PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SUV39H1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
SUV39H1	0	PRMT6	2	two hybrid	Weimann M (2013)	1
MAST1	9	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	APOE	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	APOE	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
LOXL4	1	SUV39H1	0	two hybrid	Weimann M (2013)	1
MAST1	9	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
LOXL4	1	CCT6B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIP13	0	LOXL4	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
LOXL4	1	CCT6A	1	affinity chromatography technology	Huttlin EL (2017)	1
ECSIT	3	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
LOXL4	1	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
RNF32	0	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
APOE	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
LOXL4	1	APOE	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
AP1M2	2	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
LOXL4	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
SUV39H1	0	CCT6A	1	affinity chromatography technology	Hauri S (2016)	1
LOXL4	1	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
MAST1	9	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
CCT6B	2	CCT6A	1	biochemical	Wan C (2015)	1
LOXL4	1	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
EXOC6	1	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
CDC37	0	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
RNF32	0	MAST1	9	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	LOXL4	1	two hybrid	Soler-Lopez M (2011)	1
LOXL4	1	SEPHS2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF32	0	LONP1	9	two hybrid	Soler-Lopez M (2011)	1