PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKAR2B	1	OFD1	3	affinity chromatography technology	Hein MY (2015)	1
TPTE2	3	CCDC77	1	bioid	St-Denis N (2016)	1
MAPRE1	0	PRKAR2B	1	affinity chromatography technology	Huttlin EL (2017)	1
CEP135	2	KIAA0753	1	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP89	2	CCDC14	2	bioid	Gupta GD (2015)	1
CEP170	4	CCDC77	1	bioid	Gupta GD (2015)	1
NINL	1	CCDC77	1	bioid	Gupta GD (2015)	1
OFD1	3	NEDD1	1	bioid	Gupta GD (2015)	1
ODF2	1	KIAA0753	1	bioid	Gupta GD (2015)	1
LTBR	0	CCDC77	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP120	5	MED4	2	bioid	Gupta GD (2015)	1
MED4	2	KIAA0753	1	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
DYNLL1	0	CCDC77	1	affinity chromatography technology	Hein MY (2015)	1
IKZF5	0	CCDC77	1	affinity chromatography technology	Huttlin EL (2017)	1
PPP2R3C	1	OFD1	3	affinity chromatography technology	Hein MY (2015)	1
PCM1	5	CCDC77	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
MAPRE1	0	PCM1	5	affinity chromatography technology	Hein MY (2015)	1
CDC14A	4	CEP135	2	bioid	St-Denis N (2016)	1
FGFR1OP	0	SPICE1	2	affinity chromatography technology	Hein MY (2015)	1
KIAA0753	1	CCDC77	1	bioid	Gupta GD (2015)	1
CEP128	1	CCDC77	1	bioid	Gupta GD (2015)	1
CCDC136	1	CCDC77	1	affinity chromatography technology	Huttlin EL (2017)	1
CDC14A	4	CEP290	5	bioid	St-Denis N (2016)	1
CEP89	2	MED4	2	bioid	Gupta GD (2015)	1
MED4	2	PCM1	5	bioid, affinity chromatography technology, affinity chromatography technology, bioid	Lambert JP (2015), Lambert JP (2015), Gupta GD (2015), Gupta GD (2015)	4
OFD1	3	DYNLL1	0	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015), Boldt K (2016)	4
CEP128	1	CEP170	4	bioid	Gupta GD (2015)	1
MED4	2	CCDC14	2	bioid	Lambert JP (2015)	1
LTBR	0	ODF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ODF2	1	CEP135	2	bioid	Gupta GD (2015)	1
SPICE1	2	NEDD1	1	bioid	Gupta GD (2015)	1
PRDM5	1	CCDC77	1	affinity chromatography technology	Huttlin EL (2017)	1
CEP120	5	CEP170	4	bioid	Gupta GD (2015)	1
MED4	2	CCDC77	1	bioid	Lambert JP (2015)	1
FGFR1OP	0	CEP170	4	affinity chromatography technology	Hein MY (2015)	1
SPICE1	2	PCM1	5	affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
TPTE2	3	OFD1	3	bioid	St-Denis N (2016)	1
CEP128	1	NINL	1	bioid	Gupta GD (2015)	1
CEP290	5	MAPRE1	0	affinity chromatography technology	Gupta GD (2015)	1
TPTE2	3	MED4	2	bioid	St-Denis N (2016)	1
SYT12	0	CCDC77	1	affinity chromatography technology	Huttlin EL (2017)	1
IKZF5	0	KIAA0753	1	affinity chromatography technology	Huttlin EL (2017)	1
CEP290	5	OFD1	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
PCM1	5	CEP120	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	NEDD1	1	bioid	Gupta GD (2015)	1
CEP128	1	CEP120	5	bioid	Gupta GD (2015)	1
CEP135	2	CCDC77	1	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
PCM1	5	CEP170	4	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CEP63	2	KIF7	3	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CEP170	4	NEDD1	1	bioid	Gupta GD (2015)	1
PPP2R3C	1	CCDC77	1	affinity chromatography technology	Hein MY (2015)	1
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CCDC14	2	CEP290	5	affinity chromatography technology	Hein MY (2015)	1
CEP120	5	FGFR1OP	0	bioid	Gupta GD (2015)	1
CEP128	1	SPICE1	2	bioid	Gupta GD (2015)	1
KIAA0753	1	KIF7	3	bioid	Gupta GD (2015)	1
LATS2	1	NINL	1	bioid	Couzens AL (2013)	1
NINL	1	NEDD1	1	bioid	Gupta GD (2015)	1
PCM1	5	KIAA0753	1	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
MED4	2	KIF7	3	bioid	Lambert JP (2015)	1
MCPH1	4	CCDC77	1	two hybrid	Liu X (2017)	1
MED4	2	FGFR1OP	0	bioid	Lambert JP (2015)	1
PRKAR2B	1	CEP170	4	affinity chromatography technology	Hein MY (2015)	1
CEP89	2	CEP170	4	bioid	Gupta GD (2015)	1
CEP170	4	MAPRE1	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
NINL	1	KIF7	3	bioid	Gupta GD (2015)	1
CEP128	1	CEP290	5	bioid	Gupta GD (2015)	1
CDC14A	4	ODF2	1	bioid	St-Denis N (2016)	1
PRKAR2B	1	PCM1	5	affinity chromatography technology	Hein MY (2015)	1
CEP290	5	FGFR1OP	0	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
CDC14A	4	CCDC77	1	bioid	St-Denis N (2016)	1
SPICE1	2	CEP135	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	KIF7	3	bioid	Gupta GD (2015)	1
DYNLL1	0	PCM1	5	affinity chromatography technology	Hein MY (2015)	1
PPP2R3C	1	PCM1	5	affinity chromatography technology	Hein MY (2015)	1
SPICE1	2	CCDC77	1	bioid	Gupta GD (2015)	1
NINL	1	CEP170	4	bioid	Gupta GD (2015)	1
CEP135	2	PCM1	5	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
LATS2	1	SPICE1	2	bioid	Couzens AL (2013)	1
LATS2	1	OFD1	3	bioid	Couzens AL (2013)	1
CEP135	2	MAPRE1	0	affinity chromatography technology	Gupta GD (2015)	1
CEP89	2	FGFR1OP	0	bioid	Gupta GD (2015)	1
CEP63	2	CEP128	1	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
PCM1	5	CEP89	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
SPICE1	2	KIAA0753	1	bioid	Gupta GD (2015)	1
MED4	2	CEP135	2	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
ODF2	1	CCDC77	1	bioid	Gupta GD (2015)	1
CEP128	1	KIF7	3	bioid	Gupta GD (2015)	1
LATS2	1	CCDC77	1	bioid	Couzens AL (2013)	1
CEP135	2	CCDC14	2	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
ODF2	1	CEP170	4	bioid	Gupta GD (2015)	1
ODF2	1	KIF7	3	bioid	Gupta GD (2015)	1
KIAA0753	1	FGFR1OP	0	bioid, affinity chromatography technology	Firat-Karalar EN (2014), Hein MY (2015)	2
ODF2	1	OFD1	3	bioid	Gupta GD (2015)	1
CEP128	1	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP120	5	CCDC77	1	bioid	Gupta GD (2015)	1
CEP63	2	CCDC77	1	bioid	Gupta GD (2015)	1
CEP63	2	SPICE1	2	bioid	Firat-Karalar EN (2014)	1
OFD1	3	CCDC77	1	affinity chromatography technology	Hein MY (2015)	1
CEP128	1	CEP89	2	bioid	Gupta GD (2015)	1
CCDC14	2	FGFR1OP	0	bioid, affinity chromatography technology, affinity chromatography technology	Firat-Karalar EN (2014), Hein MY (2015), Hein MY (2015)	3
CEP128	1	MED4	2	bioid	Gupta GD (2015)	1
PCM1	5	CCDC14	2	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
CEP135	2	FGFR1OP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
PPP2R3C	1	KIAA0753	1	affinity chromatography technology	Hein MY (2015)	1
TPTE2	3	KIAA0753	1	bioid	St-Denis N (2016)	1
OFD1	3	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	5
ODF2	1	FGFR1OP	0	bioid	Gupta GD (2015)	1
KIAA0753	1	CEP170	4	bioid	Gupta GD (2015)	1
PRKAR2B	1	CCDC77	1	affinity chromatography technology	Hein MY (2015)	1
OFD1	3	MAPRE1	0	affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
SPICE1	2	KIF7	3	bioid	Gupta GD (2015)	1
LATS2	1	CEP89	2	bioid	Couzens AL (2013)	1
NINL	1	PCM1	5	bioid	Gupta GD (2015)	1
LTBR	0	CEP120	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NINL	1	FGFR1OP	0	bioid	Gupta GD (2015)	1
SPICE1	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
MED4	2	OFD1	3	bioid	Lambert JP (2015)	1
CEP128	1	KIAA0753	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CCDC14	2	CCDC77	1	affinity chromatography technology	Hein MY (2015)	1
CEP89	2	KIF7	3	bioid	Gupta GD (2015)	1
ODF2	1	NEDD1	1	bioid	Gupta GD (2015)	1
PCM1	5	KIF7	3	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
PCM1	5	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
OFD1	3	CEP170	4	bioid	Gupta GD (2015)	1
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CDC14A	4	SPICE1	2	bioid	St-Denis N (2016)	1
NINL	1	OFD1	3	bioid	Gupta GD (2015)	1
ODF2	1	CEP120	5	bioid	Gupta GD (2015)	1
CEP290	5	PCM1	5	bioid	Gupta GD (2015)	1
CEP63	2	KIAA0753	1	bioid, bioid, affinity chromatography technology, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	4
MAPRE1	0	CCDC77	1	affinity chromatography technology	Hein MY (2015)	1
CEP120	5	OFD1	3	bioid	Gupta GD (2015)	1
KIAA0753	1	OFD1	3	bioid, bioid, bioid, affinity chromatography technology	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	4
CEP128	1	LATS2	1	bioid	Gupta GD (2015)	1
TPTE2	3	KIF7	3	bioid	St-Denis N (2016)	1
NINL	1	CEP89	2	bioid	Gupta GD (2015)	1
MED4	2	CEP290	5	bioid, affinity chromatography technology, bioid	Lambert JP (2015), Gupta GD (2015), Gupta GD (2015)	3
TPTE2	3	CCDC14	2	bioid	St-Denis N (2016)	1
CEP63	2	OFD1	3	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
MAPRE1	0	FGFR1OP	0	affinity chromatography technology	Hein MY (2015)	1
KIAA0753	1	CEP120	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
OFD1	3	FGFR1OP	0	bioid, affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Hein MY (2015), Hein MY (2015)	3
CEP89	2	OFD1	3	bioid	Gupta GD (2015)	1
IKZF5	0	ODF2	1	affinity chromatography technology	Huttlin EL (2017)	1
CEP135	2	NEDD1	1	bioid	Gupta GD (2015)	1
TPTE2	3	CEP290	5	bioid	St-Denis N (2016)	1
CEP128	1	DYNLL1	0	bioid	Gupta GD (2015)	1
PCM1	5	FGFR1OP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP63	2	MED4	2	bioid	Gupta GD (2015)	1
CEP290	5	KIF7	3	affinity chromatography technology	Gupta GD (2015)	1
CEP128	1	FGFR1OP	0	bioid	Gupta GD (2015)	1
CEP128	1	PPP2R3C	1	bioid	Gupta GD (2015)	1
CEP89	2	CCDC77	1	bioid	Gupta GD (2015)	1
FGFR1OP	0	CCDC77	1	affinity chromatography technology	Hein MY (2015)	1
CEP128	1	CCDC14	2	bioid	Gupta GD (2015)	1
LATS2	1	PCM1	5	bioid	Couzens AL (2013)	1
CEP290	5	NEDD1	1	bioid	Gupta GD (2015)	1
PCM1	5	CEP63	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
PCM1	5	NEDD1	1	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP290	5	KIAA0753	1	bioid	Gupta GD (2015)	1
MED4	2	CEP170	4	bioid	Lambert JP (2015)	1
CEP135	2	CEP170	4	bioid	Gupta GD (2015)	1
CEP290	5	CCDC77	1	affinity chromatography technology	Gupta GD (2015)	1
CEP135	2	CEP290	5	affinity chromatography technology	Hein MY (2015)	1
CEP63	2	CCDC14	2	two hybrid, bioid, bioid, affinity chromatography technology, bioid	Camargo LM (2007), Firat-Karalar EN (2014), Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	5
FGFR1OP	0	PPP2R3C	1	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Gupta GD (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	5
NEDD1	1	CCDC77	1	affinity chromatography technology	Hein MY (2015)	1
CEP120	5	SPICE1	2	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	3
KIAA0753	1	CCDC14	2	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP89	2	KIAA0753	1	bioid	Gupta GD (2015)	1
NINL	1	CCDC14	2	bioid	Gupta GD (2015)	1
CCDC14	2	OFD1	3	bioid, bioid, affinity chromatography technology, affinity chromatography technology	Firat-Karalar EN (2014), Gupta GD (2015), Hein MY (2015), Hein MY (2015)	4
CEP128	1	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
MED4	2	SPICE1	2	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
CEP135	2	CEP120	5	bioid	Gupta GD (2015)	1
NINL	1	KIAA0753	1	bioid	Gupta GD (2015)	1
KIF7	3	CCDC77	1	affinity chromatography technology	Hein MY (2015)	1
CEP63	2	FGFR1OP	0	bioid	Gupta GD (2015)	1
CEP290	5	CEP170	4	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
MED4	2	ODF2	1	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2