PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CASP8	1	HDAC7	4	enzymatic study	Scott FL (2008)	1
ARHGDIA	3	MSN	0	biochemical, biochemical	Gajate C (2005), Wan C (2015)	2
CASP8AP2	3	FADD	1	affinity chromatography technology	Imai Y (1999)	1
CFLAR	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
BIRC3	1	IKBKB	1	imaging technique	Chen TC (2014)	1
MAP1LC3B	1	PRKCI	1	affinity chromatography technology	Behrends C (2010)	1
CASP2	1	NOL3	0	affinity chromatography technology	Koseki T (1998)	1
CASP6	0	CASP8	1	enzymatic study, enzymatic study, enzymatic study	Cowling V (2002), Guo Y (2002), Srinivasula SM (1996)	3
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
EZR	8	TNFRSF1A	3	biochemical	Gajate C (2005)	1
PTEN	24	CASP8	1	affinity chromatography technology, affinity chromatography technology	Crockett DK (2005), Crockett DK (2005)	2
CASP10	1	CASP2	1	enzymatic study	Srinivasula SM (1996)	1
CASP3	0	CASP7	1	enzymatic study	Walsh JG (2008)	1
BID	1	FASLG	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
CFLAR	1	TNFRSF1A	3	genetic interference	Ma Y (2017)	1
CASP10	1	RIPK1	2	affinity chromatography technology	Chaudhary PM (2000)	1
VHL	0	PARK7	0	affinity chromatography technology	Parsanejad M (2014)	1
MAP3K14	1	IKBKB	1	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Luftig MA (2001), Woronicz JD (1997), Li Q (2006), Huttlin EL (2017)	4
TNFRSF1A	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won M (2010), Zilberman-Rudenko J (2016), Moquin DM (2013)	3
TNF	0	TNFAIP3	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skaug B (2011), Tokunaga F (2012), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	5
PARK7	0	PDIA6	1	affinity chromatography technology	Malty RH (2017)	1
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
CASP8	1	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
FAF1	1	CUL3	17	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
CASP8	1	BCL2L1	0	genetic interference	Guo Y (2002)	1
BID	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
HIP1	4	IFT57	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Gervais FG (2002), Gervais FG (2002), Gervais FG (2002)	3
CASP8	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (2000), Oshima S (2009), Bertrand MJ (2008), Knox PG (2011), Kim S (2010), Cheung HH (2009), Tenev T (2011), Tenev T (2011), Mahul-Mellier AL (2011), Legarda-Addison D (2009), Biton S (2011), Bellail AC (2012), Bellail AC (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Puliyappadamba VT (2013), Wu P (2014), Wu P (2014), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Moquin DM (2013), Ranjan K (2016), Zinngrebe J (2016), Nakazawa S (2016), Zheng M (2016)	27
TNFRSF10A	0	FADD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Sinha SK (2004), Guo F (2005), Gonzalvez F (2012), Jeong M (2017), Huttlin EL (2017)	6
LRRK2	5	TRADD	0	affinity chromatography technology	Ho CC (2009)	1
FAS	2	MAPK8	3	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
BCAP31	0	BCL2	0	pull down, affinity chromatography technology	Ng FW (1997), Ng FW (1997)	2
CASP8	1	PARK7	0	pull down	Fu K (2012)	1
CFLAR	1	BCL2L1	0	affinity chromatography technology	Han DK (1997)	1
RIPK1	2	BIRC2	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Xu M (2009), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Fu J (2016), Vu NT (2016), Vu NT (2016)	12
TLR3	2	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Cusson-Hermance N (2005), Zinngrebe J (2016)	2
TNFRSF1A	3	UBC	7	affinity chromatography technology	Nakazawa S (2016)	1
RHOA	0	BID	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
TP53	0	PARK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fan J (2008), Fan J (2008), Kim SJ (2012)	3
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
TRAF1	0	SQSTM1	0	affinity chromatography technology	Greenfeld H (2015)	1
XIAP	0	ARHGDIA	3	affinity chromatography technology, affinity chromatography technology	Liu J (2011), Liu J (2012)	2
IKBKB	1	TNFRSF1A	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Zhang SQ (2000), Chaudhary PM (2000), Fan YH (2011), Park KJ (2002), Guan YJ (2011), Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008), Chen TC (2014)	9
RALBP1	2	TRAF2	1	imaging technique	Chen TC (2014)	1
BIRC3	1	TRAF1	0	pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Roy N (1997), Li X (2002), Goncharov T (2013), Chen TC (2014), Greenfeld H (2015)	5
CASP8	1	RB1	2	enzymatic study	Lemaire C (2005)	1
CASP8	1	GREB1	8	two hybrid	Arroyo R (2015)	1
BIRC3	1	CASP7	1	pull down, affinity chromatography technology	Roy N (1997), Eckelman BP (2006)	2
USP2	0	RIPK1	2	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2012)	4
PPP2CA	7	HDAC7	4	enzymatic study, affinity chromatography technology, affinity chromatography technology	Martin M (2008), Martin M (2008), Martin M (2008)	3
CASP8	1	PRSS50	0	two hybrid	Arroyo R (2015)	1
CASP8	1	IL13RA2	0	two hybrid	Arroyo R (2015)	1
TRAF6	0	TP53	0	enzymatic study, affinity chromatography technology	Zhang X (2016), Zhang X (2016)	2
MAP3K14	1	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luftig MA (2001), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Choudhary S (2013)	6
CASP10	1	TNFRSF10B	1	biochemical, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997)	2
CASP8	1	PRKCI	1	two hybrid	Wang J (2011)	1
ARHGDIA	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
TP53	0	CRYAB	0	affinity chromatography technology, affinity chromatography technology	Jin X (2009), Watanabe G (2009)	2
CDK9	3	CHEK1	2	genetic interference	Shen JP (2017)	1
CASP1	1	BCAP31	0	enzymatic study	Ng FW (1997)	1
23429	0	FADD	1	affinity chromatography technology	Zheng L (2001)	1
TP53	0	BAX	3	imaging technique, affinity chromatography technology, pull down	Chen TC (2014), Kim EM (2014), Kim EM (2014)	3
BCL2	0	CASP8	1	affinity chromatography technology, genetic interference, two hybrid, affinity chromatography technology	Poulaki V (2001), Guo Y (2002), Zhu J (2005), Zhu J (2005)	4
MSN	0	BID	1	biochemical	Gajate C (2005)	1
CHUK	5	RIPK1	2	biochemical	Poyet JL (2000)	1
CHUK	5	CASP8	1	affinity chromatography technology	Chaudhary PM (2000)	1
CASP10	1	FASLG	0	biochemical	Gajate C (2005)	1
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
TNFAIP3	3	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song HY (1996), Song HY (1996), Heyninck K (1999), Greenfeld H (2015), Greenfeld H (2015)	5
MTOR	14	PTEN	24	genetic interference	Shen JP (2017)	1
CASP8	1	LYPD3	0	two hybrid	Arroyo R (2015)	1
XIAP	0	BCL2	0	pull down, enzymatic study	Edison N (2017), Edison N (2017)	2
TRAF2	1	RIPK3	2	affinity chromatography technology	Yu PW (1999)	1
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
MAPK8	3	TRAF2	1	affinity chromatography technology	Gravestein LA (1998)	1
HIP1	4	BFAR	0	affinity chromatography technology	Roth W (2003)	1
UBC	7	CHD3	19	pull down	Nathan JA (2013)	1
CASP8	1	CNBP	0	two hybrid	Arroyo R (2015)	1
TLR3	2	FADD	1	affinity chromatography technology	Zinngrebe J (2016)	1
FAS	2	FADD	1	biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gajate C (2005), MacFarlane M (1997), Pan G (1997), Huang B (1996), Huang B (1996), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Chinnaiyan AM (1995), Thomas LR (2002), Kumar A (2001), Lee EW (2012), Zhang M (2011), Huttlin EL (2015), Chen TC (2014), Jeong M (2017), Huttlin EL (2017), Kleber S (2008), Torii S (1999), Torii S (1999), Chang HY (1999)	20
IFT57	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	Gervais FG (2002), Gervais FG (2002)	2
CASP8	1	QDPR	0	two hybrid	Arroyo R (2015)	1
SQSTM1	0	FAS	2	affinity chromatography technology, affinity chromatography technology	Liang X (2013), Liang X (2013)	2
UBC	7	IKBKB	1	pull down	Zhang X (2017)	1
CASP10	1	CASP4	1	enzymatic study	Srinivasula SM (1996)	1
RIPK1	2	CLIP3	4	affinity chromatography technology	Fujikura D (2012)	1
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
CASP6	0	XIAP	0	affinity chromatography technology	Lee JS (2012)	1
CASP8	1	S100A14	0	two hybrid	Arroyo R (2015)	1
MAPK14	0	RB1	2	enzymatic study, affinity chromatography technology	Delston RB (2011), Li H (2001)	2
CASP8	1	PSMC3IP	0	two hybrid	Arroyo R (2015)	1
PPP2CA	7	CARD11	4	enzymatic study	Eitelhuber AC (2011)	1
FAS	2	ARHGDIA	3	biochemical	Gajate C (2005)	1
BAX	3	CASP3	0	biochemical	Chandra D (2004)	1
BIRC2	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
PTEN	24	UBC	7	protein complementation assay, affinity chromatography technology	Li Y (2014), Li Y (2014)	2
PRKCI	1	SQSTM1	0	two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe	Sanchez P (1998), Sanchez P (1998), Sanchez P (1998), Sanchez P (1998), Behrends C (2010), Brajenovic M (2004), Lamark T (2003), Lamark T (2003), Lamark T (2003), Yang JQ (2010), Yang JQ (2010), Erdogan E (2006), Milan E (2015), Tsai LC (2015), Tsai LC (2015), Tsai LC (2015)	16
UBC	7	BAP1	4	pull down, pull down, pull down, pull down	Duerksen-Hughes PJ (1989), Daou S (2015), Kwasna D (2018), Hanpude P (2017)	4
TNFRSF10A	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kaunisto A (2009), Kaunisto A (2009), Sinha SK (2004), Guo F (2005), Jin Z (2009), Gonzalvez F (2012), Gonzalvez F (2012), Jeong M (2017), Huttlin EL (2017)	10
BFAR	0	BCL2	0	affinity chromatography technology, two hybrid	Zhang H (2000), Zhang H (2000)	2
PARK7	0	PRDX6	0	affinity chromatography technology	Malty RH (2017)	1
CASP1	1	TRAF2	1	affinity chromatography technology	Labbe K (2011)	1
IKBKB	1	TNFAIP3	3	enzymatic study, affinity chromatography technology	Zetoune FS (2001), Xiong Y (2011)	2
BFAR	0	BCL2L1	0	affinity chromatography technology	Zhang H (2000)	1
HDAC7	4	RHOA	0	affinity chromatography technology	Huttlin EL (2017)	1
BIRC3	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, imaging technique	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Wang J (2011), McDonald ER (2004), Chen TC (2014)	7
USP2	0	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Mahul-Mellier AL (2011), Mahul-Mellier AL (2011)	2
RIPK1	2	IKBKB	1	biochemical, pull down	Yang Y (2011), Poyet JL (2000)	2
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
BIRC2	1	RIPK3	2	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
CASP8	1	USP2	0	affinity chromatography technology	Mahul-Mellier AL (2011)	1
RHOA	0	BIRC2	1	pull down	Marivin A (2013)	1
CHD3	19	VIM	0	two hybrid	Goehler H (2004)	1
CASP2	1	BCL2L1	0	genetic interference	Guo Y (2002)	1
MAPK14	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sudo T (2000), Sudo T (2000), Kawai K (2008), Kawai K (2008)	4
CASP6	0	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
CASP10	1	DEDD2	1	affinity chromatography technology	Alcivar A (2003)	1
VHL	0	PRKCI	1	enzymatic study	Okuda H (2001)	1
SQSTM1	0	RIPK1	2	pull down, affinity chromatography technology, affinity chromatography technology	Sanz L (1999), Sanz L (1999), Sanz L (1999)	3
MAPK8	3	BCL2	0	enzymatic study	Kang CB (2005)	1
CUL3	17	VIM	0	affinity chromatography technology	Bennett EJ (2010)	1
PARK7	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Zucchelli S (2010), Zucchelli S (2010)	2
TRADD	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Park YC (2000), Tsao DH (2000), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Vince JE (2009), Jang HD (2001), Park KJ (2003), Lin B (2016)	12
XIAP	0	CASP7	1	pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Tenev T (2005), Paulsen M (2008), Huang Y (2001), Huang Y (2001), Chai J (2001), Chai J (2001), Huang Y (2003), Huang Y (2003), Sun M (2009), Takahashi R (1998), Lee JS (2012), Lin YF (2013), Lin YF (2013), Hou Y (2017)	20
BCAP31	0	CASP8	1	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical	Ng FW (1997), Ng FW (1997), Ng FW (1997), Iwasawa R (2011), Chandra D (2004), Breckenridge DG (2002), Breckenridge DG (2002)	7
VHL	0	PPP2CA	7	affinity chromatography technology, affinity chromatography technology	Guo J (2016), Guo J (2016)	2
TNFSF10	2	CASP3	0	enzymatic study	Gillissen B (2013)	1
TRAF2	1	XIAP	0	affinity chromatography technology	Vince JE (2009)	1
CASP7	1	ARHGDIA	3	enzymatic study	Walsh JG (2008)	1
CASP8	1	EPSTI1	0	two hybrid	Arroyo R (2015)	1
NOD1	3	CASP1	1	affinity chromatography technology	Inohara N (1999)	1
UBC	7	PRKCI	1	pull down	Zhang X (2017)	1
MLKL	1	RIPK3	2	affinity chromatography technology	Pescatore A (2016)	1
MAPK1	1	CEBPB	2	enzymatic study	Hanlon M (2001)	1
CHUK	5	CARD11	4	affinity chromatography technology, imaging technique	McCully RR (2008), Sommer K (2005)	2
MAPK1	1	MTOR	14	genetic interference	Srivas R (2016)	1
TP53	0	BLM	2	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Sengupta S (2004), Sengupta S (2004), Sengupta S (2004), Wang XW (2001), Wang XW (2001), Wang XW (2001), Wang XW (2001), Garkavtsev IV (2001), Garkavtsev IV (2001), Yang Q (2002), Yang Q (2002), Wang J (2013)	12
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
MAPK14	0	BCL2L1	0	enzymatic study	Wang J (2012)	1
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
CHUK	5	TRAF6	0	affinity chromatography technology	Kishida S (2005)	1
CASP8	1	SORBS1	2	affinity chromatography technology	Zhang M (2003)	1
XIAP	0	NOD1	3	pull down	Krieg A (2009)	1
CLIP3	4	TNFRSF1A	3	two hybrid, affinity chromatography technology	Fujikura D (2012), Fujikura D (2012)	2
UBC	7	CDKN1B	1	affinity chromatography technology	Huang G (2014)	1
TOPORS	6	UBC	7	enzymatic study	Rajendra R (2004)	1
CASP8	1	GLCE	0	two hybrid	Arroyo R (2015)	1
CHUK	5	PRKCI	1	pull down, affinity chromatography technology, affinity chromatography technology	Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999)	3
XIAP	0	CASP10	1	two hybrid, affinity chromatography technology	Rolland T (2014), McDonald ER (2004)	2
CASP8	1	KLK5	1	two hybrid	Arroyo R (2015)	1
CASP14	2	CASP10	1	affinity chromatography technology	Hu S (1998)	1
EZR	8	CASP8	1	biochemical	Gajate C (2005)	1
BID	1	TNFRSF10B	1	biochemical	Gajate C (2005)	1
VHL	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Chen K (2016), Chen K (2016)	2
CASP8	1	PPP2CA	7	affinity chromatography technology	Xu J (2015)	1
CASP8	1	BAP1	4	two hybrid	Arroyo R (2015)	1
CASP3	0	MAPK8	3	enzymatic study	Enomoto A (2003)	1
CASP8	1	TOPORS	6	affinity chromatography technology	Yao Z (2007)	1
RIPK1	2	FADD	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen D (2002), Young JA (2011), Tenev T (2011), Ramakrishnan P (2011), Legarda-Addison D (2009), ODonnell MA (2012), Vanlangenakker N (2011), Biton S (2011), Biton S (2011), Lee EW (2012), Puliyappadamba VT (2013), Wu P (2014), Huttlin EL (2015), Baratchian M (2016), Moquin DM (2013), Ranjan K (2016), Pescatore A (2016), Zheng M (2016)	18
CASP8	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pan JA (2011), Huang S (2013), Huang S (2013)	3
MAP1LC3B	1	SQSTM1	0	two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Behrends C (2010), Vinayagam A (2011), Kirkin V (2009), Kirkin V (2009), Liang X (2013), Liang X (2013), Novak I (2010), Novak I (2010), Rogov VV (2012), Gao W (2013), Maruyama Y (2014), Maruyama Y (2014), Maruyama Y (2014), Yamashita SI (2014), Wurzer B (2015), Wurzer B (2015), Wurzer B (2015), Sun A (2017), Cohen-Kaplan V (2016), Dou Z (2015), Galindo-Moreno M (2017)	22
CASP14	2	CASP8	1	affinity chromatography technology	Hu S (1998)	1
MAPK8	3	BCL2L1	0	imaging technique, enzymatic study	Chen TC (2014), Wang J (2012)	2
TNF	0	RALBP1	2	affinity chromatography technology	Micheau O (2003)	1
PEA15	0	FADD	1	pull down, affinity chromatography technology	Kitsberg D (1999), Condorelli G (1999)	2
PARK7	0	BCL2L1	0	pull down, pull down, affinity chromatography technology	Ren H (2011), Ren H (2011), Ren H (2011)	3
TNFRSF1A	3	CASP2	1	affinity chromatography technology	Duan H (1997)	1
RHOA	0	FADD	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
SERPINB5	0	PRDX6	0	biochemical	Wan C (2015)	1
CASP2	1	BID	1	enzymatic study, enzymatic study	Paroni G (2001), Guo Y (2002)	2
ARHGDIA	3	EZR	8	biochemical, biochemical	Gajate C (2005), Wan C (2015)	2
MAP3K14	1	CHUK	5	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Regnier CH (1997), Regnier CH (1997), Xiao G (2000), Luftig MA (2001), Ninomiya-Tsuji J (1999), Ninomiya-Tsuji J (1999), Qing G (2007), Sanjo H (2010), Hu WH (2004), Liao G (2004), Li Q (2006), Chen TC (2014), Huttlin EL (2017)	13
BIRC3	1	CASP3	0	pull down, affinity chromatography technology	Roy N (1997), Rajalingam K (2006)	2
UBC	7	RHOA	0	affinity chromatography technology	Huang G (2014)	1
LRRK2	5	VIM	0	affinity chromatography technology, affinity chromatography technology	Daechsel JC (2007), Sen S (2009)	2
CASP7	1	CRYAB	0	affinity chromatography technology, affinity chromatography technology	Lee JS (2012), Jeong WJ (2012)	2
FIS1	0	BCAP31	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Iwasawa R (2011), Iwasawa R (2011), Iwasawa R (2011), Iwasawa R (2011)	4
CASP3	0	PARP1	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Nicholson DW (1995), Lueschen S (1998), Walsh JG (2008), Boucher D (2012), Luo S (2010), Betin VM (2009)	6
CASP10	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
MAPK8	3	CASP10	1	biochemical	Gajate C (2005)	1
SQSTM1	0	MTOR	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Duran A (2011), Linares JF (2015), Linares JF (2015)	3
PTEN	24	VHL	0	genetic interference	Shen JP (2017)	1
MAPK8	3	FASLG	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
TOPORS	6	PARP1	3	affinity chromatography technology	Pungaliya P (2007)	1
CHEK1	2	TP53	0	affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study	Tian H (2002), Sengupta S (2004), Tian H (2002), Goudelock DM (2003), Shieh SY (2000)	5
PTEN	24	BEX1	0	two hybrid	Arroyo R (2015)	1
CDKN1B	1	TRAF2	1	two hybrid, imaging technique	Rual JF (2005), Chen TC (2014)	2
MSN	0	FASLG	0	biochemical	Gajate C (2005)	1
TNFAIP3	3	BIRC3	1	affinity chromatography technology	Yamaguchi N (2013)	1
TP53	0	CHUK	5	affinity chromatography technology	Huang WC (2007)	1
CASP8	1	FAF1	1	affinity chromatography technology, affinity chromatography technology	Knox PG (2011), Caballero-Lopez MJ (2017)	2
CASP1	1	PARP1	3	enzymatic study	Gu Y (1995)	1
PRDX6	0	RHOA	0	biochemical	Havugimana PC (2012)	1
NLRC4	2	NOD1	3	affinity chromatography technology	Damiano JS (2004)	1
TNF	0	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Legler DF (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Skaug B (2011), Fu J (2013), Fritsch J (2014), Schlicher L (2016)	10
CASP8	1	XIAP	0	genetic interference, affinity chromatography technology, affinity chromatography technology	Guo Y (2002), Lee JS (2012), McDonald ER (2004)	3
TNFSF10	2	TNFAIP3	3	affinity chromatography technology	Bellail AC (2012)	1
CUL3	17	ARHGDIA	3	affinity chromatography technology	Bennett EJ (2010)	1
PRDX6	0	CASP8	1	pull down, affinity chromatography technology, affinity chromatography technology, protein complementation assay	Choi H (2011), Choi H (2011), Choi H (2011), Choi H (2011)	4
TNFRSF1A	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CASP8	1	CASP7	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
BIRC2	1	CASP3	0	pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Clem RJ (2001), Rajalingam K (2006)	5
CASP8	1	TNFRSF1A	3	biochemical	Gajate C (2005)	1
BID	1	BAX	3	imaging technique	Chen TC (2014)	1
CASP8	1	CARD11	4	affinity chromatography technology	McCully RR (2008)	1
TNF	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Yamaguchi N (2015)	2
TNFRSF10A	0	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kaunisto A (2009), Gonzalvez F (2012), Jeong M (2017)	4
CASP2	1	BCL2	0	genetic interference	Guo Y (2002)	1
CRYAB	0	BCL2	0	affinity chromatography technology, affinity chromatography technology	Launay N (2010), Launay N (2010)	2
CASP8	1	IL24	0	two hybrid	Arroyo R (2015)	1
TICAM1	3	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Sasai M (2010), Sasai M (2010), Jiang Z (2004), Wang YY (2004), Sato S (2003), Sato S (2003), Sato S (2003), Takaki H (2009), Verstak B (2014), Hu YH (2015)	10
CHUK	5	MTOR	14	affinity chromatography technology, affinity chromatography technology, biochemical	Dan HC (2008), Dan HC (2008), Dan HC (2008)	3
GZMB	0	CASP7	1	enzymatic study	Cullen SP (2007)	1
ARHGDIA	3	RHOA	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, biochemical, pull down, x-ray crystallography	Ewing RM (2007), Gajate C (2005), Michaelson D (2001), Gorvel JP (1998), Faure J (2001), Man JH (2010), Rolland T (2014), Wan C (2015), Jaffe AB (2004), Kuhlmann N (2016), Kuhlmann N (2016), Kuhlmann N (2016)	12
CFLAR	1	NOL3	0	genetic interference	Koseki T (1998)	1
TNF	0	CASP8	1	affinity chromatography technology	Fritsch J (2014)	1
BIRC3	1	CASP8	1	affinity chromatography technology, affinity chromatography technology	McDonald ER (2004), Zinngrebe J (2016)	2
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
TRAF6	0	CASP8	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Bidere N (2006), Bidere N (2006), He L (2006), He L (2006), Zinngrebe J (2016)	5
PARK7	0	FADD	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Fu K (2012), Fu K (2012), Fu K (2012), Fu K (2012)	4
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
USP2	0	TRADD	0	affinity chromatography technology	Mahul-Mellier AL (2011)	1
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
CASP3	0	ATG4D	2	enzymatic study	Betin VM (2009)	1
DEDD	0	CASP8	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Zhan Y (2002), Alcivar A (2003), Stegh AH (1998), Stegh AH (1998)	4
PTEN	24	IL24	0	two hybrid	Arroyo R (2015)	1
PPP2CA	7	CHUK	5	affinity chromatography technology	Kray AE (2005)	1
MAP1LC3B	1	UBC	7	imaging technique	Liu X (2017)	1
CHUK	5	TRADD	0	biochemical	Poyet JL (2000)	1
FADD	1	RIPK3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vanlangenakker N (2011), Lee EW (2012), Lee EW (2012), Moriwaki K (2016), Pescatore A (2016)	5
CASP10	1	RNF34	1	two hybrid, affinity chromatography technology	McDonald ER (2004), McDonald ER (2004)	2
CASP8	1	ATG4D	2	enzymatic study	Betin VM (2009)	1
LRRK2	5	RIPK1	2	affinity chromatography technology	Ho CC (2009)	1
CUL3	17	FADD	1	affinity chromatography technology	Gonzalvez F (2012)	1
RB1	2	MAPK8	3	affinity chromatography technology	Li H (2001)	1
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
CASP1	1	CUL3	17	affinity chromatography technology	Garstkiewicz M (2017)	1
CHEK1	2	RB1	2	enzymatic study, pull down	Inoue Y (2007), Inoue Y (2007)	2
UBC	7	TSC22D3	1	affinity chromatography technology	Matsumoto M (2005)	1
CASP3	0	GMNN	0	enzymatic study	Roukos V (2007)	1
CDKN1B	1	RHOA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Larrea MD (2009), Larrea MD (2009), Wei Z (2013)	3
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
RNF34	1	TP53	0	affinity chromatography technology	Yang W (2007)	1
BID	1	CASP10	1	biochemical	Gajate C (2005)	1
MAPK8	3	CASP8	1	biochemical	Gajate C (2005)	1
CFLAR	1	TICAM1	3	affinity chromatography technology	Feoktistova M (2011)	1
TNF	0	FAS	2	affinity chromatography technology	Legler DF (2003)	1
CASP8	1	CDH13	5	two hybrid	Arroyo R (2015)	1
CASP8	1	ERRFI1	1	two hybrid	Arroyo R (2015)	1
GZMB	0	CASP3	0	enzymatic study, enzymatic study	Zhao T (2007), Cullen SP (2007)	2
CASP14	2	CASP1	1	affinity chromatography technology	Hu S (1998)	1
TNFRSF1A	3	TNF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Bouwmeester T (2004), Micheau O (2003), Legler DF (2003), Kuai J (2004), Skaug B (2011), Tokunaga F (2012), Klingseisen L (2012), Thoma B (1990), Keusekotten K (2013), Crowe PD (1994), Liu LS (1998), Higuchi M (1992), Chaturvedi MM (1994), Schaeffer V (2014), Fritsch J (2014), Chainy GB (1996), Huttlin EL (2015), Chen TC (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Huttlin EL (2017), Nielsen FS (2004), Ameloot P (2001)	24
FASLG	0	CFLAR	1	affinity chromatography technology	Tao RH (2011)	1
FAF1	1	IKBKB	1	affinity chromatography technology, pull down, pull down	Park MY (2007), Park MY (2007), Park MY (2007)	3
BIRC6	15	CASP7	1	affinity chromatography technology, enzymatic study	Bartke T (2004), Qiu XB (2005)	2
TRADD	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Chang YL (2014), Chang YL (2014)	2
BAX	3	CASP8	1	biochemical	Chandra D (2004)	1
VHL	0	PARP1	3	affinity chromatography technology	Lai Y (2011)	1
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
CASP8	1	CASP9	6	enzymatic study, genetic interference, enzymatic study	Guo Y (2002), Guo Y (2002), Srinivasula SM (1996)	3
BID	1	CASP8	1	biochemical, enzymatic study	Gajate C (2005), Guo Y (2002)	2
PARP1	3	BLID	0	two hybrid	Arroyo R (2015)	1
TNFAIP3	3	MTOR	14	affinity chromatography technology, imaging technique	Matsuzawa Y (2015), Matsuzawa Y (2015)	2
MAP3K14	1	UBC	7	affinity chromatography technology	Sanjo H (2010)	1
EZR	8	CASP10	1	biochemical	Gajate C (2005)	1
NOD1	3	CASP8	1	affinity chromatography technology	Inohara N (1999)	1
RHOA	0	CASP8	1	biochemical	Gajate C (2005)	1
EZR	8	MAPK8	3	biochemical	Gajate C (2005)	1
CRYAB	0	BAX	3	pull down, affinity chromatography technology, affinity chromatography technology	Mao YW (2004), Mao YW (2004), Mao YW (2004)	3
HBP1	1	RB1	2	two hybrid, pull down, affinity chromatography technology	Lavender P (1997), Lavender P (1997), Lavender P (1997)	3
SQSTM1	0	BID	1	affinity chromatography technology, affinity chromatography technology	Liang X (2013), Liang X (2013)	2
MAP1LC3A	0	CASP8	1	affinity chromatography technology, affinity chromatography technology	Pan JA (2011), Pan JA (2011)	2
APAF1	8	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cho DH (2004), Li P (1997), Chu ZL (2001), Hu Y (1998), Pan G (1998), Srinivasula SM (2001), Srinivasula SM (2001), Sun M (2009), Choi H (2011), Wo L (2016), Vu NT (2016)	11
FAS	2	CASP10	1	biochemical, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Vincenz C (1997), MacFarlane M (1997)	3
BIRC2	1	CASP9	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Deveraux QL (1998), Deveraux QL (1998), Eckelman BP (2006), Cheung HH (2006), Kulathila R (2009), Kulathila R (2009), Vucic D (2000), Rolland T (2014), McDonald ER (2004), Chen TC (2014), Vu NT (2016), Vu NT (2016)	12
BCL2L1	0	BCL2	0	unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang H (2002), Lin B (2004), Kolluri SK (2008), Huttlin EL (2015), Huttlin EL (2017)	5
RALGDS	4	FADD	1	affinity chromatography technology	Ikner A (2011)	1
SERPINB9	0	CASP1	1	pull down	Annand RR (1999)	1
UBC	7	ERLIN2	2	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Jo Y (2011)	2
TICAM1	3	TRAF1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Jiang Z (2004), Su X (2006), Su X (2006), Su X (2006), Takaki H (2009)	5
MAP1LC3A	0	UBC	7	biochemical, imaging technique	Fujita N (2013), Govindaraju VK (2017)	2
CHEK1	2	PTEN	24	genetic interference	Shen JP (2017)	1
TNFRSF1A	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1996), Vince JE (2009), Vince JE (2007), Wang YB (2015)	4
TLR3	2	CASP8	1	affinity chromatography technology	Zinngrebe J (2016)	1
TNF	0	FADD	1	affinity chromatography technology	Fritsch J (2014)	1
APAF1	8	CASP8	1	affinity chromatography technology	Hu Y (1998)	1
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
CASP8	1	FASLG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Legler DF (2003), Tao RH (2011)	4
CASP8	1	VPS45	0	two hybrid	Arroyo R (2015)	1
YBX1	1	TP53	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kojic S (2004), Okamoto T (2000), Okamoto T (2000), Tian B (2011), Fogeron ML (2013), Horikawa I (2014)	6
PTEN	24	RHOA	0	affinity chromatography technology, affinity chromatography technology	Chang CC (2012), Chang CC (2012)	2
RHOA	0	MAPK8	3	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
CASP8	1	CASP4	1	enzymatic study	Srinivasula SM (1996)	1
CUL3	17	PDIA6	1	affinity chromatography technology	Bennett EJ (2010)	1
FADD	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Won M (2010), Saitoh Y (2016)	2
CASP8	1	TSC22D3	1	affinity chromatography technology	Delfino DV (2011)	1
TNFSF10	2	PPP2CA	7	affinity chromatography technology	Xu J (2015)	1
TICAM1	3	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meylan E (2004), Meylan E (2004), Chang M (2009), Hu YH (2015)	4
PPP2CA	7	TP53	0	affinity chromatography technology	Shouse GP (2011)	1
TNF	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Fritsch J (2014), Yamaguchi N (2015)	7
TNFSF10	2	RIPK1	2	affinity chromatography technology	Bellail AC (2012)	1
CASP1	1	PLA2G4B	0	enzymatic study	Lueschen S (1998)	1
MAP1LC3B	1	CUL3	17	pull down	Genau HM (2015)	1
CASP8	1	TICAM1	3	affinity chromatography technology	Feoktistova M (2011)	1
MAP3K14	1	TRAF2	1	pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Luftig MA (2001), Luftig MA (2001), Malinin NL (1997), Malinin NL (1997), Malinin NL (1997), Sanjo H (2010), Kanno Y (2010), Zheng C (2010), Song HY (1997), Liao G (2004), Choudhary S (2013), Lee S (2014), Rolland T (2014)	13
CASP10	1	CASP6	0	enzymatic study	Srinivasula SM (1996)	1
RHOA	0	CASP10	1	biochemical	Gajate C (2005)	1
CHEK1	2	BLM	2	affinity chromatography technology, imaging technique, genetic interference	Sengupta S (2004), Sengupta S (2004), Srivas R (2016)	3
LRRK2	5	RHOA	0	affinity chromatography technology	Chan D (2011)	1
TFCP2	1	CASP8	1	two hybrid	Stelzl U (2005)	1
TRAF1	0	TRADD	0	affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Wicovsky A (2009)	2
FAS	2	EZR	8	biochemical	Gajate C (2005)	1
TNFRSF10A	0	TRADD	0	affinity chromatography technology	Chaudhary PM (1997)	1
SQSTM1	0	CASP9	6	affinity chromatography technology	Huang S (2013)	1
PARP1	3	BCL2	0	pull down	Song D (2002)	1
CASP8	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin Z (2009), Jin Z (2009), Gonzalvez F (2012), Xu J (2015)	4
ARHGDIA	3	MAPK8	3	biochemical	Gajate C (2005)	1
MAP1LC3B	1	CASP8	1	two hybrid	Vinayagam A (2011)	1
TNFRSF1A	3	TRADD	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Y (1999), Schuetze S (1999), Pan G (1997), Hsu H (1996), Hsu H (1996), Hsu H (1996), Shu HB (1996), Blankenship JW (2009), Kolliputi N (2009), Fujikura D (2012), Park KJ (2002), Guan YJ (2011), Hsu H (1995), Kumar A (2001), Zheng L (2006), Kim TW (2013), Zhang H (2004), Chang YL (2014), Nakazawa S (2016), Huttlin EL (2017)	20
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
COPS6	0	MAPK1	1	affinity chromatography technology, enzymatic study	Fang L (2015), Fang L (2015)	2
CASP10	1	DEDD	0	affinity chromatography technology	Alcivar A (2003)	1
MSN	0	FADD	1	biochemical	Gajate C (2005)	1
MAPK1	1	CHEK1	2	biochemical	Wan C (2015)	1
GMNN	0	CASP8	1	affinity chromatography technology	Hein MY (2015)	1
COPS6	0	CDKN1B	1	affinity chromatography technology	Choi HH (2015)	1
CASP10	1	CASP8AP2	3	two hybrid	McDonald ER (2004)	1
MAPK1	1	CASP9	6	enzymatic study	Allan LA (2003)	1
FAS	2	TRADD	0	affinity chromatography technology	Kumar A (2001)	1
PTEN	24	BAP1	4	affinity chromatography technology	Crockett DK (2005)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
XIAP	0	RIPK3	2	pull down	Bertrand MJ (2011)	1
CASP8	1	TRADD	0	affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kolliputi N (2009)	2
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
CASP8	1	MAPK1	1	affinity chromatography technology	Yao Z (2007)	1
CASP14	2	CASP4	1	affinity chromatography technology	Hu S (1998)	1
TP53	0	CDK9	3	genetic interference, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	De Falco G (2000), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006)	6
TNF	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legler DF (2003), Haas TL (2009), Ea CK (2006), Ramakrishnan P (2011), Skaug B (2011), Darding M (2011), Tokunaga F (2012), Klingseisen L (2012), Schaeffer V (2014), Fritsch J (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	14
CFLAR	1	DEDD	0	affinity chromatography technology, pull down	Roth W (2002), Zhan Y (2002)	2
TLR3	2	BIRC2	1	affinity chromatography technology	Zinngrebe J (2016)	1
CASP8	1	CASP1	1	enzymatic study	Srinivasula SM (1996)	1
MSN	0	CASP8	1	biochemical	Gajate C (2005)	1
BIRC3	1	RIPK3	2	pull down, affinity chromatography technology, enzymatic study	Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	3
DEDD2	1	CFLAR	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Roth W (2002), Roth W (2002), Zhan Y (2002), Zhan Y (2002)	4
CASP8	1	ANGPTL4	2	two hybrid	Arroyo R (2015)	1
CASP10	1	CASP1	1	enzymatic study	Srinivasula SM (1996)	1
CFLAR	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kataoka T (2000), Chaudhary PM (2000), Rebe C (2007), Feoktistova M (2011), Ranjan K (2016), Ranjan K (2016)	6
23429	0	TP53	0	affinity chromatography technology	Chen D (2009)	1
TRAF2	1	USP2	0	two hybrid, affinity chromatography technology, pull down, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Mahul-Mellier AL (2011), Rolland T (2014), Mahul-Mellier AL (2012), Mahul-Mellier AL (2012)	7
TRAF6	0	CASP4	1	affinity chromatography technology	Lakshmanan U (2007)	1
TNFRSF10B	1	CUL3	17	affinity chromatography technology	Gonzalvez F (2012)	1
CASP3	0	TRAF1	0	imaging technique	Chen TC (2014)	1
TP53	0	BCL2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Heo KS (2011), Jung JH (2011), Jung JH (2011), Mancini F (2009), Mancini F (2009)	5
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
BCL2L1	0	TP53	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Vinayagam A (2011), Tang WH (2014), Saxena R (2016), Stegh AH (2010), Kim EM (2014)	5
CASP6	0	RB1	2	enzymatic study	Lemaire C (2005)	1
MAP1LC3A	0	OPTN	1	two hybrid, affinity chromatography technology, pull down, pull down	Wild P (2011), Wild P (2011), Liu Z (2014), Wild P (2011)	4
CASP8	1	SNRPD3	0	two hybrid	Wang J (2011)	1
BCL2L10	0	BCL2	0	affinity chromatography technology	Ke N (2001)	1
MAP3K14	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Mochida Y (2000), Song HY (1997), Li Q (2006), Chen TC (2014)	4
TNF	0	OPTN	1	affinity chromatography technology	Klingseisen L (2012)	1
BFAR	0	CASP10	1	affinity chromatography technology	Zhang H (2000)	1
FADD	1	NLRC4	2	affinity chromatography technology	Raghawan AK (2017)	1
MAPK1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique	Persons DL (2000), How PC (2011), Srivastav RK (2011), Fogeron ML (2013), Chen TC (2014)	5
BCL2L1	0	MTOR	14	affinity chromatography technology, enzymatic study	Ramanathan A (2009), Ramanathan A (2009)	2
PARP1	3	TP53	0	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, pull down, pull down	Gueven N (2004), Malanga M (1998), Vaziri H (1997), Vaziri H (1997), Wesierska-Gadek J (2003), Simbulan-Rosenthal CM (2003)	6
PPP2CA	7	BCL2	0	enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Deng X (1998), Deng X (1998), Deng X (1998), Tamura Y (2004), Tamura Y (2004)	5
CASP8	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Feoktistova M (2012), McDonald ER (2004), Zinngrebe J (2016)	4
CARD11	4	USP2	0	affinity chromatography technology, affinity chromatography technology	Li Y (2013), Li Y (2013)	2
TLR3	2	BIRC3	1	affinity chromatography technology	Zinngrebe J (2016)	1
CASP10	1	TRAF1	0	enzymatic study	Leo E (2001)	1
VHL	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roe JS (2006), Roe JS (2006), Roe JS (2006), Lai Y (2011), Lai Y (2011)	5
TRAF2	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Kataoka T (2000), Kataoka T (2000)	3
CHEK1	2	BCL2L1	0	enzymatic study	Wang J (2012)	1
BIRC2	1	TRAF1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Shu HB (1996), Li X (2002), Li S (2011), Mace PD (2010), Rothe M (1995), Varfolomeev E (2006), Goncharov T (2013), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017)	11
TRAF2	1	IKBKB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Devin A (2001), Li S (2009), Li S (2009), Li HY (2008), Shen RR (2012), Shen RR (2012), Zhang W (2010), Chen TC (2014), Mei ZZ (2016)	9
CASP3	0	BID	1	enzymatic study, enzymatic study	Paroni G (2001), Walsh JG (2008)	2
CASP3	0	BLM	2	enzymatic study	Freire R (2001)	1
SERPINB9	0	COPS6	0	two hybrid	Stelzl U (2005)	1
LRRK2	5	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Park S (2016), Park S (2016)	2
MLKL	1	RIPK1	2	affinity chromatography technology	Pescatore A (2016)	1
TP53	0	MAPK14	0	protein complementation assay, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Srivastav RK (2011), Zhang S (2006), Mo JS (2010), Gong X (2010), Perfettini JL (2005), Perfettini JL (2005), Bulavin DV (1999), Bulavin DV (1999)	8
USP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study	Bremm A (2010), Li Y (2013), Li Y (2013), Rolland T (2014), Li Y (2013)	5
NOD1	3	CASP4	1	affinity chromatography technology	Inohara N (1999)	1
TNFSF10	2	CASP8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Bellail AC (2012), Gonzalvez F (2012), Jennewein C (2012), Li Y (2013), Xu J (2015)	6
BCL2	0	CHUK	5	affinity chromatography technology	Bodur C (2012)	1
CASP8	1	OPTN	1	affinity chromatography technology, affinity chromatography technology	Nakazawa S (2016), Nakazawa S (2016)	2
TNFRSF10A	0	SQSTM1	0	affinity chromatography technology	Jin Z (2009)	1
CASP1	1	NLRC4	2	affinity chromatography technology, affinity chromatography technology	Damiano JS (2004), Damiano JS (2001)	2
TSC22D3	1	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Ayroldi E (2014), Ayroldi E (2014), Ayroldi E (2014), Ayroldi E (2014), Ayroldi E (2014)	5
CASP3	0	CASP2	1	enzymatic study, enzymatic study	Paroni G (2001), Walsh JG (2008)	2
BIRC2	1	CASP2	1	pull down	Cheung HH (2006)	1
PARP1	3	IL24	0	two hybrid, affinity chromatography technology	Arroyo R (2015), Arroyo R (2015)	2
CASP8	1	VIM	0	two hybrid	Stelzl U (2005)	1
BAX	3	CASP7	1	biochemical	Chandra D (2004)	1
CUL3	17	SNRPD3	0	affinity chromatography technology	Bennett EJ (2010)	1
MAP3K14	1	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
CASP8	1	SOX2	4	two hybrid	Arroyo R (2015)	1
CASP7	1	CASP9	6	enzymatic study	Walsh JG (2008)	1
CASP8AP2	3	FAS	2	affinity chromatography technology	Imai Y (1999)	1
MAPK14	0	MAPK8	3	affinity chromatography technology	Chan PM (2008)	1
HECTD3	8	TP53	0	two hybrid	Li Y (2013)	1
CASP8	1	CHD3	19	two hybrid	Stelzl U (2005)	1
CEBPB	2	RB1	2	pull down, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology	Charles A (2001), Wang J (2008), Chen PL (1996), Chen PL (1996), Chen PL (1996), Chen PL (1996)	6
BIRC2	1	CASP7	1	pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Choi YE (2009), Choi YE (2009), Tenev T (2005), Eckelman BP (2006), Vucic D (2000)	6
CASP8	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Shu HB (1997), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Micheau O (2002), Han DK (1997), Han DK (1997), Han DK (1997), Roth W (2002), Zhang L (2009), Tenev T (2011), Kerr E (2012), Sinha SK (2004), Lee EW (2012), Rebe C (2007), Rebe C (2007), Kaunisto A (2009), Feoktistova M (2011), Feoktistova M (2011), Huttlin EL (2015), Huttlin EL (2017)	23
BCL2	0	BID	1	unspecified method, unspecified method, pull down, affinity chromatography technology, biochemical, unspecified method	Chen L (2005), Real PJ (2004), Kolluri SK (2008), Chipuk JE (2008), Chipuk JE (2008), Certo M (2006)	6
CASP7	1	PLA2G4B	0	enzymatic study	Lueschen S (1998)	1
CASP8	1	UMPS	4	two hybrid	Arroyo R (2015)	1
SOX2	4	CHD3	19	affinity chromatography technology	Cox JL (2013)	1
FAS	2	RIPK1	2	two hybrid	Stanger BZ (1995)	1
MAP1LC3B	1	TP53	0	affinity chromatography technology	Horikawa I (2014)	1
MAP1LC3A	0	PRKCI	1	affinity chromatography technology	Behrends C (2010)	1
CASP10	1	FADD	1	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, pull down, pull down	Gajate C (2005), Vincenz C (1997), Vincenz C (1997), Srinivasula SM (1997), Srinivasula SM (1997), Wang J (2001), McDonald ER (2004), Choi H (2011), Choi H (2011)	9
CASP8	1	BLID	0	two hybrid	Arroyo R (2015)	1
CFLAR	1	CASP3	0	affinity chromatography technology, pull down, two hybrid	Shu HB (1997), Han DK (1997), Han DK (1997)	3
ARHGDIA	3	CASP8	1	biochemical	Gajate C (2005)	1
IKBKB	1	CASP8	1	affinity chromatography technology	Chaudhary PM (2000)	1
CASP8	1	CLIP3	4	affinity chromatography technology	Fujikura D (2012)	1
BID	1	FADD	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
MAP1LC3A	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, affinity chromatography technology	Shvets E (2008), Shvets E (2008), Behrends C (2010), Gao Z (2010), Pan JA (2011), Pankiv S (2007), Pankiv S (2007), Shvets E (2011), Tung YT (2010), Bjorkoy G (2005), Kirkin V (2009), Lim J (2011), Lim J (2011), Pan JA (2012), Lee DY (2013), Wang BS (2013), Wang BS (2013), Sansanwal P (2012), Shi J (2013), Fujita N (2013), Chen X (2014), Liu XD (2014), Noda NN (2008), Noda NN (2008), Matsuzawa Y (2015), Matsuzawa Y (2015), Rui YN (2015), Rui YN (2015), Ciuffa R (2015), Wang N (2013), Hua F (2015), Rui YN (2015), Cha-Molstad H (2015), Paul S (2012), Puvirajesinghe TM (2016), Wang L (2017), Cha-Molstad H (2017), Peng H (2017), Lee Y (2017)	39
IFT57	1	BFAR	0	affinity chromatography technology	Roth W (2003)	1
CASP8	1	ATAD2	6	two hybrid	Arroyo R (2015)	1
TNFRSF10B	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Bellail AC (2012)	2
CDK9	3	TRAF2	1	affinity chromatography technology	MacLachlan TK (1998)	1
CASP10	1	PRDX6	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, protein complementation assay	Choi H (2011), Choi H (2011), Choi H (2011), Choi H (2011), Choi H (2011), Choi H (2011)	6
VHL	0	UBC	7	pull down	Lisztwan J (1999)	1
LRRK2	5	BAX	3	affinity chromatography technology	Charan RA (2014)	1
TNFAIP3	3	CHUK	5	affinity chromatography technology	Zetoune FS (2001)	1
RB1	2	CDK9	3	pull down, affinity chromatography technology, enzymatic study, enzymatic study, biochemical, enzymatic study	Simone C (2002), Simone C (2002), De Luca A (1997), Garriga J (1996), Garriga J (1996), Grana X (1994)	6
FAS	2	MSN	0	biochemical	Gajate C (2005)	1
CDK9	3	YBX1	1	affinity chromatography technology	Jeronimo C (2007)	1
TRADD	0	NOL3	0	genetic interference	Koseki T (1998)	1
CASP8	1	MAP3K14	1	affinity chromatography technology	Chaudhary PM (2000)	1
ERLIN2	2	CASP8	1	affinity chromatography technology	Jo Y (2011)	1
TNFRSF10A	0	CUL3	17	affinity chromatography technology	Gonzalvez F (2012)	1
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
MAPK14	0	CASP3	0	affinity chromatography technology	Alvarado-Kristensson M (2004)	1
TNFRSF10B	1	TRADD	0	affinity chromatography technology	Chaudhary PM (1997)	1
ARHGDIA	3	BID	1	biochemical	Gajate C (2005)	1
COPS6	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	6
TNFRSF1A	3	KHDRBS1	1	affinity chromatography technology	Pincheira R (2008)	1
CASP10	1	CASP9	6	enzymatic study	Srinivasula SM (1996)	1
CASP6	0	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
TP53	0	SNRPD3	0	affinity chromatography technology	Fogeron ML (2013)	1
CUL3	17	RHOA	0	affinity chromatography technology, affinity chromatography technology	Chen Y (2009), Dubiel D (2017)	2
MAPK1	1	YBX1	1	enzymatic study	Coles LS (2005)	1
RHOA	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
BCL2L1	0	CASP9	6	affinity chromatography technology, imaging technique	Hu Y (1998), Chen TC (2014)	2
CUL3	17	UMPS	4	affinity chromatography technology	Bennett EJ (2010)	1
NOD1	3	CASP9	6	affinity chromatography technology	Inohara N (1999)	1
XIAP	0	UBC	7	x-ray crystallography, pull down, pull down, pull down	Tse MK (2011), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Nakatani Y (2012)	4
NOD1	3	CASP2	1	affinity chromatography technology	Inohara N (1999)	1
MAPK8	3	TNFRSF1A	3	biochemical	Gajate C (2005)	1
FADD	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Chaudhary PM (1997), Kim Y (2002), Guo F (2005), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017)	8
FAF1	1	FADD	1	pull down, affinity chromatography technology	Ryu SW (2003), Ryu SW (2003)	2
MAPK8	3	TFCP2	1	enzymatic study	Ylisastigui L (2005)	1
TRAF1	0	UBC	7	affinity chromatography technology	Greenfeld H (2015)	1
BLM	2	PARP1	3	affinity chromatography technology	Wang J (2013)	1
XIAP	0	FAF1	1	two hybrid, pull down, affinity chromatography technology, imaging technique	Caballero-Lopez MJ (2017), Caballero-Lopez MJ (2017), Caballero-Lopez MJ (2017), Caballero-Lopez MJ (2017)	4
RHOA	0	TNFRSF1A	3	biochemical	Gajate C (2005)	1
EZR	8	FASLG	0	biochemical, affinity chromatography technology	Gajate C (2005), Parlato S (2000)	2
CASP7	1	CASP2	1	enzymatic study	Paroni G (2001)	1
TNF	0	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006)	2
CASP8	1	RALBP1	2	affinity chromatography technology	Micheau O (2003)	1
BIRC3	1	CASP10	1	affinity chromatography technology	McDonald ER (2004)	1
CASP7	1	PARP1	3	enzymatic study, enzymatic study, enzymatic study	Lueschen S (1998), Walsh JG (2008), Boucher D (2012)	3
CASP10	1	23429	0	affinity chromatography technology, affinity chromatography technology	Zheng L (2001), Zheng L (2001)	2
RHOA	0	FASLG	0	biochemical	Gajate C (2005)	1
LRRK2	5	FADD	1	affinity chromatography technology	Ho CC (2009)	1
FAS	2	NOL3	0	genetic interference	Koseki T (1998)	1
SQSTM1	0	CUL3	17	imaging technique, affinity chromatography technology	Lau A (2010), Mori Y (2015)	2
TNFRSF10B	1	TNFAIP3	3	affinity chromatography technology	Bellail AC (2012)	1
UBC	7	NOD1	3	pull down, x-ray crystallography	Ver Heul AM (2013), Ver Heul AM (2013)	2
PTEN	24	COPS6	0	two hybrid	Stelzl U (2005)	1
LRRK2	5	TRAF2	1	enzymatic study	Zach S (2010)	1
SERPINB9	0	CASP10	1	affinity chromatography technology	Kummer JA (2007)	1
CFLAR	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Abedini MR (2008), Saha A (2011), Saha A (2011)	4
CUL3	17	YBX1	1	affinity chromatography technology	Bennett EJ (2010)	1
CHUK	5	TNFRSF1A	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008)	3
CASP8	1	CDK9	3	genetic interference	Shen JP (2017)	1
MLKL	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Petersen SL (2015), Petersen SL (2015)	2
MAPK1	1	TFCP2	1	enzymatic study	Ylisastigui L (2005)	1
BCAP31	0	BCL2L1	0	pull down, affinity chromatography technology, affinity chromatography technology	Ng FW (1997), Ng FW (1997), Mund T (2003)	3
BCL2L1	0	CASP8AP2	3	affinity chromatography technology	Chinnaiyan AM (1997)	1
RB1	2	TP53	0	affinity chromatography technology, pull down	Delston RB (2011), Sommer MH (1994)	2
FAS	2	TNFRSF1A	3	biochemical	Gajate C (2005)	1
TP53	0	SQSTM1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Di Lello P (2006), Horikawa I (2014), Kang JH (2016), Kang JH (2016)	4
XIAP	0	CASP9	6	two hybrid, far western blotting, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Rual JF (2005), Davoodi J (2004), Deveraux QL (1998), Deveraux QL (1998), Richter BW (2001), Morizane Y (2005), Fu J (2003), Fu J (2003), Hao Y (2004), Varfolomeev E (2007), Vucic D (2002), Qiu XB (2005), Srinivasula SM (2001), Cheung HH (2006), Kulathila R (2009), Shiozaki EN (2003), Davoodi J (2007), Checinska A (2007), Huang Y (2003), Sun M (2009), Martin SA (2005), Lee JS (2012), Rolland T (2014), McDonald ER (2004), Chen TC (2014)	25
CASP8	1	BCL2L10	0	two hybrid	Arroyo R (2015)	1
FAS	2	FAF1	1	affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology	Chu K (1995), Ryu SW (1999), Ryu SW (1999), Imai Y (2002), Ryu SW (2003)	5
FAS	2	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Shu HB (1997), MacFarlane M (1997), Huttlin EL (2015), Jeong M (2017), Huttlin EL (2017), Kleber S (2008)	7
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
CDKN1B	1	VHL	0	genetic interference	Shen JP (2017)	1
TNFRSF10A	0	CASP10	1	affinity chromatography technology	MacFarlane M (1997)	1
TLR3	2	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang M (2011), Jiang Z (2003), Jiang Z (2003), Cusson-Hermance N (2005), Zinngrebe J (2016)	5
CASP8	1	SCGB2A2	0	two hybrid	Arroyo R (2015)	1
TP53	0	BIRC6	15	affinity chromatography technology, affinity chromatography technology	Tang W (2015), Tang W (2015)	2
BIRC6	15	CASP9	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Hao Y (2004), Bartke T (2004), Qiu XB (2005), Qiu XB (2005), Qiu XB (2005)	5
FIS1	0	CASP8	1	affinity chromatography technology	Iwasawa R (2011)	1
PARK7	0	BAX	3	pull down	Ren H (2011)	1
SERPINB9	0	TP53	0	two hybrid	Stelzl U (2005)	1
FAS	2	BID	1	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
DEDD2	1	CASP8	1	affinity chromatography technology, pull down, affinity chromatography technology	Zhan Y (2002), Zhan Y (2002), Alcivar A (2003)	3
UBC	7	BIRC6	15	affinity chromatography technology	Matsumoto M (2005)	1
TRAF6	0	MTOR	14	affinity chromatography technology, enzymatic study	Linares JF (2013), Linares JF (2013)	2
TNFSF10	2	FADD	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Bellail AC (2012), Jennewein C (2012), Xu J (2015)	4
TNF	0	CHUK	5	affinity chromatography technology, genetic interference	Haas TL (2009), Sahu I (2014)	2
CFLAR	1	FADD	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Han DK (1997), Kerr E (2012), Rebe C (2007), Choi H (2011), Feoktistova M (2011), Ranjan K (2016), Jeong M (2017)	13
MAP3K14	1	CASP3	0	imaging technique	Chen TC (2014)	1
BCL2	0	SQSTM1	0	affinity chromatography technology, pull down	Zhou L (2013), Zhou L (2014)	2
APAF1	8	XIAP	0	biochemical, affinity chromatography technology, affinity chromatography technology	Srinivasula SM (2001), Srinivasula SM (2001), Sun M (2009)	3
FADD	1	TRADD	0	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henshall DC (2003), Hsu H (1996), Hsu H (1996), Thomas LR (2002), Guan YJ (2011), Park KJ (2003), Qi Z (2014)	7
MSN	0	TNFRSF1A	3	biochemical	Gajate C (2005)	1
MAPK1	1	PRDX6	0	enzymatic study	Wu Y (2009)	1
CHD3	19	TP53	0	two hybrid, two hybrid	Minty A (2000), Goehler H (2004)	2
CASP10	1	CASP7	1	enzymatic study	Srinivasula SM (1996)	1
BCL2L10	0	BAX	3	affinity chromatography technology	Ke N (2001)	1
CRYAB	0	CASP3	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Stegh AH (2008), Stegh AH (2008), Stegh AH (2008), Lee JS (2012), Jeong WJ (2012)	5
PEA15	0	MAPK1	1	two hybrid, pull down, affinity chromatography technology	Formstecher E (2001), Formstecher E (2001), Casar B (2007)	3
TNFRSF10A	0	TNFRSF10B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guo F (2005), Jin Z (2009), Huttlin EL (2017)	3
LYPD3	0	MTOR	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC6	15	CASP3	0	affinity chromatography technology, pull down, enzymatic study	Bartke T (2004), Qiu XB (2005), Qiu XB (2005)	3
CASP8	1	YBX1	1	two hybrid	Arroyo R (2015)	1
CASP8	1	PRDM14	1	two hybrid	Arroyo R (2015)	1
CUL3	17	QDPR	0	affinity chromatography technology	Bennett EJ (2010)	1
RIPK3	2	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu PW (1999), Yu PW (1999), Li S (2011), Lee EW (2012), Petersen SL (2015), Moquin DM (2013), Moriwaki K (2016)	7
CASP8	1	BIRC6	15	enzymatic study	Qiu XB (2005)	1
CASP8	1	SERPINB5	0	two hybrid	Arroyo R (2015)	1
BLM	2	CASP8	1	affinity chromatography technology	Hein MY (2015)	1
CASP8	1	CASP3	0	enzymatic study, enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996), Chandra D (2004)	3
UBC	7	KHDRBS1	1	pull down	Zhang X (2017)	1
TRAF1	0	CHUK	5	affinity chromatography technology, affinity chromatography technology	Wicovsky A (2009), Henkler F (2003)	2
FAF1	1	UBC	7	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Song EJ (2005), Lee JJ (2012), Song J (2009), Song J (2009), Song J (2009), Lee JJ (2013), Lee JJ (2013), Nathan JA (2013), Baron Y (2014), Alexandru G (2008), Lee JJ (2012)	11
COPS6	0	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
CASP6	0	TRAF1	0	enzymatic study	Leo E (2001)	1
TRAF2	1	CASP8AP2	3	pull down, affinity chromatography technology	Choi YH (2001), Choi YH (2001)	2
CASP8	1	CHEK1	2	genetic interference	Shen JP (2017)	1
IL13RA2	0	CHEK1	2	affinity chromatography technology	Huttlin EL (2017)	1
CASP7	1	RB1	2	enzymatic study, enzymatic study	Lemaire C (2005), Fattman CL (2001)	2
FADD	1	FASLG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Gajate C (2005), Micheau O (2003), Legler DF (2003), Tao RH (2011), Chen TC (2014)	5
TICAM1	3	TRAF2	1	two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid	Sasai M (2010), Sasai M (2010), Sasai M (2010), Jiang Z (2004), Takaki H (2009)	5
BCL2	0	IKBKB	1	affinity chromatography technology	Bodur C (2012)	1
FASLG	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CASP10	1	RB1	2	enzymatic study	Lemaire C (2005)	1
CASP10	1	CASP3	0	enzymatic study	Srinivasula SM (1996)	1
MSN	0	CASP10	1	biochemical	Gajate C (2005)	1
RIPK3	2	TNFRSF1A	3	affinity chromatography technology	Yu PW (1999)	1
BCL2	0	BAX	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hoetelmans RW (2004), Lin B (2004), Lin B (2004), Oltvai ZN (1993), Komatsu K (2000), Geng F (2011), Bodur C (2012), Trisciuoglio D (2013), Zhang H (2000), Diaz JL (1997), Dlugosz PJ (2006), Konopleva M (2006), Konopleva M (2006), Czabotar PE (2011)	14
FAS	2	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1997), MacFarlane M (1997), Jeong M (2017)	3
CASP10	1	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Vincenz C (1997)	2
CHEK1	2	VHL	0	genetic interference	Shen JP (2017)	1
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
IKBKB	1	MTOR	14	affinity chromatography technology, affinity chromatography technology, biochemical	Dan HC (2008), Dan HC (2008), Dan HC (2008)	3
CASP8	1	MTOR	14	genetic interference	Shen JP (2017)	1
SERPINB9	0	CASP8	1	affinity chromatography technology	Kummer JA (2007)	1
CASP8	1	PLA2G4B	0	enzymatic study	Lueschen S (1998)	1
CASP7	1	VIM	0	enzymatic study	Walsh JG (2008)	1
FADD	1	KHDRBS1	1	affinity chromatography technology, affinity chromatography technology	Ramakrishnan P (2011), Ramakrishnan P (2011)	2
BAX	3	XIAP	0	affinity chromatography technology	Gogada R (2011)	1
TNFRSF10A	0	TRAF2	1	affinity chromatography technology	Gonzalvez F (2012)	1
BIRC3	1	CASP1	1	affinity chromatography technology, affinity chromatography technology	Labbe K (2011), Labbe K (2011)	2
RHOA	0	EZR	8	biochemical	Gajate C (2005)	1
MAPK8	3	FADD	1	biochemical	Gajate C (2005)	1
CASP8	1	CASP2	1	enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996)	2
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
CASP8	1	NLRC4	2	affinity chromatography technology, affinity chromatography technology	Kumar Y (2010), Raghawan AK (2017)	2
TNFAIP3	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang M (2013), Wang M (2013), Liu J (2013), Liu J (2013)	4
IKBKB	1	TP53	0	enzymatic study	Xia Y (2009)	1
CASP7	1	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
CEBPB	2	CASP1	1	affinity chromatography technology, affinity chromatography technology	Buck M (2001), Buck M (2001)	2
OPTN	1	UBC	7	affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down	Wild P (2011), Fenner BJ (2009), Zhu G (2007), Zhu G (2007), Wagner S (2008), Gleason CE (2011), Nagabhushana A (2011), Korac J (2012), Wild P (2011), Tumbarello DA (2015), Heo JM (2015), Ordureau A (2015), Richter B (2016), Richter B (2016), Nakazawa S (2016), Zhang X (2017), Kliza K (2017), Bansal M (2018)	18
ARHGDIA	3	TNFRSF1A	3	biochemical	Gajate C (2005)	1
CHEK1	2	MTOR	14	genetic interference, genetic interference, genetic interference	Shen JP (2017), Srivas R (2016), Srivas R (2016)	3
CASP6	0	CHD3	19	two hybrid	Stelzl U (2005)	1
SQSTM1	0	MAPK1	1	affinity chromatography technology	Linares JF (2011)	1
FADD	1	CLIP3	4	affinity chromatography technology	Fujikura D (2012)	1
CASP9	6	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
TNFRSF1A	3	TRAF6	0	affinity chromatography technology	Chang YL (2014)	1
CASP8	1	RIPK3	2	affinity chromatography technology	Lee EW (2012)	1
OPTN	1	SQSTM1	0	affinity chromatography technology, pull down	Liu Z (2014), Liu Z (2014)	2
CASP14	2	CASP2	1	affinity chromatography technology	Hu S (1998)	1
RHOA	0	MSN	0	biochemical	Gajate C (2005)	1
CASP8	1	ATP1A3	15	two hybrid	Arroyo R (2015)	1
CASP8AP2	3	CASP8	1	affinity chromatography technology	Imai Y (1999)	1
KHDRBS1	1	SORBS1	2	unspecified method	Asbach B (2012)	1
CASP8	1	TNFRSF10B	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Kaunisto A (2009), Guo F (2005), Gonzalvez F (2012), Gonzalvez F (2012), Huttlin EL (2015), Huttlin EL (2017), Xu L (2017), Xu L (2017)	12
BCL2L1	0	BLID	0	pull down, affinity chromatography technology, affinity chromatography technology	Broustas CG (2010), Broustas CG (2010), Broustas CG (2010)	3
FADD	1	DEDD	0	affinity chromatography technology, pull down, affinity chromatography technology	Roth W (2002), Stegh AH (1998), Stegh AH (1998)	3
TNFSF10	2	TRAF2	1	affinity chromatography technology	Bellail AC (2012)	1
TNFRSF1A	3	TRAF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hsu H (1996), Mosialos G (1995), Wicovsky A (2009)	3
CASP3	0	CASP6	0	enzymatic study, enzymatic study, imaging technique	Srinivasula SM (1996), Walsh JG (2008), Chen TC (2014)	3
CASP8	1	TRAF1	0	affinity chromatography technology, enzymatic study	Micheau O (2003), Leo E (2001)	2
TNFSF10	2	CUL3	17	affinity chromatography technology	Xu J (2015)	1
FAS	2	TNFRSF10B	1	biochemical	Gajate C (2005)	1
TP53	0	VIM	0	affinity chromatography technology	Horikawa I (2014)	1
TNFSF10	2	CFLAR	1	affinity chromatography technology, affinity chromatography technology	Bangert A (2012), Jennewein C (2012)	2
CEBPB	2	CASP8	1	affinity chromatography technology, affinity chromatography technology	Buck M (2001), Buck M (2001)	2
TRAF2	1	MTOR	14	imaging technique	Chen TC (2014)	1
BFAR	0	CASP8	1	affinity chromatography technology	Zhang H (2000)	1
BID	1	MAPK8	3	biochemical	Gajate C (2005)	1
CASP8	1	RNF34	1	two hybrid, affinity chromatography technology	McDonald ER (2004), McDonald ER (2004)	2
RNF34	1	CASP9	6	affinity chromatography technology	McDonald ER (2004)	1
XIAP	0	RIPK1	2	pull down	Bertrand MJ (2011)	1
CASP8	1	AGR3	2	two hybrid	Arroyo R (2015)	1
HECTD3	8	CASP8	1	affinity chromatography technology, affinity chromatography technology, pull down	Li Y (2013), Li Y (2013), Li Y (2013)	3
CUL3	17	KHDRBS1	1	affinity chromatography technology	Bennett EJ (2010)	1
SERPINB5	0	RHOA	0	affinity chromatography technology	Huttlin EL (2015)	1
CASP3	0	VIM	0	enzymatic study	Walsh JG (2008)	1
EZR	8	FADD	1	biochemical, affinity chromatography technology, imaging technique	Gajate C (2005), Young JA (2011), Chen TC (2014)	3
FADD	1	TNFRSF1A	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Hsu H (1996), Kumar A (2001), Zheng L (2006)	4
CASP8	1	NOL3	0	genetic interference, affinity chromatography technology	Koseki T (1998), Koseki T (1998)	2
CASP3	0	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
XIAP	0	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
MAPK8	3	TP53	0	affinity chromatography technology, pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Hu MC (1997), Yin ZM (2004), Yin ZM (2004), Fuchs SY (1998), Topisirovic I (2009), Drago-Ferrante R (2008), Wang J (2000), Chang NS (2003), Fuchs SY (1998)	9
MAPK8	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
CUL3	17	PPP2CA	7	affinity chromatography technology	Bennett EJ (2010)	1
BFAR	0	UBC	7	enzymatic study	Rong J (2011)	1
BCL2L1	0	CASP1	1	affinity chromatography technology	Chinnaiyan AM (1997)	1
CHEK1	2	PARP1	3	genetic interference	Shen JP (2017)	1
NOD1	3	RNF34	1	two hybrid, affinity chromatography technology, pull down	Zhang R (2014), Zhang R (2014), Zhang R (2014)	3
TOPORS	6	TP53	0	two hybrid, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Weger S (2002), Rajendra R (2004), Pungaliya P (2007), Yao Z (2007), Yao Z (2007), Weger S (2005)	6
XIAP	0	CASP3	0	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Suzuki Y (2001), Suzuki Y (2001), Silke J (2002), Riedl SJ (2001), Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Nakhaei P (2012), Qiu XB (2005), Nomura T (2003), Paulsen M (2008), Scott FL (2005), Mufti AR (2006), Rajalingam K (2006), Dudich E (2006), Chai J (2001), Checinska A (2007), Sun M (2009), Takahashi R (1998), Conde C (2012), Walsh JG (2008), Lee JS (2012), Lin YF (2013), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Hou Y (2017)	30
TRAF1	0	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Shu HB (1997), Kataoka T (2000), Kataoka T (2000), Rolland T (2014)	4
ARHGDIA	3	CASP10	1	biochemical	Gajate C (2005)	1
FAS	2	RHOA	0	biochemical, imaging technique	Gajate C (2005), Chen TC (2014)	2
CASP8	1	KLK9	1	two hybrid	Arroyo R (2015)	1
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
CASP3	0	CASP9	6	enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Qiu XB (2005), Denault JB (2007), Srinivasula SM (2001), Walsh JG (2008), Chen TC (2014)	5
CASP8	1	RALGDS	4	affinity chromatography technology, affinity chromatography technology	Ikner A (2011), Ikner A (2011)	2
TNFRSF1A	3	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Blankenship JW (2009), Vince JE (2009)	2
MLKL	1	CASP8	1	affinity chromatography technology	Hein MY (2015)	1
MSN	0	EZR	8	biochemical, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Gary R (1995), Gary R (1993), Gary R (1993), Hein MY (2015)	5
SERPINB9	0	CASP4	1	pull down	Annand RR (1999)	1
CHEK1	2	XIAP	0	pull down, affinity chromatography technology, pull down	Galvan V (2004), Galvan V (2004), Galvan V (2004)	3
MAP3K14	1	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varfolomeev E (2007), Kanno Y (2010), Lee S (2014), Lee S (2014)	4
USP2	0	BAP1	4	enzymatic study	Mashtalir N (2014)	1
CASP8	1	NR1H4	0	pull down	Stegh AH (2002)	1
MAPK14	0	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Tsuchiya Y (2010)	2
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
UBC	7	CHUK	5	pull down	Zhang X (2017)	1
FAS	2	RB1	2	affinity chromatography technology	Huttlin EL (2015)	1
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
LRRK2	5	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Ho DH (2015), Ho DH (2015), Ho DH (2015)	3
KHDRBS1	1	RIPK1	2	pull down, affinity chromatography technology	Ramakrishnan P (2011), Ramakrishnan P (2011)	2
MSN	0	TNFRSF10B	1	biochemical	Gajate C (2005)	1
ARHGDIA	3	CDKN1B	1	two hybrid	Stelzl U (2005)	1
MAPK1	1	TNFRSF1A	3	enzymatic study, affinity chromatography technology, pull down	Frankel SK (2001), Ibeas E (2009), Ibeas E (2009)	3
XIAP	0	CASP4	1	affinity chromatography technology	Silke J (2002)	1
TRAF2	1	FADD	1	affinity chromatography technology	Gonzalvez F (2012)	1
CDKN1B	1	MAPK8	3	pull down, affinity chromatography technology, affinity chromatography technology	Chang TS (2003), Chang TS (2003), Chang TS (2003)	3
CASP3	0	PLA2G4B	0	enzymatic study	Lueschen S (1998)	1
COPS6	0	NOD1	3	affinity chromatography technology, affinity chromatography technology	da Silva Correia J (2007), da Silva Correia J (2007)	2
GZMB	0	SERPINB9	0	pull down	Sun J (1996)	1
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
KHDRBS1	1	CASP8	1	affinity chromatography technology	Ramakrishnan P (2011)	1
MSN	0	MAPK8	3	biochemical	Gajate C (2005)	1
TNFRSF1A	3	NOL3	0	genetic interference	Koseki T (1998)	1
MAPK14	0	TFCP2	1	enzymatic study	Ylisastigui L (2005)	1
BCAP31	0	BFAR	0	affinity chromatography technology	Roth W (2003)	1
CASP3	0	ARHGDIA	3	enzymatic study	Walsh JG (2008)	1
APAF1	8	CASP4	1	affinity chromatography technology	Hu Y (1998)	1
PPP2CA	7	IKBKB	1	affinity chromatography technology	Kray AE (2005)	1
BCL2L1	0	BID	1	unspecified method, unspecified method, unspecified method, imaging technique	Chen L (2005), Kuwana T (2005), Certo M (2006), Chen TC (2014)	4
MAPK8	3	MTOR	14	affinity chromatography technology	Kwak D (2012)	1
OPTN	1	TRADD	0	affinity chromatography technology	Zhu G (2007)	1
CASP7	1	TNFRSF1A	3	enzymatic study	Ethell DW (2001)	1
LRRK2	5	CASP8	1	affinity chromatography technology	Ho CC (2009)	1
TRAF6	0	CARD11	4	affinity chromatography technology	McCully RR (2008)	1
FADD	1	NOL3	0	genetic interference	Koseki T (1998)	1
TP53	0	UMPS	4	genetic interference	Xie L (2013)	1
CASP3	0	BCL2	0	enzymatic study	Liang Y (2002)	1
CASP8	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Micheau O (2003), Knox PG (2011), Mahul-Mellier AL (2011), Gonzalvez F (2012), Gonzalvez F (2012), Xu L (2017), Xu L (2017)	7
TRAF6	0	YBX1	1	two hybrid	Wang J (2011)	1
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
FASLG	0	TNFRSF1A	3	biochemical, affinity chromatography technology	Gajate C (2005), Legler DF (2003)	2
FAS	2	FASLG	0	biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Gajate C (2005), Micheau O (2003), Starling GC (1997), Schneider P (1997), Legler DF (2003), Tao RH (2011), Chen TC (2014)	7
HIP1	4	CASP8	1	affinity chromatography technology, affinity chromatography technology	Gervais FG (2002), Gervais FG (2002)	2
OPTN	1	TNFRSF1A	3	affinity chromatography technology	Klingseisen L (2012)	1
TRAF1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Hsu H (1996), Wicovsky A (2009), Rolland T (2014)	3
OPTN	1	RIPK1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nagabhushana A (2011), Zhu G (2007), Zhu G (2007), Klingseisen L (2012), Nakazawa S (2016)	5
BLM	2	XIAP	0	genetic interference	Vizeacoumar FJ (2013)	1
PEA15	0	CASP8	1	pull down, affinity chromatography technology	Kitsberg D (1999), Condorelli G (1999)	2
CASP8	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Yao Z (2007), Yao Z (2007)	2
TNFSF10	2	TNFRSF10B	1	pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaptein A (2000), Walczak H (1997), Hymowitz SG (1999), Hymowitz SG (1999), Bellail AC (2012), Jennewein C (2012), Xu J (2015)	7
23429	0	CASP8	1	affinity chromatography technology	Tan K (2017)	1
CASP8	1	BEX1	0	two hybrid	Arroyo R (2015)	1
TRAF6	0	IKBKB	1	affinity chromatography technology	Bidere N (2006)	1
CASP8	1	VHL	0	genetic interference	Shen JP (2017)	1
MAPK1	1	BCL2	0	enzymatic study, affinity chromatography technology	Tamura Y (2004), Tamura Y (2004)	2
BAX	3	CASP9	6	biochemical	Chandra D (2004)	1
GZMB	0	CASP8	1	enzymatic study	Cullen SP (2007)	1
CHUK	5	TRAF2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Regnier CH (1997), Devin A (2001), Li S (2009), Shen RR (2012), Zhang W (2010), Chen TC (2014)	6
CASP8	1	NSD3	6	two hybrid	Arroyo R (2015)	1
IKBKB	1	PRKCI	1	pull down, affinity chromatography technology, affinity chromatography technology	Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999)	3
AGR3	2	LYPD3	0	two hybrid	Fletcher GC (2003)	1
CASP8	1	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
PTEN	24	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Freeman DJ (2003), Freeman DJ (2003), Zhou M (2003), Zhou M (2003), Hong SW (2013), Li Y (2008)	6
CASP3	0	RB1	2	enzymatic study, enzymatic study	Lemaire C (2005), Fattman CL (2001)	2
TRADD	0	RIPK1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Hsu H (1996), Ea CK (2006), Guan YJ (2011), Jeon J (2014), Lin B (2016)	7
PARK7	0	PTEN	24	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Das F (2011), Das F (2011), Kim YC (2009), Kim YC (2009)	4
CUL3	17	IKBKB	1	affinity chromatography technology	Lee DF (2009)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
MAP1LC3B	1	OPTN	1	imaging technique, unspecified method, pull down, x-ray crystallography, affinity chromatography technology, pull down	Wild P (2011), Wild P (2011), Rogov VV (2013), Rogov VV (2013), Rogov VV (2013), Wild P (2011)	6
TNFRSF10B	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Bellail AC (2012), Gonzalvez F (2012)	2
RIPK3	2	TICAM1	3	affinity chromatography technology	Meylan E (2004)	1
TICAM1	3	TNFAIP3	3	affinity chromatography technology	Wang YY (2004)	1
BCL2L1	0	APAF1	8	affinity chromatography technology, affinity chromatography technology	Hu Y (1998), Pan G (1998)	2
CASP8	1	PDIA6	1	two hybrid	Wang J (2011)	1
TICAM1	3	TLR3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2004), Hu YH (2015), Zinngrebe J (2016)	3
CASP8	1	HBP1	1	two hybrid	Arroyo R (2015)	1
IKBKB	1	TRAF1	0	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid	Sughra K (2010), Sughra K (2010), Sughra K (2010), Henkler F (2003)	4
CASP2	1	CRYAB	0	affinity chromatography technology	Jeong WJ (2012)	1
CASP10	1	CFLAR	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Micheau O (2003), Goltsev YV (1997), Srinivasula SM (1997), Srinivasula SM (1997), Srinivasula SM (1997), Feoktistova M (2011), Chen TC (2014)	7
MAPK14	0	CASP8	1	affinity chromatography technology	Alvarado-Kristensson M (2004)	1
GZMB	0	BID	1	enzymatic study	Cullen SP (2007)	1
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
TNFRSF10B	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Gonzalvez F (2012)	4
CASP8	1	PLIN4	7	two hybrid	Wang J (2011)	1
PTEN	24	XIAP	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Van Themsche C (2009), Van Themsche C (2009), Van Themsche C (2009), Ahmed SF (2012)	4
EZR	8	TNFRSF10B	1	biochemical	Gajate C (2005)	1
ARHGDIA	3	FASLG	0	biochemical	Gajate C (2005)	1
CRYAB	0	BCL2L1	0	pull down, affinity chromatography technology, affinity chromatography technology	Mao YW (2004), Mao YW (2004), Mao YW (2004)	3
EZR	8	BID	1	biochemical	Gajate C (2005)	1
CASP2	1	CASP9	6	genetic interference	Guo Y (2002)	1
CDK9	3	SQSTM1	0	biochemical	Garcia-Martinez LF (1997)	1
CASP9	6	RB1	2	enzymatic study	Lemaire C (2005)	1
DEDD2	1	DEDD	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Zhan Y (2002), Alcivar A (2003), Alcivar A (2003), Alcivar A (2003), Zhan Y (2002), Zhan Y (2002)	6
BIRC2	1	TNFAIP3	3	affinity chromatography technology	Yamaguchi N (2013)	1
NOD1	3	CFLAR	1	affinity chromatography technology	Inohara N (1999)	1
CASP8	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Oshima S (2009), Saitoh Y (2016)	2
BCL2L1	0	BAX	3	affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Strobel T (1998), Zhang H (2002), Gillissen B (2003), Ren H (2011), Ren H (2011), Chinnaiyan AM (1997), Diaz JL (1997), Wang X (2009), Wang X (2009), Czabotar PE (2011), Czabotar PE (2011), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Tong J (2017), Huttlin EL (2017), Kim EM (2014)	17
TNFRSF10A	0	TNFSF10	2	affinity chromatography technology	Pan G (1997)	1
ARHGDIA	3	FADD	1	biochemical	Gajate C (2005)	1
MAP1LC3B	1	MAP1LC3A	0	affinity chromatography technology	Behrends C (2010)	1
CASP8	1	CDKN1B	1	genetic interference	Shen JP (2017)	1
CASP2	1	XIAP	0	genetic interference	Guo Y (2002)	1
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6
CASP8	1	PARP1	3	enzymatic study	Betin VM (2009)	1
MAPK14	0	CNBP	0	affinity chromatography technology	Varjosalo M (2013)	1
TNF	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Fritsch J (2014)	2
CASP8	1	CASC3	0	two hybrid	Arroyo R (2015)	1
BLID	0	BCL2	0	affinity chromatography technology	Broustas CG (2010)	1
CASP8	1	CASP8	1	two hybrid, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study	Stelzl U (2005), Guo Y (2002), Blanchard H (2000), Srinivasula SM (1996), Yao Z (2007)	5
MTOR	14	TP53	0	affinity chromatography technology, genetic interference	Su WC (2009), Ye H (2016)	2
CASP8	1	ST14	2	two hybrid	Arroyo R (2015)	1