PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SEC13	0	NUP160	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loiodice I (2004), Huttlin EL (2015), Huttlin EL (2017)	3
B9D2	0	DNMT1	5	bioid	Gupta GD (2015)	1
MATR3	2	SUGP2	3	affinity chromatography technology	Hein MY (2015)	1
B9D2	0	PWP2	2	bioid	Gupta GD (2015)	1
B9D2	0	CCAR2	9	bioid	Gupta GD (2015)	1
MATR3	2	YLPM1	6	affinity chromatography technology	Hein MY (2015)	1
TMEM231	1	TCTN1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
NUP133	4	NUP98	5	affinity chromatography technology, bioid	Belgareh N (2001), Kim DI (2014)	2
B9D2	0	MKS1	3	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
NUP85	6	NUP153	1	bioid, affinity chromatography technology	Kim DI (2014), Hein MY (2015)	2
SEC13	0	NUP85	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loiodice I (2004), Huttlin EL (2015), Huttlin EL (2017)	3
NUP107	1	NUP133	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, x-ray crystallography, biochemical, bioid, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loiodice I (2004), Belgareh N (2001), Belgareh N (2001), Belgareh N (2001), Belgareh N (2001), Belgareh N (2001), Kaur S (2010), Zuccolo M (2007), Glavy JS (2007), Glavy JS (2007), Havugimana PC (2012), Whittle JR (2009), Wan C (2015), Kim DI (2014), Kim DI (2014), Kim DI (2014), Hein MY (2015), Boldt K (2016)	18
B9D2	0	NUP50	0	bioid	Gupta GD (2015)	1
NUP85	6	NUP50	0	bioid	Kim DI (2014)	1
B9D2	0	TCTN3	2	bioid	Gupta GD (2015)	1
DNMT1	5	KDM1A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Clements EG (2012), Clements EG (2012), Cui S (2011), Cui S (2011)	4
TNRC6B	10	CNOT7	0	affinity chromatography technology	Braun JE (2011)	1
TCTN2	2	MKS1	3	bioid	Gupta GD (2015)	1
B9D2	0	NUP107	1	bioid	Gupta GD (2015)	1
SEC13	0	NUP98	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
B9D2	0	RAVER1	2	bioid	Gupta GD (2015)	1
B9D2	0	CPSF7	4	bioid	Gupta GD (2015)	1
B9D2	0	DCAF7	4	bioid	Gupta GD (2015)	1
B9D2	0	CNOT7	0	bioid	Gupta GD (2015)	1
TCTN1	2	B9D2	0	affinity chromatography technology	Huttlin EL (2017)	1
NUP107	1	NUP85	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loiodice I (2004), Kaur S (2010), Glavy JS (2007), Wan C (2015), Kim DI (2014), Kim DI (2014), Kim DI (2014), Hein MY (2015)	8
NUP133	4	NUP50	0	bioid	Kim DI (2014)	1
B9D2	0	KDM1A	2	bioid	Gupta GD (2015)	1
B9D2	0	CKB	1	bioid	Gupta GD (2015)	1
B9D2	0	LIN54	1	bioid	Gupta GD (2015)	1
B9D2	0	LEMD3	4	bioid	Gupta GD (2015)	1
B9D2	0	NUP43	0	bioid	Gupta GD (2015)	1
NUP107	1	NUP58	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
B9D2	0	SUGP2	3	bioid	Gupta GD (2015)	1
B9D2	0	PASK	7	bioid	Gupta GD (2015)	1
B9D2	0	NUP98	5	bioid	Gupta GD (2015)	1
TCTN3	2	TCTN1	2	affinity chromatography technology	Boldt K (2016)	1
MATR3	2	NCOA5	1	affinity chromatography technology	Hein MY (2015)	1
B9D2	0	YTHDF3	6	bioid	Gupta GD (2015)	1
CC2D2A	3	B9D1	1	bioid	Gupta GD (2015)	1
B9D2	0	NOP58	3	bioid	Gupta GD (2015)	1
B9D2	0	BCOR	2	bioid	Gupta GD (2015)	1
BCOR	2	PCGF1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Gearhart MD (2006), Gearhart MD (2006), Gearhart MD (2006), Gao Z (2012), Junco SE (2013), Junco SE (2013), Hein MY (2015), Oliviero G (2015), Oliviero G (2015), Oliviero G (2015), Oliviero G (2015), Hauri S (2016)	13
TCTN3	2	LEMD3	4	bioid	Gupta GD (2015)	1
NUP85	6	NUP98	5	biochemical, bioid	Wan C (2015), Kim DI (2014)	2
B9D2	0	TNRC6B	10	bioid	Gupta GD (2015)	1
MKS1	3	YTHDF1	1	bioid	Gupta GD (2015)	1
B9D2	0	NUP160	0	bioid	Gupta GD (2015)	1
NUP160	0	NUP153	1	bioid, affinity chromatography technology	Kim DI (2014), Hein MY (2015)	2
B9D2	0	B9D1	1	bioid, affinity chromatography technology	Gupta GD (2015), Boldt K (2016)	2
NUP107	1	NUP50	0	bioid, affinity chromatography technology	Kim DI (2014), Hein MY (2015)	2
SEC13	0	NUP43	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NUP107	1	NUP98	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, bioid, affinity chromatography technology	Kaur S (2010), Glavy JS (2007), Glavy JS (2007), Wan C (2015), Kim DI (2014), Hein MY (2015)	6
B9D2	0	RCOR1	0	bioid	Gupta GD (2015)	1
B9D2	0	YTHDF1	1	bioid	Gupta GD (2015)	1
CC2D2A	3	MKS1	3	bioid	Gupta GD (2015)	1
CNOT7	0	RAVER1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NUP153	1	NUP98	5	affinity chromatography technology	Hein MY (2015)	1
MATR3	2	FAM208A	5	affinity chromatography technology	Hein MY (2015)	1
PCGF1	1	ARID1B	80	affinity chromatography technology	Oliviero G (2015)	1
B9D2	0	HNRNPM	1	bioid	Gupta GD (2015)	1
NUP160	0	NUP133	4	biochemical	Wan C (2015)	1
B9D2	0	TCTN2	2	bioid	Gupta GD (2015)	1
B9D2	0	SRSF10	0	bioid	Gupta GD (2015)	1
B9D2	0	RBM12B	3	bioid	Gupta GD (2015)	1
BCOR	2	IBTK	3	affinity chromatography technology	Oliviero G (2015)	1
MATR3	2	ZNF326	3	affinity chromatography technology	Hein MY (2015)	1
B9D2	0	YTHDF2	0	bioid	Gupta GD (2015)	1
B9D2	0	RPRD2	2	bioid	Gupta GD (2015)	1
TMEM231	1	TCTN2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
NUP133	4	NUP153	1	bioid, affinity chromatography technology	Kim DI (2014), Hein MY (2015)	2
NUP160	0	NUP50	0	bioid	Kim DI (2014)	1
B9D2	0	MTR	4	bioid	Gupta GD (2015)	1
TCTN1	2	MKS1	3	affinity chromatography technology	Huttlin EL (2017)	1
B9D2	0	PPIH	1	bioid	Gupta GD (2015)	1
B9D2	0	ZNF318	6	bioid	Gupta GD (2015)	1
MATR3	2	FUBP3	0	affinity chromatography technology	Hein MY (2015)	1
MKS1	3	TNRC6B	10	bioid	Gupta GD (2015)	1
B9D2	0	WDR33	3	bioid	Gupta GD (2015)	1
B9D2	0	MOB4	0	bioid	Gupta GD (2015)	1
B9D2	0	FAM208A	5	bioid	Gupta GD (2015)	1
B9D2	0	RBM20	6	bioid	Gupta GD (2015)	1
B9D2	0	IBTK	3	bioid	Gupta GD (2015)	1
B9D1	1	MTR	4	bioid	Gupta GD (2015)	1
TCTN1	2	TCTN2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
B9D2	0	ARID1B	80	bioid	Gupta GD (2015)	1
NUP107	1	NUP160	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Loiodice I (2004), Kaur S (2010), Glavy JS (2007), Kim DI (2014), Hein MY (2015)	5
B9D2	0	NUP58	0	bioid	Gupta GD (2015)	1
B9D2	0	ANP32A	3	bioid	Gupta GD (2015)	1
HNRNPM	1	ZNF326	3	biochemical	Havugimana PC (2012)	1
TMEM231	1	MKS1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Boldt K (2016)	2
NUP160	0	NUP85	6	biochemical, bioid, affinity chromatography technology	Wan C (2015), Kim DI (2014), Kim DI (2014)	3
B9D2	0	ZNF326	3	bioid	Gupta GD (2015)	1
B9D2	0	MATR3	2	bioid	Gupta GD (2015)	1
FAM208A	5	NOP58	3	genetic interference	Horlbeck MA (2018)	1
NUP160	0	NUP98	5	bioid	Kim DI (2014)	1
TCTN2	2	LEMD3	4	bioid	Gupta GD (2015)	1
TMEM231	1	B9D2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
B9D2	0	NCOA5	1	bioid	Gupta GD (2015)	1
MATR3	2	RBM12B	3	affinity chromatography technology	Hein MY (2015)	1
NUP58	0	NUP98	5	affinity chromatography technology	Hein MY (2015)	1
NUP43	0	NUP50	0	bioid	Kim DI (2014)	1
EIF4ENIF1	1	NUP50	0	affinity chromatography technology	Boldt K (2016)	1
NUP43	0	NUP160	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loiodice I (2004), Huttlin EL (2015), Kim DI (2014), Huttlin EL (2017)	4
NUP43	0	NUP153	1	bioid, affinity chromatography technology	Kim DI (2014), Hein MY (2015)	2
CC2D2A	3	TCTN3	2	bioid	Gupta GD (2015)	1
TCTN2	2	TCTN3	2	affinity chromatography technology	Boldt K (2016)	1
RCOR1	0	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Hakimi MA (2002), You A (2001), You A (2001), Gocke CB (2008), Chen Y (2006), Yang M (2006), Shi YJ (2005), Shi YJ (2005), Lee MG (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Hwang S (2011), Lin Y (2010), Nicholson TB (2011), Nicholson TB (2011), Cui S (2011), Adamo A (2011), Adamo A (2011), Bantscheff M (2011), Mosammaparast N (2013), Lin Y (2010), Wan C (2015), Boldt K (2016)	25
B9D2	0	NUP85	6	bioid	Gupta GD (2015)	1
CPSF7	4	NUP133	4	biochemical	Havugimana PC (2012)	1
B9D2	0	RGPD3	2	bioid	Gupta GD (2015)	1
SEC13	0	NUP107	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loiodice I (2004), Kaur S (2010), Glavy JS (2007), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
B9D2	0	GRIP1	1	bioid	Gupta GD (2015)	1
NUP43	0	NUP85	6	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, genetic interference	Loiodice I (2004), Huttlin EL (2015), Kim DI (2014), Kim DI (2014), Kim DI (2014), Xu C (2015), Huttlin EL (2017), Horlbeck MA (2018)	8
B9D2	0	TJP1	2	bioid	Gupta GD (2015)	1
TCTN1	2	CC2D2A	3	affinity chromatography technology	Huttlin EL (2017)	1
B9D2	0	YLPM1	6	bioid	Gupta GD (2015)	1
SEC13	0	NUP133	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loiodice I (2004), Huttlin EL (2015), Huttlin EL (2017)	3
CC2D2A	3	B9D2	0	bioid	Gupta GD (2015)	1
B9D2	0	NUP153	1	bioid	Gupta GD (2015)	1
NUP43	0	NUP133	4	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Loiodice I (2004), Huttlin EL (2015), Kim DI (2014), Huttlin EL (2017)	4
B9D2	0	NUP133	4	bioid	Gupta GD (2015)	1
B9D2	0	SEC13	0	bioid	Gupta GD (2015)	1
B9D2	0	PCGF1	1	bioid	Gupta GD (2015)	1
NUP107	1	NUP153	1	biochemical, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Kim DI (2014), Hein MY (2015), Hein MY (2015)	5
MKS1	3	B9D1	1	bioid, affinity chromatography technology	Gupta GD (2015), Boldt K (2016)	2
B9D2	0	FUBP3	0	bioid	Gupta GD (2015)	1
NUP50	0	NUP153	1	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Smitherman M (2000), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
NUP43	0	NUP107	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Loiodice I (2004), Kaur S (2010), Glavy JS (2007), Huttlin EL (2015), Kim DI (2014), Hein MY (2015), Huttlin EL (2017)	7
NUP43	0	NUP98	5	affinity chromatography technology, bioid, affinity chromatography technology	Huttlin EL (2015), Kim DI (2014), Huttlin EL (2017)	3
NUP160	0	LEMD3	4	bioid	Kim DI (2014)	1
MATR3	2	HNRNPM	1	affinity chromatography technology	Hein MY (2015)	1
TMEM231	1	B9D1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
B9D2	0	EIF4ENIF1	1	bioid	Gupta GD (2015)	1
PCGF1	1	IBTK	3	affinity chromatography technology	Oliviero G (2015)	1
YTHDF3	6	YTHDF1	1	affinity chromatography technology	Huttlin EL (2017)	1