PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BARD1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Dong Y (2003), Dong Y (2003), Feki A (2005), Jiang J (2011), Tembe V (2015), Tembe V (2015), Tembe V (2015)	7
MCM2	3	TUBA1A	13	affinity chromatography technology	Drissi R (2015)	1
CDCA7L	5	CCDC33	3	two hybrid	Rolland T (2014)	1
CDC7	2	MCM2	3	two hybrid, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Kneissl M (2003), Kneissl M (2003), Gerard A (2006), Martin L (2007), Martin L (2007), Montagnoli A (2006), Suzuki T (2012), Masai H (2000)	8
TRIM25	5	JADE1	6	affinity chromatography technology	Choudhury NR (2017)	1
CDC7	2	MCM6	5	enzymatic study	Masai H (2000)	1
ING5	3	MEAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Ullah M (2008), Huttlin EL (2017)	3
MAP2K1	8	ING5	3	genetic interference	Srivas R (2016)	1
CDCA7L	5	ING5	3	two hybrid	Rolland T (2014)	1
APC	5	ING5	3	two hybrid	Bandyopadhyay S (2010)	1
CCDC33	3	ING5	3	two hybrid	Rolland T (2014)	1
NEDD1	1	ING5	3	affinity chromatography technology	Hein MY (2015)	1
CDKN1A	1	ING5	3	two hybrid	Vinayagam A (2011)	1
TRIM25	5	ING5	3	affinity chromatography technology	Choudhury NR (2017)	1
KAT7	3	MEAF6	0	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Huttlin EL (2017)	2
NXF1	0	CTR9	10	affinity chromatography technology	Castello A (2012)	1
MCM4	3	CDC7	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
HGS	5	ING5	3	two hybrid	Rolland T (2014)	1
BRPF1	8	MEAF6	0	pull down, affinity chromatography technology	Ullah M (2008), Huttlin EL (2017)	2
CDK9	3	ING5	3	genetic interference	Srivas R (2016)	1
MBIP	0	ING5	3	two hybrid	Rolland T (2014)	1
MCM6	5	ING5	3	two hybrid, affinity chromatography technology	Rual JF (2005), Doyon Y (2006)	2
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
JADE1	6	MEAF6	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Saksouk N (2009), Avvakumov N (2012), Avvakumov N (2012), Huttlin EL (2017)	4
APC	5	CDK9	3	genetic interference	Shen JP (2017)	1
HAP1	1	HGS	5	two hybrid, pull down, affinity chromatography technology	Li Y (2002), Li Y (2002), Li Y (2002)	3
NXF1	0	MCM4	3	affinity chromatography technology	Castello A (2012)	1
ING5	3	MCM2	3	affinity chromatography technology	Doyon Y (2006)	1
BARD1	4	HAP1	1	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
MCM2	3	TRIM25	5	affinity chromatography technology	Drissi R (2015)	1
PRMT5	3	EP300	36	genetic interference	Wong AS (2016)	1
ING5	3	C3orf62	0	two hybrid	Rolland T (2014)	1
BARD1	4	MCM6	5	affinity chromatography technology	Woods NT (2012)	1
MBIP	0	TADA3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang YL (2008), Huttlin EL (2015), Huttlin EL (2017)	3
ING5	3	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
EP300	36	NEDD1	1	affinity chromatography technology	Jung SY (2005)	1
KAT7	3	JADE1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Foy RL (2008), Saksouk N (2009), Avvakumov N (2012), Avvakumov N (2012), Huttlin EL (2015), Siriwardana NS (2014), Siriwardana NS (2014), Siriwardana NS (2014), Huttlin EL (2017)	10
KAT7	3	BRD1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Fryland T (2016)	2
BRD1	5	VIM	0	two hybrid	Stelzl U (2005)	1
ING5	3	KAT6B	27	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006)	2
EP300	36	MCM4	3	pull down	Karmakar S (2010)	1
APC	5	NAV2	10	two hybrid	Bandyopadhyay S (2010)	1
EP300	36	MCM2	3	pull down	Karmakar S (2010)	1
KAT6A	19	EP300	36	affinity chromatography technology	Rokudai S (2009)	1
KAT6A	19	MEAF6	0	affinity chromatography technology, affinity chromatography technology	Ullah M (2008), Huttlin EL (2017)	2
TADA3	0	EP300	36	affinity chromatography technology, affinity chromatography technology	Wang T (2001), Germaniuk-Kurowska A (2007)	2
HAP1	1	PCM1	5	two hybrid	Engelender S (1997)	1
ING5	3	NAV2	10	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRIM25	5	BRD1	5	affinity chromatography technology	Choudhury NR (2017)	1
HAP1	1	ING5	3	two hybrid	Goehler H (2004)	1
PRMT5	3	SMARCE1	1	pull down	Pal S (2003)	1
HGS	5	KRT40	0	two hybrid	Rolland T (2014)	1
CDC7	2	ING5	3	genetic interference	Srivas R (2016)	1
NXF1	0	HGS	5	affinity chromatography technology	Castello A (2012)	1
ING5	3	BRD1	5	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Fryland T (2016)	2
KAT7	3	MCM2	3	enzymatic study	Iizuka M (2006)	1
ING5	3	DEUP1	0	two hybrid	Rolland T (2014)	1
CDKN1A	1	EP300	36	pull down, affinity chromatography technology	Cazzalini O (2008), Cazzalini O (2008)	2
HTT	14	TP53	0	pull down, affinity chromatography technology	Steffan JS (2000), Steffan JS (2000)	2
APLP1	1	HAP1	1	two hybrid	Goehler H (2004)	1
KAT7	3	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Iizuka M (2008), Iizuka M (2008), Iizuka M (2008)	3
HTT	14	ING5	3	two hybrid	Suter B (2013)	1
MEAF6	0	BRPF3	2	affinity chromatography technology	Huttlin EL (2017)	1
CDC7	2	CDK9	3	two hybrid	Wang J (2011)	1
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
TADA3	0	ING5	3	two hybrid	Goehler H (2004)	1
TAF1D	0	HAP1	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
TP53	0	CDK9	3	genetic interference, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	De Falco G (2000), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006)	6
MCM2	3	VIM	0	affinity chromatography technology	Drissi R (2015)	1
SMARCE1	1	ING5	3	two hybrid	Rolland T (2014)	1
CCDC33	3	PRMT5	3	affinity chromatography technology	Huttlin EL (2017)	1
CTR9	10	ING5	3	affinity chromatography technology	Hein MY (2015)	1
BARD1	4	KAT7	3	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
ING5	3	EP300	36	affinity chromatography technology, affinity chromatography technology	Shiseki M (2003), Shiseki M (2003)	2
MOV10	6	HGS	5	affinity chromatography technology	Castello A (2012)	1
MCM4	3	MCM2	3	pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Ishimi Y (1996), Tan BC (2006), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Boldt K (2016)	11
MCM2	3	MCM6	5	two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Yabuta N (2003), Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Rolland T (2014), Wan C (2015), Hein MY (2015), Drissi R (2015), Boldt K (2016)	15
JADE2	4	MEAF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ING5	3	MCM4	3	affinity chromatography technology	Doyon Y (2006)	1
TRIM25	5	MAP2K1	8	affinity chromatography technology	Choudhury NR (2017)	1
VIM	0	APLP1	1	two hybrid	Vinayagam A (2011)	1
KXD1	1	CCDC33	3	two hybrid	Rual JF (2005)	1
TADA3	0	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang T (2001), Gamper AM (2008), Sekaric P (2007), Fogeron ML (2013), Nag A (2007), Nag A (2007)	6
KAT7	3	JADE2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Huttlin EL (2015), Huttlin EL (2017)	3
NXF1	0	ING5	3	affinity chromatography technology	Castello A (2012)	1
KAT6A	19	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Rokudai S (2009), Rokudai S (2009), Rokudai S (2009), Rokudai S (2013), Rokudai S (2013)	5
BARD1	4	MOV10	6	affinity chromatography technology	Woods NT (2012)	1
ING5	3	KAT6A	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Ullah M (2008), Hein MY (2015)	3
FAM118B	0	VIM	0	two hybrid	Vinayagam A (2011)	1
KXD1	1	ING5	3	two hybrid	Rual JF (2005)	1
TP53	0	CDKN1A	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Tian H (2002), Vinayagam A (2011), Kinyamu HK (2003), Giono LE (2007), Chen TC (2014)	5
BARD1	4	KRT40	0	two hybrid	Rolland T (2014)	1
ING5	3	JADE2	4	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Doyon Y (2006), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	5
CTR9	10	CDK9	3	affinity chromatography technology	Hein MY (2015)	1
TP53	0	MOV10	6	affinity chromatography technology	Li X (2015)	1
MEAF6	0	JADE3	1	affinity chromatography technology	Huttlin EL (2017)	1
HGS	5	CCDC33	3	two hybrid	Rual JF (2005)	1
HAP1	1	HTT	14	two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, two hybrid	Li XJ (1995), Li SH (1998), Li SH (1998), Li SH (1998), Li XJ (1995), Li XJ (1995), Li SH (1998), Goehler H (2004), Goehler H (2004)	9
MEST	2	ING5	3	two hybrid	Vinayagam A (2011)	1
SMARCE1	1	KRT40	0	two hybrid	Rolland T (2014)	1
ING5	3	KRT40	0	two hybrid	Rolland T (2014)	1
KAT6A	19	BRPF1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rokudai S (2009), Rokudai S (2009), Ullah M (2008), Ullah M (2008), Laue K (2008)	5
NXF1	0	KRT40	0	two hybrid	Rolland T (2014)	1
VIM	0	ING5	3	two hybrid	Goehler H (2004)	1
APC	5	HGS	5	two hybrid	Bandyopadhyay S (2010)	1
TAF1D	0	ING5	3	two hybrid	Vinayagam A (2011)	1
NXF1	0	SMARCE1	1	affinity chromatography technology	Castello A (2012)	1
BARD1	4	ING5	3	two hybrid	Goehler H (2004)	1
APLP1	1	ING5	3	two hybrid	Goehler H (2004)	1
ICA1	2	ING5	3	two hybrid	Rolland T (2014)	1
ARFIP2	0	ING5	3	two hybrid	Rolland T (2014)	1
BRD1	5	MEAF6	0	affinity chromatography technology	Fryland T (2016)	1
CDKN1A	1	APLP1	1	two hybrid	Vinayagam A (2011)	1
MOV10	6	ING5	3	affinity chromatography technology	Castello A (2012)	1
PCM1	5	ING5	3	two hybrid	Rual JF (2005)	1
BARD1	4	CDK9	3	affinity chromatography technology	Woods NT (2012)	1
KAT7	3	ING5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Doyon Y (2006), Doyon Y (2006), Iizuka M (2008), Huttlin EL (2017)	6
TUBA1A	13	ING5	3	genetic interference	Srivas R (2016)	1
MOV10	6	SMARCE1	1	affinity chromatography technology	Castello A (2012)	1
TP53	0	PRMT5	3	affinity chromatography technology	Horikawa I (2014)	1
HAP1	1	KAT7	3	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
MEAF6	0	KAT6B	27	affinity chromatography technology	Huttlin EL (2017)	1
MOV10	6	ARFIP2	0	affinity chromatography technology	Castello A (2012)	1
CDKN1A	1	IKZF3	1	two hybrid	Rolland T (2014)	1
ING5	3	BRPF1	8	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Doyon Y (2006), Ullah M (2008), Ullah M (2008), Ullah M (2008)	4
IKZF3	1	ING5	3	two hybrid	Rolland T (2014)	1
TP53	0	VIM	0	affinity chromatography technology	Horikawa I (2014)	1
FAM118B	0	ING5	3	two hybrid	Vinayagam A (2011)	1
ING5	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shiseki M (2003), Shiseki M (2003), Iizuka M (2008), Iizuka M (2008), Saha A (2011)	5
MCM4	3	MCM6	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
TRIM25	5	MCM4	3	affinity chromatography technology	Choudhury NR (2017)	1
HTT	14	TUBA1A	13	affinity chromatography technology	Mitsui K (2002)	1
HGS	5	ARFIP2	0	two hybrid	Rolland T (2014)	1
CDKN1A	1	TUBA1A	13	two hybrid, affinity chromatography technology	Vinayagam A (2011), Fogeron ML (2013)	2
TP53	0	TUBA1A	13	affinity chromatography technology	Fogeron ML (2013)	1
ING5	3	BRPF3	2	affinity chromatography technology	Doyon Y (2006)	1
ING5	3	PRMT5	3	two hybrid	Weimann M (2013)	1
TRIM25	5	IKZF3	1	affinity chromatography technology	Choudhury NR (2017)	1
CDCA7L	5	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
CDC7	2	CDKN1A	1	pull down	Ramachandran N (2004)	1
PCM1	5	NEDD1	1	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
VIM	0	HAP1	1	two hybrid	Goehler H (2004)	1
MOV10	6	MCM4	3	affinity chromatography technology	Castello A (2012)	1
KAT7	3	BRPF3	2	affinity chromatography technology	Huttlin EL (2017)	1
ING5	3	JADE1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Saksouk N (2009), Avvakumov N (2012)	3
CEP44	2	ING5	3	two hybrid	Rolland T (2014)	1
KAT7	3	JADE3	1	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Huttlin EL (2017)	2
VIM	0	KAT7	3	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Stelzl U (2005), Vinayagam A (2011), Goehler H (2004)	4
CEP44	2	NEDD1	1	bioid	Gupta GD (2015)	1
HGS	5	MEST	2	pull down	Pridgeon JW (2009)	1
APC	5	TRIM25	5	two hybrid	Arroyo R (2015)	1
CDKN1A	1	VIM	0	two hybrid	Vinayagam A (2011)	1
MBIP	0	CTR9	10	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GCSH	0	ING5	3	two hybrid	Stelzl U (2005)	1
ING5	3	JADE3	1	affinity chromatography technology	Doyon Y (2006)	1
MAP2K1	8	KAT7	3	enzymatic study	Zou C (2013)	1
C3orf62	0	EP300	36	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2