PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BRMS1	1	SAP30	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meehan WJ (2004), Meehan WJ (2004), Hein MY (2015)	3
SIN3A	13	SAP30	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Fleischer TC (2003), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1999), Yochum GS (2001), Kuzmichev A (2002), Kuzmichev A (2002), Kuzmichev A (2002), Laherty CD (1998), Viiri KM (2006), Viiri KM (2006), Nakamura T (2002), Lai A (2001), Skowyra D (2001), Zhang Y (1998), Zhang Y (1998), Xie T (2011), Xie T (2011), Bantscheff M (2011), Hein MY (2015)	21
MXD3	1	NUP62CL	0	affinity chromatography technology	Huttlin EL (2017)	1
BRMS1L	1	SIN3A	13	affinity chromatography technology, affinity chromatography technology	Nikolaev AY (2004), Nikolaev AY (2004)	2
MXD3	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
SAP130	2	SUDS3	3	affinity chromatography technology	Fleischer TC (2003)	1
SIN3A	13	MNT	2	two hybrid, pull down	Meroni G (1997), Meroni G (1997)	2
MXD3	1	EDEM2	3	affinity chromatography technology	Huttlin EL (2017)	1
SMC3	16	MXD1	2	two hybrid, pull down	Gupta K (1998), Gupta K (1998)	2
MXD1	2	SAP130	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MXD3	1	MAX	0	two hybrid, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Billin AN (1999), Gupta K (1998), Meroni G (1997), FitzGerald MJ (1999), Meroni G (2000), Huttlin EL (2017), Cheng J (2017), Hauri S (2016)	8
MXD3	1	TSPYL2	4	affinity chromatography technology	Huttlin EL (2017)	1
MAGEA11	1	MXD3	1	two hybrid	Rual JF (2005)	1
MXD3	1	MNT	2	affinity chromatography technology	Huttlin EL (2017)	1
SAP30	1	SAP130	2	affinity chromatography technology	Hein MY (2015)	1
ARID4B	1	SAP30	1	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
MNT	2	MAX	0	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meroni G (1997), Meroni G (1997), Matsuoka Y (2008), Kim J (2010), Li X (2015), Cheng J (2017), Hauri S (2016)	7
MXD3	1	ASPM	9	affinity chromatography technology	Huttlin EL (2017)	1
ING2	0	BRMS1L	1	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Huttlin EL (2017)	2
ARID4B	1	SUDS3	3	affinity chromatography technology	Fleischer TC (2003)	1
MXD3	1	SAP30	1	affinity chromatography technology	Huttlin EL (2017)	1
ING2	0	ARID4B	1	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Huttlin EL (2017)	2
SAP30	1	SUDS3	3	affinity chromatography technology	Hein MY (2015)	1
MXD3	1	ZMYM3	0	affinity chromatography technology	Huttlin EL (2017)	1
MAX	0	SIN3A	13	affinity chromatography technology, affinity chromatography technology	Li X (2015), Cheng J (2017)	2
MXD3	1	SAP30L	0	affinity chromatography technology	Huttlin EL (2017)	1
BRMS1	1	NFKB1	2	affinity chromatography technology, affinity chromatography technology	Liu Y (2006), Liu Y (2006)	2
SIN3A	13	MXD3	1	two hybrid, affinity chromatography technology	Meroni G (1997), Huttlin EL (2017)	2
MXD1	2	MNT	2	affinity chromatography technology	Cheng J (2017)	1
MXI1	2	SMC3	16	two hybrid, pull down	Gupta K (1998), Gupta K (1998)	2
EDEM2	3	TXNDC11	1	affinity chromatography technology	Huttlin EL (2017)	1
MAX	0	MXI1	2	two hybrid, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Billin AN (1999), Gupta K (1998), Meroni G (1997), FitzGerald MJ (1999), Engstrom LD (2004), Dugast-Darzacq C (2004), Kim J (2010), Rolland T (2014), Li X (2015), Hauri S (2016)	11
MXD1	2	BRMS1L	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ING2	0	SAP30	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Hein MY (2015), Huttlin EL (2017)	3
ING2	0	BRMS1	1	affinity chromatography technology	Huttlin EL (2017)	1
MXD3	1	BRMS1	1	affinity chromatography technology	Huttlin EL (2017)	1
MXI1	2	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
MXD3	1	NFKB1	2	affinity chromatography technology, affinity chromatography technology, biochemical	Matthews JR (1993), Mellits KH (1993), Mellits KH (1993)	3
ING2	0	SAP30L	0	affinity chromatography technology	Huttlin EL (2017)	1
MXD3	1	RCOR3	0	affinity chromatography technology	Huttlin EL (2017)	1
TFIP11	5	RCOR3	0	two hybrid	Rolland T (2014)	1
MXD3	1	KIF20B	3	affinity chromatography technology	Huttlin EL (2017)	1
SIN3A	13	BRMS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Hurst DR (2013), Meehan WJ (2004), Meehan WJ (2004)	4
SAP30L	0	SIN3A	13	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Viiri KM (2006), Viiri KM (2006), Viiri KM (2006), Korkeamaeki H (2008), Bantscheff M (2011)	5
MXD1	2	ARID4B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARID4B	1	SAP130	2	affinity chromatography technology, biochemical	Fleischer TC (2003), Wan C (2015)	2
ASPM	9	CENPB	0	affinity chromatography technology	Hein MY (2015)	1
MXD3	1	CENPB	0	affinity chromatography technology	Huttlin EL (2017)	1
MXD1	2	SAP30	1	pull down	Spronk CA (2000)	1
BRMS1	1	SUDS3	3	two hybrid, affinity chromatography technology, two hybrid	Hurst DR (2006), Hurst DR (2006), Meehan WJ (2004)	3
SIN3A	13	ARID4B	1	affinity chromatography technology, affinity chromatography technology, biochemical	Fleischer TC (2003), Fleischer TC (2003), Wan C (2015)	3
MAX	0	SAP130	2	affinity chromatography technology	Li X (2015)	1
MAX	0	MXD1	2	pull down, pull down, two hybrid, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee CM (2002), Ayer DE (1993), Gupta K (1998), Nair SK (2003), Hatakeyama S (2005), Wang Z (2006), Gordan JD (2007), Ayer DE (1993), Naderi S (1999), Huttlin EL (2015), FitzGerald MJ (1999), Huttlin EL (2017), Cheng J (2017), Hauri S (2016)	14
BRMS1L	1	SAP30	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nikolaev AY (2004), Nikolaev AY (2004), Hein MY (2015)	3
MXD3	1	BRMS1L	1	affinity chromatography technology	Huttlin EL (2017)	1
ING2	0	SUDS3	3	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Huttlin EL (2017)	2
MXD3	1	TXNDC11	1	affinity chromatography technology	Huttlin EL (2017)	1
MXD3	1	MXI1	2	affinity chromatography technology	Huttlin EL (2017)	1
MXD1	2	MXD3	1	affinity chromatography technology	Cheng J (2017)	1
MXD3	1	TFIP11	5	affinity chromatography technology	Huttlin EL (2017)	1
BRMS1L	1	BRMS1	1	affinity chromatography technology	Nikolaev AY (2004)	1
MXD1	2	BRMS1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SIN3A	13	MXD1	2	pull down, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Swanson KA (2004), Swanson KA (2004), Brubaker K (2000), Ayer DE (1995), Farias EF (2010), Huttlin EL (2015), Huttlin EL (2017), Cheng J (2017)	8
SMC3	16	MXD3	1	two hybrid, pull down	Gupta K (1998), Gupta K (1998)	2
ING2	0	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Shi X (2006), Huttlin EL (2017)	4
ING2	0	SAP130	2	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Huttlin EL (2017)	2
MXD3	1	SUDS3	3	affinity chromatography technology	Huttlin EL (2017)	1
SIN3A	13	SUDS3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fleischer TC (2003), Fleischer TC (2003), Fleischer TC (2003), Alland L (2002), Alland L (2002), Alland L (2002), Huttlin EL (2015), Huttlin EL (2017)	8
MXI1	2	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
MXD3	1	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
MXD1	2	SAP30L	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KRTAP10-7	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
SIN3A	13	SAP130	2	affinity chromatography technology, affinity chromatography technology, biochemical	Fleischer TC (2003), Fleischer TC (2003), Wan C (2015)	3
MXD3	1	ARID4B	1	affinity chromatography technology	Huttlin EL (2017)	1
MXD3	1	ING2	0	affinity chromatography technology	Huttlin EL (2017)	1
MXD3	1	SAP130	2	affinity chromatography technology	Huttlin EL (2017)	1
MXD1	2	SUDS3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2