PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ERCC1	1	MUS81	1	affinity chromatography technology, affinity chromatography technology	Perez-Oliva AB (2015), Huttlin EL (2017)	2
MSH6	2	TOPBP1	5	affinity chromatography technology, affinity chromatography technology	Liu Y (2010), Liu Y (2010)	2
SLX4	6	NUP50	0	affinity chromatography technology	Svendsen JM (2009)	1
RPA1	0	MRE11	3	affinity chromatography technology	Marechal A (2014)	1
SLX4	6	PCNA	0	affinity chromatography technology	Ghosal G (2012)	1
SLX4	6	PSMB4	2	affinity chromatography technology	Svendsen JM (2009)	1
ERCC1	1	TOPBP1	5	biochemical	Wan C (2015)	1
EGLN3	0	MSH6	2	affinity chromatography technology	Rodriguez J (2016)	1
DDB1	6	DCAF10	2	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006)	2
SLX4	6	APP	1	pull down	Olah J (2011)	1
PCNA	0	SUMO1	0	pull down	Moldovan GL (2012)	1
FANCD2	3	ERCC4	2	affinity chromatography technology	Unno J (2014)	1
SLX4	6	MSH3	4	affinity chromatography technology	Svendsen JM (2009)	1
KPNA1	5	NUP50	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
DDB1	6	UBC	7	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Matsumoto M (2005)	2
EGLN3	0	GID8	1	affinity chromatography technology	Rodriguez J (2016)	1
SLX4	6	SLX1B	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Svendsen JM (2009), Svendsen JM (2009), Wan B (2013), Wan B (2013), Wan B (2013)	5
SLX1B	0	ERCC4	2	affinity chromatography technology	Svendsen JM (2009)	1
SLX4	6	ERCC4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, biochemical, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), Kim Y (2011), Andersen SL (2009), Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Fekairi S (2009), Kim Y (2013), Wilson JS (2013), Wilson JS (2013), Wan B (2013), Wan B (2013), Wan B (2013), Perez-Oliva AB (2015), Schuster B (2013), Bogliolo M (2013)	20
SLX4	6	NUP188	7	affinity chromatography technology	Svendsen JM (2009)	1
SLX4IP	3	ERCC4	2	affinity chromatography technology	Svendsen JM (2009)	1
TERF2	2	TERF2IP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	OConnor MS (2004), OConnor MS (2004), OConnor MS (2004), Li B (2000), Zhu XD (2000), Zhu XD (2000), Chen Y (2011), Chen Y (2011), Chen Y (2011), Chen Y (2011), Liu D (2004), Liu D (2004), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Her YR (2009), Havugimana PC (2012), Her YR (2013), Wan C (2015), Hein MY (2015), Her J (2015), Arat N Oe (2012), Li JS (2017), Jeong YY (2016), Ilic A (2017), Ilic A (2017)	28
UBE2I	0	APP	1	enzymatic study	Gocke CB (2005)	1
RPA1	0	TEX10	3	affinity chromatography technology	Marechal A (2014)	1
VCP	6	SUMO1	0	affinity chromatography technology	Yu CC (2013)	1
UBC	7	SUMO3	0	affinity chromatography technology	Sahin U (2014)	1
EGLN3	0	MRE11	3	affinity chromatography technology	Rodriguez J (2016)	1
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
MUS81	1	EME1	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Ciccia A (2003), Fekairi S (2009), Matos J (2011), Zeng S (2009), Nair N (2014), Huttlin EL (2017), Gwon GH (2014), Zhou X (2016), Phung HTT (2018)	9
EME1	3	APP	1	pull down, affinity chromatography technology	Olah J (2011), Huttlin EL (2017)	2
RPA1	0	MSH2	4	affinity chromatography technology, biochemical	Marechal A (2014), Wan C (2015)	2
FANCD2	3	NBN	1	affinity chromatography technology	Nakanishi K (2002)	1
MSH2	4	MSH3	4	affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, biochemical, pull down	Wang Y (2003), Guerrette S (1998), Bocker T (1999), Bocker T (1999), Acharya S (1996), Palombo F (1996), Havugimana PC (2012), Owen BA (2009)	8
EGLN3	0	TSPYL1	3	affinity chromatography technology	Rodriguez J (2016)	1
NUP50	0	APP	1	pull down	Olah J (2011)	1
KPNA1	5	FANCD2	3	biochemical	Wan C (2015)	1
MUS81	1	DDB1	6	affinity chromatography technology, pull down	Zhou X (2016), Zhou X (2016)	2
MSH2	4	MSH6	2	biochemical, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, biochemical, affinity chromatography technology, imaging technique	Wang Y (2000), Wang Y (2003), Guerrette S (1998), Bocker T (1999), Bocker T (1999), Acharya S (1996), Matton N (2000), Matton N (2000), Yang Q (2004), Havugimana PC (2012), Gradia S (1997), Owen BA (2009), Wan C (2015), Hein MY (2015), Chen TC (2014)	15
SLX1A	0	ERCC4	2	pull down, pull down	Munoz IM (2009), Fekairi S (2009)	2
UBC	7	SUMO1	0	affinity chromatography technology	Sahin U (2014)	1
SLX4	6	PNMA2	0	affinity chromatography technology	Svendsen JM (2009)	1
LRRC1	1	APP	1	pull down	Olah J (2011)	1
DDB1	6	EME1	3	pull down	Zhou X (2016)	1
VCP	6	PLK1	0	affinity chromatography technology	Yu CC (2013)	1
SLX4	6	KPNA1	5	affinity chromatography technology	Svendsen JM (2009)	1
EGLN3	0	NUP188	7	affinity chromatography technology	Rodriguez J (2016)	1
UBE2I	0	SLX4	6	affinity chromatography technology, pull down	Guervilly JH (2015), Guervilly JH (2015)	2
DCLRE1B	2	MRE11	3	affinity chromatography technology	Bae JB (2008)	1
DDB1	6	PCNA	0	affinity chromatography technology	Angers S (2006)	1
SLX1B	0	SLX4IP	3	affinity chromatography technology	Svendsen JM (2009)	1
SPRTN	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Ghosal G (2012), Ghosal G (2012), Davis EJ (2012), Davis EJ (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012)	8
SUMO2	0	ERCC4	2	pull down, pull down	Ouyang J (2009), Ouyang J (2015)	2
SLX4	6	SLX4IP	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012)	5
EGLN3	0	DCAF10	2	affinity chromatography technology	Rodriguez J (2016)	1
SUMO2	0	NBN	1	pull down	Ouyang J (2009)	1
USP45	3	ERCC1	1	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, enzymatic study, affinity chromatography technology	Perez-Oliva AB (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015)	6
SLX4	6	MSH2	4	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012)	4
EGLN3	0	LRRC1	1	affinity chromatography technology	Rodriguez J (2016)	1
NBN	1	TERF2IP	1	biochemical	Havugimana PC (2012)	1
APP	1	ERCC1	1	pull down	Virok DP (2011)	1
EGLN3	0	TOPBP1	5	affinity chromatography technology	Rodriguez J (2016)	1
SLX4	6	PLK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), So J (2015)	5
SLX4	6	TOPBP1	5	affinity chromatography technology	Gritenaite D (2014)	1
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
TOPBP1	5	RPA1	0	imaging technique	Gong Z (2010)	1
PLK1	0	ERCC4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Huttlin EL (2017)	3
DCLRE1B	2	TERF2IP	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
MRE11	3	MSH2	4	biochemical	Wang Y (2000)	1
SLX4	6	GID8	1	affinity chromatography technology	Svendsen JM (2009)	1
SLX4	6	ERCC1	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), Kim Y (2011), Munoz IM (2009), Munoz IM (2009), Kim Y (2013), Huttlin EL (2015), Perez-Oliva AB (2015), Huttlin EL (2017), Schuster B (2013), Bogliolo M (2013)	12
SLX1A	0	ERCC1	1	pull down	Munoz IM (2009)	1
MSH3	4	RPA1	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Marechal A (2014)	2
UBC	7	MRE11	3	affinity chromatography technology	Matsumoto M (2005)	1
SLX4	6	SUMO3	0	pull down, affinity chromatography technology	Guervilly JH (2015), Guervilly JH (2015)	2
FANCD2	3	SLX4	6	affinity chromatography technology, imaging technique, affinity chromatography technology	Unno J (2014), Yamamoto KN (2011), Yamamoto KN (2011)	3
EGLN3	0	PCNA	0	affinity chromatography technology	Rodriguez J (2016)	1
SLX4	6	DDB1	6	affinity chromatography technology	Ghosal G (2012)	1
MUS81	1	PLK1	0	affinity chromatography technology	Matos J (2011)	1
TERF2	2	MRE11	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Zhu XD (2000), Zhu XD (2000), Li B (2008), Havugimana PC (2012)	4
PCNA	0	RPA1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ohta S (2002), Ogi T (2010), Takasaki Y (2001), Gong Z (2011), Miccoli L (2005), Han J (2014)	6
MUS81	1	TERF2	2	affinity chromatography technology, affinity chromatography technology	Zeng S (2009), Zeng S (2009)	2
SLX4	6	SLX4	6	affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology	Schuster B (2013), Yin J (2016), Yin J (2016), Yin J (2016)	4
TERF2	2	DDB1	6	affinity chromatography technology	Giannone RJ (2010)	1
RPA1	0	TERF2	2	affinity chromatography technology	Marechal A (2014)	1
TERF2IP	1	MRE11	3	affinity chromatography technology, affinity chromatography technology, biochemical	OConnor MS (2004), Liu D (2004), Havugimana PC (2012)	3
MSH3	4	MSH6	2	biochemical	Havugimana PC (2012)	1
PCNA	0	FANCD2	3	affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Howlett NG (2009), Howlett NG (2009), Howlett NG (2009), Chen X (2016)	4
RPA1	0	SPRTN	0	imaging technique	Machida Y (2012)	1
SLX4	6	SPRTN	0	affinity chromatography technology, affinity chromatography technology	Ghosal G (2012), Ghosal G (2012)	2
UBC	7	FANCD2	3	pull down, affinity chromatography technology	Rego MA (2012), Yamamoto KN (2011)	2
SLX4	6	NOP53	2	affinity chromatography technology	Svendsen JM (2009)	1
SLX1A	0	MUS81	1	pull down, pull down	Munoz IM (2009), Fekairi S (2009)	2
SLX4	6	MUS81	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), Kim Y (2011), Munoz IM (2009), Munoz IM (2009), Fekairi S (2009), Kim Y (2013), Wilson JS (2013), Wan B (2013), Wan B (2013), Wan B (2013), Rolland T (2014), Yu H (2011), Nair N (2014), Nair N (2014), Nair N (2014), Ouyang J (2015), Huttlin EL (2017), Schuster B (2013), Bogliolo M (2013)	21
EGLN3	0	PLK1	0	affinity chromatography technology	Rodriguez J (2016)	1
SUMO2	0	EME1	3	pull down, pull down	Ouyang J (2009), Ouyang J (2015)	2
SLX4	6	UBC	7	pull down	Lachaud C (2014)	1
EGLN3	0	SLX4	6	affinity chromatography technology	Rodriguez J (2016)	1
MSH6	2	PCNA	0	far western blotting, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, far western blotting, affinity chromatography technology, biochemical, affinity chromatography technology	Kleczkowska HE (2001), Kleczkowska HE (2001), Clark AB (2000), Ohta S (2002), Jascur T (2011), Schoepf B (2012), Havugimana PC (2012), Dzantiev L (2004), Han J (2014), Wan C (2015), Hein MY (2015)	11
TSPYL1	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
USP45	3	ERCC4	2	affinity chromatography technology, affinity chromatography technology	Perez-Oliva AB (2015), Perez-Oliva AB (2015)	2
SLX4	6	SLX1A	0	two hybrid, pull down, pull down, biochemical, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Fekairi S (2009), Fekairi S (2009), Fekairi S (2009), Kim Y (2013), Wan B (2013), Wan B (2013), Wan B (2013)	11
SLX1A	0	EME1	3	pull down	Munoz IM (2009)	1
UBC	7	USP45	3	pull down	Kwasna D (2018)	1
SLX4	6	PGAM5	4	affinity chromatography technology	Svendsen JM (2009)	1
SLX1B	0	PLK1	0	affinity chromatography technology	Svendsen JM (2009)	1
NBN	1	MSH2	4	biochemical	Wang Y (2000)	1
SLX1B	0	EME1	3	affinity chromatography technology	Svendsen JM (2009)	1
MSH3	4	PCNA	0	far western blotting, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, two hybrid	Kleczkowska HE (2001), Kleczkowska HE (2001), Clark AB (2000), Ohta S (2002), Ohta S (2002), Rolland T (2014)	6
NBN	1	MSH6	2	biochemical	Wang Y (2000)	1
RPA1	0	UBC	7	affinity chromatography technology	Marechal A (2014)	1
NBN	1	MRE11	3	biochemical, affinity chromatography technology, biochemical, two hybrid, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Cerosaletti KM (2003), Trujillo KM (1998), Matsuzaki K (2008), Desai-Mehta A (2001), Desai-Mehta A (2001), Desai-Mehta A (2001), Zheng L (2009), Goldberg M (2003), Goldberg M (2003), Goldberg M (2003), Cho YW (2007), Nakanishi K (2002), Shimada M (2009), Shimada M (2009), Yanagihara H (2011), Falck J (2005), Falck J (2005), Falck J (2005), Wu J (2012), Alt JR (2005), Havugimana PC (2012), Wijnhoven P (2015), Suhasini AN (2013), Suhasini AN (2013), Nicholson J (2017)	26
SUMO2	0	MSH2	4	pull down, pull down	Ouyang J (2009), Ouyang J (2015)	2
SLX4	6	TEX10	3	affinity chromatography technology	Svendsen JM (2009)	1
USP45	3	SLX4	6	affinity chromatography technology, affinity chromatography technology	Perez-Oliva AB (2015), Perez-Oliva AB (2015)	2
SLX4	6	SUMO1	0	affinity chromatography technology	Guervilly JH (2015)	1
MUS81	1	VCP	6	genetic interference	Vizeacoumar FJ (2013)	1
EGLN3	0	PGAM5	4	affinity chromatography technology	Rodriguez J (2016)	1
UBC	7	SUMO2	0	affinity chromatography technology	Sahin U (2014)	1
ERCC1	1	ERCC4	2	pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	de Laat WL (1998), Park CH (1994), Ciccia A (2007), Havugimana PC (2012), Lan L (2004), Lan L (2004), Lan L (2004), Huttlin EL (2015), Wan C (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015), Liccardi G (2014), Huttlin EL (2017), Friboulet L (2013)	14
PCNA	0	MSH2	4	affinity chromatography technology, far western blotting	Ohta S (2002), Dzantiev L (2004)	2
SLX4	6	DCAF10	2	affinity chromatography technology	Svendsen JM (2009)	1
SLX4	6	MSH6	2	affinity chromatography technology	Ghosal G (2012)	1
EGLN3	0	DDB1	6	affinity chromatography technology	Rodriguez J (2016)	1
SUMO2	0	SLX4	6	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ouyang J (2009), Ouyang J (2015), Ouyang J (2015), Ouyang J (2015), Guervilly JH (2015), Guervilly JH (2015)	6
VCP	6	TERF2	2	affinity chromatography technology	Yu CC (2013)	1
EGLN3	0	MSH2	4	affinity chromatography technology	Rodriguez J (2016)	1
DCLRE1B	2	TERF2	2	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Freibaum BD (2006), Chen Y (2011), Lenain C (2006), Lenain C (2006), Hein MY (2015)	5
TERF2	2	NBN	1	affinity chromatography technology, affinity chromatography technology, biochemical	Zhu XD (2000), Zhu XD (2000), Havugimana PC (2012)	3
RPA1	0	NBN	1	affinity chromatography technology	Marechal A (2014)	1
SLX1B	0	MUS81	1	affinity chromatography technology	Svendsen JM (2009)	1
FANCD2	3	RPA1	0	affinity chromatography technology	Unno J (2014)	1
ERCC1	1	RPA1	0	fluorescent resonance energy transfe	Friboulet L (2013)	1
SLX4	6	LRRC1	1	affinity chromatography technology	Svendsen JM (2009)	1
SLX1B	0	ERCC1	1	affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Huttlin EL (2017)	2
SLX4	6	TERF2	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, imaging technique, x-ray crystallography, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Wilson JS (2013), Wilson JS (2013), Wilson JS (2013), Wan B (2013), Wan B (2013), Wan B (2013), Wan B (2013), Wan B (2013), Ouyang J (2015)	11
EGLN3	0	VCP	6	affinity chromatography technology	Rodriguez J (2016)	1
RPA1	0	DDB1	6	affinity chromatography technology	Marechal A (2014)	1
PLK1	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PSMB4	2	APP	1	pull down	Olah J (2011)	1
TOPBP1	5	DDB1	6	affinity chromatography technology	Wang J (2013)	1
SLX4	6	TSPYL1	3	affinity chromatography technology	Svendsen JM (2009)	1
SUMO2	0	MUS81	1	pull down, pull down	Ouyang J (2009), Ouyang J (2015)	2
SLX4	6	TERF2IP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012)	3
EGLN3	0	ERCC4	2	affinity chromatography technology	Rodriguez J (2016)	1
MRE11	3	MSH6	2	biochemical	Wang Y (2000)	1
SUMO2	0	SLX4IP	3	pull down, pull down	Ouyang J (2009), Ouyang J (2015)	2
SLX4	6	MRE11	3	affinity chromatography technology	Ouyang J (2015)	1
VCP	6	SUMO2	0	affinity chromatography technology	Yu CC (2013)	1
EGLN3	0	KPNA1	5	affinity chromatography technology	Rodriguez J (2016)	1
DCLRE1B	2	FANCD2	3	affinity chromatography technology, affinity chromatography technology	Bae JB (2008), Bae JB (2008)	2
USP45	3	NOP53	2	affinity chromatography technology	Sowa ME (2009)	1
ERCC1	1	SLX4IP	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SLX4	6	DCLRE1B	2	affinity chromatography technology	Salewsky B (2012)	1
SUMO2	0	MRE11	3	pull down	Ouyang J (2009)	1
SPRTN	0	UBC	7	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Machida Y (2012), Machida Y (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Centore RC (2012), Davis EJ (2012)	7
MUS81	1	ERCC4	2	affinity chromatography technology	Huttlin EL (2017)	1
SLX4	6	VCP	6	affinity chromatography technology	Ghosal G (2012)	1
ERCC1	1	MSH2	4	affinity chromatography technology, affinity chromatography technology, biochemical	Lan L (2004), Lan L (2004), Lan L (2004)	3
SLX1A	0	SLX1B	0	affinity chromatography technology	Huttlin EL (2017)	1
PLK1	0	TOPBP1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TOPBP1	5	NBN	1	affinity chromatography technology, affinity chromatography technology	Morishima K (2007), Morishima K (2007)	2
ERCC4	2	MSH2	4	affinity chromatography technology, affinity chromatography technology	Lan L (2004), Lan L (2004)	2
FANCD2	3	MSH2	4	affinity chromatography technology, genetic interference	Williams SA (2011), Peng M (2014)	2
SUMO2	0	TEX10	3	pull down	Ouyang J (2009)	1
SLX4	6	NBN	1	affinity chromatography technology	Ouyang J (2015)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
SLX4	6	EME1	3	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down	Svendsen JM (2009), Munoz IM (2009), Munoz IM (2009), Fekairi S (2009), Fekairi S (2009)	5
UBE2I	0	SUMO3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Li T (2006), Boutell C (2011), Hecker CM (2006), Tatham MH (2001), Wan C (2015), Huttlin EL (2017)	7
MUS81	1	FANCD2	3	genetic interference	Vizeacoumar FJ (2013)	1
PLK1	0	SLX4IP	3	affinity chromatography technology	Svendsen JM (2009)	1
UBE2I	0	TERF2	2	enzymatic study	Her J (2015)	1
SPRTN	0	PCNA	0	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Centore RC (2012), Centore RC (2012), Ghosal G (2012), Ghosal G (2012), Ghosal G (2012), Ghosal G (2012), Machida Y (2012), Machida Y (2012), Davis EJ (2012), Davis EJ (2012), Juhasz S (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Juhasz S (2012), Centore RC (2012)	16
SLX4	6	RPA1	0	affinity chromatography technology	Ouyang J (2015)	1