PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RAB7A	0	VPS18	4	pull down	Lin X (2014)	1
RILP	0	VPS41	3	pull down	Lin X (2014)	1
KPNA2	0	RILP	0	two hybrid	Wang J (2011)	1
LDB2	0	RILP	0	two hybrid	DeGrado-Warren J (2008)	1
SNF8	2	VPS36	3	two hybrid, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bowers K (2006), Bowers K (2006), Im YJ (2008), Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Wang T (2006), Wan C (2015), Huttlin EL (2017)	9
RILP	0	VPS11	3	pull down	Lin X (2014)	1
RILP	0	VPS16	6	pull down	Lin X (2014)	1
RILP	0	VPS18	4	pull down	Lin X (2014)	1
RAB7A	0	VPS11	3	pull down	Lin X (2014)	1
RAB7A	0	RILP	0	two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cantalupo G (2001), Cantalupo G (2001), Caplan S (2001), Liang C (2008), Lin X (2014), Lin X (2014), Hein MY (2015), Song P (2016), Song P (2016), Gomez-Suaga P (2014)	10
RILP	0	SNF8	2	pull down	Wang T (2006)	1
VPS18	4	VPS41	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wartosch L (2015), Hein MY (2015), van der Kant R (2015), van der Kant R (2015), Huttlin EL (2017), Hunter MR (2017), Hunter MR (2017), Hunter MR (2017), Hunter MR (2017)	11
RILP	0	VPS36	3	pull down	Wang T (2006)	1
VPS41	3	VPS11	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), van der Kant R (2015), Huttlin EL (2017), Hunter MR (2017)	4
VPS16	6	VPS41	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Hein MY (2015), van der Kant R (2015), van der Kant R (2015), Huttlin EL (2017)	6
RILP	0	338382	0	affinity chromatography technology	Liang C (2008)	1
VPS11	3	VPS39	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), van der Kant R (2015), Huttlin EL (2017)	4
RAB7A	0	VPS39	3	pull down	Lin X (2014)	1
VPS11	3	VPS18	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Kim BY (2001), Huttlin EL (2015), Wartosch L (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017), Hunter MR (2017)	8
RAB7A	0	VPS16	6	pull down	Lin X (2014)	1
RILP	0	VPS39	3	pull down	Lin X (2014)	1
RCHY1	0	RILP	0	two hybrid	Wang J (2011)	1
VPS16	6	VPS18	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Kim BY (2001), Havugimana PC (2012), Wartosch L (2015), Wartosch L (2015), Wartosch L (2015), Hein MY (2015), Hein MY (2015), Graham SC (2013), van der Kant R (2015), van der Kant R (2015)	11
RAB7A	0	VPS41	3	pull down	Lin X (2014)	1
VPS11	3	VPS16	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Kim BY (2001), Hein MY (2015), Hein MY (2015), van der Kant R (2015), van der Kant R (2015)	6