PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SPOP	1	UBE2D2	0	pull down	An J (2015)	1
SPOP	1	LRCH4	5	two hybrid	Zhang P (2017)	1
SPOP	1	TRAF6	0	pull down	Zapata JM (2001)	1
NCOA3	3	PGR	1	pull down, affinity chromatography technology, affinity chromatography technology	Giangrande PH (2000), An BS (2009), An BS (2006)	3
FAF1	1	CUL3	17	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
BRMS1	1	SPOP	1	affinity chromatography technology, affinity chromatography technology, pull down	Kim B (2011), Kim B (2011), Kim B (2011)	3
ZBTB16	4	SPOP	1	two hybrid	Rual JF (2005)	1
SPOP	1	GMEB1	4	two hybrid	Zhang P (2017)	1
UBE2I	0	TRAF6	0	enzymatic study, enzymatic study	Li Y (2013), Pham LV (2008)	2
DAXX	5	SPOP	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	La M (2004), Liu F (2012), Kwon JE (2006), Kwon JE (2006), Wang J (2011), Wang J (2011), Zhang P (2017)	7
CUL3	17	GLI2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin X (2016), Jin X (2016), Jin X (2016)	3
LRCH4	5	RTN4	4	two hybrid	Rual JF (2005)	1
BMI1	0	AR	3	affinity chromatography technology	Cao Q (2014)	1
SPOP	1	GLI3	10	x-ray crystallography, unspecified method, enzymatic study, two hybrid	Pierce WK (2015), Pierce WK (2015), Marzahn MR (2016), Zhang P (2017)	4
ESR1	0	TRAF6	0	affinity chromatography technology	Robinson LJ (2009)	1
UBE2I	0	NUDCD3	0	two hybrid	Rual JF (2005)	1
DAXX	5	SUMO1	0	two hybrid, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, two hybrid, x-ray crystallography, two hybrid	Lin DY (2002), Ryu SW (2000), Ryu SW (2000), Ryu SW (2000), Escobar-Cabrera E (2011), Escobar-Cabrera E (2011), Naik MT (2011), Chang CC (2011), Chang CC (2011), Chen A (2006), Chen A (2006), Saul VV (2014), Ullmann R (2012), Lin DY (2006), Lin DY (2006), Ullmann R (2012), Ullmann R (2012), Lin DY (2006), Naik MT (2011), Li C (2017)	20
SRRM1	2	DHX15	5	biochemical	Wan C (2015)	1
DAXX	5	CUL3	17	affinity chromatography technology, affinity chromatography technology	Kwon JE (2006), Kwon JE (2006)	2
ATM	9	RANBP9	5	affinity chromatography technology, enzymatic study	Palmieri D (2016), Palmieri D (2016)	2
SPOP	1	UBE2I	0	two hybrid	Zhang P (2017)	1
BRD4	8	SPOP	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology	Dai X (2017), Dai X (2017), Dai X (2017), Dai X (2017), Zhang P (2017), Zhang P (2017), Zhang P (2017), Zhang P (2017)	8
SPOP	1	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Byun B (2008), Byun B (2008), Zhang P (2015), Zhang P (2015)	4
CHAF1A	1	RBFOX2	5	two hybrid	Ravasi T (2010)	1
EGLN2	4	SPOP	1	pull down, pull down	Zhang L (2017), Zhang L (2017)	2
SPOP	1	SUMO1	0	two hybrid	Zhang P (2017)	1
NANOG	0	SPOP	1	affinity chromatography technology	Oliviero G (2015)	1
ESR1	0	PIAS1	4	two hybrid	Kobayashi S (2004)	1
CUL3	17	BMI1	0	affinity chromatography technology	Hernandez-Munoz I (2005)	1
SPOP	1	INF2	5	two hybrid	Zhang P (2017)	1
SPOP	1	RBFOX2	5	two hybrid	Zhang P (2017)	1
SPOP	1	DOK2	2	affinity chromatography technology	Ewing RM (2007)	1
ARIH1	3	CUL3	17	affinity chromatography technology	Kelsall IR (2013)	1
SUMO1	0	ZCCHC12	1	affinity chromatography technology, two hybrid, two hybrid	Cho G (2009), Hecker CM (2006), Rolland T (2014)	3
SIRT2	1	CDC20	1	enzymatic study	Kim HS (2011)	1
SPOP	1	DPPA2	0	two hybrid	Rual JF (2005)	1
ERF	9	SPOP	1	affinity chromatography technology, pull down	Gan W (2015), Gan W (2015)	2
SPOP	1	SETD2	20	two hybrid	Zhang P (2017)	1
SPOP	1	ZCCHC12	1	two hybrid	Zhang P (2017)	1
DDIT3	1	CUL3	17	affinity chromatography technology, biochemical	Huang X (2012), Huang X (2012)	2
AR	3	PIAS3	2	two hybrid	Kotaja N (2000)	1
RBPJ	1	DEK	1	affinity chromatography technology	Li X (2015)	1
RTN4	4	SPOP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AMOTL2	5	GCC1	1	two hybrid	Rual JF (2005)	1
ATM	9	MRE11	3	unspecified method, biochemical, affinity chromatography technology	Kim ST (1999), Wang Y (2000), Falck J (2005)	3
CHD3	19	SUMO1	0	two hybrid, pull down	Minty A (2000), Goodarzi AA (2011)	2
AR	3	UBE2I	0	two hybrid, affinity chromatography technology, genetic interference, enzymatic study	Poukka H (1999), Poukka H (1999), Poukka H (1999), Ogawa H (2009)	4
RTN3	2	RTN4	4	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
RBPJ	1	H2AFY	1	affinity chromatography technology	Li X (2015)	1
SPOP	1	PIAS3	2	two hybrid	Zhang P (2017)	1
MYD88	1	SPOP	1	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Wang J (2011), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	5
SPOP	1	TRAF1	0	pull down	Zapata JM (2001)	1
ZBTB16	4	UBE2I	0	two hybrid, enzymatic study	Chao TT (2007), Kang SI (2003)	2
SPOP	1	SPOP	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down	La M (2004), Theurillat JP (2014), Theurillat JP (2014), Marzahn MR (2016)	4
SPOP	1	SRRM1	2	two hybrid, two hybrid	Wang J (2011), Zhang P (2017)	2
MYD88	1	TRAF6	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Zhou J (2011), Zhou J (2011), Zhang X (2013), Zhang X (2013), Hirata Y (2006)	6
UBE2I	0	CACUL1	0	affinity chromatography technology	Fukuda T (2017)	1
CUL3	17	KPNA6	1	affinity chromatography technology	Bennett EJ (2010)	1
NCOA3	3	PIAS1	4	affinity chromatography technology, affinity chromatography technology	Li S (2012), Li S (2012)	2
ERG	1	BRD2	2	affinity chromatography technology	Dai X (2017)	1
SPOP	1	CHD3	19	two hybrid	Zhang P (2017)	1
SPOP	1	FAF1	1	two hybrid	Zhang P (2017)	1
RFWD2	0	UBE2D1	0	pull down, pull down	Choi HH (2011), Lu G (2014)	2
RBFOX2	5	ESR1	0	pull down	Norris JD (2002)	1
SPOP	1	BMI1	0	affinity chromatography technology	Hernandez-Munoz I (2005)	1
SPOP	1	KPNA5	1	two hybrid	Zhang P (2017)	1
SPOP	1	CACUL1	0	two hybrid	Zhang P (2017)	1
NANOG	0	MRE11	3	affinity chromatography technology	Oliviero G (2015)	1
ERG	1	AR	3	affinity chromatography technology, affinity chromatography technology	Yu J (2010), Grasso CS (2012)	2
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
CUL3	17	FADD	1	affinity chromatography technology	Gonzalvez F (2012)	1
BRD4	8	ERG	1	affinity chromatography technology, affinity chromatography technology	Dai X (2017), Dai X (2017)	2
ATM	9	DAXX	5	enzymatic study	Tang J (2013)	1
BRMS1	1	CUL3	17	affinity chromatography technology	Kim B (2011)	1
SPOP	1	AMOTL2	5	two hybrid	Zhang P (2017)	1
SPOP	1	RANBP9	5	two hybrid	Zhang P (2017)	1
DEK	1	DAXX	5	affinity chromatography technology	Hollenbach AD (2002)	1
DEK	1	SPOP	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Theurillat JP (2014), Theurillat JP (2014), Theurillat JP (2014), Zhang P (2017)	4
UBE2I	0	PIAS3	2	two hybrid, two hybrid	Bandyopadhyay S (2010), Wang J (2011)	2
CUL3	17	NUP50	0	affinity chromatography technology, biochemical	Bennett EJ (2010), Wan C (2015)	2
SPOP	1	DHX15	5	two hybrid	Zhang P (2017)	1
SPOP	1	ATM	9	affinity chromatography technology, affinity chromatography technology	Zhang D (2014), Zhang D (2014)	2
CDC20	1	CUL3	17	affinity chromatography technology	Wu F (2017)	1
AR	3	NCOA3	3	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tan JA (2000), Gnanapragasam VJ (2001), Tan JA (2000), Wang Q (2004), Axlund SD (2010)	5
ESR1	0	CAPRIN1	5	affinity chromatography technology	Tarallo R (2011)	1
BMI1	0	ZBTB16	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical	Barna M (2002), Barna M (2002), Barna M (2002), Barna M (2002), Boukarabila H (2009), Boukarabila H (2009), Boukarabila H (2009), Boukarabila H (2009), Boukarabila H (2009)	9
ESR1	0	SRRM1	2	affinity chromatography technology	Tarallo R (2011)	1
DUSP7	3	SPOP	1	affinity chromatography technology	Guo ZQ (2016)	1
SPOP	1	CAPRIN1	5	two hybrid	Zhang P (2017)	1
UBE2I	0	BMI1	0	two hybrid	Markson G (2009)	1
AR	3	PIAS1	4	two hybrid, affinity chromatography technology	Kotaja N (2000), Toropainen S (2015)	2
SPOP	1	ZMYND8	5	two hybrid	Zhang P (2017)	1
GLI2	4	SPOP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Zeng C (2014), Zhi X (2016), Zhi X (2016), Zhang P (2017)	4
DAXX	5	CDC20	1	affinity chromatography technology	Kwan PS (2013)	1
ZBTB16	4	ESR1	0	pull down	Martin PJ (2003)	1
BRD4	8	BRD2	2	affinity chromatography technology	Rahman S (2011)	1
PGR	1	SPOP	1	affinity chromatography technology, affinity chromatography technology	Gao K (2015), Gao K (2015)	2
CUL3	17	KPNA5	1	affinity chromatography technology	Bennett EJ (2010)	1
ESR1	0	CUL3	17	affinity chromatography technology	Byun B (2008)	1
SPOP	1	H2AFY	1	two hybrid	Zhang P (2017)	1
AR	3	BRD3	6	affinity chromatography technology	Dai X (2017)	1
SPOP	1	TCOF1	1	two hybrid	Zhang P (2017)	1
ARIH1	3	UBE2D1	0	pull down	Capili AD (2004)	1
BRD3	6	BRD2	2	affinity chromatography technology	Huttlin EL (2017)	1
DEK	1	DHX15	5	biochemical	Havugimana PC (2012)	1
SPOP	1	RBPJ	1	two hybrid	Zhang P (2017)	1
BMI1	0	DEK	1	affinity chromatography technology, affinity chromatography technology	Abdouh M (2016), Abdouh M (2016)	2
BRD4	8	PTEN	24	genetic interference	Shen JP (2017)	1
CACUL1	0	AR	3	affinity chromatography technology, affinity chromatography technology, pull down	Choi H (2016), Choi H (2016), Choi H (2016)	3
RANBP9	5	ESR1	0	pull down	Poirier MB (2006)	1
ERG	1	BRD3	6	affinity chromatography technology	Dai X (2017)	1
SPOP	1	KPNA6	1	affinity chromatography technology	Ewing RM (2007)	1
SPOP	1	RPRD2	2	two hybrid	Zhang P (2017)	1
SPOP	1	BRD2	2	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Dai X (2017), Dai X (2017), Zhang P (2017), Zhang P (2017), Zhang P (2017)	5
ZBTB16	4	SUMO1	0	two hybrid, pull down	Chao TT (2007), Kang SI (2003)	2
PTEN	24	SPOP	1	affinity chromatography technology	Guo ZQ (2016)	1
SUMO1	0	PIAS1	4	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, pull down	Lee BH (2003), Kahyo T (2001), Stehmeier P (2009), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Gocke CB (2008), Ullmann R (2012), Ledsaak M (2016)	12
BRD4	8	BMI1	0	genetic interference	Wong AS (2016)	1
PIAS1	4	SPOP	1	two hybrid, two hybrid	Wang J (2011), Zhang P (2017)	2
DAXX	5	AR	3	two hybrid, pull down, affinity chromatography technology, pull down	Lin DY (2004), Lin DY (2004), Lin DY (2004), Sun S (2016)	4
FAF1	1	FADD	1	pull down, affinity chromatography technology	Ryu SW (2003), Ryu SW (2003)	2
PIP4K2B	2	SPOP	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Bunce MW (2008), Bunce MW (2008), Bunce MW (2008), Bunce MW (2008)	4
ARIH1	3	SPOP	1	affinity chromatography technology	Huttlin EL (2017)	1
SUMO1	0	PIAS3	2	two hybrid, two hybrid, pull down	Stehmeier P (2009), Hecker CM (2006), Hecker CM (2006)	3
PTEN	24	BMI1	0	affinity chromatography technology, affinity chromatography technology	Fan C (2009), Fan C (2009)	2
ESR1	0	UBE2I	0	two hybrid, enzymatic study	Kobayashi S (2004), Sentis S (2005)	2
NCOA3	3	SPOP	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid	Li C (2011), Li C (2011), Li C (2011), Li C (2011), Li C (2011), Li C (2011), Geng C (2013), Geng C (2013), Zhang P (2017)	9
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
H2AFY	1	DEK	1	affinity chromatography technology	Ouararhni K (2006)	1
GCC1	1	SPOP	1	two hybrid	Yu H (2011)	1
CUL3	17	SRRM1	2	affinity chromatography technology	Bennett EJ (2010)	1
ATM	9	SETD2	20	genetic interference	Shen JP (2017)	1
SPOP	1	CBX4	1	two hybrid	Zhang P (2017)	1
SPOP	1	CTDSPL2	0	two hybrid	Zhang P (2017)	1
AR	3	ZBTB16	4	two hybrid	van de Wijngaart DJ (2009)	1
BMI1	0	H2AFY	1	affinity chromatography technology	Cao Q (2014)	1
ATM	9	TRAF6	0	pull down	Hinz M (2010)	1
RANBP9	5	AR	3	two hybrid, affinity chromatography technology, pull down	Rao MA (2002), Rao MA (2002), Poirier MB (2006)	3
SPOP	1	PIP5K1B	0	affinity chromatography technology	Ewing RM (2007)	1
RANBP9	5	UBE2I	0	affinity chromatography technology	Chang LK (2008)	1
PTEN	24	ESR1	0	pull down	Lin HK (2004)	1
CUL3	17	NCOA3	3	affinity chromatography technology	Ferry C (2011)	1
SPOP	1	BRD3	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Dai X (2017), Dai X (2017), Zhang P (2017), Zhang P (2017), Zhang P (2017)	5
GIT2	2	SPOP	1	two hybrid	Wang J (2011)	1
FADD	1	MYD88	1	two hybrid	Wang J (2011)	1
CUL3	17	NUDCD3	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
EGLN2	4	CUL3	17	affinity chromatography technology	Zhang L (2017)	1
SPOP	1	HMGCS1	0	two hybrid	Zhang P (2017)	1
FADD	1	DAXX	5	affinity chromatography technology	Meinecke I (2007)	1
CUL3	17	CAPRIN1	5	affinity chromatography technology	Bennett EJ (2010)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
BRD4	8	AR	3	affinity chromatography technology, affinity chromatography technology	Dai X (2017), Dai X (2017)	2
KPNA5	1	NUP50	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
NCOA3	3	ESR1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Wong CW (2001), Tikkanen MK (2000), Tikkanen MK (2000), Feng Q (2006), Long X (2008), Long X (2008), Dutertre M (2003), Jaber BM (2004), Torchia J (1997), Torchia J (1997), Karmakar S (2010), Takeshita A (1997), Zhao HH (2001), Wu RC (2004), Lanz RB (2010), Heck S (2009), Heck S (2009), Heck S (2009), Heck S (2009), Gunther JR (2008), Amazit L (2007), Mc Ilroy M (2006), Shao D (2004), Monroe DG (2003), Bai Y (2003), Bramlett KS (2001), Suen CS (1998), Chen H (1999), Rubio MF (2006), Han SJ (2016), Han SJ (2016), Li W (2015), Yi P (2015), Yi P (2017)	34
PGR	1	ESR1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Giulianelli S (2012), Giulianelli S (2012), Giulianelli S (2012)	3
NUP50	0	KPNA6	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
UBE2I	0	DAXX	5	two hybrid, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, two hybrid	Ryu SW (2000), Knipscheer P (2008), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Chang CC (2011), Lin DY (2006), Lin DY (2006)	8
BMI1	0	CHD3	19	affinity chromatography technology	Cao Q (2014)	1
PTEN	24	UBE2I	0	affinity chromatography technology, affinity chromatography technology	Waite KA (2003), Huang J (2012)	2
ESR1	0	TCOF1	1	affinity chromatography technology	Tarallo R (2011)	1
CUL3	17	UBE2D1	0	pull down	Sumara I (2007)	1
ERG	1	SPOP	1	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Gan W (2015), Gan W (2015), Gan W (2015), Gan W (2015), An J (2015), An J (2015), An J (2015), An J (2015)	8
FADD	1	SPOP	1	two hybrid	Wang J (2011)	1
SIRT2	1	RTN4	4	affinity chromatography technology	Ewing RM (2007)	1
CUL3	17	RBFOX2	5	affinity chromatography technology	Bennett EJ (2010)	1
SPOP	1	UBE2D1	0	pull down	An J (2015)	1
SPOP	1	GDI1	1	affinity chromatography technology	Ewing RM (2007)	1
CUL3	17	H2AFY	1	affinity chromatography technology	Hernandez-Munoz I (2005)	1
AR	3	SPOP	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	van de Wijngaart DJ (2009), An J (2014), An J (2014), An J (2014), Geng C (2014), Geng C (2014), Geng C (2014)	7
ESR1	0	DEK	1	affinity chromatography technology	Tarallo R (2011)	1
SRRM1	2	DEK	1	affinity chromatography technology	McGarvey T (2000)	1
ERG	1	CUL3	17	affinity chromatography technology	Gan W (2015)	1
SPOP	1	MRE11	3	two hybrid	Zhang P (2017)	1
SPOP	1	CDC20	1	affinity chromatography technology, pull down	Wu F (2017), Wu F (2017)	2
NUP50	0	SPOP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATM	9	BMI1	0	affinity chromatography technology, affinity chromatography technology	Facchino S (2010), Pan MR (2011)	2
BRMS1	1	KPNA5	1	two hybrid	Hurst DR (2006)	1
DDIT3	1	AMOTL2	5	two hybrid	Rolland T (2014)	1
SPOP	1	SIRT2	1	affinity chromatography technology	Ewing RM (2007)	1
SPOP	1	RTN3	2	two hybrid	Rual JF (2005)	1
SPOP	1	CHAF1A	1	two hybrid	Zhang P (2017)	1
UBE2D2	0	CUL3	17	pull down	Plafker KS (2009)	1
BRMS1	1	UBE2D1	0	pull down	Liu Y (2013)	1
UBE2E3	0	SPOP	1	pull down	Plafker KS (2009)	1
TRAF6	0	RANBP9	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Wang L (2011), Wang L (2011), Wang L (2011), Wang L (2011), Wang L (2011), Zhang J (2014)	6
SPOP	1	NUDCD3	0	two hybrid	Zhang P (2017)	1
RFWD2	0	UBE2D2	0	pull down, pull down, pull down	Dornan D (2006), Dornan D (2004), Choi HH (2011)	3
MSRB3	0	SPOP	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
SUMO1	0	CHAF1A	1	pull down	Uwada J (2010)	1
BMI1	0	CAPRIN1	5	affinity chromatography technology	Cao Q (2014)	1
BRD4	8	BRD3	6	affinity chromatography technology, biochemical	Rahman S (2011), Wan C (2015)	2
ESR1	0	DHX15	5	affinity chromatography technology	Tarallo R (2011)	1
PTEN	24	UBE2D1	0	genetic interference	Vizeacoumar FJ (2013)	1
GIT2	2	TRAF1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
DDIT3	1	SPOP	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Zhang P (2014), Zhang P (2014)	3
CUL3	17	DHX15	5	affinity chromatography technology	Bennett EJ (2010)	1
PTEN	24	AR	3	pull down, affinity chromatography technology	Lin HK (2004), Lin HK (2004)	2
NCOA3	3	PTEN	24	affinity chromatography technology, affinity chromatography technology	Yang C (2013), Yang C (2013)	2
BRD4	8	CUL3	17	affinity chromatography technology	Dai X (2017)	1
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
BMI1	0	RBFOX2	5	affinity chromatography technology	Cao Q (2014)	1
UBE2I	0	CHD3	19	two hybrid	Lee BH (2003)	1
SPOP	1	GCC2	6	two hybrid	Zhang P (2017)	1
MRE11	3	GCC2	6	biochemical	Wan C (2015)	1
CBX4	1	BMI1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xia ZB (2003), Satijn DP (1997), Satijn DP (1997), Aoto T (2008), Maertens GN (2009), Gao Z (2012), Gao Z (2012), Vandamme J (2011), Cao Q (2014), Hein MY (2015), Sanchez A (2016), Hauri S (2016), Hauri S (2016)	13
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
SPOP	1	CUL3	17	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li C (2011), Cummings CM (2009), Choo YY (2011), Choo YY (2012), Plafker KS (2009), Kwon JE (2006), Kwon JE (2006), Wang J (2011), Wimuttisuk W (2014), Theurillat JP (2014), Sakaue T (2017)	11
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
SOST	2	SPOP	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
RFWD2	0	SPOP	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2E3	0	CUL3	17	pull down	Plafker KS (2009)	1
RXRB	0	SPOP	1	two hybrid, two hybrid	Rual JF (2005), Wang J (2011)	2
AR	3	BRD2	2	affinity chromatography technology	Dai X (2017)	1