PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PSMC4	6	PSMC1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Um JW (2010), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	9
HDAC3	5	TBL1X	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2002), Zhang J (2002), Zhang J (2002), Guenther MG (2000), Guenther MG (2000), Choi HK (2008), Bantscheff M (2011), Joshi P (2013)	8
USP44	2	PSMC2	2	affinity chromatography technology	Lan X (2016)	1
USP44	2	TCOF1	1	affinity chromatography technology	Sowa ME (2009)	1
USP44	2	PSMC4	6	affinity chromatography technology	Lan X (2016)	1
USP44	2	MRPS21	1	affinity chromatography technology	Sowa ME (2009)	1
PSMC4	6	PSMC2	2	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ewing RM (2007), Hartmann-Petersen R (2001), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	8
USP44	2	TBL2	1	affinity chromatography technology	Sowa ME (2009)	1
USP49	1	USP44	2	affinity chromatography technology	Sowa ME (2009)	1
USP44	2	MRPL40	1	affinity chromatography technology	Sowa ME (2009)	1
USP44	2	HIST1H2BA	0	enzymatic study	Lan X (2016)	1
USP44	2	NCOR1	9	affinity chromatography technology, affinity chromatography technology	Lan X (2016), Lan X (2016)	2
HIST1H2BA	0	HDAC3	5	pull down	Li X (2014)	1
USP44	2	KRR1	1	affinity chromatography technology	Sowa ME (2009)	1
USP44	2	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Lan X (2016), Lan X (2016)	2
USP44	2	CETN2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sowa ME (2009), Huttlin EL (2017), Lan X (2016), Lan X (2016), Lan X (2016)	5
USP44	2	SARS2	5	affinity chromatography technology	Sowa ME (2009)	1
USP44	2	NCOR2	12	affinity chromatography technology	Lan X (2016)	1
USP44	2	PSMC1	2	affinity chromatography technology	Lan X (2016)	1
USP49	1	PSMC5	4	affinity chromatography technology, affinity chromatography technology	Zhang Z (2013), Zhang Z (2013)	2
USP44	2	PSMC5	4	affinity chromatography technology	Lan X (2016)	1
PSMC2	2	PSMC5	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Tipler CP (1997), Kim YC (2011), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	7
USP44	2	POLR2G	0	affinity chromatography technology	Sowa ME (2009)	1
TBL1X	1	NCOR2	12	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Yoon HG (2003), Guenther MG (2002), Li J (2000), Li J (2000), Li J (2000), Guenther MG (2000), Guenther MG (2000), Guenther MG (2000), Oberoi J (2011)	9
USP44	2	TBL1X	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lan X (2016), Lan X (2016), Lan X (2016)	3
MRPS21	1	PSMC1	2	genetic interference	Horlbeck MA (2018)	1
NCOR1	9	TBL1X	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Zhang J (2002), Zhang J (2002), Zhang J (2002), Zhang J (2002), Zhang J (2002), Li J (2000), Li J (2000), Guenther MG (2000), Choi HK (2008), Yoon HG (2005), Li J (2012), Lan X (2016)	17
MRPL53	0	TBL2	1	biochemical	Havugimana PC (2012)	1
USP44	2	MRPL23	1	affinity chromatography technology	Sowa ME (2009)	1
PSMC5	4	PSMC1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Hartmann-Petersen R (2001), Kim YC (2011), Kim YC (2011), Lee SH (2012), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	9
PTTG1	0	USP44	2	affinity chromatography technology, imaging technique	Zou Y (2017), Zou Y (2017)	2
USP44	2	MRPL53	0	affinity chromatography technology	Sowa ME (2009)	1
PSMC1	2	PSMC2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Gorbea C (2000), Hartmann-Petersen R (2001), Kaneko T (2009), Kaneko T (2009), Kim YC (2011), Kim YC (2011), Shim SM (2012), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	13
USP49	1	KRR1	1	affinity chromatography technology	Sowa ME (2009)	1
TBL1X	1	TBL1XR1	23	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Perissi V (2008), Choi HK (2008), Bantscheff M (2011), Lan X (2016)	4
NCOR1	9	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Fischle W (2002), Fischle W (2002), Fischle W (2001), Zhang J (2002), Zhang J (2002), Zhang J (2002), Li J (2000), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Alenghat T (2006), Jiang S (2006), Wen YD (2000), Wen YD (2000), Wen YD (2000), Liu XF (2004), Yoon HG (2005), Yoon HG (2005), Zhu P (2006), Bantscheff M (2011), Joshi P (2013)	26
HDAC3	5	TBL1XR1	23	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2002), Choi HK (2008), Zhu P (2006), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Jung H (2017)	7
HIST1H2BA	0	CETN2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCOR2	12	NCOR1	9	biochemical, two hybrid	Li J (2000), Korutla L (2005)	2
PSMC4	6	PSMC5	4	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Hendil KB (2009), Kaneko T (2009), Kaneko T (2009), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Albers M (2005), Albers M (2005), Huttlin EL (2017)	13
NCOR1	9	TBL1XR1	23	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Zhang J (2002), Choi HK (2008), Yoon HG (2005), Bantscheff M (2011), Jung H (2017)	10
USP49	1	CETN2	0	affinity chromatography technology	Sowa ME (2009)	1
USP44	2	TBL1XR1	23	affinity chromatography technology, affinity chromatography technology	Lan X (2016), Lan X (2016)	2
NCOR2	12	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Guenther MG (2000), Guenther MG (2000), Guenther MG (2000), Fischle W (2002), Fischle W (2002), Guenther MG (2002), Guenther MG (2002), Guenther MG (2002), Guenther MG (2002), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Guenther MG (2000), Guenther MG (2000), Kim MY (2006), Wang L (2006), Torres-Padilla ME (2002), Codina A (2005), Wen YD (2000), Rajendran P (2011), Liu A (2006), Bantscheff M (2011), Joshi P (2013), Xu F (2016)	27