PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPT	1	SMAD2	5	affinity chromatography technology	Ueberham U (2014)	1
CAMK2A	6	CREB1	1	enzymatic study	Shimomura A (1996)	1
PSMC5	4	GIT1	10	affinity chromatography technology	Huttlin EL (2017)	1
CYLD	2	HNRNPK	4	affinity chromatography technology	Elliott PR (2016)	1
CAMK2A	6	CAMK2G	4	affinity chromatography technology	So J (2015)	1
PRKN	1	HNRNPK	4	affinity chromatography technology	Zanon A (2013)	1
CAMK2A	6	SMAD2	5	imaging technique	Chen TC (2014)	1
DNAAF2	2	CAMK2B	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ACTN4	4	CAMK2A	6	two hybrid, two hybrid	Walikonis RS (2001), Walikonis RS (2001)	2
CDK5R1	0	MAPT	1	enzymatic study	Sasaki K (2009)	1
CDK5R1	0	ACTN1	5	two hybrid, affinity chromatography technology, pull down	Dhavan R (2002), Dhavan R (2002), Dhavan R (2002)	3
CAMK2A	6	PLCG1	6	affinity chromatography technology	Pang J (2008)	1
HDAC5	4	ACTN4	4	affinity chromatography technology	Greco TM (2011)	1
CDK5R1	0	CAMK2A	6	two hybrid, affinity chromatography technology, pull down	Dhavan R (2002), Dhavan R (2002), Dhavan R (2002)	3
ACTN1	5	ACTN4	4	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
CYLD	2	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Kim JY (2009), Kim JY (2009)	2
CAMK2A	6	CHMP5	0	affinity chromatography technology	Ewing RM (2007)	1
GIT1	10	PLCG1	6	affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Haendeler J (2003), Haendeler J (2003)	3
HDAC5	4	PSMC5	4	affinity chromatography technology	Greco TM (2011)	1
RAD23A	1	PSMC5	4	affinity chromatography technology, pull down	Scanlon TC (2009), Zhu Q (2004)	2
CAMK2A	6	CAMK2A	6	enzymatic study	Tan KM (2001)	1
CAMK2A	6	ITGA2B	2	enzymatic study	Hillery CA (1991)	1
PRKN	1	CAMK2A	6	affinity chromatography technology	Fallon L (2002)	1
MAPT	1	YWHAB	1	affinity chromatography technology, affinity chromatography technology	Hashiguchi M (2000), Nellist M (2002)	2
MAPT	1	PRKN	1	affinity chromatography technology, affinity chromatography technology	Moore DJ (2008), Petrucelli L (2004)	2
DGUOK	1	GNAO1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FKBP8	1	PSMC5	4	affinity chromatography technology	Nakagawa T (2007)	1
CYLD	2	PSMC5	4	affinity chromatography technology	Elliott PR (2016)	1
HSP90AA1	7	ACTN1	5	affinity chromatography technology	Falsone SF (2005)	1
HAX1	1	CAMK2A	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKN	1	SLC6A3	6	affinity chromatography technology	Jiang H (2004)	1
AKT1	1	CAMK2A	6	affinity chromatography technology	Klein JB (2005)	1
CAMK2A	6	CAMK2B	9	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Boldt K (2016)	2
DNAAF2	2	CAMK2A	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPT	1	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Chun J (2004), Chun J (2004)	2
CAMK2A	6	PTTG1	0	enzymatic study	Hellmuth S (2014)	1
HSP90AA1	7	CAMK2G	4	affinity chromatography technology	Taipale M (2012)	1
CAMK2B	9	YWHAB	1	enzymatic study	Ellis JJ (2003)	1
CYLD	2	AKT1	1	enzymatic study, affinity chromatography technology	Yang WL (2013), Yang WL (2013)	2
PRKN	1	PTTG1	0	enzymatic study	Lee SB (2015)	1
CAMK2A	6	DLG1	2	affinity chromatography technology, enzymatic study	Gardoni F (2003), Gardoni F (2003)	2
PRKN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Taipale M (2012), Zanon A (2013)	3
CAMK2A	6	RCHY1	0	enzymatic study	Duan S (2007)	1
HAX1	1	CAMK2B	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNAAF2	2	GNAO1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKN	1	GRIN2B	30	affinity chromatography technology, imaging technique	Fallon L (2002), Chen TC (2014)	2
CAMK2A	6	SSBP2	2	affinity chromatography technology	Boldt K (2016)	1
HSP90AA1	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Sato S (2000), Basso AD (2002), Su CH (2011), Klein JB (2005), Sun L (2012)	7
HSP90AA1	7	CAMK2A	6	affinity chromatography technology	Taipale M (2012)	1
CAMK2A	6	YWHAB	1	enzymatic study	Ellis JJ (2003)	1
HDAC5	4	YWHAQ	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Vega RB (2004), Vega RB (2004), Ha CH (2010), Greco TM (2011), Xu C (2012), Joshi P (2013), Walkinshaw DR (2013)	7
CREB1	1	ATF1	0	affinity chromatography technology	Li X (2015)	1
CAMK2A	6	GNAO1	21	biochemical	Wan C (2015)	1
CDK5R1	0	HSP90AA1	7	pull down	Stankiewicz M (2010)	1
NOS3	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Brouet A (2001), Brouet A (2001), Dimmeler S (1999), Chen TC (2014)	4
CAMK2A	6	MAPT	1	enzymatic study	Virdee K (2007)	1
HSP90AA1	7	CAMK2B	9	affinity chromatography technology	Taipale M (2012)	1
SQSTM1	0	CAMK2A	6	pull down	Pridgeon JW (2004)	1
NUFIP1	0	GNAO1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HAX1	1	MAPT	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CAMK2A	6	DCTN1	6	affinity chromatography technology	Boldt K (2016)	1
PRKN	1	PSMC5	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tsai YC (2003), Tsai YC (2003), Um JW (2010), Sarraf SA (2013)	4
PPM1F	1	CAMK2A	6	enzymatic study	Tan KM (2001)	1
CAMK2G	4	SMAD2	5	enzymatic study	Wicks SJ (2000)	1
CYLD	2	YWHAQ	0	affinity chromatography technology	Elliott PR (2016)	1
CYLD	2	DCTN2	0	affinity chromatography technology	Elliott PR (2016)	1
KCNC1	3	CAMK2A	6	affinity chromatography technology	El-Haou S (2009)	1
HSP90AA1	7	CAMK2D	3	affinity chromatography technology	Taipale M (2012)	1
CAMK2A	6	CAMK2D	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), So J (2015), Huttlin EL (2017)	3
RAD23A	1	PRKN	1	enzymatic study, affinity chromatography technology	Scanlon TC (2009), Sarraf SA (2013)	2
RAD23A	1	PTTG1	0	affinity chromatography technology	Jin L (2008)	1
HSP90AA1	7	NOS3	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Venema RC (2003), Venema RC (2003), Harris MB (2000), Harris MB (2000), Stepp DW (2002), Fontana J (2002), Fontana J (2002), Brouet A (2001), Brouet A (2001)	9
HDAC5	4	HSP90AA1	7	affinity chromatography technology	Greco TM (2011)	1
NUFIP1	0	MAPT	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CAMK2D	3	CAMK2G	4	affinity chromatography technology	Huttlin EL (2017)	1
FKBP8	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Edlich F (2007), Edlich F (2007), Okamoto T (2006), Okamoto T (2006), Okamoto T (2006), Skarra DV (2011)	6
CAMK2G	4	RCHY1	0	enzymatic study	Duan S (2007)	1
CAMK2A	6	GIT1	10	affinity chromatography technology	Pang J (2008)	1
HNRNPK	4	CAMK2A	6	biochemical	Havugimana PC (2012)	1
KCNC1	3	DLG1	2	affinity chromatography technology	El-Haou S (2009)	1
GRIN2B	30	DLG1	2	affinity chromatography technology, two hybrid	Inanobe A (2002), Niethammer M (1996)	2
CAMK2A	6	ARL3	1	affinity chromatography technology	Boldt K (2016)	1
NINL	1	DCTN1	6	affinity chromatography technology	Boldt K (2016)	1
DGUOK	1	MAPT	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CYLD	2	CAMK2D	3	affinity chromatography technology	Sowa ME (2009)	1
DCTN1	6	DCTN2	0	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Splinter D (2012), Huttlin EL (2015), Wan C (2015), Gupta GD (2015), Huttlin EL (2017), Boldt K (2016)	7
SMAD2	5	AKT1	1	affinity chromatography technology	Song K (2006)	1
CAMK2A	6	HDAC5	4	affinity chromatography technology	Pang J (2008)	1
RCHY1	0	CAMK2D	3	affinity chromatography technology	Ma-Lauer Y (2016)	1
CYLD	2	CAMK2A	6	affinity chromatography technology	Thein S (2014)	1
DCTN2	0	ARMC1	2	biochemical	Wan C (2015)	1
AKT1	1	CREB1	1	enzymatic study	Du K (1998)	1
AKT1	1	DCTN1	6	two hybrid	Vinayagam A (2011)	1
NOS3	7	CAMK2A	6	affinity chromatography technology	Fleming I (2001)	1
PRKN	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, imaging technique	Sarraf SA (2013), Song P (2016), Song P (2016), Song P (2016), Song P (2016), Hou XO (2015), Geisler S (2014)	7
HSP90AA1	7	ZMYM1	2	affinity chromatography technology	Hein MY (2015)	1
CDCA8	0	MAPT	1	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	PLCG1	6	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang Y (2006), Wang Y (2006), Wang Y (2006), Wang Y (2006)	4
CYLD	2	HSP90AA1	7	affinity chromatography technology	Elliott PR (2016)	1
CAMK2A	6	SLC6A3	6	affinity chromatography technology	Sakrikar D (2012)	1
CAMK2A	6	YWHAQ	0	affinity chromatography technology	Pang J (2008)	1
AKT1	1	PSMC5	4	two hybrid	Arroyo R (2015)	1
DLG3	1	CAMK2A	6	affinity chromatography technology	Ewing RM (2007)	1
MAPT	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Babu JR (2005), Babu JR (2005), Rui YN (2015)	3
NINL	1	CAMK2A	6	affinity chromatography technology	Boldt K (2016)	1
FKBP8	1	CAMK2A	6	affinity chromatography technology	Weiwad M (2005)	1
ACTN4	4	CAMK2B	9	two hybrid, two hybrid	Walikonis RS (2001), Walikonis RS (2001)	2
ARMC1	2	MAPT	1	affinity chromatography technology	Huttlin EL (2017)	1
HAX1	1	GNAO1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DLG3	1	DLG1	2	affinity chromatography technology	Hein MY (2015)	1
CYLD	2	DCTN1	6	affinity chromatography technology	Elliott PR (2016)	1
DCTN2	0	GNAO1	21	two hybrid	Stelzl U (2005)	1
AKT1	1	MAPT	1	enzymatic study	Sadik G (2009)	1
NINL	1	CAMK2B	9	bioid	Gupta GD (2015)	1
YWHAB	1	CYLD	2	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Elliott PR (2016)	2
PRKN	1	DLG1	2	imaging technique	Chen TC (2014)	1
DGUOK	1	CAMK2A	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
HDAC5	4	YWHAB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Grozinger CM (2000), Greco TM (2011), Joshi P (2013), Couzens AL (2013)	4
CAMK2A	6	CALM3	0	affinity chromatography technology	Ewing RM (2007)	1
RRP7A	1	MAPT	1	affinity chromatography technology	Huttlin EL (2017)	1
DLG3	1	GRIN2B	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Sans N (2003), Sans N (2003), Inanobe A (2002), Irie M (1997), Lim IA (2002), Lim IA (2002)	6
ARMC1	2	CAMK2A	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CAMK2A	6	PSMC5	4	enzymatic study	Djakovic SN (2012)	1
CAMK2A	6	GRIN2B	30	pull down	Bayer KU (2001)	1
NOS3	7	ACTN4	4	two hybrid	Soler-Lopez M (2011)	1
NINL	1	DCTN2	0	affinity chromatography technology	Boldt K (2016)	1
HNRNPK	4	PLCG1	6	affinity chromatography technology	Huttlin EL (2017)	1
ARMC1	2	CAMK2B	9	affinity chromatography technology	Huttlin EL (2015)	1
NUFIP1	0	CAMK2A	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAQ	0	HNRNPK	4	pull down	Meek SE (2004)	1
CAMK2A	6	RIMS1	6	enzymatic study	Sun L (2003)	1
DNAAF2	2	MAPT	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARMC1	2	GNAO1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DGUOK	1	CAMK2B	9	affinity chromatography technology	Huttlin EL (2015)	1
RAD23A	1	SQSTM1	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Scanlon TC (2009)	3
ACTN1	5	CAMK2A	6	imaging technique	Chen TC (2014)	1
CAMK2G	4	GRIN2B	30	enzymatic study	Wechsler A (1998)	1
CAMK2D	3	CAMK2B	9	affinity chromatography technology	Huttlin EL (2017)	1
CAMK2A	6	ZMYM1	2	affinity chromatography technology	So J (2015)	1
CDCA8	0	CAMK2A	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RRP7A	1	CAMK2A	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKN	1	PLCG1	6	affinity chromatography technology	Dehvari N (2009)	1
MAPT	1	DCTN1	6	two hybrid, two hybrid, pull down, biochemical, affinity chromatography technology, bioid	Magnani E (2007), Magnani E (2007), Magnani E (2007), Magnani E (2007), Magnani E (2007), Gupta GD (2015)	6
NUFIP1	0	CAMK2B	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAD23A	1	CAMK2A	6	affinity chromatography technology	Tsai NP (2012)	1
CAMK2A	6	ATF1	0	enzymatic study	Shimomura A (1996)	1
CAMK2A	6	DCTN2	0	affinity chromatography technology	Boldt K (2016)	1
NINL	1	CYLD	2	bioid	Gupta GD (2015)	1