Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
CASP9	842	NIVOCASAN	CHEMBL2105721	inhibitor	ChemblInteractions
CASP9	842	CELECOXIB	CHEMBL118		PharmGKB
CASP9	842	EMRICASAN	CHEMBL197672	inhibitor	ChemblInteractions

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
CASP9	rs4645983	AA + AG	adalimumab	efficacy	no	After 4 and 12 weeks of treatment, a greater percentage of those with the AA pr AG genotype had biological and clinical response to treatment as compared to those with the GG genotype. Biological response assessed using change in C-reactive protein (CRP), and clinical response assessed using change in inflammatory bowel disease questionnaire (IBDQ) value. However, neither of these associations remained significant after correction for multiple testing (p=0.228 and p=0.238, respectively). Please note that alleles have been complemented to the plus chromosomal strand.	Genotypes AA + AG is associated with increased response to adalimumab in people with Crohn Disease as compared to genotype GG.	25712183	1444936470