PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
INO80	5	YY1	7	affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Chen L (2011), Wu S (2007), Wu S (2007), Wu S (2007), Cai Y (2007), Cai Y (2007), Hauri S (2016)	7
BAP1	4	ASXL1	15	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Scheuermann JC (2010), Yu H (2010), Bott M (2011), Bott M (2011), Abdel-Wahab O (2012), Daou S (2015), Daou S (2015), Daou S (2015), Sahtoe DD (2016), LaFave LM (2015), Hauri S (2016), Hauri S (2016)	14
ASXL1	15	PSMC6	0	affinity chromatography technology	Hauri S (2016)	1
HCFC1	4	OGT	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology	Wysocka J (2003), Wysocka J (2003), Mazars R (2010), Daou S (2011), Capotosti F (2011), Capotosti F (2011), Capotosti F (2011), Havugimana PC (2012), Hauri S (2016)	9
PSMD4	1	PSMD2	2	biochemical, biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Hamazaki J (2007), Havugimana PC (2012), Su V (2013), Kristensen AR (2012), Wan C (2015), Sparks A (2014)	6
PTEN	24	CASP8	1	affinity chromatography technology, affinity chromatography technology	Crockett DK (2005), Crockett DK (2005)	2
BRCA1	7	CAMK2D	3	affinity chromatography technology	Ertych N (2016)	1
MCRS1	1	BRCA1	7	two hybrid, affinity chromatography technology	Hill SJ (2014), Hill SJ (2014)	2
BAP1	4	HACD3	2	affinity chromatography technology	Hauri S (2016)	1
INO80	5	HIST2H2AC	1	affinity chromatography technology	Lee HS (2014)	1
BAP1	4	PSMD11	0	affinity chromatography technology	Hauri S (2016)	1
BAP1	4	FOXK2	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Yu H (2010), Okino Y (2015), Okino Y (2015), Okino Y (2015), Li X (2015), Ji Z (2014), Ji Z (2014), Ji Z (2014), Ji Z (2014), Shan L (2016), Shan L (2016), Shan L (2016), Hauri S (2016)	15
BAP1	4	HSPA2	3	affinity chromatography technology	Machida YJ (2009)	1
BAP1	4	IPO4	9	affinity chromatography technology	Sowa ME (2009)	1
BAP1	4	ANAPC7	2	affinity chromatography technology	Sowa ME (2009)	1
PSMC6	0	PSMD3	5	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
BAP1	4	HCFC2	1	affinity chromatography technology	Hauri S (2016)	1
SMS	1	BAP1	4	affinity chromatography technology	Hein MY (2015)	1
ASXL2	6	KDM1B	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	4
CBX1	0	L3MBTL2	1	affinity chromatography technology	Hauri S (2016)	1
HCFC1	4	YY1	7	affinity chromatography technology, affinity chromatography technology, pull down	Yu H (2010), Yu H (2010), Yu H (2010)	3
PSMC4	6	PSMC2	2	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ewing RM (2007), Hartmann-Petersen R (2001), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	8
BAP1	4	EFNA2	3	biochemical	Yu H (2010)	1
ASXL1	15	PGAM5	4	affinity chromatography technology	Hauri S (2016)	1
OGT	4	MCRS1	1	affinity chromatography technology	Hauri S (2016)	1
ASXL2	6	OGT	4	affinity chromatography technology, affinity chromatography technology	Daou S (2015), Hauri S (2016)	2
HIST2H2AC	1	RBBP7	1	affinity chromatography technology	Verreault A (1998)	1
USP21	2	USP28	3	enzymatic study, enzymatic study	Loch CM (2012), Loch CM (2012)	2
MAP3K1	4	PSMD4	1	enzymatic study	Charlaftis N (2014)	1
BAG4	2	BAP1	4	two hybrid	Arroyo R (2015)	1
PTEN	24	TUBA1C	1	affinity chromatography technology	Maddika S (2011)	1
BAP1	4	PSMC2	2	affinity chromatography technology	Hauri S (2016)	1
PTEN	24	UBC	7	protein complementation assay, affinity chromatography technology	Li Y (2014), Li Y (2014)	2
BAP1	4	SSR4	1	affinity chromatography technology	Hauri S (2016)	1
UBC	7	BAP1	4	pull down, pull down, pull down, pull down	Duerksen-Hughes PJ (1989), Daou S (2015), Kwasna D (2018), Hanpude P (2017)	4
PSMD11	0	PSMD4	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Sparks A (2014)	3
HCFC1	4	HCFC2	1	biochemical, affinity chromatography technology	Yokoyama A (2004), Huttlin EL (2017)	2
FOXK1	5	USP28	3	affinity chromatography technology	Li X (2015)	1
BRCA1	7	HSPA9	2	affinity chromatography technology	Ertych N (2016)	1
BAP1	4	PSMD3	5	affinity chromatography technology	Hauri S (2016)	1
HSPA1A	0	HSPA2	3	biochemical	Havugimana PC (2012)	1
CASP8	1	USP2	0	affinity chromatography technology	Mahul-Mellier AL (2011)	1
ASXL1	15	PSMC5	4	affinity chromatography technology	Hauri S (2016)	1
BAP1	4	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
HIST2H2AC	1	UBC	7	pull down, pull down	Long L (2014), Zhang X (2017)	2
TRIM63	0	USP2	0	enzymatic study	Loch CM (2012)	1
FOXK2	9	KDM1B	4	affinity chromatography technology	Li X (2015)	1
XRCC3	1	BAP1	4	two hybrid	Arroyo R (2015)	1
BRCA1	7	HIST1H2AB	0	enzymatic study, enzymatic study	Kalb R (2014), McGinty RK (2014)	2
L3MBTL2	1	BAP1	4	affinity chromatography technology, affinity chromatography technology	LaFave LM (2015), LaFave LM (2015)	2
TUBA1C	1	PGAM5	4	affinity chromatography technology	Hein MY (2015)	1
NBN	1	BAP1	4	two hybrid	Arroyo R (2015)	1
PSMD11	0	PSMD2	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PSMD2	2	PSMC2	2	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, biochemical, affinity chromatography technology	Gorbea C (2000), Um JW (2010), Lee SH (2012), Shim SM (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Sun S (2017)	8
PSMC2	2	PSMD8	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Grune T (2011), Kim YC (2011), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	7
PSMC4	6	PSMD8	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	5
ESR1	0	RBBP7	1	pull down, affinity chromatography technology	Creekmore AL (2008), Tarallo R (2011)	2
CASP8	1	BAP1	4	two hybrid	Arroyo R (2015)	1
BAP1	4	MCRS1	1	affinity chromatography technology, affinity chromatography technology	Peng J (2015), Peng J (2015)	2
BRCA1	7	BAP1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Jensen DE (1998), Jensen DE (1998), Jensen DE (1998), Jensen DE (1998)	4
ASXL1	15	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
PSMD3	5	PSMD4	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
PSMC2	2	PSME3	0	biochemical	Havugimana PC (2012)	1
UBC	7	OGT	4	pull down	Zhang X (2017)	1
CBX1	0	CBX3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Rosnoblet C (2011), Hauri S (2016), Hauri S (2016)	8
USP21	2	BAP1	4	enzymatic study	Loch CM (2012)	1
PSMD11	0	PSMD8	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
BRCA1	7	PSMD11	0	affinity chromatography technology	Ertych N (2016)	1
USP21	2	HIST2H2AA3	0	enzymatic study	Richly H (2010)	1
PPM1G	1	HIST2H2AC	1	affinity chromatography technology	Yadav L (2017)	1
BCAR3	5	BAP1	4	two hybrid	Arroyo R (2015)	1
PTEN	24	SSR4	1	pull down	Verrastro I (2015)	1
ASXL2	6	HCFC1	4	affinity chromatography technology, affinity chromatography technology	Daou S (2015), Hauri S (2016)	2
TRIM63	0	BAP1	4	enzymatic study	Loch CM (2012)	1
PSMD7	1	PSMC6	0	affinity chromatography technology, biochemical, biochemical, biochemical	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
IPO4	9	PSMC2	2	biochemical	Wan C (2015)	1
ASXL1	15	PSMD8	1	affinity chromatography technology	Hauri S (2016)	1
PSMD4	1	PSMC5	4	biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Hamazaki J (2007), Hamazaki J (2007), Thompson D (2009), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	6
ESR1	0	PGAM5	4	affinity chromatography technology	Tarallo R (2011)	1
BRCA1	7	CBX1	0	pull down	Wu W (2015)	1
ASXL1	15	PSMC2	2	affinity chromatography technology	Hauri S (2016)	1
ASXL1	15	HCFC1	4	affinity chromatography technology, affinity chromatography technology	Daou S (2015), Hauri S (2016)	2
ASXL1	15	MBD6	5	affinity chromatography technology	Hauri S (2016)	1
ASXL2	6	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
UBC	7	PSMC5	4	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhu Q (2004), Zhang X (2017)	3
BAP1	4	HSPA1A	0	biochemical	Yu H (2010)	1
BAP1	4	ANKRD17	10	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009)	2
AHCYL2	4	FOXK1	5	affinity chromatography technology	Huttlin EL (2017)	1
PSMC5	4	PSMD8	1	affinity chromatography technology, biochemical, biochemical, biochemical	Kim YC (2011), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
PTPRJ	5	BAP1	4	two hybrid	Arroyo R (2015)	1
PSME3	0	ELF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	PSMC5	4	affinity chromatography technology	Ertych N (2016)	1
YY1	7	MCRS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cai Y (2007), Cai Y (2007), Hauri S (2016)	3
USP28	3	BAP1	4	enzymatic study	Loch CM (2012)	1
PSMC2	2	PSMD11	0	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
IPO4	9	IPO5	0	biochemical	Havugimana PC (2012)	1
HCFC2	1	OGT	4	affinity chromatography technology	Huttlin EL (2017)	1
USP28	3	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, pull down	Loch CM (2012), Zhen Y (2014), Wen Y (2015), Wen Y (2015), Wen Y (2015), Wrigley JD (2017), Kwasna D (2018)	7
PSMD3	5	PSMD8	1	affinity chromatography technology, biochemical, biochemical, biochemical	Wei SJ (2008), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
PSMC4	6	PSMD11	0	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
BAP1	4	UBE2O	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, biochemical, affinity chromatography technology	Sowa ME (2009), Mashtalir N (2014), Mashtalir N (2014), Mashtalir N (2014), Mashtalir N (2014), Hauri S (2016)	6
BAP1	4	PSMD2	2	affinity chromatography technology	Hauri S (2016)	1
BAP1	4	PGAM5	4	affinity chromatography technology	Hauri S (2016)	1
BAP1	4	HAT1	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009)	2
FOXK2	9	MCRS1	1	affinity chromatography technology	Li X (2015)	1
PSMD7	1	PSMD11	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
TRIM63	0	PSMD4	1	enzymatic study, enzymatic study	Uchiki T (2009), Kim HT (2012)	2
HSPA1A	0	HAT1	0	biochemical	Kristensen AR (2012)	1
KLF5	4	HCFC1	4	affinity chromatography technology	Qin J (2015)	1
BAP1	4	PSMC4	6	affinity chromatography technology	Hauri S (2016)	1
ASXL1	15	OGT	4	affinity chromatography technology, affinity chromatography technology	Daou S (2015), Hauri S (2016)	2
KIAA1107	3	BAP1	4	affinity chromatography technology	Hein MY (2015)	1
FOXK1	5	FOXK2	9	affinity chromatography technology	Li X (2015)	1
CAMK2D	3	OGT	4	affinity chromatography technology	Huttlin EL (2017)	1
TUBA1C	1	PSMC5	4	affinity chromatography technology	Hein MY (2015)	1
UBC	7	ANAPC7	2	affinity chromatography technology, pull down	Matsumoto M (2005), Nathan JA (2013)	2
PSMD7	1	PSMD2	2	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
PSMC6	0	PSMD2	2	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
UBC	7	PSMC6	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
BAP1	4	PPM1G	1	affinity chromatography technology	Sowa ME (2009)	1
PSMC2	2	UBC	7	pull down, pull down	Jacobson AD (2014), Zhang X (2017)	2
INO80	5	BAP1	4	affinity chromatography technology	Lee HS (2014)	1
UBC	7	PSMD7	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
TSNAX	1	BAP1	4	affinity chromatography technology	Hein MY (2015)	1
PSMC2	2	PSMC5	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Tipler CP (1997), Kim YC (2011), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	7
IGF1R	5	BAP1	4	two hybrid	Arroyo R (2015)	1
PTEN	24	BAP1	4	affinity chromatography technology	Crockett DK (2005)	1
UBC	7	PSMD4	1	pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Fallon L (2006), Wang Q (2005), Leonchiks A (2002), Isasa M (2010), Wang Q (2005), Wang Q (2005), Haririnia A (2007), Fenner BJ (2009), Raasi S (2005), Nathan JA (2013), Beal R (1996), Uchiki T (2009), Young P (1998), Fujiwara K (2004), Dimitrov S (2005), Yoshimoto N (2009), Hawryluk MJ (2006), Nakayasu ES (2013), Nakayasu ES (2013), Tomaic V (2015), Aguileta MA (2015), Zhang X (2017), Kristariyanto YA (2017)	23
BRCA1	7	PSMC4	6	affinity chromatography technology	Ertych N (2016)	1
PSMC5	4	PSME3	0	biochemical	Havugimana PC (2012)	1
BAP1	4	RBBP7	1	affinity chromatography technology	Sowa ME (2009)	1
AHCYL2	4	PSMD4	1	biochemical	Wan C (2015)	1
BAP1	4	ZNF131	0	biochemical	Yu H (2010)	1
BAP1	4	PSMD8	1	affinity chromatography technology	Hauri S (2016)	1
ESR1	0	FOXK2	9	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Liu Y (2015), Liu Y (2015), Liu Y (2015), Liu Y (2015)	4
USP2	0	HIST2H2AC	1	enzymatic study	Yu M (2016)	1
UBC	7	PSMD11	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
ZNF131	0	HCFC2	1	affinity chromatography technology	Varier RA (2016)	1
AHCYL2	4	FOXK2	9	affinity chromatography technology	Huttlin EL (2017)	1
USP15	4	PSMD7	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015)	2
PSMC2	2	PSMC6	0	biochemical, biochemical, biochemical, biochemical	Tipler CP (1997), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
HIST2H2AC	1	USP15	4	affinity chromatography technology	Long L (2014)	1
USP21	2	USP15	4	enzymatic study, enzymatic study	Loch CM (2012), Loch CM (2012)	2
ASXL2	6	FOXK1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Daou S (2015), Huttlin EL (2017), Hauri S (2016)	4
ESR1	0	PSMC5	4	pull down	vom Baur E (1996)	1
BAP1	4	PSMD7	1	affinity chromatography technology	Hauri S (2016)	1
UBC	7	PSMD2	2	pull down	Zhang X (2017)	1
PSMD7	1	PSMD8	1	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
UBC	7	PSME3	0	affinity chromatography technology	Matsumoto M (2005)	1
BRCA1	7	CBX3	1	affinity chromatography technology, pull down	Hill SJ (2014), Wu W (2015)	2
ESR1	0	HSPA2	3	affinity chromatography technology	Dhamad AE (2016)	1
BRCA1	7	PSMD3	5	affinity chromatography technology	Ertych N (2016)	1
USP28	3	USP15	4	enzymatic study	Loch CM (2012)	1
GOPC	5	BAP1	4	affinity chromatography technology	Huttlin EL (2017)	1
NBN	1	IPO5	0	affinity chromatography technology	Falck J (2005)	1
PSMC4	6	PSMD7	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
BAP1	4	HIST2H2AC	1	enzymatic study, affinity chromatography technology, enzymatic study	Scheuermann JC (2010), Lee HS (2014), Sahtoe DD (2016)	3
PSMC5	4	PSMC6	0	pull down, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Hartmann-Petersen R (2001), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	6
KLF5	4	OGT	4	affinity chromatography technology	Qin J (2015)	1
ESR1	0	BAP1	4	two hybrid	Arroyo R (2015)	1
KDM1B	4	OGT	4	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang Y (2015), Yang Y (2015), Yang Y (2015)	3
MAP3K1	4	BAP1	4	enzymatic study	Charlaftis N (2014)	1
BAP1	4	FOXK1	5	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Yu H (2010), Okino Y (2015), Okino Y (2015), Okino Y (2015), Li X (2015), Hauri S (2016)	8
ASXL1	15	FOXK1	5	affinity chromatography technology, affinity chromatography technology	Daou S (2015), Hauri S (2016)	2
PSMC6	0	PSMD11	0	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
OGT	4	HACD3	2	affinity chromatography technology	Hauri S (2016)	1
PSMC5	4	PSMD11	0	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
BAP1	4	ASXL2	6	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Yu H (2010), Huttlin EL (2015), Daou S (2015), Daou S (2015), Daou S (2015), Daou S (2015), Daou S (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	12
PPM1G	1	PSMD2	2	affinity chromatography technology	Yadav L (2017)	1
BAP1	4	PSMC6	0	affinity chromatography technology	Hauri S (2016)	1
OGT	4	SSR4	1	affinity chromatography technology	Hauri S (2016)	1
CAMK2D	3	HCFC1	4	affinity chromatography technology	Huttlin EL (2017)	1
RBBP7	1	BRCA1	7	affinity chromatography technology, two hybrid, pull down, far western blotting, pull down	Chen GC (2001), Chen GC (2001), Yarden RI (2001), Yarden RI (2001), Yarden RI (1999)	5
HCFC1	4	RBBP7	1	affinity chromatography technology	Wysocka J (2003)	1
BRCA1	7	PSME3	0	affinity chromatography technology	Ertych N (2016)	1
ESR1	0	ZNF131	0	affinity chromatography technology, affinity chromatography technology	Oh Y (2013), Oh Y (2013)	2
BRCA1	7	NBN	1	biochemical, biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Chiba N (2001), Zhong Q (1999), Shimada M (2009), Chen L (2008), Hill SJ (2014), Goldstein M (2015), Goldstein M (2015), Parameswaran B (2015)	9
BAP1	4	HIST1H2AB	0	enzymatic study	Daou S (2015)	1
PSMC4	6	PSMD3	5	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
ESR1	0	HSPA1A	0	affinity chromatography technology, affinity chromatography technology	Dhamad AE (2016), Dhamad AE (2016)	2
PSMD2	2	PSME3	0	biochemical	Havugimana PC (2012)	1
PPM1G	1	PSMC4	6	affinity chromatography technology	Yadav L (2017)	1
UBC	7	PSMD3	5	pull down	Zhang X (2017)	1
PSMD4	1	PSME3	0	affinity chromatography technology	Andersen KM (2009)	1
USP15	4	PSMD11	0	affinity chromatography technology	Sowa ME (2009)	1
BAP1	4	EIF4EBP3	0	affinity chromatography technology	Sowa ME (2009)	1
BAP1	4	HCFC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, biochemical, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Machida YJ (2009), Machida YJ (2009), Machida YJ (2009), Yu H (2010), Yu H (2010), Yu H (2010), Yu H (2010), Pena-Llopis S (2012), Pena-Llopis S (2012), Bott M (2011), Bott M (2011), Misaghi S (2009), Mashtalir N (2014), Eletr ZM (2013), Eletr ZM (2013), Daou S (2015), Hauri S (2016)	19
ESR1	0	KLF5	4	affinity chromatography technology, affinity chromatography technology, pull down	Guo P (2010), Guo P (2010), Guo P (2010)	3
BRCA1	7	PSMD4	1	affinity chromatography technology	Ertych N (2016)	1
L3MBTL2	1	UBE2O	5	affinity chromatography technology	Huttlin EL (2017)	1
PTEN	24	HSPA2	3	affinity chromatography technology	Maddika S (2011)	1
FOXK2	9	ASXL1	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Daou S (2015), Hauri S (2016)	3
PTEN	24	ESR1	0	pull down	Lin HK (2004)	1
PSMD7	1	PSMC2	2	affinity chromatography technology, biochemical, biochemical, biochemical	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
PTEN	24	ANAPC7	2	affinity chromatography technology, affinity chromatography technology	Song MS (2011), Song MS (2011)	2
IGF1R	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Santen RJ (2005), Song RX (2004), Yoshimaru T (2013)	3
UBC	7	ASXL1	15	pull down	Daou S (2015)	1
HIST1H2AB	0	UBC	7	affinity chromatography technology	Sharma N (2013)	1
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
BRCA1	7	IPO5	0	affinity chromatography technology	Ertych N (2016)	1
FOXK2	9	PRDM10	3	affinity chromatography technology	Li X (2015)	1
BAP1	4	PSME3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
TRIM63	0	USP28	3	enzymatic study	Loch CM (2012)	1
BRCA1	7	PSMC2	2	affinity chromatography technology	Ertych N (2016)	1
PSMD7	1	PSMD3	5	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Wei SJ (2008), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
BAP1	4	OGT	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yu H (2010), Mashtalir N (2014), Daou S (2015), Hauri S (2016), Hauri S (2016)	6
ASXL1	15	PSMC4	6	affinity chromatography technology	Hauri S (2016)	1
PSMC4	6	PSMC6	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	4
PSMD2	2	PSMD3	5	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
RBBP7	1	HAT1	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Campos EI (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Marin TL (2017), Marin TL (2017), Hauri S (2016)	8
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
ASXL2	6	MBD6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	3
BRCA1	7	PSMC6	0	affinity chromatography technology	Ertych N (2016)	1
TUBA1C	1	SSR4	1	affinity chromatography technology	Hein MY (2015)	1
PSMD11	0	PSMD3	5	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
PSMD7	1	PSMD4	1	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
PPM1G	1	HIST1H2AB	0	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
BAP1	4	ZC3H13	8	biochemical	Yu H (2010)	1
BAP1	4	ELF2	1	biochemical	Yu H (2010)	1
ESR1	0	HIST2H2AC	1	pull down	Nalvarte I (2010)	1
BAP1	4	IPO5	0	affinity chromatography technology	Sowa ME (2009)	1
L3MBTL2	1	CBX3	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trojer P (2007), Trojer P (2011), Trojer P (2011), Trojer P (2011), Hauri S (2016), Hauri S (2016)	6
RBBP7	1	FOXK1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PSMC2	2	PSMD3	5	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
PSMC6	0	PSMD4	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
PSMC2	2	PSMD4	1	biochemical, biochemical, biochemical, biochemical, pull down, biochemical, affinity chromatography technology	Kim YC (2011), Shim SM (2012), Havugimana PC (2012), Kristensen AR (2012), Berko D (2014), Wan C (2015), Sun S (2017)	7
FOXK1	5	HCFC1	4	affinity chromatography technology	Okino Y (2015)	1
BAP1	4	PSMC5	4	affinity chromatography technology	Hauri S (2016)	1
UBC	7	ASXL2	6	pull down	Daou S (2015)	1
BAP1	4	HIST2H2AA3	0	enzymatic study	Mashtalir N (2014)	1
RB1CC1	9	BAP1	4	two hybrid	Arroyo R (2015)	1
HSPA9	2	HSPA2	3	biochemical	Wan C (2015)	1
USP15	4	ZC3H13	8	biochemical	Havugimana PC (2012)	1
PSMC4	6	PSMD4	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
PTEN	24	MCRS1	1	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down	Okumura K (2005), Okumura K (2005), Okumura K (2005), Okumura K (2005)	4
ASXL3	30	BAP1	4	affinity chromatography technology, affinity chromatography technology	Srivastava A (2015), Srivastava A (2015)	2
PSMC4	6	PSMD2	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ewing RM (2007), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	6
BAP1	4	AHCYL2	4	affinity chromatography technology	Sowa ME (2009)	1
TEPSIN	1	BAP1	4	affinity chromatography technology	Hein MY (2015)	1
BAP1	4	PSMD4	1	affinity chromatography technology	Hauri S (2016)	1
BRCA1	7	USP2	0	two hybrid, two hybrid	Woods NT (2012), Hayes SD (2012)	2
RBBP7	1	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
TRIM63	0	USP15	4	enzymatic study	Loch CM (2012)	1
BAP1	4	MBD6	5	affinity chromatography technology	Hauri S (2016)	1
BRCA1	7	OGT	4	affinity chromatography technology	Ertych N (2016)	1
TRIM63	0	USP21	2	enzymatic study	Loch CM (2012)	1
USP2	0	BAP1	4	enzymatic study	Mashtalir N (2014)	1
CAMK2D	3	BAP1	4	affinity chromatography technology	Huttlin EL (2017)	1
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
BRCA1	7	PSMD7	1	affinity chromatography technology	Ertych N (2016)	1
PSMD7	1	PSMC5	4	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
ESR1	0	HACD3	2	affinity chromatography technology	Tarallo R (2011)	1
BRCA1	7	ESR1	0	imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Zheng L (2001), Fan S (2001), Fan S (2001), Kawai H (2002), Fan S (2002), Fan S (2002), Nakuci E (2006), Wang C (2005), Wang C (2005), Dizin E (2010), Dizin E (2010), Ma Y (2010), Ma Y (2010), Fan S (2001), Ma YX (2005), Ma YX (2005), Ma YX (2005), Ma Y (2007), Ma Y (2007), Kawai H (2002), Jung YS (2014), Kawai H (2002), Kawai H (2002)	23
LINC00598	0	BAP1	4	unspecified method, unspecified method	Xi J (2017), Xi J (2017)	2
UBC	7	PSMC4	6	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
MAP3K1	4	USP28	3	enzymatic study	Charlaftis N (2014)	1
UBC	7	HIST2H2AA3	0	pull down	Zhang X (2017)	1
BRCA1	7	HCFC1	4	affinity chromatography technology	Ertych N (2016)	1
BAP1	4	CBX1	0	affinity chromatography technology	Sowa ME (2009)	1
FOXK2	9	HCFC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Okino Y (2015), Li X (2015), Ji Z (2014), Ji Z (2014), Ji Z (2014)	5
PSMD8	1	PSME3	0	biochemical	Havugimana PC (2012)	1
BRCA1	7	PGAM5	4	affinity chromatography technology	Hill SJ (2014)	1
USP21	2	USP2	0	enzymatic study	Loch CM (2012)	1
BRCA1	7	HIST2H2AC	1	enzymatic study, enzymatic study	Chen A (2002), Thakar A (2010)	2
BRCA1	7	PSMD2	2	affinity chromatography technology	Ertych N (2016)	1
PSMC5	4	PSMD2	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Hamazaki J (2007), Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	5
PTEN	24	HIST1H2AB	0	pull down	Verrastro I (2015)	1
RBBP7	1	FOXK2	9	affinity chromatography technology, affinity chromatography technology, pull down	Huttlin EL (2015), Huttlin EL (2017), Shan L (2016)	3
HAT1	0	HIST2H2AC	1	enzymatic study	Verreault A (1998)	1
PSMC4	6	PSMC5	4	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Hendil KB (2009), Kaneko T (2009), Kaneko T (2009), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Albers M (2005), Albers M (2005), Huttlin EL (2017)	13
RB1CC1	9	UBC	7	pull down	Choi JD (2012)	1
USP15	4	BAP1	4	enzymatic study	Loch CM (2012)	1
PSMD7	1	HCFC1	4	biochemical	Wan C (2015)	1
PSMD4	1	PSMD8	1	pull down, pull down, affinity chromatography technology, biochemical, biochemical, biochemical	Isasa M (2010), Boehringer J (2012), Boehringer J (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	6
BAP1	4	KLF5	4	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Qin J (2015), Qin J (2015), Qin J (2015), Qin J (2015), Qin J (2015)	5
OGT	4	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
UBC	7	PSMD8	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
HSPA1A	0	PSMC5	4	pull down	Hjerpe R (2016)	1
FOXK2	9	ASXL2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Daou S (2015), Ji Z (2014), Hauri S (2016)	4
PSMC6	0	PSMD8	1	affinity chromatography technology, biochemical, biochemical, biochemical	Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
ESR1	0	TUBA1C	1	pull down	Nalvarte I (2010)	1
UBC	7	UBE2O	5	affinity chromatography technology	Bish RA (2007)	1
PTEN	24	HSPA1A	0	affinity chromatography technology	Maddika S (2011)	1
IPO4	9	HAT1	0	affinity chromatography technology	Campos EI (2010)	1
PSMD2	2	PSMD8	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
ESR1	0	HSPA9	2	affinity chromatography technology	Dhamad AE (2016)	1
PSME3	0	L3MBTL2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BAP1	4	KDM1B	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Yu H (2010), Hein MY (2015), Hauri S (2016)	5
INO80	5	MCRS1	1	affinity chromatography technology, affinity chromatography technology	Chen L (2011), Cai Y (2007)	2
BAP1	4	HSPA9	2	biochemical	Yu H (2010)	1
BAG4	2	HSPA2	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
USP21	2	UBC	7	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study	Bremm A (2010), Faesen AC (2011), Ye Y (2011), Urbe S (2012), Loch CM (2012), Ernst A (2013), Ye Y (2011), Wauer T (2015), Leung I (2016), Michel MA (2017)	10
PSMD11	0	PSME3	0	biochemical	Havugimana PC (2012)	1
BAP1	4	PRDM10	3	biochemical	Yu H (2010)	1
BAP1	4	YY1	7	biochemical, biochemical, affinity chromatography technology, pull down, pull down	Yu H (2010), Yu H (2010), Yu H (2010), Yu H (2010), Yu H (2010)	5
BRCA1	7	MAP3K1	4	two hybrid	Woods NT (2012)	1
BAP1	4	CBX3	1	affinity chromatography technology	Sowa ME (2009)	1
PSMC5	4	PSMD3	5	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
BRCA1	7	TUBA1C	1	affinity chromatography technology	Ertych N (2016)	1