PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRAM1	4	SKAP2	1	affinity chromatography technology	Moog-Lutz C (2001)	1
APP	1	PSEN1	11	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
CDC37	0	APP	1	two hybrid	Soler-Lopez M (2011)	1
PCGF1	1	DPPA4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Oliviero G (2015), Oliviero G (2015), Oliviero G (2015), Oliviero G (2015), Oliviero G (2015)	5
A2M	8	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
LCP2	0	APP	1	pull down	Olah J (2011)	1
MAST1	9	APOE	1	two hybrid	Soler-Lopez M (2011)	1
PRAM1	4	MBD1	1	affinity chromatography technology	Villa R (2006)	1
FXR2	2	PRAM1	4	two hybrid	Rolland T (2014)	1
PSEN1	11	CDC37	0	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
RNF32	0	APOE	1	two hybrid	Soler-Lopez M (2011)	1
POU5F1	0	PCGF1	1	affinity chromatography technology	Oliviero G (2015)	1
A2M	8	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
LYN	2	TP53	0	affinity chromatography technology, affinity chromatography technology	Ren X (2003), Ren X (2003)	2
MAST1	9	APP	1	two hybrid	Soler-Lopez M (2011)	1
LYN	2	SKAP1	0	pull down	Marie-Cardine A (1997)	1
NEK6	2	PRAM1	4	two hybrid, pull down, enzymatic study	Vaz Meirelles G (2010), Vaz Meirelles G (2010), Vaz Meirelles G (2010)	3
RNF32	0	PSEN1	11	two hybrid	Soler-Lopez M (2011)	1
PRAM1	4	KRT40	0	two hybrid	Rolland T (2014)	1
RARA	5	FAS	2	affinity chromatography technology	Tao RH (2011)	1
PCGF1	1	PRAM1	4	affinity chromatography technology	Oliviero G (2015)	1
APOE	1	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
POU5F1	0	DPPA4	0	affinity chromatography technology	Oliviero G (2015)	1
UBE2E2	1	APP	1	pull down	Olah J (2011)	1
CDC37	0	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
NEK6	2	KRT40	0	two hybrid	Rolland T (2014)	1
HDAC3	5	MBD1	1	affinity chromatography technology	Villa R (2006)	1
MBD1	1	APP	1	pull down	Olah J (2011)	1
LCP2	0	FXR2	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PRAM1	4	NCOR1	9	affinity chromatography technology	Atsumi A (2006)	1
POU5F1	0	PRAM1	4	affinity chromatography technology	Oliviero G (2015)	1
NEK6	2	CDC37	0	affinity chromatography technology	Ewing RM (2007)	1
PCGF1	1	NANOG	0	biochemical, affinity chromatography technology	Oliviero G (2015), Oliviero G (2015)	2
RARA	5	SUV39H1	0	affinity chromatography technology	Carbone R (2006)	1
TP53	0	PRAM1	4	affinity chromatography technology	Insinga A (2004)	1
DPPA4	0	PRAM1	4	affinity chromatography technology	Oliviero G (2015)	1
RNF32	0	APP	1	pull down, two hybrid, pull down	Olah J (2011), Soler-Lopez M (2011), Virok DP (2011)	3
MAST1	9	A2M	8	two hybrid	Soler-Lopez M (2011)	1
LYN	2	SKAP2	1	affinity chromatography technology	Kouroku Y (1998)	1
A2M	8	CDC37	0	two hybrid	Soler-Lopez M (2011)	1
PRAM1	4	SUV39H1	0	affinity chromatography technology, imaging technique	Carbone R (2006), Carbone R (2006)	2
SKAP1	0	APP	1	pull down	Olah J (2011)	1
ABI2	4	PRAM1	4	two hybrid	Rolland T (2014)	1
SKAP2	1	APP	1	pull down	Olah J (2011)	1
RARA	5	PRAM1	4	affinity chromatography technology	Tao RH (2011)	1
APP	1	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
UBE2E2	1	PRAM1	4	pull down, affinity chromatography technology	Kraemer OH (2008), Kraemer OH (2008)	2
PRAM1	4	LCP2	0	affinity chromatography technology	Moog-Lutz C (2001)	1
A2M	8	APOE	1	affinity chromatography technology, pull down, two hybrid	Krimbou L (1998), Krimbou L (1998), Soler-Lopez M (2011)	3
CDC37	0	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	APOE	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	APP	1	two hybrid	Soler-Lopez M (2011)	1
PRAM1	4	CCDC57	8	two hybrid	Rolland T (2014)	1
SKAP1	0	PRAM1	4	two hybrid	Rolland T (2014)	1
TRIM27	2	TP53	0	affinity chromatography technology, pull down, enzymatic study	Chu Y (2011), Chu Y (2011), Chu Y (2011)	3
RNF32	0	PRAM1	4	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
NCOR1	9	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Yoon HG (2003), Fischle W (2002), Fischle W (2002), Fischle W (2001), Zhang J (2002), Zhang J (2002), Zhang J (2002), Li J (2000), Li J (2000), Li J (2000), Li J (2000), Underhill C (2000), Alenghat T (2006), Jiang S (2006), Wen YD (2000), Wen YD (2000), Wen YD (2000), Liu XF (2004), Yoon HG (2005), Yoon HG (2005), Zhu P (2006), Bantscheff M (2011), Joshi P (2013)	26
PRAM1	4	LYN	2	affinity chromatography technology	Moog-Lutz C (2001)	1
TRIM27	2	PRAM1	4	affinity chromatography technology, two hybrid, two hybrid	Cao T (1998), Cao T (1998), Rolland T (2014)	3
FAS	2	PRAM1	4	affinity chromatography technology	Tao RH (2011)	1
RARA	5	HDAC3	5	pull down	Franco PJ (2003)	1
PSEN1	11	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
SKAP1	0	SKAP2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MBD1	1	SUV39H1	0	affinity chromatography technology, pull down, imaging technique	Fujita N (2003), Fujita N (2003), Fujita N (2003)	3
CDC37	0	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
TRIM27	2	NEK6	2	two hybrid	Rolland T (2014)	1
NANOG	0	PRAM1	4	affinity chromatography technology	Oliviero G (2015)	1
RNF32	0	MAST1	9	two hybrid	Soler-Lopez M (2011)	1
LCP2	0	LYN	2	affinity chromatography technology, pull down	Gross BS (1999), Gross BS (1999)	2
PRAM1	4	HDAC3	5	affinity chromatography technology, affinity chromatography technology	Atsumi A (2006), Villa R (2006)	2
RARA	5	NCOR1	9	two hybrid, pull down, pull down, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, far western blotting, affinity chromatography technology, two hybrid, pull down, pull down, pull down	Dowell P (1999), Dowell P (1999), Guidez F (1998), Guidez F (1998), Li CW (2009), Loinder K (2004), Loinder K (2004), Minucci S (2000), Grignani F (1998), Grignani F (1998), DiRenzo J (1997), Zhu P (2006), Wang J (2011), Hoerlein AJ (1995), DiRenzo J (1997), DiRenzo J (1997)	16
SUV39H1	0	HDAC3	5	affinity chromatography technology, pull down	Vaute O (2002), Vaute O (2002)	2
MAST1	9	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
UBE2E2	1	TRIM27	2	two hybrid	Napolitano LM (2011)	1
TP53	0	NCOR1	9	affinity chromatography technology, imaging technique	Dohi Y (2008), Ali A (2013)	2