PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBL4A	0	VAPB	2	affinity chromatography technology, affinity chromatography technology	Xu Y (2012), Baron Y (2014)	2
VAPB	2	BAG6	2	affinity chromatography technology, affinity chromatography technology	Baron Y (2014), Baron Y (2014)	2
USP13	2	UBL4A	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sowa ME (2009), Liu Y (2014), Liu Y (2014), Liu Y (2014)	4
FAF2	4	RNF126	2	affinity chromatography technology	Alexandru G (2008)	1
UBL4A	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu Y (2012), Xu Y (2013)	3
GET4	3	FAF2	4	affinity chromatography technology, affinity chromatography technology	Xu Y (2013), Xu Y (2013)	2
HUWE1	22	RPS19	1	affinity chromatography technology	Thompson JW (2014)	1
SRPRB	0	UBL4A	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Xu Y (2012)	2
FAF2	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lee JN (2008), Alexandru G (2008), Alexandru G (2008), Mueller B (2008), Alexandru G (2012), Xu Y (2013), Christianson JC (2012), Besten Wd (2012), Madsen L (2014), Raman M (2015)	10
FAF2	4	VAPB	2	affinity chromatography technology	Christianson JC (2012)	1
UBL4A	0	RNF126	2	affinity chromatography technology, pull down, pull down	Xu Y (2012), Krysztofinska EM (2016), Krysztofinska EM (2016)	3
RNF126	2	GET4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AMFR	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JN (2008), Lee JN (2008), Alexandru G (2008), Wang Q (2011), Xu Y (2013), Wang Q (2011), Christianson JC (2012), Christianson JC (2012), Zhang T (2015)	9
HUWE1	22	ASNA1	2	affinity chromatography technology	Thompson JW (2014)	1
BAG6	2	HUWE1	22	affinity chromatography technology	Rodrigo-Brenni MC (2014)	1
UBL4A	0	GET4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu Y (2012), Huttlin EL (2015), Huttlin EL (2017)	4
USP13	2	GET4	3	affinity chromatography technology	Liu Y (2014)	1
UBL4A	0	ASNA1	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu Y (2012)	2
BAG6	2	VCP	6	affinity chromatography technology, affinity chromatography technology, biochemical	Wang Q (2011), Yu CC (2013), Xu Y (2013)	3
AMFR	2	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhong X (2004), Zhong X (2004), Lee JN (2008), Cao J (2007), Ballar P (2007), Ballar P (2007), Ye Y (2005), Ye Y (2005), Zhong X (2004), Yang H (2010), Yang H (2010), Ballar P (2010), Jo Y (2011), St-Pierre P (2012), Grelle G (2006), Scheich C (2007), Ballar P (2006), Haenzelmann P (2011), Haenzelmann P (2011), Haenzelmann P (2011), Wang Q (2011), Yu CC (2013), Erzurumlu Y (2013), Liu S (2013), Wang Q (2011), Grelle G (2006), Grelle G (2006), Grelle G (2006), Grelle G (2006), Christianson JC (2012), Zhang T (2015), Khodayari N (2017)	32
AMFR	2	HSPA5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jo Y (2011), Chang YW (2014), Chang YW (2014), Chang YW (2015), Chang YW (2015)	5
AMFR	2	UBL4A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang Q (2011), Wang Q (2011), Liu Y (2014), Liu Y (2014)	4
SGTA	1	GET4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Huttlin EL (2015)	3
USP13	2	FAF2	4	affinity chromatography technology	Sowa ME (2009)	1
VAPB	2	VCP	6	affinity chromatography technology	Baron Y (2014)	1
UBL4A	0	HSPA5	0	affinity chromatography technology, affinity chromatography technology	Xu Y (2012), Hein MY (2015)	2
SSBP1	0	UBL4A	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Xu Y (2012)	2
UBL4A	0	TRAF4	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
RNF126	2	ASNA1	2	affinity chromatography technology	Huttlin EL (2015)	1
HUWE1	22	GET4	3	affinity chromatography technology	Thompson JW (2014)	1
UBL4A	0	SGTA	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography	Sowa ME (2009), Xu Y (2012), Xu Y (2012), Xu Y (2012), Xu Y (2012), Xu Y (2012), Xu Y (2012), Leznicki P (2013), Taipale M (2014), Taipale M (2014), Darby JF (2014), Darby JF (2014), Darby JF (2014)	13
RPS19	1	UBL4A	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Xu Y (2012)	2
HUWE1	22	HSPA5	0	affinity chromatography technology	Thompson JW (2014)	1
CDK18	3	UBL4A	0	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Hein MY (2015)	2
BAG6	2	GET4	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, pull down	Xu Y (2013), Xu Y (2013), Mock JY (2015), Huttlin EL (2015), Hein MY (2015), Rodrigo-Brenni MC (2014), Huttlin EL (2017), Mock JY (2017), Mock JY (2017), Mock JY (2017), Mock JY (2017)	11
BAG6	2	ASNA1	2	biochemical, affinity chromatography technology, biochemical	Kristensen AR (2012), Baron Y (2014), Rodrigo-Brenni MC (2014)	3
VAPB	2	ASNA1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baron Y (2014), Baron Y (2014), Baron Y (2014)	3
BAG6	2	FAF2	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu Y (2012), Xu Y (2013), Xu Y (2013), Raman M (2015)	4
USP13	2	AMFR	2	affinity chromatography technology, pull down, affinity chromatography technology	Liu Y (2014), Liu Y (2014), Liu Y (2014)	3
GET4	3	ASNA1	2	affinity chromatography technology, two hybrid	Huttlin EL (2015), Yu H (2011)	2
CDK18	3	BAG6	2	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Hein MY (2015)	2
UBL4A	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Xu Y (2012)	2
AMFR	2	SRPRB	0	affinity chromatography technology	Jo Y (2011)	1
UBL4A	0	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Thompson JW (2014)	2
VCP	6	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Thompson JW (2014)	2
HSPA5	0	SSBP1	0	biochemical	Havugimana PC (2012)	1
VAPB	2	GET4	3	affinity chromatography technology	Baron Y (2014)	1
SGTA	1	BAG6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, pull down	Winnefeld M (2006), Xu Y (2012), Xu Y (2012), Xu Y (2012), Leznicki P (2013), Taipale M (2014), Taipale M (2014), Rolland T (2014), Darby JF (2014), Darby JF (2014), Darby JF (2014), Liu Y (2014), Krysztofinska EM (2016), Krysztofinska EM (2016)	14
FAF2	4	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Thompson JW (2014)	2
VCP	6	HSPA5	0	affinity chromatography technology	Yu CC (2013)	1
AMFR	2	GET4	3	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Liu Y (2014)	2
HSPA5	0	BAG6	2	affinity chromatography technology	Hein MY (2015)	1
VCP	6	RNF126	2	affinity chromatography technology	Yu CC (2013)	1
UBL4A	0	BAG6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Wang Q (2011), Wang Q (2011), Mariappan M (2010), Xu Y (2012), Xu Y (2012), Xu Y (2012), Xu Y (2012), Mock JY (2015), Mock JY (2015), Kuwabara N (2015), Kuwabara N (2015), Kuwabara N (2015), Wu W (2014), Wu W (2014), Wan C (2015), Hein MY (2015), Rodrigo-Brenni MC (2014), Huttlin EL (2017)	19
VCP	6	GET4	3	affinity chromatography technology	Yu CC (2013)	1
AMFR	2	BAG6	2	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Wang Q (2011), Wang Q (2011), Xu Y (2012), Xu Y (2012), Xu Y (2012), Wang Q (2011), Liu Y (2014), Zhang T (2015)	9
HSPA5	0	FAF2	4	affinity chromatography technology	Hein MY (2015)	1
SGTA	1	ASNA1	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
USP13	2	VCP	6	pull down, affinity chromatography technology	Liu Y (2014), Liu Y (2014)	2
USP13	2	BAG6	2	affinity chromatography technology, pull down, pull down	Liu Y (2014), Liu Y (2014), Liu Y (2014)	3
BAG6	2	RNF126	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down	Rolland T (2014), Huttlin EL (2015), Hein MY (2015), OConnor HF (2015), Rodrigo-Brenni MC (2014), Rodrigo-Brenni MC (2014), Rodrigo-Brenni MC (2014), Huttlin EL (2017), Krysztofinska EM (2016), Krysztofinska EM (2016), Krysztofinska EM (2016)	11