PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HMGA2	1	SMAD9	0	affinity chromatography technology	Monzen K (2008)	1
HIST1H3A	3	PCGF1	1	bioid	Lambert JP (2015)	1
HMGA2	1	APEX1	1	pull down	Sgarra R (2008)	1
CREB1	1	HMGA2	1	affinity chromatography technology	Li X (2015)	1
OBSL1	9	HMGA2	1	affinity chromatography technology	Hanson D (2014)	1
NFATC1	12	XRCC6	3	affinity chromatography technology	Gabriel CH (2016)	1
OBSL1	9	SYNCRIP	6	affinity chromatography technology	Hanson D (2014)	1
HMGA2	1	PIAS3	2	two hybrid, affinity chromatography technology	Zentner MD (2001), Zentner MD (2001)	2
DLST	3	XRCC6	3	affinity chromatography technology	Malty RH (2017)	1
HMGA2	1	PTBP1	2	pull down	Sgarra R (2008)	1
HMGA2	1	NFKB1	2	pull down, far western blotting	Noro B (2003), Noro B (2003)	2
POU5F1	0	PCGF1	1	affinity chromatography technology	Oliviero G (2015)	1
PRKCA	7	HMGA2	1	enzymatic study	Banks GC (2000)	1
OBSL1	9	PTBP1	2	affinity chromatography technology	Hanson D (2014)	1
HDGF	0	HIST1H3A	3	affinity chromatography technology, bioid	Zhao J (2011), Lambert JP (2015)	2
HMGA2	1	PA2G4	1	pull down, far western blotting	Sgarra R (2008), Sgarra R (2008)	2
NFKB1	2	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Palvimo JJ (1996), Dhar SK (2006), Williams SA (2006), Williams SA (2006), Hassa PO (2005), Hassa PO (2005), Sasaki CY (2005), Jeon YJ (2010), Urban MB (1991), Beauchef G (2012), Ryo A (2003), Burstein E (2005), Beinke S (2002), Sharif-Askari E (2010), Mifflin RC (2002), Nie M (2003), Nehra R (2010), Wang J (2011), Mellits KH (1993), Gallois C (1998), Milanovic M (2013), Milanovic M (2013), Kwon JH (2003), Cimen I (2011), Saha RN (2007), Wi SM (2014), Wi SM (2014), Hochrainer K (2012), Longoni N (2013), Li X (2015)	31
NPM1	0	RELA	1	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Wang J (2011), Xu Y (2008), Xu Y (2008), Xu Y (2008)	4
HIST1H3A	3	CREB1	1	affinity chromatography technology	Sun HS (2003)	1
HMGA2	1	SYNCRIP	6	pull down, far western blotting	Sgarra R (2008), Sgarra R (2008)	2
PCBP2	3	PTBP1	2	two hybrid, two hybrid, pull down, pull down	Kim JH (2000), Kim JH (2000), Kim JH (2000), Kim JH (2000)	4
RB1	2	E4F1	3	two hybrid, pull down, affinity chromatography technology	Fajas L (2000), Fajas L (2000), Fajas L (2000)	3
HMGA2	1	PCBP2	3	pull down	Sgarra R (2008)	1
POU5F1	0	PSIP1	2	affinity chromatography technology	Oliviero G (2015)	1
NPM1	0	PA2G4	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okada M (2007), Okada M (2007), Okada M (2007), Liu Z (2009), Oh SM (2010), Hein MY (2015)	6
SMAD9	0	E4F1	3	two hybrid	Colland F (2004)	1
NPM1	0	HIST1H3A	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Swaminathan V (2005), Haindl M (2008), Shuaib M (2010), Shuaib M (2010)	4
RB1	2	PA2G4	1	affinity chromatography technology, pull down, affinity chromatography technology	Xia X (2001), Xia X (2001), Oh SM (2010)	3
HMGA2	1	E4F1	3	pull down, affinity chromatography technology, far western blotting	Tessari MA (2003), Tessari MA (2003), Tessari MA (2003)	3
HMGA2	1	SMAD1	0	affinity chromatography technology	Monzen K (2008)	1
OBSL1	9	NPM1	0	affinity chromatography technology	Hanson D (2014)	1
NFATC1	12	OBSL1	9	affinity chromatography technology	Huttlin EL (2017)	1
OBSL1	9	XRCC6	3	affinity chromatography technology	Hanson D (2014)	1
RB1	2	HMGA2	1	affinity chromatography technology, pull down, far western blotting	Fedele M (2006), Fedele M (2006), Fedele M (2006)	3
DLST	3	HMGA2	1	affinity chromatography technology	Malty RH (2017)	1
NFATC1	12	CREB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Gabriel CH (2016), Gabriel CH (2016)	3
PTBP1	2	NPM1	0	affinity chromatography technology	Tarapore P (2006)	1
POU5F1	0	HMGA2	1	affinity chromatography technology	Oliviero G (2015)	1
HDGF	0	PSIP1	2	affinity chromatography technology	Zhao J (2011)	1
RELA	1	PIAS3	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Jang HD (2004), Jang HD (2004), Jang HD (2004), Jang HD (2004), Liu Y (2012)	5
HDGF	0	HMGA2	1	affinity chromatography technology	Zhao J (2011)	1
PRKCA	7	HIST1H3A	3	enzymatic study	Metzger E (2010)	1
PCGF1	1	HMGA2	1	affinity chromatography technology	Oliviero G (2015)	1
HDGF	0	XRCC6	3	affinity chromatography technology	Zhao J (2011)	1
HIST1H3A	3	HMGA2	1	bioid	Lambert JP (2015)	1
OBSL1	9	PSIP1	2	affinity chromatography technology	Hanson D (2014)	1
HIST1H3A	3	PSIP1	2	unspecified method, pull down	Sankaran SM (2016), Sankaran SM (2016)	2
NPM1	0	PRKCA	7	affinity chromatography technology	Chen R (2013)	1
NPM1	0	PSIP1	2	affinity chromatography technology	Hein MY (2015)	1
HMGA2	1	RELA	1	pull down	Noro B (2003)	1
OBSL1	9	PCBP2	3	affinity chromatography technology	Hanson D (2014)	1
SMAD9	0	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
NFATC1	12	HMGA2	1	affinity chromatography technology	Li X (2015)	1
HIST1H3A	3	XRCC6	3	affinity chromatography technology, bioid	Fnu S (2011), Lambert JP (2015)	2
OBSL1	9	PA2G4	1	affinity chromatography technology	Hanson D (2014)	1
HMGA2	1	PSIP1	2	pull down, far western blotting	Sgarra R (2008), Sgarra R (2008)	2
PRMT6	2	HMGA2	1	enzymatic study, far western blotting	Sgarra R (2006), Sgarra R (2006)	2
APEX1	1	NPM1	0	affinity chromatography technology	Vascotto C (2009)	1
HMGA2	1	NPM1	0	far western blotting, far western blotting	Sgarra R (2006), Sgarra R (2008)	2
HMGA2	1	XRCC6	3	pull down, far western blotting	Sgarra R (2008), Sgarra R (2008)	2
HMGA2	1	SMAD5	2	affinity chromatography technology	Monzen K (2008)	1
NPM1	0	RB1	2	affinity chromatography technology	Haindl M (2008)	1
SMAD1	0	SMAD5	2	two hybrid	Colland F (2004)	1