PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TSG101	1	RAB11FIP3	2	two hybrid, affinity chromatography technology	Horgan CP (2012), Horgan CP (2012)	2
RAB11FIP4	2	DUSP14	2	affinity chromatography technology	Huttlin EL (2017)	1
RAB11A	4	RAB11FIP3	2	two hybrid, far western blotting, pull down, pull down, fluorescent resonance energy transfe	Hales CM (2001), Hales CM (2001), Fielding AB (2005), Inoue H (2008), Jing J (2009)	5
GFI1B	1	RAB11FIP4	2	two hybrid	Lim J (2006)	1
ARF6	0	RAB11FIP3	2	pull down, imaging technique, affinity chromatography technology, pull down	Fielding AB (2005), Fielding AB (2005), Fielding AB (2005), Inoue H (2008)	4
RAB11FIP4	2	RAB11FIP5	1	two hybrid	Wallace DM (2002)	1
ARF6	0	RAB11FIP4	2	affinity chromatography technology, imaging technique, pull down	Fielding AB (2005), Fielding AB (2005), Fielding AB (2005)	3
RAB11FIP4	2	FBXO28	2	affinity chromatography technology	Huttlin EL (2017)	1
RAB11FIP2	2	RAB11FIP5	1	affinity chromatography technology	Cullis DN (2002)	1
RAB11FIP4	2	SPECC1	1	affinity chromatography technology	Huttlin EL (2017)	1
RAB11FIP4	2	TNIP2	1	affinity chromatography technology	Huttlin EL (2017)	1
ARF6	0	KIAA0368	0	affinity chromatography technology	Ewing RM (2007)	1
RAB11FIP4	2	KIAA0368	0	two hybrid	Gorbea C (2010)	1
RAB11FIP4	2	SELENBP1	2	affinity chromatography technology	Huttlin EL (2017)	1
RAB11FIP4	2	RAB11FIP4	2	two hybrid	Wallace DM (2002)	1
RAB11FIP4	2	RAB11FIP2	2	two hybrid	Wallace DM (2002)	1
RAB11FIP4	2	S100A3	1	affinity chromatography technology	Huttlin EL (2017)	1
RAB11FIP4	2	RAB11FIP3	2	two hybrid, affinity chromatography technology	Wallace DM (2002), Huttlin EL (2017)	2
RAB11FIP4	2	RAB11A	4	two hybrid, far western blotting, pull down	Wallace DM (2002), Wallace DM (2002), Fielding AB (2005)	3
RAB11FIP2	2	RAB11A	4	two hybrid, two hybrid, far western blotting, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lindsay AJ (2002), Hales CM (2001), Hales CM (2001), Prekeris R (2001), Wei J (2006), Ducharme NA (2006), Nedvetsky PI (2007), Hein MY (2015), Huttlin EL (2017)	9
TSG101	1	RAB11FIP4	2	two hybrid, affinity chromatography technology	Horgan CP (2012), Horgan CP (2012)	2
ARF6	0	RAB11FIP5	1	pull down	Fielding AB (2005)	1
RAB11A	4	RAB11FIP5	1	pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Prekeris R (2000), Prekeris R (2000), Hales CM (2001), Prekeris R (2001), Fielding AB (2005), Hein MY (2015), Huttlin EL (2017)	7
RAB11FIP4	2	LRRC15	2	affinity chromatography technology	Huttlin EL (2017)	1