PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL3	17	PCNA	0	affinity chromatography technology	Bennett EJ (2010)	1
CDC45	1	TRAPPC3	0	two hybrid	Wang J (2011)	1
MCM7	5	ORC6	0	pull down	Ramachandran N (2004)	1
CDKN1A	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Ono T (2000), McKenzie PP (2003), McKenzie PP (2003), Law BK (2002), Harper JW (1993), Harper JW (1993), Yam CH (1999), Selma Dagtas A (2010), Naderi S (2005), Varshochi R (2005), Jeong JH (2010), Hsu SP (2008), Scholz A (2003), Peiretti A (2003), Peiretti A (2003), Derjuga A (2001), Kim YB (2000), Park US (2000), Kim WH (2000), Kokontis JM (1998), Orend G (1998), Wu G (1997), Liu J (1997), Bendjennat M (2003), Zheleva DI (2002), Mandal M (1998), Bao GC (2006), Mattock H (2001), Chen Z (2002), Chen J (1996), Chen J (1996), Levkau B (1998), Levkau B (1998), Ramachandran N (2004), Lacy ER (2005), Akagi M (1996), Zhao J (1998), Zhang Y (1999), Poon RY (1998), Gorospe M (1996), Varjosalo M (2013), Varjosalo M (2013), Fogeron ML (2013), Huttlin EL (2015), Hall JR (2014), Hein MY (2015), Hein MY (2015), Chen TC (2014), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	51
MCM4	3	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC45	1	ORC2	0	two hybrid	Kneissl M (2003)	1
CAMK1G	3	CDC45	1	two hybrid	Wang J (2011)	1
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
ORC3	3	ORC6	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Vashee S (2001), Sibani S (2005), Sibani S (2005), Ramachandran N (2004)	6
EGLN3	0	CDKN2A	1	affinity chromatography technology	Rodriguez J (2016)	1
FBXO6	0	PCNA	0	affinity chromatography technology	Liu B (2012)	1
MRE11	3	RFC1	1	biochemical	Wang Y (2000)	1
MCM10	2	CDKN2A	1	pull down	Ramachandran N (2004)	1
CCL2	0	MCM7	5	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
EGLN3	0	BRCA2	6	affinity chromatography technology	Rodriguez J (2016)	1
PDS5B	3	PCNA	0	affinity chromatography technology	Brough R (2012)	1
MCM4	3	MCM7	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology	Yabuta N (2003), Fujita M (1997), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	9
NTRK1	1	MCM6	5	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	PDS5B	3	affinity chromatography technology	Emdal KB (2015)	1
ORC6	0	ORC2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Huttlin EL (2015), Huttlin EL (2017)	8
UBC	7	RFC1	1	pull down	Zhang X (2017)	1
ORC3	3	ORC1	3	pull down, affinity chromatography technology	Ramachandran N (2004), Hein MY (2015)	2
CCL2	0	CDC45	1	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
EGLN3	0	MRE11	3	affinity chromatography technology	Rodriguez J (2016)	1
CUL3	17	ACTR1A	1	affinity chromatography technology	Bennett EJ (2010)	1
CDC45	1	ORC6	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM6	5	ORC6	0	pull down	Ramachandran N (2004)	1
CUL3	17	AAR2	2	affinity chromatography technology	Bennett EJ (2010)	1
MCM4	3	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
HIST1H3A	3	MCM6	5	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	MCM4	3	affinity chromatography technology	Emdal KB (2015)	1
CCL2	0	ORC2	0	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
CDC45	1	ORC5	0	pull down	Ramachandran N (2004)	1
MCM3	2	MCM4	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Mulvaney KM (2016)	4
NTRK1	1	MCM3	2	affinity chromatography technology	Emdal KB (2015)	1
CDK2	0	MCM6	5	affinity chromatography technology	Neganova I (2011)	1
POLA1	0	PCNA	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CUL3	17	MCM6	5	affinity chromatography technology	Bennett EJ (2010)	1
FBXO6	0	MCM3	2	affinity chromatography technology	Liu B (2012)	1
BRCA2	6	PCNA	0	affinity chromatography technology	Brough R (2012)	1
MCM7	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
UBC	7	ACTR1A	1	affinity chromatography technology	Matsumoto M (2005)	1
CDC45	1	CEP55	2	two hybrid	Rolland T (2014)	1
AAR2	2	CDC45	1	affinity chromatography technology	Cloutier P (2017)	1
CCL2	0	MCM3	2	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
PCNA	0	MCM4	3	affinity chromatography technology	Han J (2014)	1
NTRK1	1	CDC45	1	affinity chromatography technology	Emdal KB (2015)	1
L3MBTL1	1	CDC45	1	affinity chromatography technology	Gurvich N (2010)	1
NTRK1	1	RFC1	1	affinity chromatography technology	Emdal KB (2015)	1
CDC45	1	CDK2	0	affinity chromatography technology, affinity chromatography technology	Alexandrow MG (2005), Alexandrow MG (2005)	2
HIF1AN	0	CDC45	1	affinity chromatography technology	Rodriguez J (2016)	1
CDK2	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koundrioukoff S (2000), Zhang H (1993), Neganova I (2011), Wu SM (1998), Chen Z (2002), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
ORC1	3	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (2002), Vashee S (2001), Vashee S (2001), Mendez J (2002), Mendez J (2002), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015), Hein MY (2015)	11
DTD1	0	TOPBP1	5	affinity chromatography technology, affinity chromatography technology	Chowdhury A (2010), Chowdhury A (2010)	2
HIST1H3A	3	MCM4	3	affinity chromatography technology	Huttlin EL (2017)	1
CCL2	0	PCNA	0	affinity chromatography technology, affinity chromatography technology	Bronze-da-Rocha E (2011), Bronze-da-Rocha E (2011)	2
ACTR1A	1	MCM7	5	biochemical	Havugimana PC (2012)	1
CDK2	0	BRCA2	6	enzymatic study	Esashi F (2005)	1
L3MBTL1	1	PCNA	0	affinity chromatography technology	Gurvich N (2010)	1
MCM4	3	CDC45	1	affinity chromatography technology	Tan BC (2006)	1
HIF1AN	0	PCNA	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	TOPBP1	5	affinity chromatography technology	Rodriguez J (2016)	1
POLA1	0	MCM3	2	biochemical	Havugimana PC (2012)	1
CDK2	0	ORC2	0	enzymatic study, pull down	Mendez J (2002), Ramachandran N (2004)	2
MCM4	3	ORC6	0	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
DTD1	0	CDC45	1	affinity chromatography technology, affinity chromatography technology	Chowdhury A (2010), Chowdhury A (2010)	2
NTRK1	1	CUL3	17	affinity chromatography technology	Emdal KB (2015)	1
L3MBTL1	1	MCM7	5	affinity chromatography technology, affinity chromatography technology	Gurvich N (2010), Hauri S (2016)	2
ORC5	0	ORC6	0	two hybrid	Kneissl M (2003)	1
ALB	1	CDC45	1	affinity chromatography technology	Zhou M (2004)	1
RPS6KB2	3	PCNA	0	affinity chromatography technology	Roy R (2014)	1
EGLN3	0	CDC45	1	affinity chromatography technology	Rodriguez J (2016)	1
UBC	7	MRE11	3	affinity chromatography technology	Matsumoto M (2005)	1
HIF1AN	0	MCM6	5	affinity chromatography technology	Rodriguez J (2016)	1
MCM3	2	CDC45	1	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Mulvaney KM (2016)	3
EGLN3	0	PCNA	0	affinity chromatography technology	Rodriguez J (2016)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
PCNA	0	CDC45	1	biochemical	Wan C (2015)	1
MCM3	2	CDK2	0	affinity chromatography technology, pull down, pull down	Li J (2011), Li J (2011), Ramachandran N (2004)	3
MCM3	2	ORC5	0	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
NTRK1	1	ORC3	3	affinity chromatography technology	Emdal KB (2015)	1
CUL3	17	MCM7	5	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Rutz N (2015)	2
EGLN3	0	MCM7	5	affinity chromatography technology	Rodriguez J (2016)	1
MCM7	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC45	1	TOPBP1	5	affinity chromatography technology, affinity chromatography technology	Chowdhury A (2010), Chowdhury A (2010)	2
L3MBTL1	1	MCM6	5	affinity chromatography technology	Gurvich N (2010)	1
NTRK1	1	POLA1	0	affinity chromatography technology	Emdal KB (2015)	1
L3MBTL1	1	MCM3	2	affinity chromatography technology	Gurvich N (2010)	1
MCM3	2	MCM6	5	biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Mulvaney KM (2016)	6
BRCA2	6	CDC45	1	affinity chromatography technology	Brough R (2012)	1
CUL3	17	CDC45	1	affinity chromatography technology	Bennett EJ (2010)	1
EGLN3	0	CDK2	0	affinity chromatography technology	Rodriguez J (2016)	1
POLA1	0	CDC45	1	pull down	Kukimoto I (1999)	1
HIF1AN	0	AAR2	2	affinity chromatography technology	Rodriguez J (2016)	1
MCM10	2	CDKN1A	1	pull down	Ramachandran N (2004)	1
RPS6KB2	3	MCM3	2	affinity chromatography technology	Roy R (2014)	1
MCM10	2	MCM7	5	biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Izumi M (2000), Ramachandran N (2004), Huttlin EL (2015), Huttlin EL (2017)	4
CDC45	1	ACTR1A	1	biochemical	Wan C (2015)	1
MCM6	5	MCM10	2	two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ramachandran N (2004), Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
UBC	7	CDC45	1	pull down	Zhang X (2017)	1
MCM4	3	ORC3	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDKN1A	1	PCNA	0	two hybrid, pull down, pull down, pull down, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Frouin I (2003), Watanabe H (1998), Fotedar R (1996), Jonsson ZO (1998), Gulbis JM (1996), Touitou R (2001), Yu P (2001), Yu P (2001), Chen X (2007), Chen X (2007), Wang SC (2006), Carujo S (2006), Garcia-Wilson E (2005), Howlett NG (2009), Jin Y (2008), Lee JY (2009), Ando T (2001), Ando T (2001), Takasaki Y (2001), Logette E (2011), Mistafa O (2010), Mistafa O (2010), Bruning JB (2004), Punchihewa C (2012), Mattock H (2001), Waga S (1994), Waga S (1994), Poon RY (1996), Zhang Y (1999), Warbrick E (1995), Warbrick E (1995), Poon RY (1998), Poon RY (1998), Wang J (2011), Fogeron ML (2013), Rolland T (2014), Rizzardi LF (2014), Trombetta A (2013), Trombetta A (2013), Kim DH (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Coleman KE (2015), Huttlin EL (2017), Roessig L (2001), Roessig L (2001)	48
CDC45	1	MCM6	5	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM6	5	MCM7	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ryu MJ (2006), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
L3MBTL1	1	BRCA2	6	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	CDK2	0	affinity chromatography technology	Emdal KB (2015)	1
UBC	7	CDKN2A	1	pull down, imaging technique	Zhang X (2017), Zhang X (2017)	2
FBXO6	0	CDC45	1	affinity chromatography technology	Liu B (2012)	1
MCM4	3	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
PDS5B	3	CDC45	1	affinity chromatography technology	Brough R (2012)	1
MCM6	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC45	1	MCM10	2	pull down	Ramachandran N (2004)	1
EGLN3	0	AAR2	2	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	MCM3	2	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	MCM4	3	affinity chromatography technology	Rodriguez J (2016)	1
L3MBTL1	1	MCM4	3	affinity chromatography technology, affinity chromatography technology	Gurvich N (2010), Huttlin EL (2017)	2
CDC45	1	CDKN1A	1	pull down, imaging technique	Ramachandran N (2004), Chen TC (2014)	2
MCM10	2	MCM4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	MCM10	2	affinity chromatography technology	Emdal KB (2015)	1
CDK2	0	MCM4	3	enzymatic study, enzymatic study	Ishimi Y (2000), Komamura-Kohno Y (2006)	2
UBC	7	CEP55	2	pull down	Zhang X (2017)	1
NTRK1	1	MCM7	5	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	ACTR1A	1	affinity chromatography technology	Emdal KB (2015)	1
CUL3	17	MCM3	2	affinity chromatography technology	Bennett EJ (2010)	1
ORC1	3	ORC5	0	two hybrid, two hybrid, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Hein MY (2015)	4
CDK2	0	MCM7	5	affinity chromatography technology	Neganova I (2011)	1
ORC3	3	ORC5	0	two hybrid, two hybrid, biochemical, pull down, affinity chromatography technology, pull down, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Dhar SK (2001), Pinto S (1999), Vashee S (2001), Havugimana PC (2012), Ramachandran N (2004)	8
HIF1AN	0	CDK2	0	affinity chromatography technology	Rodriguez J (2016)	1
MCM6	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
BRCA2	6	PDS5B	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Brough R (2012), Brough R (2012), Brough R (2012)	3
MCM4	3	MCM6	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
CDK2	0	POLA1	0	enzymatic study, affinity chromatography technology, enzymatic study	Matsuo K (2000), Dehde S (2001), Dehde S (2001)	3
ORC2	0	ORC5	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Dhar SK (2001), Vashee S (2001), Vashee S (2001), Keller C (2002), Havugimana PC (2012), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015)	13
CDC45	1	HIST1H3A	3	affinity chromatography technology	Liu H (2010)	1
MRE11	3	POLA1	0	genetic interference	van Pel DM (2013)	1
RPS6KB2	3	CDC45	1	affinity chromatography technology	Roy R (2014)	1
HIST1H3A	3	MCM7	5	affinity chromatography technology	Huttlin EL (2017)	1
CDC45	1	ORC3	3	pull down	Ramachandran N (2004)	1
RPS6KB2	3	ALB	1	affinity chromatography technology	Roy R (2014)	1
ORC2	0	MCM3	2	biochemical	Mendez J (2000)	1
MCM3	2	MCM10	2	pull down	Ramachandran N (2004)	1
RFC1	1	PCNA	0	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, far western blotting, affinity chromatography technology, biochemical, affinity chromatography technology	Maruyama T (2002), Fotedar R (1996), Fotedar R (1996), Mossi R (1997), van der Kuip H (1999), Ohta S (2002), Ohta S (2002), Dahm K (2002), Havugimana PC (2012), Montecucco A (1998), Uhlmann F (1997), Dzantiev L (2004), Han J (2014), Wan C (2015), Hein MY (2015)	15
MRE11	3	CDC45	1	genetic interference	van Pel DM (2013)	1
MCM7	5	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC45	1	RFC1	1	biochemical	Wan C (2015)	1
CDC45	1	MCM7	5	two hybrid, two hybrid, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kukimoto I (1999), Liu P (2006)	4
UBC	7	AAR2	2	affinity chromatography technology	Matsumoto M (2005)	1
HIST1H3A	3	RFC1	1	bioid	Lambert JP (2015)	1
NTRK1	1	MRE11	3	affinity chromatography technology	Emdal KB (2015)	1
MCM10	2	ORC3	3	pull down	Ramachandran N (2004)	1
MCM3	2	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1997), Fujita M (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	10
MCM7	5	ORC3	3	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
ORC2	0	ORC3	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Dhar SK (2001), Matsuoka S (2007), Pinto S (1999), Pinto S (1999), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Havugimana PC (2012), Vermeulen M (2010), Wan C (2015), Hein MY (2015)	17
CDC45	1	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC45	1	CDKN2A	1	pull down	Ramachandran N (2004)	1
NTRK1	1	PCNA	0	affinity chromatography technology	Emdal KB (2015)	1
HIF1AN	0	MCM3	2	affinity chromatography technology	Rodriguez J (2016)	1
PCNA	0	MCM7	5	affinity chromatography technology	Han J (2014)	1
FBXO6	0	MCM7	5	affinity chromatography technology	Liu B (2012)	1
ORC1	3	CDK2	0	affinity chromatography technology, enzymatic study	Mendez J (2002), Mendez J (2002)	2
ORC2	0	MCM10	2	two hybrid, affinity chromatography technology, pull down	Izumi M (2000), Izumi M (2000), Ramachandran N (2004)	3
CDKN2A	1	PCNA	0	affinity chromatography technology, affinity chromatography technology, pull down	Souza-Rodrigues E (2007), Souza-Rodrigues E (2007), Souza-Rodrigues E (2007)	3
CDKN2A	1	MCM6	5	affinity chromatography technology, affinity chromatography technology, pull down	Souza-Rodrigues E (2007), Souza-Rodrigues E (2007), Souza-Rodrigues E (2007)	3