PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TK1	0	CDKN1A	1	affinity chromatography technology, pull down	Huang DY (2001), Huang DY (2001)	2
RFC5	2	RBM48	1	two hybrid	Stelzl U (2005)	1
FAM118B	0	RBM48	1	two hybrid	Vinayagam A (2011)	1
PRG2	2	RBM48	1	two hybrid	Stelzl U (2005)	1
SULT1E1	0	RBM48	1	two hybrid	Stelzl U (2005)	1
BTBD2	4	RBM48	1	two hybrid	Stelzl U (2005)	1
ZNF24	1	RBM48	1	two hybrid	Stelzl U (2005)	1
HSPB3	1	RBM48	1	two hybrid	Stelzl U (2005)	1
CDKN1A	1	RBM48	1	two hybrid	Vinayagam A (2011)	1
PPP1R8	0	RBM48	1	two hybrid	Stelzl U (2005)	1
SAT1	0	RBM48	1	two hybrid	Stelzl U (2005)	1
TNFSF10	2	RBM48	1	two hybrid	Stelzl U (2005)	1
APLP1	1	RBM48	1	two hybrid	Goehler H (2004)	1
TRDMT1	1	RBM48	1	two hybrid	Stelzl U (2005)	1
C11orf49	0	RBM48	1	two hybrid	Stelzl U (2005)	1
HSPB1	2	RBM48	1	two hybrid	Stelzl U (2005)	1
HSPB1	2	VIM	0	two hybrid	Katsogiannou M (2014)	1
ANXA7	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
TK1	0	APLP1	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
GADD45G	0	CDKN1A	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Azam N (2001), Azam N (2001), Azam N (2001), Nakayama K (1999)	4
FXYD6	0	RBM48	1	two hybrid	Stelzl U (2005)	1
PSMD11	0	RBM48	1	two hybrid	Stelzl U (2005)	1
ARMC7	1	RBM48	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blomen VA (2015), Hart T (2015), Hart T (2015), Hart T (2015), Huttlin EL (2017)	5
COX17	0	RBM48	1	two hybrid	Stelzl U (2005)	1
PNP	1	RBM48	1	two hybrid	Stelzl U (2005)	1
RPA2	0	NUDT21	0	affinity chromatography technology	Marechal A (2014)	1
RPA2	0	RFC5	2	affinity chromatography technology	Marechal A (2014)	1
RPA2	0	HSPB1	2	affinity chromatography technology	Marechal A (2014)	1
TK1	0	RBM48	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
VIM	0	RBM48	1	two hybrid	Goehler H (2004)	1
RBM48	1	NBEA	15	affinity chromatography technology	Huttlin EL (2017)	1
ZNF24	1	APLP1	1	two hybrid, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005)	2
HSPB1	2	GSTO1	0	two hybrid, affinity chromatography technology	Katsogiannou M (2014), Katsogiannou M (2014)	2
HSPB1	2	SAT1	0	two hybrid	Katsogiannou M (2014)	1
GSE1	14	RBM48	1	two hybrid	Stelzl U (2005)	1
TRIB3	0	RBM48	1	two hybrid	Stelzl U (2005)	1
MPHOSPH6	1	RBM48	1	two hybrid	Stelzl U (2005)	1
NUDT21	0	VIM	0	biochemical	Havugimana PC (2012)	1
BID	1	RBM48	1	two hybrid	Vinayagam A (2011)	1
MLLT3	0	RBM48	1	two hybrid	Stelzl U (2005)	1
NUDT21	0	RBM48	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
PCDHA4	1	APLP1	1	two hybrid	Stelzl U (2005)	1
PCDHA4	1	RBM48	1	two hybrid	Stelzl U (2005)	1
CDKN2C	0	APLP1	1	two hybrid	Stelzl U (2005)	1
SMN1	0	ERH	0	affinity chromatography technology	Fuller HR (2010)	1
VIM	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
HSPB1	2	SMN1	0	affinity chromatography technology	MacIntyre DA (2008)	1
ERH	0	RBM48	1	two hybrid	Stelzl U (2005)	1
MNAT1	0	RBM48	1	two hybrid	Stelzl U (2005)	1
GSTO1	0	RBM48	1	two hybrid	Stelzl U (2005)	1
FAM118B	0	VIM	0	two hybrid	Vinayagam A (2011)	1
CDK5RAP2	3	RBM48	1	two hybrid	Stelzl U (2005)	1
WDR33	3	RBM48	1	two hybrid	Stelzl U (2005)	1
MAP7D1	2	RBM48	1	two hybrid	Stelzl U (2005)	1
RPA2	0	WDR33	3	affinity chromatography technology	Marechal A (2014)	1
BID	1	RPA2	0	affinity chromatography technology	Liu Y (2011)	1
CDKN1A	1	APLP1	1	two hybrid	Vinayagam A (2011)	1
ID2	0	RBM48	1	two hybrid	Stelzl U (2005)	1
SMN1	0	RBM48	1	two hybrid	Vinayagam A (2011)	1
ANXA7	0	VIM	0	two hybrid	Vinayagam A (2011)	1
MAFG	1	RBM48	1	two hybrid	Stelzl U (2005)	1
RAB27A	0	RBM48	1	two hybrid	Stelzl U (2005)	1
HSPB1	2	MPHOSPH6	1	two hybrid	Katsogiannou M (2014)	1
TAF9	2	RBM48	1	two hybrid	Stelzl U (2005)	1
SMN1	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
PAFAH1B3	1	RBM48	1	two hybrid	Stelzl U (2005)	1
MAFG	1	VIM	0	two hybrid	Stelzl U (2005)	1
PNP	1	APLP1	1	two hybrid	Stelzl U (2005)	1
SERPINB9	0	RBM48	1	two hybrid	Stelzl U (2005)	1
RPA2	0	RBM48	1	two hybrid	Stelzl U (2005)	1
SAT1	0	APLP1	1	two hybrid	Stelzl U (2005)	1
CDKN1A	1	VIM	0	two hybrid	Vinayagam A (2011)	1
GLYAT	3	RBM48	1	two hybrid	Stelzl U (2005)	1
GADD45G	0	RBM48	1	two hybrid	Goehler H (2004)	1
CCDC106	1	RBM48	1	two hybrid	Stelzl U (2005)	1
CDKN2C	0	RBM48	1	two hybrid	Stelzl U (2005)	1
ANXA7	0	RBM48	1	two hybrid	Vinayagam A (2011)	1
OSGEP	1	RBM48	1	two hybrid	Vinayagam A (2011)	1
MPHOSPH6	1	APLP1	1	two hybrid	Stelzl U (2005)	1
RPA2	0	MNAT1	0	affinity chromatography technology	Marechal A (2014)	1