PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SPRTN	0	BRAP	0	affinity chromatography technology	Hein MY (2015)	1
TWIST1	0	BRAP	0	affinity chromatography technology	Yang F (2012)	1
KLHDC3	1	BRAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRAP	0	TANC2	13	two hybrid	Fatima S (2015)	1
BRCA1	7	SKP2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lu Y (2012), Lu Y (2012), Parameswaran B (2015)	3
BRAP	0	NUMA1	10	two hybrid, two hybrid	Davies RG (2013), Fatima S (2015)	2
ZNF526	1	BRAP	0	affinity chromatography technology	Hein MY (2015)	1
NEDD8	0	HRAS	2	biochemical	Havugimana PC (2012)	1
BRAP	0	USP15	4	two hybrid, affinity chromatography technology, two hybrid	Hayes SD (2012), Hayes SD (2012), Hayes SD (2012)	3
UBC	7	IKBKB	1	pull down	Zhang X (2017)	1
SKP2	2	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, imaging technique	Amador V (2007), Hwang CY (2007), Calvisi DF (2009), Bendjennat M (2003), Wu L (2012), Wu L (2012), Abbas T (2008), Ungermannova D (2005), Chen TC (2014)	9
BRAP	0	DNMT1	5	two hybrid, pull down	Fatima S (2015), Fatima S (2015)	2
KSR1	0	MAP2K1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen C (2008), Harrison RE (2004), Gloeckner CJ (2007), Hein MY (2015)	4
IKBKB	1	CUL1	7	affinity chromatography technology	Orel L (2010)	1
BRAP	0	APOA1	0	two hybrid	Fatima S (2015)	1
BRAP	0	TEX35	0	two hybrid	Fatima S (2015)	1
UBC	7	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Matsumoto M (2005), Bennett EJ (2010), Bish RA (2007), Wu K (2016)	4
UBE2H	3	BRAP	0	two hybrid	Markson G (2009)	1
BRAP	0	NFKBIB	2	affinity chromatography technology, affinity chromatography technology	Liao YC (2011), Liao YC (2011)	2
BRAP	0	UBB	4	two hybrid	Fatima S (2015)	1
CUL2	3	BRAP	0	affinity chromatography technology	Bennett EJ (2010)	1
BRAP	0	CCDC105	0	two hybrid	Fatima S (2015)	1
UBC	7	NEDD8	0	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Matsumoto M (2005), Bennett EJ (2010), Singh RK (2012), Singh RK (2012)	4
BRAP	0	CCDC30	1	two hybrid	Fatima S (2015)	1
BRAP	0	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Liao YC (2011), Liao YC (2011)	2
IKBKB	1	TWIST1	0	enzymatic study	Zhong J (2013)	1
KLHDC3	1	NEDD8	0	affinity chromatography technology	Huttlin EL (2015)	1
BRAP	0	SMARCE1	1	two hybrid	Fatima S (2015)	1
HRAS	2	BRAF	12	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Stang S (1997), Reuter CW (1995), Huttlin EL (2017), Eisenhardt AE (2016), Ivanov AA (2017)	5
BRAP	0	LINC00852	0	two hybrid	Fatima S (2015)	1
HRAS	2	RAF1	3	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Stang S (1997), Germani A (2003), Mitin NY (2004), Vargiu P (2004), Yuryev A (2003), Li W (2000), Li W (2000), Kiyono M (2000), Janoueix-Lerosey I (1998), Boettner B (2000), Karbowniczek M (2006), Han L (1995), Jelinek T (1994), Romero F (1999), Morcos P (1996), Hu CD (1995), Hu CD (1995), Rodriguez-Viciana P (1997), Huang YZ (2003), Stang S (1997), Dougherty MK (2005), Ji H (2016), Fridman M (2000), Ivanov AA (2017)	24
SERPINB13	1	BRAP	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL2	3	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Bish RA (2007), Wu K (2016)	3
SKP2	2	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
BRAP	0	FAM184A	2	two hybrid	Fatima S (2015)	1
HRAS	2	MAP2K1	8	affinity chromatography technology	Jelinek T (1994)	1
SKP2	2	PHLPP1	4	affinity chromatography technology	Huttlin EL (2017)	1
CDKN1A	1	UBB	4	affinity chromatography technology	Fogeron ML (2013)	1
BRAP	0	SYNE2	19	two hybrid, two hybrid	Davies RG (2013), Fatima S (2015)	2
BRAP	0	90827	0	two hybrid	Fatima S (2015)	1
KSR1	0	TANC2	13	affinity chromatography technology	Boldt K (2016)	1
BRAP	0	BRK1	0	two hybrid	Fatima S (2015)	1
BRAP	0	ATMIN	0	two hybrid	Fatima S (2015)	1
BRAP	0	SHCBP1L	1	two hybrid	Fatima S (2015)	1
EGLN3	0	BRAP	0	affinity chromatography technology	Rodriguez J (2016)	1
USP4	3	USP15	4	affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang L (2012), Loch CM (2012), Das T (2017)	3
CDKN1A	1	USP4	3	two hybrid	Vinayagam A (2011)	1
TWIST1	0	SKP2	2	affinity chromatography technology	Ruan D (2017)	1
PRODH	1	BRAP	0	affinity chromatography technology	Huttlin EL (2017)	1
BRAP	0	BRAF	12	affinity chromatography technology	Chen C (2008)	1
FAM184A	2	BRCA1	7	two hybrid	Hill SJ (2014)	1
BRCA1	7	CUL2	3	affinity chromatography technology	Ertych N (2016)	1
BRAP	0	EFHC1	1	two hybrid, affinity chromatography technology	Fatima S (2015), Huttlin EL (2017)	2
CDKN1A	1	CUL2	3	affinity chromatography technology, affinity chromatography technology	Starostina NG (2010), Starostina NG (2010)	2
CDKN1A	1	BRAP	0	affinity chromatography technology	Asada M (2004)	1
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
TRIM55	2	USP4	3	enzymatic study	Loch CM (2012)	1
BRAP	0	MAP2K1	8	affinity chromatography technology	Chen C (2008)	1
IKBKB	1	NFKBIB	2	enzymatic study, affinity chromatography technology, enzymatic study	Woronicz JD (1997), Woronicz JD (1997), Lee FS (1998)	3
BRAP	0	AKAP3	0	two hybrid, pull down	Fatima S (2015), Fatima S (2015)	2
BRAF	12	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Weber CK (2001), Weber CK (2001), Kilili GK (2010), Chen C (2008), Chen C (2008), Lito P (2012), Huttlin EL (2017)	7
NEDD8	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
BRAP	0	TRIM55	2	two hybrid	Woodsmith J (2012)	1
CUL2	3	SKP2	2	affinity chromatography technology	Kimura Y (2007)	1
FBXO2	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wen H (2010), Glenn KA (2008), Jeong YT (2013), Reitsma JM (2017)	4
EGLN3	0	BRCA1	7	affinity chromatography technology	Rodriguez J (2016)	1
CUL1	7	CDKN1A	1	affinity chromatography technology	Yu ZK (1998)	1
KLHDC3	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	5
BRAP	0	RBM12	6	two hybrid	Fatima S (2015)	1
MAP2K1	8	BRAF	12	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, genetic interference, affinity chromatography technology	Loewenberg M (2006), Kilili GK (2010), Chen C (2008), Pardo OE (2006), Gloeckner CJ (2007), Gloeckner CJ (2007), Hein MY (2015), Huttlin EL (2017), Xie P (2009), Xie P (2009), Hart T (2015), Eisenhardt AE (2016)	12
EGLN3	0	USP15	4	affinity chromatography technology	Rodriguez J (2016)	1
BRAP	0	ZNF382	2	two hybrid	Fatima S (2015)	1
SPRTN	0	UBB	4	affinity chromatography technology	Kim MS (2013)	1
CDC14A	4	BRAP	0	two hybrid, affinity chromatography technology, pull down	Chen JS (2009), Chen JS (2009), Chen JS (2009)	3
BRCA1	7	DNMT1	5	affinity chromatography technology	Hill SJ (2014)	1
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
EGLN3	0	NEDD8	0	affinity chromatography technology	Rodriguez J (2016)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
RAF1	3	BRAP	0	affinity chromatography technology	Chen C (2008)	1
BRAP	0	KSR1	0	affinity chromatography technology	Chen C (2008)	1
UBC	7	RBM12	6	affinity chromatography technology	Matsumoto M (2005)	1
UBC	7	BRAP	0	affinity chromatography technology, two hybrid, pull down, pull down, enzymatic study	Bish RA (2007), Fatima S (2015), Zhang X (2017), Shoji S (2017), Shoji S (2017)	5
BRAP	0	ZNF521	3	two hybrid	Fatima S (2015)	1
IKBKB	1	EGLN3	0	affinity chromatography technology, pull down, affinity chromatography technology	Xue J (2010), Xue J (2010), Fu J (2013)	3
BRAP	0	USP4	3	two hybrid, affinity chromatography technology, two hybrid	Hayes SD (2012), Hayes SD (2012), Hayes SD (2012)	3
UBC	7	SYNE2	19	pull down	Nathan JA (2013)	1
HRAS	2	BRAP	0	affinity chromatography technology	Matheny SA (2004)	1
BRAP	0	BRAP	0	affinity chromatography technology, two hybrid	Takashima O (2013), Fatima S (2015)	2
BRAP	0	TRIM41	6	two hybrid	Woodsmith J (2012)	1
KSR1	0	BRAF	12	affinity chromatography technology	Chen C (2008)	1
KSR1	0	RAF1	3	enzymatic study	Mueller J (2001)	1
BRAP	0	FBXO2	0	two hybrid	Fatima S (2015)	1
BRCA1	7	NUMA1	10	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
UBC	7	USP4	3	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down	Matsumoto M (2005), Faesen AC (2011), Song EJ (2010), Clerici M (2014), Kwasna D (2018)	5
BRAP	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Takashima O (2013), Takashima O (2013)	2
SPRTN	0	UBC	7	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Machida Y (2012), Machida Y (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Centore RC (2012), Davis EJ (2012)	7
BRCA1	7	BRAP	0	two hybrid, pull down, two hybrid	Li S (1998), Li S (1998), Chen CF (1996)	3
BRAP	0	PHLPP1	4	two hybrid, pull down	Fatima S (2015), Fatima S (2015)	2
BRAP	0	HMG20A	0	two hybrid, affinity chromatography technology, two hybrid	Davies RG (2013), Davies RG (2013), Fatima S (2015)	3
SKP2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2003), Min KW (2003), Lisztwan J (1998), Lisztwan J (1998), Marti A (1999), Zheng N (2002), Menon S (2008), Chew EH (2007), Chew EH (2007), Ji P (2006), Sabile A (2006), Tan P (1999), Lin HK (2009), Nie L (2011), Chua YS (2011), Huang Z (2004), Wu J (2012), Koyama-Nasu R (2007), Bashir T (2010), Saiga T (2009), Choo YY (2011), Jonason JH (2007), Jonason JH (2007), Bennett EJ (2010), Michel JJ (1998), Carrano AC (1999), Lyapina SA (1998), Lyapina SA (1998), Wu J (2012), Yu ZK (1998), Yu ZK (1998), Rodier G (2008), Swarnalatha M (2013), Cordero-Espinoza L (2013), Yumimoto K (2013), Chung FZ (2014), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Zhang S (2016), Zhang S (2016), Huttlin EL (2017), Kuchay S (2017), Reitsma JM (2017), Reitsma JM (2017), Ma X (2017)	46
USP4	3	IKBKB	1	affinity chromatography technology	Fan YH (2011)	1
MAP2K1	8	RAF1	3	pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yeung K (2000), Yeung K (2000), Dasgupta P (2004), Dasgupta P (2004), Dasgupta P (2004), Boussiotis VA (1997), Kilili GK (2010), Kubota Y (2011), Madonna S (2008), Takekawa M (2005), Gloeckner CJ (2007), Zhu J (2005), Zhu J (2005), Blaukat A (2000), Wang J (2009), Hein MY (2015), Mitra S (2016)	17
CUL1	7	BRAP	0	affinity chromatography technology, affinity chromatography technology	Takashima O (2013), Takashima O (2013)	2
BRAP	0	SKP2	2	pull down, affinity chromatography technology	Lanctot AA (2017), Lanctot AA (2017)	2
BRAP	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
EGLN3	0	RAF1	3	affinity chromatography technology	Rodriguez J (2016)	1