PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CTNNB1	30	APC2	9	pull down, pull down, two hybrid, affinity chromatography technology	Nakagawa H (1998), Gomes NP (2006), Hart M (1999), Schneikert J (2013)	4
NR4A1	4	RNF111	2	affinity chromatography technology	Zhou F (2014)	1
SMAD7	1	CTNNB1	30	affinity chromatography technology, imaging technique, affinity chromatography technology	Edlund S (2005), Edlund S (2005), Tang Y (2008)	3
KDM5B	27	CDC20	1	affinity chromatography technology	Zhou W (2009)	1
AXIN2	1	APC2	9	two hybrid	van Es JH (1999)	1
GSK3A	1	AXIN2	1	affinity chromatography technology	Varjosalo M (2013)	1
RNF111	2	SMAD7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Koinuma D (2003), Koinuma D (2003), Erker Y (2013), Elkouris M (2016)	4
AXIN1	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
APC	5	CTNNB1	30	affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su LK (1993), Su LK (1993), Kucerova D (2001), Tickenbrock L (2003), Davies G (2001), Ryo A (2001), Homma MK (2002), Tickenbrock L (2003), Davies G (2001), Satoh K (1997), Eklof Spink K (2001), Eklof Spink K (2001), Sierra J (2006), Choi J (2004), Huang X (2009), Brocardo MG (2011), Xing Y (2004), Xing Y (2004), Xing Y (2004), Hamada F (2004), Hamada F (2004), Schneikert J (2013), Hsi LC (1999), Hein MY (2015), Hein MY (2015), Chen TC (2014), Kuslansky Y (2016), Novellasdemunt L (2017), Novellasdemunt L (2017)	29
FBXW11	2	KDM5B	27	affinity chromatography technology	Kim TY (2014)	1
NR4A1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun Z (2011), Sun Z (2011), Lu WJ (2015)	3
NR4A1	4	RLIM	1	affinity chromatography technology	Zhou F (2014)	1
FBXW11	2	AXIN1	1	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015)	2
ANKRD6	0	GSK3B	1	affinity chromatography technology	Schwarz-Romond T (2002)	1
GSK3B	1	AXIN1	1	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Mak BC (2003), Hino S (2005), Oosterveen T (2007), Kim MJ (2008), Kitagawa M (1999), Cha B (2011), Cha B (2011), Arnold HK (2009), Kashikar ND (2011), Kashikar ND (2011), Zhou F (2012), Yan D (2012), Zhang YG (2012), Sue Ng S (2010), Kim JW (2003), Tang Y (2008), Luo W (2007), Li VS (2012), Rosano L (2009), Yamamoto H (2006), Fei C (2013), Wang J (2011), Varjosalo M (2013), Gao C (2014), Varjosalo M (2013), Castellone MD (2005), Hein MY (2015), Chen TC (2014), Chen Y (2016), Novellasdemunt L (2017)	36
FBXW11	2	AXIN2	1	affinity chromatography technology	Kim TY (2014)	1
ANKRD6	0	AXIN2	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Schwarz-Romond T (2002), Schwarz-Romond T (2002), Schwarz-Romond T (2002)	3
GSK3A	1	CTNNB1	30	enzymatic study, affinity chromatography technology	Koo J (2015), Hein MY (2015)	2
GSK3B	1	APC	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davies G (2001), Varjosalo M (2013), Novellasdemunt L (2017)	3
AXIN2	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
GSK3B	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
MAP3K2	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Greenblatt MB (2016), Greenblatt MB (2016), Greenblatt MB (2016), Greenblatt MB (2016)	4
AXIN2	1	APC	5	affinity chromatography technology	von Kries JP (2000)	1
CTNNB1	30	GSK3B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davies G (2001), Kishida S (1999), Fischer L (2002), Kitagawa M (1999), Hart M (1999), Su Y (2008), Huang X (2009), Ding Q (2005), Piao S (2008), Varjosalo M (2013), Gao C (2014), Koo J (2015), Chen TC (2014), Lu D (2012), Kuslansky Y (2016), Novellasdemunt L (2017), Lu WJ (2015)	17
SMAD7	1	NR4A1	4	affinity chromatography technology, affinity chromatography technology	Zhou F (2014), Zhou F (2014)	2
FBXW11	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe N (2005), Fuchs SY (1999), Gao D (2011), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Low TY (2014)	8
AXIN2	1	RNF146	4	affinity chromatography technology	Zhang Y (2011)	1
KDM5B	27	AXIN2	1	affinity chromatography technology	Zhou W (2009)	1
AXIN1	1	AXIN2	1	affinity chromatography technology	Sue Ng S (2010)	1
NR4A1	4	AXIN2	1	affinity chromatography technology	Zhou F (2014)	1
FBXW11	2	APC	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014), Huttlin EL (2017)	3
AXIN1	1	APC	5	pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Hino S (2005), Kitagawa M (1999), Sue Ng S (2010), Tran H (2012), Li VS (2012), Hein MY (2015), Hein MY (2015), Novellasdemunt L (2017)	12
AXIN2	1	RNF111	2	affinity chromatography technology	Zhou F (2014)	1
AXIN1	1	GSK3A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Arnold HK (2009), Fei C (2013), Varjosalo M (2013), Hein MY (2015), Chen Y (2016)	5
FBXW11	2	GSK3B	1	two hybrid	Wallach T (2013)	1
AXIN2	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	von Kries JP (2000), Schwarz-Romond T (2002), Varjosalo M (2013), Varjosalo M (2013)	4
APC	5	RNF146	4	affinity chromatography technology	Tran H (2012)	1
AXIN2	1	SMAD7	1	affinity chromatography technology, pull down	Zhou F (2014), Elkouris M (2016)	2
AXIN2	1	CTNNB1	30	affinity chromatography technology	von Kries JP (2000)	1
AXIN2	1	CDC20	1	affinity chromatography technology, affinity chromatography technology	Hadjihannas MV (2012), Hadjihannas MV (2012)	2
AXIN2	1	RLIM	1	affinity chromatography technology	Zhou F (2014)	1
CTNNB1	30	AXIN1	1	pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Hocevar BA (2003), Hino S (2005), Stoothoff WH (2002), Kim MJ (2008), Kitagawa M (1999), Kitagawa M (1999), Arnold HK (2009), Zhang YG (2012), Godin JD (2010), Godin JD (2010), Sue Ng S (2010), Sue Ng S (2010), Tang Y (2008), Li VS (2012), Yamamoto H (2006), Fei C (2013), Hein MY (2015), Kuslansky Y (2016), Novellasdemunt L (2017)	25
SMAD7	1	AXIN1	1	affinity chromatography technology	Tang Y (2008)	1