PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CFTR	5	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vij N (2006), Ballar P (2010), Goldstein RF (2007), Goldstein RF (2007), Sun F (2006), Sun F (2006), Wang X (2006), Morito D (2008), Pankow S (2015)	9
EDEM3	2	LMAN1	3	affinity chromatography technology	Butnaru CM (2017)	1
PLTP	3	CANX	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EDEM3	2	RPN2	0	affinity chromatography technology	Butnaru CM (2017)	1
PTPRN	3	CANX	4	bioid, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
POGLUT1	1	CANX	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BSCL2	2	CANX	4	affinity chromatography technology, affinity chromatography technology	Ito D (2007), Ito D (2007)	2
CANX	4	LPA	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bonen DK (1998), Nassir F (2003), White AL (1999)	3
CHST15	1	CANX	4	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
BCAP31	0	CFTR	5	affinity chromatography technology	Wang B (2008)	1
ZNRF4	1	CANX	4	affinity chromatography technology, affinity chromatography technology	Neutzner A (2011), Neutzner A (2011)	2
NDRG1	2	CANX	4	affinity chromatography technology, affinity chromatography technology	Tu LC (2007), Tu LC (2007)	2
OGFOD3	2	CANX	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CANX	4	KCNH2	5	affinity chromatography technology, affinity chromatography technology	Wang Y (2012), Walker VE (2007)	2
CHST9	2	CANX	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBXN4	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Alexandru G (2008), Lim PJ (2009), Liang J (2006), Lim PJ (2009), Madsen L (2014), Raman M (2015)	6
UBXN4	0	CANX	4	biochemical, affinity chromatography technology	Liang J (2006), Liang J (2006)	2
LMAN1	3	CANX	4	imaging technique, biochemical	Abe F (2009), Wan C (2015)	2
RPN2	0	VCP	6	biochemical	Wan C (2015)	1
CD3D	0	CANX	4	affinity chromatography technology, imaging technique	van Leeuwen JE (1996), Chen TC (2014)	2
APOB	8	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fisher EA (2008), Rutledge AC (2009), Zhang J (2017)	3
WNT3A	0	CANX	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POMK	1	CANX	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CFTR	5	CANX	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosser MF (2008), Wang X (2006), Pankow S (2015)	3
CFTR	5	EGFR	5	affinity chromatography technology	Pankow S (2015)	1
EGFR	5	EDEM1	3	affinity chromatography technology	Yao Z (2017)	1
EGFR	5	CANX	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tong J (2014), Li J (2013), Yao Z (2017)	3
PTPRN	3	RPN2	0	bioid	St-Denis N (2016)	1
EGFR	5	APOB	8	affinity chromatography technology, affinity chromatography technology	Li J (2013), Yao Z (2017)	2
VCP	6	CANX	4	affinity chromatography technology, biochemical	Yu CC (2013), Wan C (2015)	2
CANX	4	RPN2	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TOR1A	0	CANX	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Naismith TV (2009), Zhao C (2013), Huttlin EL (2015)	3
NPHS1	2	CANX	4	affinity chromatography technology, affinity chromatography technology, imaging technique	Drozdova T (2013), Drozdova T (2013), Drozdova T (2013)	3
PTPRE	1	CANX	4	affinity chromatography technology, affinity chromatography technology	Li X (2016), Yadav L (2017)	2
NDRG1	2	VCP	6	affinity chromatography technology	Tu LC (2007)	1
CANX	4	EDEM1	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Oda Y (2003), Tamura T (2011), Zuber C (2007), Christianson JC (2012), Tang HY (2014)	5
FAM187B	0	CANX	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CHST8	3	CANX	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EDEM3	2	CANX	4	affinity chromatography technology, affinity chromatography technology	Butnaru CM (2017), Butnaru CM (2017)	2
RPN2	0	APOB	8	affinity chromatography technology	Huttlin EL (2017)	1
MTNR1A	1	CANX	4	affinity chromatography technology, pull down	Daulat AM (2007), Benleulmi-Chaachoua A (2016)	2
CANX	4	APOB	8	affinity chromatography technology, affinity chromatography technology	Vilas GL (2004), Liao W (1998)	2
CD3D	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Zhong X (2004)	2
NDRG1	2	RPN2	0	affinity chromatography technology	Tu LC (2007)	1
LMAN1	3	VCP	6	affinity chromatography technology	Haines DS (2012)	1
BCAP31	0	LMAN1	3	fluorescent resonance energy transfe, imaging technique	Abe F (2009), Abe F (2009)	2
BCAP31	0	CANX	4	affinity chromatography technology, biochemical	Zuppini A (2002), Breckenridge DG (2002)	2