PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
C4orf17	0	TUBA4A	1	two hybrid	Stelzl U (2005)	1
SUV39H1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
KDM1A	2	CHD3	19	affinity chromatography technology, affinity chromatography technology	Wang Y (2009), Li Q (2011)	2
C4orf17	0	PRMT1	3	two hybrid	Weimann M (2013)	1
COPS6	0	TUBA4A	1	affinity chromatography technology	Bennett EJ (2010)	1
C4orf17	0	SH3GL3	1	two hybrid	Stelzl U (2005)	1
C4orf17	0	SUV39H1	0	two hybrid	Weimann M (2013)	1
C4orf17	0	CHD3	19	two hybrid	Stelzl U (2005)	1
CRK	0	C4orf17	0	two hybrid	Grossmann A (2015)	1
C4orf17	0	COPS6	0	two hybrid	Stelzl U (2005)	1
C4orf17	0	KDM1A	2	two hybrid	Weimann M (2013)	1