chromatography technology	Ewing RM (2007)	1
UBC	7	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study	Nathan JA (2013), Bish RA (2007), Thompson JW (2014), Kristariyanto YA (2015), Zhang X (2017), Michel MA (2017)	6
NPM1	0	RPS3	0	affinity chromatography technology	Hein MY (2015)	1
UPF3A	2	CDK5RAP3	0	affinity chromatography technology	Huttlin EL (2017)	1
CDKN2A	1	HUWE1	22	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Chio II (2012), Hein MY (2015), Lee CK (2015), Lee CK (2015), Sander B (2017)	9
HSPB1	2	HSPA8	4	biochemical	Wan C (2015)	1
MME	3	HSPA8	4	affinity chromatography technology	DallEra MA (2007)	1
HUWE1	22	MDM2	2	affinity chromatography technology, enzymatic study	Kurokawa M (2013), Kurokawa M (2013)	2
CDK5RAP3	0	UFC1	0	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Kwon J (2010)	2
HSPB1	2	CDK5RAP3	0	two hybrid	Katsogiannou M (2014)	1
AMTN	0	CDK5RAP3	0	affinity chromatography technology	Huttlin EL (2017)	1
MDM2	2	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Lu TL (2010), Okoro DR (2013)	2
MDM2	2	CDKN2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Zhang Y (2003), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Clark PA (2002), Clark PA (2002), Clark PA (2002), Pomerantz J (1998), Ivanchuk SM (2008), Wang C (2005), Wang X (2001), Midgley CA (2000), Shen J (2011), Li L (2010), Li L (2010), Li X (2011), Woods YL (2004), Bouska A (2008), Lindstroem MS (2007), Lohrum MA (2000), Wang J (2006), Wang J (2006), Wang J (2006), Drago-Ferrante R (2008), Schuster K (2007), Hogan C (2008), Rizos H (2000), Gargano B (2008), Kamijo T (1998), Wang S (2010), Jones R (2007), Stott FJ (1998), Lo D (2014), Pimkina J (2009), Blattner C (2002), Leslie PL (2015), Bothner B (2003), Ivanov AA (2017)	42
CDK5RAP3	0	UBC	7	affinity chromatography technology	Kwon J (2010)	1
TSPYL4	2	CDK5RAP3	0	two hybrid	Rolland T (2014)	1
CDK5RAP3	0	TAB1	1	two hybrid	Wang J (2011)	1
RPL10A	0	MDM2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDRGK1	1	UFC1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SIGLECL1	0	CDK5RAP3	0	affinity chromatography technology	Huttlin EL (2017)	1
CDK5RAP3	0	RPL10A	0	affinity chromatography technology	Kwon J (2010)	1
TMEM206	5	UFL1	4	affinity chromatography technology	Huttlin EL (2017)	1