PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TCL1A	0	CALCOCO2	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
TCL1A	0	EP300	36	affinity chromatography technology, affinity chromatography technology	Pekarsky Y (2008), Pekarsky Y (2008)	2
TCL1A	0	AKT3	3	affinity chromatography technology	Laine J (2002)	1
JUNB	0	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Narayanan K (2004), Narayanan K (2004), Narayanan K (2004), Wang CC (2007), Wang WM (2011)	5
JUNB	0	TCL1A	0	affinity chromatography technology	Pekarsky Y (2008)	1
JUNB	0	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
TCL1A	0	PRTFDC1	0	two hybrid	Rolland T (2014)	1
ATM	9	TCL1A	0	affinity chromatography technology, pull down	Gaudio E (2011), Gaudio E (2011)	2
TXLNA	3	TXLNB	0	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Li S (2011), Li S (2011), Rolland T (2014), Huttlin EL (2017)	4
TCL1A	0	CARD9	3	two hybrid	Rolland T (2014)	1
TCL1A	0	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid	Laine J (2002), Laine J (2000), French SW (2002), French SW (2002), Rolland T (2014), Daakour S (2016)	6
GOLGA2	2	TCL1A	0	two hybrid	Rolland T (2014)	1
DNMT3A	17	TCL1A	0	two hybrid	Rolland T (2014)	1
TCF4	26	WDR47	0	affinity chromatography technology	Li X (2015)	1
AKT1	1	AKT2	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF1	0	TCL1A	0	two hybrid	Rolland T (2014)	1
EP300	36	FOS	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Wang WM (2011), Pekarsky Y (2008), Wang C (2001)	3
FOS	0	JUNB	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	7
JUN	0	TCL1A	0	affinity chromatography technology, affinity chromatography technology	Pekarsky Y (2008), Pekarsky Y (2008)	2
TCL1A	0	TTC33	0	two hybrid	Rolland T (2014)	1
TCL1A	0	WDR47	0	two hybrid	Rolland T (2014)	1
TCL1A	0	CADPS	3	two hybrid	Rolland T (2014)	1
TCL1A	0	ALS2CR12	2	two hybrid	Rolland T (2014)	1
TCF4	26	EP300	36	affinity chromatography technology	Li J (2007)	1
AKT1	1	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Lin WN (2008), Lee IT (2010), Sundaresan NR (2011), Howie HL (2011), Chen J (2004), Chen J (2004)	6
TCL1A	0	TXLNB	0	two hybrid	Rolland T (2014)	1
TCL1A	0	HIST3H2A	0	two hybrid	Rual JF (2005)	1
TCL1A	0	LSM3	2	two hybrid	Rolland T (2014)	1
FOS	0	JUN	0	pull down, two hybrid, pull down, x-ray crystallography, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, pull down, imaging technique, pull down, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, biochemical, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito T (2001), Pognonec P (1997), Pognonec P (1997), Glover JN (1995), Yang X (1999), Nomura N (1993), Finkel T (1993), Finkel T (1993), Venugopal R (1998), Kumar NV (2001), Dumin E (2006), Bandyopadhyay S (2010), Asim M (2010), Asim M (2010), Srivastav RK (2011), Bossis G (2005), Bossis G (2005), Gupta K (2000), Bachmann M (2004), Reinke AW (2013), Miyagi M (2005), Subbaramaiah K (2007), Jang M (2012), Yamaguchi K (2005), Varjosalo M (2013), Miyamoto-Sato E (2010), Miyamoto-Sato E (2010), Varjosalo M (2013), Tang HY (2006), Marden NY (2005), Adler J (2010), Adler J (2010), Adler J (2010), Billiet L (2008), Huttlin EL (2015), Hein MY (2015), Li X (2015), Li X (2015), Huttlin EL (2017)	39
EP300	36	GOLGA2	2	two hybrid	Wang J (2011)	1
TCL1A	0	TCL1A	0	affinity chromatography technology, two hybrid	Laine J (2000), Rolland T (2014)	2
TP53BP2	5	EP300	36	affinity chromatography technology	Gillotin S (2011)	1
TCL1A	0	TXLNA	3	two hybrid	Rolland T (2014)	1
TP53BP2	5	TCL1A	0	two hybrid	Rolland T (2014)	1
TP53BP2	5	TXLNA	3	two hybrid	Rolland T (2014)	1
FOS	0	TCL1A	0	affinity chromatography technology	Pekarsky Y (2008)	1
TCF4	26	TCL1A	0	two hybrid	Rolland T (2014)	1
TCL1A	0	CEP55	2	two hybrid	Rolland T (2014)	1
AKT3	3	AKT1	1	affinity chromatography technology	Huttlin EL (2017)	1
CALCOCO2	0	CEP55	2	affinity chromatography technology	Huttlin EL (2017)	1
TCL1A	0	AKT2	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Laine J (2002), Laine J (2000), Laine J (2000)	3
GOLGA2	2	TXLNA	3	two hybrid	Rolland T (2014)	1
EP300	36	JUN	0	pull down, biochemical, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Campbell KM (2002), Campbell KM (2002), Campbell KM (2002), Subbaramaiah K (2002), Duyndam MC (1999), Wang WM (2011), Deng WG (2004), Deng WG (2004), Cheng SE (2011), Cheng SE (2011), Kim BK (2014), Vries RG (2001), Deng WG (2003), Liu L (2017), Liu L (2017)	15