PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RPA1	0	MPG	3	affinity chromatography technology	Marechal A (2014)	1
VPS18	4	OBSCN	32	affinity chromatography technology	Hein MY (2015)	1
26148	0	OBSCN	32	affinity chromatography technology	Hein MY (2015)	1
RPA1	0	HNRNPD	3	affinity chromatography technology	Marechal A (2014)	1
NXF1	0	OBSCN	32	affinity chromatography technology	Castello A (2012)	1
TTN	102	OBSCN	32	two hybrid, pull down, two hybrid, affinity chromatography technology	Young P (2001), Young P (2001), Arimura T (2007), Arimura T (2007)	4
UBE2A	0	OBSCN	32	affinity chromatography technology	An H (2017)	1
RPA1	0	HNRNPL	3	affinity chromatography technology	Marechal A (2014)	1
BRCA1	7	HNRNPL	3	affinity chromatography technology	Ertych N (2016)	1
ANK1	8	KCTD6	2	two hybrid, affinity chromatography technology	Lange S (2012), Lange S (2012)	2
ANK1	8	OBSCN	32	two hybrid, pull down, affinity chromatography technology	Kontrogianni-Konstantopoulos A (2003), Kontrogianni-Konstantopoulos A (2003), Lange S (2012)	3
MPG	3	OBSCN	32	affinity chromatography technology	Liang C (2013)	1
BRCA1	7	TTN	102	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	PCNA	0	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
HNRNPD	3	HNRNPL	3	biochemical	Havugimana PC (2012)	1
BRCA1	7	RPA1	0	affinity chromatography technology, imaging technique, affinity chromatography technology	Suhasini AN (2011), Mok MT (2010), Tian F (2013)	3
UBE2A	0	TTN	102	affinity chromatography technology	An H (2017)	1
RPA1	0	OBSCN	32	affinity chromatography technology	Hein MY (2015)	1
HSF2	2	OBSCN	32	affinity chromatography technology	Hein MY (2015)	1
HNRNPD	3	BRCA1	7	affinity chromatography technology, two hybrid, affinity chromatography technology	Shimizu Y (2012), Lehner B (2004), Ertych N (2016)	3
UBE2A	0	HNRNPD	3	affinity chromatography technology	An H (2017)	1
PCNA	0	RPA1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ohta S (2002), Ogi T (2010), Takasaki Y (2001), Gong Z (2011), Miccoli L (2005), Han J (2014)	6
OBSCN	32	BRCA1	7	two hybrid	Hill SJ (2014)	1
KIAA1107	3	OBSCN	32	affinity chromatography technology	Hein MY (2015)	1
ANK1	8	TTN	102	two hybrid, pull down	Kontrogianni-Konstantopoulos A (2003), Kontrogianni-Konstantopoulos A (2003)	2
LYPD4	1	OBSCN	32	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	MOV10	6	affinity chromatography technology	Ertych N (2016)	1
KCTD6	2	OBSCN	32	affinity chromatography technology	Lange S (2012)	1
CDCA5	0	OBSCN	32	affinity chromatography technology	Hein MY (2015)	1
NPPA	1	OBSCN	32	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	OBSCN	32	affinity chromatography technology	Fei T (2017)	1
MOV10	6	OBSCN	32	affinity chromatography technology	Castello A (2012)	1
RPA1	0	MOV10	6	affinity chromatography technology	Marechal A (2014)	1
UBE2A	0	PCNA	0	enzymatic study	Unk I (2006)	1
PCNA	0	OBSCN	32	affinity chromatography technology	Hein MY (2015)	1
MOV10	6	HNRNPD	3	affinity chromatography technology	Castello A (2012)	1
LYPD4	1	VPS18	4	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPD	3	OBSCN	32	affinity chromatography technology	Hein MY (2015)	1
NXF1	0	HNRNPD	3	affinity chromatography technology	Castello A (2012)	1