PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CXXC1	3	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tate CM (2009), Lee JH (2005), Lee JH (2005), Ansari KI (2008), Butler JS (2008), Mak AB (2010), Kim J (2009), Tang Z (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	12
SRRM1	2	PAXIP1	1	affinity chromatography technology	McCracken S (2005)	1
KDM6A	8	KMT2D	30	affinity chromatography technology, affinity chromatography technology	Lee MG (2007), Kim JH (2014)	2
WDR82	3	KMT2D	30	affinity chromatography technology	Lee JH (2010)	1
ESR1	0	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mo R (2006), Mo R (2006), Shi L (2011), Shi L (2011)	4
AKT1	1	AR	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin HK (2001), Lin HK (2001), Deep G (2008), Deep G (2008), Steely AM (2017)	5
E2F2	0	KMT2D	30	affinity chromatography technology	Takeda S (2006)	1
PAXIP1	1	RBBP5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Patel SR (2007), Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Cho YW (2007), Cho YW (2007)	7
E2F6	2	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	4
SMAD9	0	ASH2L	2	two hybrid	Colland F (2004)	1
E2F6	2	KMT2D	30	affinity chromatography technology	Takeda S (2006)	1
CTNNB1	30	ASH2L	2	pull down, pull down	Sierra J (2006), Gomes NP (2006)	2
E2F5	0	KMT2D	30	affinity chromatography technology	Takeda S (2006)	1
ASH2L	2	MEN1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), MacConaill LE (2006), Hughes CM (2004), Hughes CM (2004), Hughes CM (2004)	5
SENP3	1	ASH2L	2	imaging technique	Nayak A (2014)	1
KDM6A	8	HIST2H3C	0	enzymatic study	Kristensen JB (2011)	1
PYGO2	1	RBBP5	3	pull down, affinity chromatography technology	Chen J (2010), Chen J (2010)	2
AKT1	1	ESR1	0	enzymatic study	Campbell RA (2001)	1
KDM6A	8	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee MG (2007), De Santa F (2007), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	5
PAXIP1	1	KMT2D	30	affinity chromatography technology, affinity chromatography technology	Patel SR (2007), Patel SR (2007)	2
CXXC1	3	KMT2D	30	affinity chromatography technology, affinity chromatography technology	Ansari KI (2008), Ansari KI (2008)	2
5430	0	KMT2D	30	pull down	Milne TA (2005)	1
AR	3	ASH2L	2	affinity chromatography technology, affinity chromatography technology	Grasso CS (2012), Grasso CS (2012)	2
CXXC1	3	HIST2H3C	0	affinity chromatography technology	Ansari KI (2008)	1
UBAC2	1	KMT2D	30	affinity chromatography technology	Christianson JC (2012)	1
MEN1	1	5430	0	affinity chromatography technology, pull down, imaging technique	MacConaill LE (2006), Milne TA (2005), Milne TA (2005)	3
WDR82	3	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Lee JH (2010), Tang Z (2013), Hauri S (2016)	4
SENP3	1	WDR5	2	affinity chromatography technology	Nayak A (2014)	1
SMAD1	0	MEN1	1	affinity chromatography technology	Sowa H (2003)	1
WDR5	2	KMT2D	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Wysocka J (2005), Patel SR (2007), Mo R (2006), Dharmarajan V (2012), Zhang P (2012), Zhang P (2012), Kim JH (2014), Xu Z (2012), Huttlin EL (2015), Dias J (2014), Huttlin EL (2017), Alicea-Velazquez NL (2016), Hauri S (2016)	13
EEF1B2	1	KMT2D	30	biochemical	Wan C (2015)	1
SRRM1	2	KMT2D	30	affinity chromatography technology	McCracken S (2005)	1
HERC2	9	CTNNB1	30	affinity chromatography technology	Galligan JT (2015)	1
CXXC1	3	ASH2L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tate CM (2009), Lee JH (2005), Lee JH (2005), Lee JH (2005), Ansari KI (2008), Butler JS (2008), Mak AB (2010), Kim J (2009), Tang Z (2013), Tang Z (2013), Hein MY (2015), Huttlin EL (2017)	12
AKT1	1	CTNNB1	30	enzymatic study, enzymatic study	Tian Q (2004), Fang D (2007)	2
SRRM1	2	ASH2L	2	affinity chromatography technology	McCracken S (2005)	1
EYA2	2	KMT2D	30	bioid	St-Denis N (2016)	1
PYGO2	1	WDR5	2	pull down, affinity chromatography technology	Chen J (2010), Chen J (2010)	2
CTNNB1	30	KMT2D	30	pull down, pull down	Sierra J (2006), Gomes NP (2006)	2
KDM4B	6	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Shi L (2011), Shi L (2011), Shi L (2011), Shi L (2011)	4
PYGO2	1	KMT2D	30	pull down, affinity chromatography technology	Chen J (2010), Chen J (2010)	2
SENP3	1	KMT2D	30	affinity chromatography technology	Nayak A (2014)	1
MEF2D	5	KMT2D	30	affinity chromatography technology	Rampalli S (2007)	1
WDR82	3	5430	0	affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Lee JH (2010)	2
KDM6A	8	PAXIP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee MG (2007), Patel SR (2007), Cho YW (2007)	3
PPP1R21	1	KMT2D	30	affinity chromatography technology	Hein MY (2015)	1
ESR1	0	SRRM1	2	affinity chromatography technology	Tarallo R (2011)	1
KMT2D	30	HIST2H3C	0	enzymatic study	Zhang P (2012)	1
CTNNB1	30	ESR1	0	affinity chromatography technology	Kouzmenko AP (2004)	1
WDR82	3	PAXIP1	1	affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Lee JH (2010)	2
ESR1	0	FOXK2	9	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Liu Y (2015), Liu Y (2015), Liu Y (2015), Liu Y (2015)	4
PYGO2	1	AKT1	1	affinity chromatography technology, pull down	Li Q (2015), Li Q (2015)	2
CXXC1	3	WDR82	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tate CM (2009), Butler JS (2008), Lee JH (2010), Lee JH (2010), Kim J (2009), Tang Z (2013), Tang Z (2013)	7
KDM6A	8	ASH2L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee MG (2007), Mak AB (2010), De Santa F (2007)	3
CTNNB1	30	MEN1	1	pull down, affinity chromatography technology, pull down, pull down	Sierra J (2006), Chen G (2008), Chen G (2008), Gomes NP (2006)	4
PAXIP1	1	ASH2L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Patel SR (2007), Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Cho YW (2007), Cho YW (2007)	7
MEF2D	5	SENP3	1	affinity chromatography technology	Gregoire S (2005)	1
SENP3	1	MEN1	1	imaging technique	Nayak A (2014)	1
CTNNB1	30	AR	3	pull down, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yang F (2002), Yang F (2002), Masiello D (2004), Song LN (2004), Amir AL (2003), Amir AL (2003), Mulholland DJ (2003), Mulholland DJ (2003), Pawlowski JE (2002), Mulholland DJ (2003), Levy L (2004)	11
NR3C1	2	KMT2D	30	bioid	Lempiaeinen JK (2017)	1
AR	3	KDM6A	8	affinity chromatography technology	Grasso CS (2012)	1
MEN1	1	WDR5	2	biochemical, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Hughes CM (2004), Hauri S (2016)	3
MEF2D	5	MEN1	1	affinity chromatography technology	Rampalli S (2007)	1
PYGO2	1	ASH2L	2	pull down, affinity chromatography technology	Chen J (2010), Chen J (2010)	2
MEN1	1	KMT2D	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hughes CM (2004), Hughes CM (2004), Hughes CM (2004)	3
MEN1	1	RBBP5	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), MacConaill LE (2006), Hughes CM (2004), Hughes CM (2004), Hughes CM (2004)	5
MAX	0	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim J (2010), Hauri S (2016), Hauri S (2016)	3
KDM4B	6	RBBP5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Shi L (2011), Shi L (2011), Shi L (2011), Shi L (2011)	4
RBBP5	3	WDR5	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Higa LA (2006), Wysocka J (2005), Wysocka J (2005), Patel SR (2007), Cho YW (2007), Avdic V (2011), Avdic V (2011), Avdic V (2011), Mo R (2006), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Carugo A (2016), Hauri S (2016)	20
ESR1	0	KMT2D	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Mo R (2006), Mo R (2006), Shi L (2011), Shi L (2011), Toska E (2017)	5
ASH2L	2	RBBP5	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, pull down	Yokoyama A (2004), Lee JH (2005), Lee JH (2005), Garapaty S (2009), Wysocka J (2005), Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Butler JS (2011), Avdic V (2011), Mo R (2006), Mo R (2006), Cao F (2010), Cao F (2010), Mak AB (2010), Mak AB (2010), Rolland T (2014), Tang Z (2013), Yu H (2011), Li Y (2016)	21
ESR1	0	MEN1	1	two hybrid, affinity chromatography technology	Dreijerink KM (2006), Dreijerink KM (2006)	2
ESR1	0	E2F6	2	affinity chromatography technology	Han SJ (2016)	1
SMAD1	0	AR	3	affinity chromatography technology, affinity chromatography technology, protein complementation assay, imaging technique, affinity chromatography technology	Qiu T (2007), Qiu T (2007), Qiu T (2007), Qiu T (2007), Li Y (2013)	5
SMAD9	0	KDM6A	8	two hybrid	Colland F (2004)	1
ASH2L	2	WDR5	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Wysocka J (2005), McKinnell IW (2008), McKinnell IW (2008), Patel SR (2007), Butler JS (2011), Mo R (2006), Gan Q (2011), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Havugimana PC (2012), Tang Z (2013), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Hauri S (2016)	19
CHEK2	2	KMT2D	30	genetic interference	Shen JP (2017)	1
ESR1	0	ASH2L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mo R (2006), Mo R (2006), Shi L (2011), Shi L (2011)	4
SMAD9	0	KMT2D	30	two hybrid	Colland F (2004)	1
RBM45	1	KMT2D	30	affinity chromatography technology	Hein MY (2015)	1
CTNNB1	30	RBBP5	3	pull down, pull down, affinity chromatography technology	Sierra J (2006), Gomes NP (2006), Chen J (2010)	3
CXXC1	3	RBBP5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tate CM (2009), Lee JH (2005), Lee JH (2005), Lee JH (2005), Ansari KI (2008), Butler JS (2008), Mak AB (2010), Kim J (2009), Tang Z (2013), Hein MY (2015), Huttlin EL (2017)	11
KDM4B	6	ASH2L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Shi L (2011), Shi L (2011), Shi L (2011), Shi L (2011)	4
HERC2	9	KMT2D	30	affinity chromatography technology	Galligan JT (2015)	1
KDM4B	6	ESR1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Shi L (2011), Shi L (2011), Shi L (2011), Shi L (2011)	4
FOXK2	9	KMT2D	30	affinity chromatography technology	Li X (2015)	1
KDM6A	8	RBBP5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee MG (2007), Cho YW (2007), De Santa F (2007)	3
AR	3	KMT2D	30	bioid, affinity chromatography technology, affinity chromatography technology	Lempiaeinen JK (2017), Grasso CS (2012), Grasso CS (2012)	3
RBBP5	3	HIST2H3C	0	pull down	Goo YH (2003)	1
WDR82	3	RBBP5	3	affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Tang Z (2013)	2
MAX	0	KMT2D	30	biochemical	Havugimana PC (2012)	1
KDM4B	6	KMT2D	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Shi L (2011), Shi L (2011), Shi L (2011), Shi L (2011)	4
KMT2D	30	AKT1	1	affinity chromatography technology, enzymatic study	Toska E (2017), Toska E (2017)	2
CXXC1	3	MEN1	1	affinity chromatography technology	Ansari KI (2008)	1
KMT2D	30	ASH2L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Patel SR (2007), Mo R (2006), Mo R (2006), Mo R (2006), Kim JH (2014), Li Y (2016), Alicea-Velazquez NL (2016)	7
ESR1	0	5430	0	affinity chromatography technology, imaging technique, imaging technique, pull down	Ambrosino C (2010), Zhang H (2006), Zhang H (2006), Nalvarte I (2010)	4
E2F3	0	KMT2D	30	affinity chromatography technology	Takeda S (2006)	1
MAX	0	FOXK2	9	affinity chromatography technology, affinity chromatography technology	Li X (2015), Li X (2015)	2
MAX	0	E2F6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Cheng J (2017), Hauri S (2016), Hauri S (2016)	4
PYGO2	1	CTNNB1	30	affinity chromatography technology	Li J (2013)	1
MEF2D	5	RBBP5	3	affinity chromatography technology	Rampalli S (2007)	1
PAXIP1	1	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Cho YW (2007), Cho YW (2007), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	9
EYA2	2	KDM6A	8	bioid	St-Denis N (2016)	1
FOXK2	9	RBBP5	3	affinity chromatography technology	Li X (2015)	1
SENP3	1	RBBP5	3	affinity chromatography technology	Nayak A (2014)	1
ESR1	0	RBBP5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mo R (2006), Mo R (2006), Shi L (2011), Shi L (2011)	4
WDR82	3	KDM6A	8	affinity chromatography technology	Lee JH (2010)	1
RBBP5	3	KMT2D	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wysocka J (2005), Patel SR (2007), Mo R (2006), Mo R (2006), Kim JH (2014), Hu D (2013), Alicea-Velazquez NL (2016)	7
WDR82	3	ASH2L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Lee JH (2010), Tang Z (2013), Tang Z (2013)	4
SMAD1	0	KMT2D	30	two hybrid	Colland F (2004)	1
FOXK2	9	CHEK2	2	affinity chromatography technology	Li X (2015)	1
ASH2L	2	MEF2D	5	affinity chromatography technology, affinity chromatography technology	Rampalli S (2007), Rampalli S (2007)	2