PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MCM8	3	MCM8	3	affinity chromatography technology	Nishimura K (2012)	1
VWA5A	2	MCM9	1	affinity chromatography technology	Huttlin EL (2017)	1
MCM8	3	ORC2	0	affinity chromatography technology, affinity chromatography technology	Volkening M (2005), Volkening M (2005)	2
F9	0	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
IL17RA	3	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
MCM8	3	MLH1	6	affinity chromatography technology	Traver S (2015)	1
MSH2	4	MLH1	6	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Wang Y (2000), Matton N (2000), Plotz G (2003), Plotz G (2003), Chen TC (2014)	5
TP53	0	KLHL40	4	genetic interference	Xie L (2013)	1
MCM4	3	MCM7	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology	Yabuta N (2003), Fujita M (1997), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	9
MCM9	1	MSH2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Hutchins JR (2016), Traver S (2015), Traver S (2015), Traver S (2015), Traver S (2015)	5
TP53	0	MCM8	3	genetic interference	Xie L (2013)	1
RAD50	3	MLH1	6	biochemical	Wang Y (2000)	1
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
SKP2	2	RAD50	3	affinity chromatography technology	Wu J (2012)	1
TSPYL6	0	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
MCM4	3	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM7	5	MCM8	3	affinity chromatography technology	Johnson EM (2003)	1
TUBB	3	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
MCM6	5	MCM8	3	affinity chromatography technology	Johnson EM (2003)	1
LRRC27	5	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
FAM167A	1	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
MCMBP	3	MCM7	5	affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical	Taipale M (2014), Taipale M (2014), Rolland T (2014), Wan C (2015)	4
AVIL	0	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
DEF8	4	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
SKP2	2	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
PSG8	4	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
VWA5A	2	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
KLHL40	4	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
MCM9	1	MLH1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Hutchins JR (2016), Traver S (2015), Traver S (2015), Traver S (2015), Traver S (2015)	5
KLK5	1	MCM8	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCM7	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
BPNT1	1	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
SKAP1	0	MCM8	3	affinity chromatography technology	Huttlin EL (2015)	1
TP53	0	TUBB	3	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
RAD50	3	MCM9	1	affinity chromatography technology, affinity chromatography technology	Lee KY (2015), Lee KY (2015)	2
BPNT1	1	CDC6	0	affinity chromatography technology	Huttlin EL (2017)	1
TUBB	3	XPO1	8	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
HNRNPL	3	MCM8	3	affinity chromatography technology	Fei T (2017)	1
MCMBP	3	MCM6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Jagannathan M (2014), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	5
XPO1	8	MCM8	3	affinity chromatography technology	Kirli K (2015)	1
MCM6	5	MCM7	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ryu MJ (2006), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
IQCF1	0	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
PSG8	4	MCM9	1	affinity chromatography technology	Huttlin EL (2017)	1
MCM4	3	MCM8	3	affinity chromatography technology	Johnson EM (2003)	1
SNX21	2	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
MSH2	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zink D (2002), Zink D (2002), Yang Q (2004)	3
MCM6	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MSH2	4	MCM8	3	affinity chromatography technology, affinity chromatography technology	Traver S (2015), Traver S (2015)	2
MCMBP	3	MCM4	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HNRNPL	3	LRRC27	5	affinity chromatography technology	Fei T (2017)	1
MCM4	3	MCM6	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
MCMBP	3	MCM8	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC6	0	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1999), Sugimoto N (2015), Hubbi ME (2013)	7
RAD50	3	MCM8	3	affinity chromatography technology	Lee KY (2015)	1
P4HA2	3	MCM8	3	affinity chromatography technology	Huttlin EL (2017)	1
RAD50	3	MSH2	4	biochemical	Wang Y (2000)	1
MCM8	3	CDC6	0	affinity chromatography technology, affinity chromatography technology	Volkening M (2005), Volkening M (2005)	2
MCMBP	3	MCM9	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
XPO1	8	SNX21	2	affinity chromatography technology	Kirli K (2015)	1
CDC6	0	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Mendez J (2000), Ramachandran N (2004)	5
MCM9	1	MCM8	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hutchins JR (2016), Lee KY (2015), Lee KY (2015), Traver S (2015), Traver S (2015)	7