PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TXLNB	0	SPERT	0	two hybrid	Rolland T (2014)	1
CCDC102B	0	CCDC33	3	two hybrid	Rolland T (2014)	1
CALCOCO2	0	CCDC33	3	two hybrid	Rual JF (2005)	1
BRCA1	7	ZBTB14	2	affinity chromatography technology	Gorski JJ (2011)	1
LMNA	2	FAM9B	0	two hybrid	Dittmer TA (2014)	1
SPICE1	2	FAM161A	2	bioid	Gupta GD (2015)	1
PDE4DIP	10	TFIP11	5	two hybrid	Rolland T (2014)	1
CALCOCO2	0	CEP57L1	3	two hybrid	Rolland T (2014)	1
STX11	1	FAM161A	2	two hybrid	Rolland T (2014)	1
KIAA0753	1	TRIM37	7	bioid	Firat-Karalar EN (2014)	1
ZBTB14	2	FAM161A	2	two hybrid	Rolland T (2014)	1
CEP63	2	CEP57L1	3	two hybrid	Rolland T (2014)	1
LMNA	2	TSGA10	0	two hybrid	Dittmer TA (2014)	1
CALCOCO1	2	FAM161A	2	two hybrid	Rolland T (2014)	1
FAM161A	2	NUTM1	6	two hybrid	Rolland T (2014)	1
KIAA0753	1	POC5	5	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
PDE4DIP	10	FAM161A	2	two hybrid	Rolland T (2014)	1
MTUS2	4	CEP57L1	3	two hybrid	Rolland T (2014)	1
PPFIA1	5	FAM161A	2	two hybrid	Rolland T (2014)	1
TRAF1	0	SYCE1	0	two hybrid	Rolland T (2014)	1
NINL	1	LZTS2	4	two hybrid, bioid	Rual JF (2005), Gupta GD (2015)	2
RINT1	1	FAM161A	2	two hybrid	Rolland T (2014)	1
TXLNB	0	CALCOCO1	2	affinity chromatography technology	Huttlin EL (2017)	1
FAM161A	2	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
HMBOX1	2	FAM161A	2	two hybrid	Rolland T (2014)	1
SPERT	0	CEP57L1	3	two hybrid	Rolland T (2014)	1
PPFIA1	5	BRCA1	7	two hybrid, affinity chromatography technology	Hill SJ (2014), Hill SJ (2014)	2
TFIP11	5	CARD9	3	two hybrid	Rolland T (2014)	1
MDFI	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
KRTAP5-9	0	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
TSGA10	0	FAM161A	2	two hybrid	Rolland T (2014)	1
LMNA	2	FAM161A	2	two hybrid	Dittmer TA (2014)	1
TRIM37	7	TRAF1	0	pull down	Zapata JM (2001)	1
CDR2	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
TFIP11	5	SSX2IP	0	two hybrid	Rolland T (2014)	1
KIAA0753	1	CEP44	2	bioid	Gupta GD (2015)	1
SPICE1	2	TRIM37	7	bioid	Gupta GD (2015)	1
EHMT2	4	FAM161A	2	two hybrid	Rolland T (2014)	1
BRCA1	7	LMNA	2	affinity chromatography technology	Ertych N (2016)	1
NECAB2	1	CARD9	3	two hybrid	Rolland T (2014)	1
SYCE1	0	SPERT	0	two hybrid	Rolland T (2014)	1
FAM9B	0	CEP57L1	3	two hybrid	Rolland T (2014)	1
CCDC102B	0	CEP57L1	3	two hybrid	Rolland T (2014)	1
STX11	1	CARD9	3	two hybrid	Rolland T (2014)	1
LCA5	1	CEP44	2	bioid	Gupta GD (2015)	1
CEP63	2	TXLNB	0	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
CARD9	3	LZTS2	4	two hybrid	Rolland T (2014)	1
CTR9	10	FAM161A	2	affinity chromatography technology	Hein MY (2015)	1
FAM161A	2	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
PDE4DIP	10	MTUS2	4	two hybrid	Rolland T (2014)	1
CEP63	2	SSX2IP	0	bioid	Gupta GD (2015)	1
FAM161A	2	CEP57L1	3	two hybrid	Rolland T (2014)	1
CCDC33	3	TSGA10	0	two hybrid	Rolland T (2014)	1
MID2	1	TRIM54	1	two hybrid	Rolland T (2014)	1
IKZF1	2	FAM161A	2	two hybrid	Rolland T (2014)	1
RUNDC3A	2	FAM161A	2	two hybrid	Rolland T (2014)	1
CCDC136	1	FAM161A	2	two hybrid	Rolland T (2014)	1
FAM161A	2	FAM161A	2	two hybrid	Rolland T (2014)	1
CEP44	2	CEP57L1	3	two hybrid	Rolland T (2014)	1
SPICE1	2	CEP44	2	bioid	Gupta GD (2015)	1
CEP44	2	SPERT	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
POC5	5	SSX2IP	0	bioid	Gupta GD (2015)	1
CEP70	1	TXLNB	0	two hybrid	Rolland T (2014)	1
FAM161A	2	TXLNB	0	two hybrid	Rolland T (2014)	1
TRAF1	0	TNIP1	1	affinity chromatography technology	Greenfeld H (2015)	1
DOCK8	10	FAM161A	2	two hybrid	Rolland T (2014)	1
CADPS	3	FAM161A	2	two hybrid	Rolland T (2014)	1
NINL	1	SPERT	0	two hybrid	Rual JF (2005)	1
FAM161A	2	CCDC57	8	two hybrid	Rolland T (2014)	1
SSX2IP	0	RINT1	1	bioid	Gupta GD (2015)	1
CEP63	2	CEP44	2	bioid	Gupta GD (2015)	1
POC1A	3	FAM161A	2	bioid	Gupta GD (2015)	1
TRIM54	1	SSX2IP	0	two hybrid	Rolland T (2014)	1
TXLNB	0	CEP57L1	3	two hybrid	Rolland T (2014)	1
SSX2IP	0	BRCA1	7	two hybrid	Hill SJ (2014)	1
CCDC57	8	CEP57L1	3	two hybrid	Rolland T (2014)	1
CCDC33	3	TRIM37	7	two hybrid	Xin X (2009)	1
LMNA	2	CCDC155	2	two hybrid	Dittmer TA (2014)	1
CEP70	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
KIAA0753	1	FAM161A	2	two hybrid	Rolland T (2014)	1
CCDC33	3	MIPOL1	1	two hybrid	Rolland T (2014)	1
CEP57L1	3	BRCA1	7	two hybrid	Hill SJ (2014)	1
CARD9	3	HMBOX1	2	two hybrid	Rolland T (2014)	1
SPICE1	2	KIAA0753	1	bioid	Gupta GD (2015)	1
IKZF1	2	CEP57L1	3	two hybrid	Rolland T (2014)	1
FAM161A	2	MIPOL1	1	two hybrid	Rolland T (2014)	1
SSX2IP	0	KIAA0753	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
PNMA2	0	FAM161A	2	two hybrid	Rolland T (2014)	1
LMNA	2	SYCE1	0	two hybrid	Dittmer TA (2014)	1
TRIM54	1	FAM161A	2	two hybrid	Rolland T (2014)	1
KRTAP10-7	0	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
TRIM37	7	FAM161A	2	two hybrid	Rolland T (2014)	1
LMNA	2	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
MID2	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
KRTAP5-9	0	FAM161A	2	two hybrid	Rolland T (2014)	1
LMNA	2	TFIP11	5	bioid	Roux KJ (2012)	1
FAM161A	2	ZBTB8A	0	two hybrid	Rolland T (2014)	1
CEP63	2	SPICE1	2	bioid	Firat-Karalar EN (2014)	1
KRTAP5-9	0	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
NINL	1	FAM161A	2	two hybrid	Rolland T (2014)	1
CALCOCO2	0	FAM161A	2	two hybrid	Rolland T (2014)	1
PPFIA1	5	CEP70	1	two hybrid	Venkatesan K (2009)	1
SPICE1	2	SSX2IP	0	bioid	Gupta GD (2015)	1
POC1B	2	CEP44	2	bioid	Gupta GD (2015)	1
CARD9	3	CEP57L1	3	two hybrid	Rolland T (2014)	1
POC5	5	POC1A	3	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP70	1	ZBTB8A	0	two hybrid	Rual JF (2005)	1
DHX32	3	FAM161A	2	two hybrid	Rolland T (2014)	1
NINL	1	TNIP1	1	bioid	Gupta GD (2015)	1
LZTS2	4	SSX2IP	0	affinity chromatography technology	Huttlin EL (2017)	1
CCDC102B	0	SYCE1	0	two hybrid	Rolland T (2014)	1
BRCA1	7	MCM6	5	affinity chromatography technology	Ertych N (2016)	1
ZBTB43	1	FAM161A	2	two hybrid	Rolland T (2014)	1
FAM161A	2	SYCE1	0	two hybrid	Rolland T (2014)	1
FAM161A	2	BRCA1	7	two hybrid	Hill SJ (2014)	1
PHC2	3	CARD9	3	two hybrid	Rolland T (2014)	1
CARD9	3	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
NINL	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Jin S (2009), Jin S (2009)	2
LCA5	1	TFIP11	5	bioid	Gupta GD (2015)	1
TFIP11	5	FAM161A	2	two hybrid	Rolland T (2014)	1
FAM161A	2	LCA5	1	affinity chromatography technology	Roosing S (2014)	1
STX11	1	MID2	1	two hybrid	Rolland T (2014)	1
MCM6	5	FAM161A	2	two hybrid	Rolland T (2014)	1
CCDC102B	0	FAM161A	2	two hybrid	Rolland T (2014)	1
LZTS2	4	CEP57L1	3	two hybrid	Rolland T (2014)	1
STX11	1	PPFIA1	5	affinity chromatography technology	Huttlin EL (2017)	1
SSX2IP	0	TNIP1	1	bioid	Gupta GD (2015)	1
SSX2IP	0	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
BEND5	0	FAM161A	2	two hybrid	Rolland T (2014)	1
CADPS	3	FAM9B	0	two hybrid	Rolland T (2014)	1
KRTAP10-9	1	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
CEP63	2	KIAA0753	1	bioid, bioid, affinity chromatography technology, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	4
MDFI	1	FAM161A	2	two hybrid	Rolland T (2014)	1
FAM161A	2	LZTS2	4	two hybrid	Rolland T (2014)	1
CCDC136	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
RINT1	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
EHMT2	4	CCDC33	3	two hybrid	Rual JF (2005)	1
FAM161A	2	TRIM15	0	two hybrid	Rolland T (2014)	1
NECAB2	1	CCDC33	3	two hybrid	Rual JF (2005)	1
KRTAP5-9	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
IKZF1	2	POC1A	3	affinity chromatography technology	Huttlin EL (2017)	1
PHC2	3	SSX2IP	0	two hybrid	Rolland T (2014)	1
CDR2	1	FAM161A	2	two hybrid	Rolland T (2014)	1
CEP63	2	TRIM37	7	bioid	Gupta GD (2015)	1
TSGA10	0	CEP44	2	two hybrid	Rolland T (2014)	1
TMCC2	1	CCDC33	3	two hybrid	Rolland T (2014)	1
POC5	5	POC1B	2	bioid	Gupta GD (2015)	1
MID2	1	FAM161A	2	two hybrid	Rolland T (2014)	1
TRIM54	1	CARD9	3	two hybrid	Rolland T (2014)	1
CCDC33	3	ZBTB8A	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NINL	1	CCDC33	3	two hybrid	Rual JF (2005)	1
CALCOCO2	0	MID2	1	two hybrid	Rolland T (2014)	1
TRIM54	1	CCDC102B	0	two hybrid	Rolland T (2014)	1
CARD9	3	SSX2IP	0	two hybrid	Rolland T (2014)	1
KRTAP10-7	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
FAM161A	2	SSX2IP	0	two hybrid	Rolland T (2014)	1
CCDC33	3	MDFI	1	two hybrid	Xin X (2009)	1
STX11	1	CDR2	1	affinity chromatography technology	Huttlin EL (2017)	1
ZBTB1	4	FAM161A	2	two hybrid	Rolland T (2014)	1
CARD9	3	FAM161A	2	two hybrid	Rolland T (2014)	1
CCDC33	3	FAM161A	2	two hybrid	Rolland T (2014)	1
CEP63	2	FAM161A	2	two hybrid	Rolland T (2014)	1
PHC2	3	FAM161A	2	two hybrid	Rolland T (2014)	1
TRIM54	1	CEP57L1	3	two hybrid	Rolland T (2014)	1
POC1A	3	CEP44	2	bioid	Gupta GD (2015)	1
CEP63	2	LZTS2	4	bioid	Firat-Karalar EN (2014)	1
POC1A	3	POC1B	2	affinity chromatography technology, bioid, bioid, affinity chromatography technology	Huttlin EL (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
TRAF1	0	FAM161A	2	two hybrid	Rolland T (2014)	1
LCA5	1	KIAA0753	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
FAM161A	2	POC5	5	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
LCA5	1	SSX2IP	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
TRIM37	7	SSX2IP	0	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
TFIP11	5	CEP57L1	3	two hybrid	Rolland T (2014)	1
STX11	1	CCDC33	3	two hybrid	Rolland T (2014)	1
FAM161A	2	PPM1F	1	two hybrid	Stelzl U (2005)	1
NECAB2	1	FAM161A	2	two hybrid	Rolland T (2014)	1
FAM161A	2	CCDC155	2	two hybrid	Rolland T (2014)	1
FAM161A	2	SPERT	0	two hybrid	Rolland T (2014)	1
CDR2	1	TMCC2	1	two hybrid	Rolland T (2014)	1
TSGA10	0	SPERT	0	two hybrid	Rolland T (2014)	1
MID2	1	TSGA10	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
LMNA	2	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
FAM161A	2	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
CARD9	3	CEP70	1	two hybrid	Rolland T (2014)	1
FAM161A	2	FAM9B	0	two hybrid	Rolland T (2014)	1
MID2	1	CEP57L1	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PNMA2	0	CCDC33	3	two hybrid	Rolland T (2014)	1
TNIP1	1	FAM161A	2	two hybrid	Rolland T (2014)	1
MTUS2	4	FAM161A	2	two hybrid	Rolland T (2014)	1
CEP70	1	FAM161A	2	two hybrid	Rolland T (2014)	1
POC1B	2	FAM161A	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Roosing S (2014), Roosing S (2014), Roosing S (2014)	3
CAPZA2	1	FAM161A	2	affinity chromatography technology	Hein MY (2015)	1
CEP44	2	TNIP1	1	bioid	Gupta GD (2015)	1
BEND3	4	FAM161A	2	two hybrid	Rolland T (2014)	1
NINL	1	KIAA0753	1	bioid	Gupta GD (2015)	1
FAM161A	2	FSD2	4	two hybrid	Rolland T (2014)	1
TMCC2	1	FAM161A	2	two hybrid	Rolland T (2014)	1
CEP44	2	FAM161A	2	two hybrid	Rolland T (2014)	1
TSGA10	0	CEP57L1	3	two hybrid	Rolland T (2014)	1