PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZBP1	2	CTBP1	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
ZBP1	2	CTBP2	7	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
ZBP1	2	ORC3	3	affinity chromatography technology	Li S (2011)	1
KDM1A	2	CTBP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shi YJ (2005), Lee MG (2005), Kuppuswamy M (2008), Kuppuswamy M (2008), Keutgens A (2010), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
SIAH1	2	ZBP1	2	two hybrid	Rolland T (2014)	1
CTBP2	7	CTBP1	2	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sewalt RG (1999), Wang J (2011), Corominas R (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
KLHL12	4	ZBP1	2	two hybrid	Rolland T (2014)	1
ZBP1	2	KDM1A	2	affinity chromatography technology	Li S (2011)	1
ZBP1	2	PLXDC2	3	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
ZBP1	2	ZNF516	8	affinity chromatography technology	Li S (2011)	1
ZBP1	2	FMR1	1	affinity chromatography technology	Li S (2011)	1
KDM1A	2	ZNF516	8	affinity chromatography technology	Lee MG (2005)	1
TRIP6	2	ZBP1	2	two hybrid	Rolland T (2014)	1
ZBP1	2	TRAF3	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
ZBP1	2	PALD1	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
CTBP1	2	ZNF516	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZBP1	2	VPS35	2	affinity chromatography technology	Li S (2011)	1