PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
COPS3	1	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Min KW (2005), Enchev RI (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	9
CUL3	17	FMOD	2	affinity chromatography technology, affinity chromatography technology	Wimuttisuk W (2014), Wimuttisuk W (2014)	2
CUL5	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ehrlich ES (2009), Ehrlich ES (2009), Bennett EJ (2010)	3
CAND1	2	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
RHOA	0	CAV1	0	pull down	Nethe M (2010)	1
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
CUL3	17	MAT2A	2	affinity chromatography technology, affinity chromatography technology, pull down	Bennett EJ (2010), Wang J (2016), Wang J (2016)	3
PIK3R1	6	KBTBD2	1	affinity chromatography technology, affinity chromatography technology, pull down	Zhang Z (2016), Zhang Z (2016), Zhang Z (2016)	3
RBBP8	1	KLHL15	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, unspecified method	Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016)	7
CUL3	17	KLHL5	0	affinity chromatography technology, two hybrid	Bennett EJ (2010), Wang J (2011)	2
VCP	6	FAF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Haenzelmann P (2011), Song EJ (2005), Song EJ (2005), Shin HY (2010), Haenzelmann P (2011), Haenzelmann P (2011), Kang W (2011), Alexandru G (2012), Lee JJ (2013), Lee JJ (2013), Lee JJ (2013), Yu CC (2013), Baron Y (2014), Franz A (2016), Raman M (2015)	17
VCP	6	UBE2M	0	affinity chromatography technology	Yu CC (2013)	1
COPS8	2	COPS7A	0	biochemical, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Huang X (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
CUL3	17	AURKB	2	affinity chromatography technology, affinity chromatography technology	Sumara I (2007), Krupina K (2016)	2
CUL5	1	ELOC	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kamura T (2001), Nishiya T (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Kershaw NJ (2014), Huttlin EL (2017)	18
RBM45	1	SQSTM1	0	affinity chromatography technology	Bakkar N (2015)	1
COPS7A	0	KCTD20	2	affinity chromatography technology	Hein MY (2015)	1
KBTBD4	4	NUDCD3	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	KLHL42	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cummings CM (2009), Cummings CM (2009), Bennett EJ (2010), Plafker KS (2009), Olma MH (2009), Wimuttisuk W (2014), Huttlin EL (2017)	7
CUL3	17	SF3B3	4	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Cordero-Espinoza L (2013)	2
DCUN1D1	0	COPS3	1	affinity chromatography technology	Bennett EJ (2010)	1
RHOBTB2	6	RHOBTB3	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Berthold J (2008), Berthold J (2008), Berthold J (2008)	3
GPS1	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Stotland A (2012), Huang X (2005), Sharon M (2009), Kapelari B (2000), Tsuge T (2001), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
CUL1	7	COPS9	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Ebina M (2013)	2
HSP90AA1	7	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
FAF1	1	CUL3	17	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
CUL3	17	PEF1	0	affinity chromatography technology, affinity chromatography technology, pull down	Bennett EJ (2010), McGourty CA (2016), McGourty CA (2016)	3
COPS6	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
UBE2M	0	RHOBTB1	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2M	0	KLHL20	2	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	11
USP25	0	UBC	7	enzymatic study, pull down, enzymatic study, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, enzymatic study, pull down	Faesen AC (2011), Nathan JA (2013), Meulmeester E (2008), Meulmeester E (2008), Zhang X (2017), Yang Y (2017), Wrigley JD (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kwasna D (2018)	12
KCTD17	0	KCTD5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DAXX	5	SPOP	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	La M (2004), Liu F (2012), Kwon JE (2006), Kwon JE (2006), Wang J (2011), Wang J (2011), Zhang P (2017)	7
KEAP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang DD (2005), Ichikawa T (2009), Lau A (2010), Li Y (2012), Niture SK (2013), Kaspar JW (2012), Kaspar JW (2012), Zhang DD (2004), Lo SC (2006)	9
COPS4	0	COPS7B	0	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	7
CUL3	17	GLI2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin X (2016), Jin X (2016), Jin X (2016)	3
DCUN1D1	0	RHOA	0	pull down	Huang G (2014)	1
FAF1	1	KLHL22	3	affinity chromatography technology	Alexandru G (2008)	1
UBE2M	0	KLHL42	1	affinity chromatography technology	Huttlin EL (2017)	1
NEDD8	0	KLHL15	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	KBTBD8	2	affinity chromatography technology, affinity chromatography technology, pull down	Bennett EJ (2010), Werner A (2015), Werner A (2015)	3
CUL5	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Zhu Z (2017)	3
USP25	0	KCTD13	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017)	2
SQSTM1	0	KLHL3	1	affinity chromatography technology, affinity chromatography technology	Mori Y (2015), Mori Y (2015)	2
NEDD8	0	KCTD3	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	KCTD10	1	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	PEF1	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), McGourty CA (2016)	2
DCUN1D1	0	KBTBD6	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	COPS5	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
CUL3	17	RBM45	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bakkar N (2015)	2
VCP	6	HSPD1	0	affinity chromatography technology	Fogeron ML (2013)	1
GABARAPL2	0	CUL3	17	affinity chromatography technology, pull down	Behrends C (2010), Genau HM (2015)	2
COPS7A	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uhle S (2003), Bennett EJ (2010), Huang X (2016), Reitsma JM (2017)	4
UBC	7	COPS4	0	affinity chromatography technology	Matsumoto M (2005)	1
DAXX	5	CUL3	17	affinity chromatography technology, affinity chromatography technology	Kwon JE (2006), Kwon JE (2006)	2
DCUN1D1	0	CAND1	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kim AY (2008), Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bommelje CC (2013), Kim AY (2008), Huang G (2014), Huang G (2014), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	11
CUL3	17	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Zhang Z (2016)	2
CUL5	1	COPS4	0	affinity chromatography technology	Bennett EJ (2010)	1
KLHL7	5	UBC	7	enzymatic study, pull down	Kigoshi Y (2011), Zhang X (2017)	2
KLHL18	2	RBX1	2	affinity chromatography technology	Moghe S (2012)	1
KBTBD6	0	RBX1	2	affinity chromatography technology	Genau HM (2015)	1
UBE2M	0	KBTBD6	0	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
KLHL12	4	SEC31A	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	McGourty CA (2016), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016)	5
KCTD13	1	RHOA	0	affinity chromatography technology, pull down, enzymatic study, enzymatic study	Chen Y (2009), Chen Y (2009), Chen Y (2009), Ibeawuchi SR (2015)	4
UBE2M	0	KLHL18	2	affinity chromatography technology	Huttlin EL (2017)	1
COMMD1	1	CUL3	17	affinity chromatography technology, pull down, pull down	Mao X (2011), Mao X (2011), Mao X (2011)	3
DCUN1D3	1	CUL3	17	pull down, affinity chromatography technology, pull down, imaging technique, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Monda JK (2013), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	11
DCUN1D2	0	CUL5	1	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	5
AURKB	2	KLHL21	3	affinity chromatography technology, pull down, enzymatic study	Maerki S (2009), Maerki S (2009), Maerki S (2009)	3
CUL5	1	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	COPS2	5	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
COPS5	0	HSPD1	0	affinity chromatography technology	Bennett EJ (2010)	1
PGAM5	4	CUL3	17	affinity chromatography technology, affinity chromatography technology	Lo SC (2006), Bennett EJ (2010)	2
UBXN1	0	TNFAIP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
KLHL20	2	KLHL26	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KLHL12	4	NUDCD3	0	affinity chromatography technology	McGourty CA (2016)	1
DCUN1D1	0	COPS6	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	KLHL18	2	affinity chromatography technology	Bennett EJ (2010)	1
KLHL21	3	KLHL9	1	affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Maerki S (2009)	2
COPS3	1	COPS7B	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Enchev RI (2010), Olma MH (2009), Havugimana PC (2012), Huttlin EL (2015), Huang X (2016), Huttlin EL (2017)	6
DCUN1D1	0	COPS8	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	KLHL42	1	affinity chromatography technology	Bennett EJ (2010)	1
UBXN1	0	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Wu-Baer F (2010), Fenner BJ (2009), Alexandru G (2008), LaLonde DP (2011), McNeill H (2004), Zhang X (2017)	6
CUL3	17	KLHL11	3	affinity chromatography technology, x-ray crystallography, affinity chromatography technology	Bennett EJ (2010), Canning P (2013), Huttlin EL (2017)	3
HSP90AA1	7	WNK4	5	affinity chromatography technology	Taipale M (2012)	1
COPS6	0	COPS9	1	affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Bennett EJ (2010), Rozen S (2015)	3
CUL3	17	RHOBTB1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Berthold J (2008), Berthold J (2008), Berthold J (2008), Pelham CJ (2012), Pelham CJ (2012), Ibeawuchi SR (2015)	7
COPS5	0	ELOC	0	affinity chromatography technology	Bennett EJ (2010)	1
KLHL28	1	KLHL21	3	affinity chromatography technology	Huttlin EL (2017)	1
DCUN1D5	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Bommelje CC (2013), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	5
CAV1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology	Dubiel D (2017), Dubiel D (2017)	2
COPS5	0	BTBD2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
UBC	7	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Matsumoto M (2005), Bennett EJ (2010), Bish RA (2007), Wu K (2016)	4
CUL3	17	KLHL9	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Sumara I (2007), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	7
DDIT3	1	CUL3	17	affinity chromatography technology, biochemical	Huang X (2012), Huang X (2012)	2
PEF1	0	PDCD6	2	affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, two hybrid, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Kitaura Y (2001), Kitaura Y (2001), Kitaura Y (2001), Wang J (2011), Rolland T (2014), Wan C (2015), Yu H (2011), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016)	12
CUL5	1	PDCD6	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	SF3B3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Cordero-Espinoza L (2013), Cordero-Espinoza L (2013)	3
COPS2	5	COPS4	0	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Huang X (2005), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	8
KLHL20	2	KLHL22	3	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	RCBTB1	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	COPS4	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sharon M (2009), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	14
UBXN7	3	KBTBD7	3	affinity chromatography technology	Alexandru G (2008)	1
ACLY	3	MCM7	5	affinity chromatography technology	Zhang C (2016)	1
NACC1	9	KLHL2	0	two hybrid, affinity chromatography technology	Korutla L (2009), Korutla L (2009)	2
COPS5	0	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Stotland A (2012), Bennett EJ (2010), Oh W (2006), Chun Y (2013), Chun Y (2013), Chun Y (2013), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
ACLY	3	APP	1	pull down	Olah J (2011)	1
HSP90AA1	7	KLHL23	0	affinity chromatography technology	Taipale M (2012)	1
COPS6	0	KLHL13	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
COPS6	0	KLHL9	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
HSP90AA1	7	SF3B3	4	affinity chromatography technology	Taipale M (2012)	1
ELOC	0	MCM7	5	pull down	Hubbi ME (2011)	1
COPS9	1	COPS8	2	affinity chromatography technology, biochemical	Rozen S (2015), Rozen S (2015)	2
CAND1	2	PDCD6	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	KLHL13	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Sumara I (2007), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	7
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
UBC	7	NEDD8	0	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Matsumoto M (2005), Bennett EJ (2010), Singh RK (2012), Singh RK (2012)	4
COPS5	0	CAND1	2	biochemical, affinity chromatography technology	Bornstein G (2006), Bennett EJ (2010)	2
NOTCH1	25	KCTD10	1	affinity chromatography technology, affinity chromatography technology	Ren K (2014), Ren K (2014)	2
CUL3	17	ARMC5	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
COPS8	2	COPS3	1	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Min KW (2005), Enchev RI (2010), Sharon M (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	11
COPS5	0	MCM7	5	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	SF3B3	4	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	KCTD6	2	affinity chromatography technology	Bennett EJ (2010)	1
NFE2L2	1	PGAM5	4	affinity chromatography technology	Lo SC (2008)	1
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
HSF2	2	CUL3	17	two hybrid, two hybrid, pull down, affinity chromatography technology	Xing H (2010), Xing H (2010), Xing H (2010), Xing H (2010)	4
USP25	0	KCTD10	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017), Xu D (2017)	3
COPS8	2	COPS2	5	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Yang X (2002), Huang X (2005), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	9
NEDD8	0	COPS8	2	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	AURKB	2	pull down	Huang G (2014)	1
DCUN1D1	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Wu K (2011), Bennett EJ (2010), Huang G (2011), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	16
CUL3	17	SHKBP1	4	affinity chromatography technology, two hybrid, pull down	Bennett EJ (2010), Wang J (2011), Pinkas DM (2017)	3
CUL3	17	KBTBD6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Genau HM (2015), Genau HM (2015), Huttlin EL (2017)	5
CUL1	7	PDCD6	2	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	KHSRP	5	affinity chromatography technology	Bennett EJ (2010)	1
HSPD1	0	HSPA4	3	biochemical	Wan C (2015)	1
CUL5	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ehrlich ES (2009), Ehrlich ES (2009), Ehrlich ES (2009), Bennett EJ (2010)	4
ELOC	0	SQSTM1	0	affinity chromatography technology	Chen K (2016)	1
CASP8	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pan JA (2011), Huang S (2013), Huang S (2013)	3
KCTD17	0	RBX1	2	affinity chromatography technology, pull down, affinity chromatography technology	Kasahara K (2014), Kasahara K (2014), Kasahara K (2014)	3
COPS2	5	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Huang X (2005), Bennett EJ (2010), Olma MH (2009), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	6
SEC31A	7	PDCD6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	McGourty CA (2016), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016)	6
RFWD2	0	COPS7B	0	affinity chromatography technology	Olma MH (2009)	1
CUL5	1	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	KLHL8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Nam S (2009), Huttlin EL (2017)	3
KEAP1	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, two hybrid	Niture SK (2013), Prince TL (2015), Prince TL (2015)	3
COPS7A	0	NFE2L2	1	pull down	Wang Y (2002)	1
NEDD8	0	ELOC	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
COPS4	0	KCTD10	1	genetic interference	Horlbeck MA (2018)	1
CAND1	2	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
COPS7A	0	WDR77	2	biochemical	Kristensen AR (2012)	1
COPS3	1	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Yang X (2002), Enchev RI (2010), Huang X (2005), Kapelari B (2000), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Rozen S (2015), Huttlin EL (2017)	13
COPS3	1	HSP90AA1	7	affinity chromatography technology	Min KW (2005)	1
NEDD8	0	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	RHOA	0	affinity chromatography technology	Huang G (2014)	1
DCUN1D1	0	COPS7B	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	KLHL22	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
RBX1	2	ELOC	0	affinity chromatography technology	Brower CS (2002)	1
CUL3	17	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Schenkova K (2012)	3
USP25	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu D (2017)	2
COPS6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Reitsma JM (2017)	7
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
CASP8	1	FAF1	1	affinity chromatography technology, affinity chromatography technology	Knox PG (2011), Caballero-Lopez MJ (2017)	2
DCUN1D5	0	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bommelje CC (2013), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	4
UBC	7	CAV1	0	affinity chromatography technology, imaging technique	Luo X (2017), Luo X (2017)	2
UBE2M	0	CUL3	17	enzymatic study, pull down	Huang G (2011), Schumacher FR (2015)	2
NUP50	0	APP	1	pull down	Olah J (2011)	1
FAF1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Zhang L (2012), Zhang L (2012)	4
SENP3	1	CUL1	7	affinity chromatography technology, affinity chromatography technology	Wang M (2016), Wang M (2016)	2
KHSRP	5	KLHL12	4	affinity chromatography technology, enzymatic study	Kung YA (2017), Kung YA (2017)	2
KLHL2	0	KLHL12	4	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Mai A (2004), Yu H (2011), Huttlin EL (2017)	4
UBE2M	0	APP	1	enzymatic study, pull down	Lee MR (2008), Olah J (2011)	2
KCTD5	0	MCM7	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Rutz N (2015), Rutz N (2015), Rutz N (2015)	3
NACC1	9	ENC1	0	two hybrid, affinity chromatography technology	Korutla L (2009), Korutla L (2009)	2
NEDD8	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
CUL3	17	IPP	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
KCTD17	0	KCTD2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDIT3	1	CUL1	7	affinity chromatography technology	Huang X (2012)	1
KLHL12	4	KLHL26	2	affinity chromatography technology, affinity chromatography technology	McGourty CA (2016), McGourty CA (2016)	2
SPOP	1	FAF1	1	two hybrid	Zhang P (2017)	1
CUL3	17	VCP	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Besten Wd (2012)	2
RFWD2	0	BTBD2	4	affinity chromatography technology	Olma MH (2009)	1
DCUN1D4	0	CUL1	7	pull down, enzymatic study, affinity chromatography technology	Monda JK (2013), Monda JK (2013), Keuss MJ (2016)	3
HSP90AA1	7	KBTBD4	4	affinity chromatography technology	Taipale M (2012)	1
HSPA4	3	CAND1	2	biochemical	Kristensen AR (2012)	1
UBXN1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Hu Y (2017), Hu Y (2017)	4
COPS5	0	SF3B3	4	affinity chromatography technology	Bennett EJ (2010)	1
KLHL20	2	ARHGEF12	2	enzymatic study	Lin MY (2011)	1
NEDD8	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	ABTB1	1	affinity chromatography technology, two hybrid	Bennett EJ (2010), Rolland T (2014)	2
GABARAPL2	0	KBTBD7	3	two hybrid, affinity chromatography technology, pull down	Vinayagam A (2011), Genau HM (2015), Genau HM (2015)	3
CUL5	1	MCM7	5	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	NUDCD3	0	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D2	0	CAND1	2	affinity chromatography technology, affinity chromatography technology, pull down	Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	3
COPS8	2	BTBD2	4	affinity chromatography technology	Huttlin EL (2017)	1
COPS7B	0	APP	1	pull down	Olah J (2011)	1
COPS5	0	KLHL36	11	affinity chromatography technology	Bennett EJ (2010)	1
UBE2M	0	SHKBP1	4	affinity chromatography technology	Huttlin EL (2017)	1
ENC1	0	KLHL25	6	affinity chromatography technology	Huttlin EL (2017)	1
KHSRP	5	NUP50	0	biochemical	Wan C (2015)	1
COPS7A	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Hein MY (2015)	2
COPS7A	0	BTBD2	4	affinity chromatography technology	Hein MY (2015)	1
COPS5	0	KLHL8	1	affinity chromatography technology	Bennett EJ (2010)	1
HSPA4	3	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
COPS6	0	UBE2M	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
CUL1	7	RCBTB1	1	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	KBTBD6	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS7A	0	BTBD10	4	affinity chromatography technology	Hein MY (2015)	1
KLHL28	1	KLHL24	1	affinity chromatography technology	Huttlin EL (2017)	1
RBX1	2	APP	1	pull down	Olah J (2011)	1
KBTBD7	3	KBTBD6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Genau HM (2015), Genau HM (2015), Hein MY (2015), Huttlin EL (2017)	5
KLHL18	2	NUDCD3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL1	7	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Min KW (2005), Lee JE (2011), Bennett EJ (2010), Lyapina S (2001), Reitsma JM (2017)	6
CUL3	17	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huang X (2016), Huttlin EL (2017)	3
UBXN7	3	KLHL12	4	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Raman M (2015)	2
UBXN7	3	FAF1	1	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
GAN	4	KBTBD8	2	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	PDCD6	2	affinity chromatography technology	Yu CC (2013)	1
DCUN1D1	0	KLHL23	0	affinity chromatography technology	Bennett EJ (2010)	1
SENP3	1	MCM7	5	affinity chromatography technology	Wang M (2016)	1
COPS6	0	SHKBP1	4	affinity chromatography technology	Sowa ME (2009)	1
DCUN1D1	0	COPS2	5	affinity chromatography technology	Bennett EJ (2010)	1
RHOBTB2	6	CUL5	1	two hybrid	Berthold J (2008)	1
CUL3	17	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina S (2001), Huttlin EL (2017)	3
CUL3	17	USP25	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Xu D (2017)	2
USP25	0	TNFAIP1	4	affinity chromatography technology	Huttlin EL (2017)	1
NOTCH1	25	RHOA	0	two hybrid	Daakour S (2016)	1
NEDD8	0	COPS4	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
SQSTM1	0	PIK3R1	6	far western blotting, affinity chromatography technology	Sung CK (1998), Sung CK (1998)	2
DAXX	5	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
KEAP1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang XJ (2008), Rachakonda G (2008), Rachakonda G (2008), Nioi P (2007), Chew EH (2007), Chew EH (2007), Zhang DD (2005), Furukawa M (2005), Furukawa M (2005), Furukawa M (2005), Zhang DD (2004), Cullinan SB (2004), Kobayashi A (2004), Kobayashi A (2004), McMahon M (2006), Ichikawa T (2009), Lee DF (2009), Wong DP (2010), Wong DP (2010), Lau A (2010), Lau A (2010), Hur W (2010), Bennett EJ (2010), Yao JW (2012), Li Y (2012), Choo YY (2012), Kansanen E (2011), Kansanen E (2011), Niture SK (2013), Hast BE (2014), Cleasby A (2014), Kaspar JW (2012), Kaspar JW (2012), Su C (2015), Su C (2015), Huo L (2015), Dubiel D (2015), Lo SC (2006), Wu G (2017), Villeneuve NF (2013), Villeneuve NF (2013), Villeneuve NF (2013), Dong T (2016)	43
GAN	4	CUL3	17	affinity chromatography technology, affinity chromatography technology	Zhang DD (2005), Bennett EJ (2010)	2
CUL5	1	KLHL15	1	affinity chromatography technology	Bennett EJ (2010)	1
NUDCD3	0	KLHL9	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CUL3	17	KCTD2	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Kim EJ (2017), Kim EJ (2017), Huttlin EL (2017)	4
CUL3	17	BTBD2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	5
COMMD1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology	van de Sluis B (2009), van de Sluis B (2009)	2
KLHL3	1	KLHL12	4	two hybrid	Rolland T (2014)	1
COPS6	0	KLHL18	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
CUL1	7	COPS8	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Menon S (2008), Bennett EJ (2010), Enchev RI (2012), Reitsma JM (2017)	4
UBXN1	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS3	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Reitsma JM (2017)	4
GABARAPL2	0	KLHL5	0	two hybrid	Vinayagam A (2011)	1
COPS5	0	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Olma MH (2009), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Bhansali M (2014), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	13
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
ENC1	0	RBX1	2	affinity chromatography technology	Zhang DD (2005)	1
DCUN1D1	0	KLHL8	1	affinity chromatography technology	Bennett EJ (2010)	1
RHOA	0	CASP8	1	biochemical	Gajate C (2005)	1
KLHL22	3	NUDCD3	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS4	0	BTBD2	4	affinity chromatography technology	Olma MH (2009)	1
UBXN1	0	KLHL22	3	affinity chromatography technology	Alexandru G (2008)	1
COPS7B	0	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
DCUN1D3	1	CUL5	1	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	4
RFWD2	0	KLHL42	1	affinity chromatography technology	Olma MH (2009)	1
UBXN7	3	APP	1	pull down	Olah J (2011)	1
CUL3	17	ABTB2	2	pull down, affinity chromatography technology, affinity chromatography technology	Maezawa S (2008), Maezawa S (2008), Maezawa S (2008)	3
CUL3	17	KLHL23	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
KLHL13	0	COPS2	5	affinity chromatography technology	Sowa ME (2009)	1
CUL3	17	NFE2L2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Furukawa M (2005), Cullinan SB (2004), Cullinan SB (2004)	3
COPS6	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
KEAP1	0	PGAM5	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Lo SC (2006), Lo SC (2006), Lo SC (2008), Lo SC (2008), Niture SK (2013), Lu K (2017)	7
COPS2	5	COPS7B	0	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	7
COPS6	0	KLHL24	1	affinity chromatography technology	Sowa ME (2009)	1
CUL3	17	KCTD3	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
CUL3	17	KCTD6	2	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lange S (2012), Rolland T (2014), Smaldone G (2015), Ji AX (2016), Heride C (2016), Huttlin EL (2017)	7
CUL3	17	NUP50	0	affinity chromatography technology, biochemical	Bennett EJ (2010), Wan C (2015)	2
CUL3	17	KCTD9	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Bennett EJ (2010), Rolland T (2014), Ji AX (2016), Huttlin EL (2017)	4
COPS6	0	KLHL20	2	affinity chromatography technology	Sowa ME (2009)	1
COPS8	2	GPS1	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Stotland A (2012), Sharon M (2009), Sun Y (2002), Kristensen AR (2012), Lingaraju GM (2014), Lyapina S (2001), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	10
COPS6	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
KLHL20	2	IPP	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PDCD6	2	UBC	7	affinity chromatography technology	McGourty CA (2016)	1
WDR77	2	COPS4	0	biochemical	Kristensen AR (2012)	1
KBTBD7	3	KBTBD8	2	affinity chromatography technology	Huttlin EL (2017)	1
KLHL2	0	KLHL3	1	affinity chromatography technology	Huttlin EL (2017)	1
COPS8	2	WDR77	2	biochemical	Kristensen AR (2012)	1
UBXN1	0	BTBD2	4	affinity chromatography technology	Alexandru G (2008)	1
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
COPS5	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	4
GAN	4	ARHGEF12	2	affinity chromatography technology	Johnson-Kerner BL (2015)	1
IBTK	3	COPS4	0	affinity chromatography technology	Pisano A (2015)	1
FAF1	1	TNFAIP1	4	affinity chromatography technology	Raman M (2015)	1
UBC	7	ELOC	0	pull down	Zhang X (2017)	1
RFWD2	0	COPS2	5	biochemical, affinity chromatography technology	Yi C (2002), Olma MH (2009)	2
NEDD8	0	HSPA4	3	affinity chromatography technology	Bennett EJ (2010)	1
GPS1	1	RBX1	2	affinity chromatography technology	Lyapina S (2001)	1
UBXN7	3	RBX1	2	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Bandau S (2012)	2
UBC	7	KCTD10	1	affinity chromatography technology	Matsumoto M (2005)	1
UBE2M	0	COPS5	0	affinity chromatography technology	Huttlin EL (2017)	1
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
RBX1	2	DCUN1D3	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meyer-Schaller N (2009), Huang G (2014), Keuss MJ (2016), Keuss MJ (2016)	4
UBC	7	ACLY	3	pull down, affinity chromatography technology	Nathan JA (2013), Bish RA (2007)	2
HSP90AA1	7	NUDCD3	0	affinity chromatography technology	Gano JJ (2010)	1
DCUN1D1	0	COPS7A	0	affinity chromatography technology	Bennett EJ (2010)	1
KLHL20	2	RHOA	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SQSTM1	0	CUL1	7	affinity chromatography technology	Tanji K (2012)	1
UBE2M	0	COPS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
KLHL21	3	KLHL13	0	affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Maerki S (2009)	2
CAV1	0	VCP	6	affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Kirchner P (2013), Kirchner P (2013), Chen SF (2013), Chen SF (2013)	4
KLHL20	2	NUDCD3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	KLHL25	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yanagiya A (2012), Bennett EJ (2010), Huttlin EL (2017), Zhang C (2016)	4
BTBD2	4	COPS6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	5
KEAP1	0	RBM45	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bakkar N (2015), Bakkar N (2015)	3
DCUN1D5	0	CUL5	1	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	4
HSP90AA1	7	GAN	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Johnson-Kerner BL (2015)	2
WNK4	5	CUL3	17	affinity chromatography technology, affinity chromatography technology	Wakabayashi M (2013), Shibata S (2013)	2
HSPD1	0	APP	1	affinity chromatography technology, pull down	Kumar P (2007), Olah J (2011)	2
DCUN1D5	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bommelje CC (2013), Keuss MJ (2016), Keuss MJ (2016)	3
DCUN1D3	1	CUL1	7	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Meyer-Schaller N (2009), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Zhang S (2016), Zhang S (2016)	8
KEAP1	0	ENC1	0	affinity chromatography technology	Wang XJ (2009)	1
UBE2M	0	DCUN1D3	1	pull down, pull down, pull down	Monda JK (2013), Meyer-Schaller N (2009), Keuss MJ (2016)	3
NFE2L2	1	ENC1	0	affinity chromatography technology, pull down, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Seng S (2007), Seng S (2007), Seng S (2009), Seng S (2009), Seng S (2009), Seng S (2010), Seng S (2010)	7
CASP8	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin Z (2009), Jin Z (2009), Gonzalvez F (2012), Xu J (2015)	4
KEAP1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, pull down	Gjyshi O (2015), Su C (2015), Zhang X (2017)	3
RFWD2	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
HSP90AA1	7	KLHL15	1	affinity chromatography technology	Taipale M (2012)	1
USP21	2	RBM45	1	affinity chromatography technology	Sowa ME (2009)	1
COPS5	0	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Fang L (2008), Huang X (2005), Bennett EJ (2010), Kapelari B (2000), Oh W (2006), Olma MH (2009), Havugimana PC (2012), Christmann M (2013), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Scherer PC (2016), Huttlin EL (2017), Boldt K (2016)	15
CUL3	17	PWP2	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Wimuttisuk W (2014)	2
PEF1	0	NUDCD3	0	affinity chromatography technology	McGourty CA (2016)	1
CAND1	2	HSPD1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	KHSRP	5	affinity chromatography technology	Bennett EJ (2010)	1
VCP	6	UBXN7	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down	Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Raman M (2015), Li ZH (2017), Li ZH (2017)	9
COPS5	0	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Cayli S (2009), Cayli S (2009), Cayli S (2009), Cayli S (2009), Bennett EJ (2010)	5
KLHL13	0	AURKB	2	enzymatic study, affinity chromatography technology, pull down, enzymatic study	Maerki S (2009), Sumara I (2007), Sumara I (2007), Sumara I (2007)	4
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
CUL3	17	KCTD17	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Bennett EJ (2010), Ji AX (2016), Kasahara K (2014), Kasahara K (2014), Kasahara K (2014), Pinkas DM (2017)	6
CUL3	17	IBTK	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Pisano A (2015), Pisano A (2015), Pisano A (2015), Huttlin EL (2017)	5
UBC	7	AURKB	2	affinity chromatography technology	Huang G (2014)	1
CUL3	17	KCTD20	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
NUP50	0	KLHL7	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AURKB	2	HSPD1	0	affinity chromatography technology	Fogeron ML (2013)	1
CUL5	1	CUL1	7	affinity chromatography technology	Bennett EJ (2010)	1
HSP90AA1	7	RCBTB1	1	affinity chromatography technology	Taipale M (2012)	1
IBTK	3	UBC	7	affinity chromatography technology	Pisano A (2015)	1
RBX1	2	UBE2M	0	pull down, pull down, pull down, pull down, x-ray crystallography, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, enzymatic study, pull down	Okuda H (2001), Yoshida Y (2005), Choi YS (2010), Calabrese MF (2011), Calabrese MF (2011), Kim AY (2008), Scott DC (2014), Markson G (2009), Sufan RI (2006), Huang DT (2009), Morimoto M (2003), Ohki Y (2009), Ohki Y (2009), Wang X (2015)	14
UBE2M	0	COPS2	5	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
RFWD2	0	CUL1	7	affinity chromatography technology	Olma MH (2009)	1
DCUN1D4	0	CUL3	17	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study	Monda JK (2013), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	5
USP25	0	APP	1	affinity chromatography technology	Jung ES (2015)	1
DCUN1D1	0	COPS4	0	affinity chromatography technology	Bennett EJ (2010)	1
ELOC	0	COMMD1	1	pull down	Maine GN (2007)	1
UBE2M	0	CUL1	7	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Huang G (2011), Huang G (2011), Kim AY (2008), Ponyeam W (2012), Ohki Y (2009), Zhou W (2017), Mo Z (2016)	7
DVL2	5	TNFAIP1	4	affinity chromatography technology	Hein MY (2015)	1
COPS3	1	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL1	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
KATNA1	0	HSP90AA1	7	affinity chromatography technology	Yang SW (2013)	1
CUL3	17	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huang X (2016), Huttlin EL (2017)	5
COPS2	5	BTBD1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GLI2	4	SPOP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Zeng C (2014), Zhi X (2016), Zhi X (2016), Zhang P (2017)	4
SENP3	1	VCP	6	affinity chromatography technology	Wang M (2016)	1
KCTD13	1	TNFAIP1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Sowa ME (2009), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	5
COPS3	1	GPS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Min KW (2005), Enchev RI (2010), Stotland A (2012), Sharon M (2009), Kapelari B (2000), Tsuge T (2001), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	12
USP21	2	SENP3	1	enzymatic study	Loch CM (2012)	1
COPS7A	0	COPS2	5	affinity chromatography technology, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uhle S (2003), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
RFWD2	0	COPS4	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
CUL1	7	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Oshikawa K (2003), Bennett EJ (2010)	2
NEDD8	0	COPS3	1	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
KEAP1	0	KLHL3	1	two hybrid	Rolland T (2014)	1
KLHL2	0	WNK4	5	affinity chromatography technology, enzymatic study, unspecified method, x-ray crystallography	Takahashi D (2013), Takahashi D (2013), Schumacher FR (2014), Schumacher FR (2014)	4
CUL1	7	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Min KW (2005), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Reitsma JM (2017)	6
PDCD6	2	CUL3	17	affinity chromatography technology, pull down, pull down	McGourty CA (2016), McGourty CA (2016), McGourty CA (2016)	3
CUL3	17	MCM7	5	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Rutz N (2015)	2
GABARAPL1	0	KEAP1	0	affinity chromatography technology	Behrends C (2010)	1
KLHL12	4	PDCD6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	McGourty CA (2016), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016)	5
COPS5	0	KLHL18	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
CUL3	17	COPS4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	5
CUL3	17	KLHL18	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Moghe S (2012), Moghe S (2012), Huttlin EL (2017)	5
RHOBTB2	6	CUL3	17	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Wilkins A (2004), Wilkins A (2004), Wilkins A (2004), Bennett EJ (2010), Berthold J (2008), Berthold J (2008), Berthold J (2008)	7
RFWD2	0	COPS8	2	biochemical, affinity chromatography technology	Yi C (2002), Olma MH (2009)	2
HSP90AA1	7	KLHL26	2	affinity chromatography technology	Taipale M (2012)	1
KLHL7	5	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kigoshi Y (2011), Bennett EJ (2010), Huttlin EL (2017)	3
UBXN1	0	SQSTM1	0	affinity chromatography technology	Raman M (2015)	1
DCUN1D1	0	KLHL15	1	affinity chromatography technology	Bennett EJ (2010)	1
SENP3	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yan S (2010), Yan S (2010), Wang M (2016)	3
COPS6	0	KLHL12	4	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	KCTD10	1	affinity chromatography technology, genetic interference	Bennett EJ (2010), Horlbeck MA (2018)	2
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
GABARAPL1	0	DVL2	5	affinity chromatography technology, pull down	Zhang Y (2011), Zhang Y (2011)	2
RFWD2	0	COPS3	1	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
UBXN7	3	KCTD10	1	affinity chromatography technology	Raman M (2015)	1
SQSTM1	0	GABARAPL2	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Behrends C (2010), Vinayagam A (2011), Shvets E (2011), Kirkin V (2009), Kirkin V (2009), Maruyama Y (2014), Rolland T (2014), Yu H (2011)	9
TNFAIP1	4	RHOA	0	affinity chromatography technology, pull down, enzymatic study	Chen Y (2009), Chen Y (2009), Chen Y (2009)	3
KLHL28	1	IPP	2	affinity chromatography technology	Huttlin EL (2017)	1
CAND1	2	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chua YS (2011), Chua YS (2011), Tron AE (2012), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Liu J (2002), Huttlin EL (2017)	8
IBTK	3	COPS2	5	affinity chromatography technology	Pisano A (2015)	1
DCUN1D1	0	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
UBE2M	0	CUL5	1	enzymatic study	Duda DM (2008)	1
FAF1	1	KCTD13	1	affinity chromatography technology	Raman M (2015)	1
COPS3	1	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
DCUN1D1	0	KCTD10	1	affinity chromatography technology	Bennett EJ (2010)	1
KCTD11	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, pull down	Canettieri G (2010), Correale S (2011), Smaldone G (2015)	3
CUL3	17	LRRC42	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
ENC1	0	NUDCD3	0	affinity chromatography technology	Huttlin EL (2017)	1
FAF1	1	HSPA4	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Lee JJ (2012), Kim HJ (2005), Kim HJ (2005), Lee JJ (2013), Lee JJ (2013), Kristensen AR (2012)	6
COPS5	0	PGAM5	4	affinity chromatography technology	Bennett EJ (2010)	1
BTBD1	2	BTBD2	4	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	KCTD3	2	affinity chromatography technology	Sowa ME (2009)	1
DCUN1D1	0	KLHL9	1	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D4	0	CUL5	1	pull down, enzymatic study, affinity chromatography technology	Monda JK (2013), Monda JK (2013), Keuss MJ (2016)	3
COPS8	2	COPS7B	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	5
UBXN7	3	KBTBD2	1	affinity chromatography technology	Alexandru G (2008)	1
CUL3	17	KCTD7	0	affinity chromatography technology, affinity chromatography technology	Staropoli JF (2012), Bennett EJ (2010)	2
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
UBC	7	CCNE1	1	affinity chromatography technology	Huang G (2014)	1
CUL3	17	WDR77	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Wimuttisuk W (2014)	2
COPS5	0	MAT2A	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	KLHL24	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
NEDD8	0	HSPD1	0	affinity chromatography technology	Bennett EJ (2010)	1
USP21	2	GLI2	4	affinity chromatography technology	Heride C (2016)	1
HSP90AA1	7	KLHL22	3	affinity chromatography technology	Taipale M (2012)	1
CUL3	17	ANKRD39	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
KLHL3	1	RBX1	2	affinity chromatography technology	Ohta A (2013)	1
KLHL22	3	KLHL26	2	affinity chromatography technology	Huttlin EL (2017)	1
CAND1	2	KLHL12	4	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	DVL2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin X (2016), Jin X (2016), Jin X (2016)	3
KBTBD6	0	GABARAPL2	0	affinity chromatography technology, pull down	Genau HM (2015), Genau HM (2015)	2
DDIT3	1	KEAP1	0	biochemical	Huang X (2012)	1
DCUN1D1	0	CUL5	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
DCUN1D1	0	COPS5	0	affinity chromatography technology	Bennett EJ (2010)	1
TNFAIP1	4	KCTD10	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hu X (2012), Hu X (2012), Hu X (2012), Huttlin EL (2015), Huttlin EL (2017)	5
HSP90AA1	7	KLHL25	6	affinity chromatography technology	Taipale M (2012)	1
UBXN7	3	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
COPS6	0	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Enchev RI (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	11
KEAP1	0	SQSTM1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Jain A (2010), Jain A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Inami Y (2011), Fan W (2010), Copple IM (2010), Copple IM (2010), Wright T (2013), Tanji K (2013), Ichimura Y (2013), Ichimura Y (2013), Ichimura Y (2013), Hast BE (2014), Hast BE (2014), Lerner C (2013), Rolland T (2014), Gjyshi O (2015), Bakkar N (2015), Milan E (2015), Park S (2016), Ge W (2017), Mildenberger J (2017), Lu K (2017), Lee Y (2017)	30
KLHL13	0	USP25	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu D (2017)	2
KLHL13	0	KLHL22	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Maerki S (2009), Huttlin EL (2017)	3
KLHL7	5	RBX1	2	affinity chromatography technology	Kigoshi Y (2011)	1
CUL5	1	UBC	7	affinity chromatography technology, pull down	Bennett EJ (2010), Zhang X (2017)	2
UBXN7	3	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
CUL5	1	COPS2	5	affinity chromatography technology	Bennett EJ (2010)	1
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
KLHL13	0	NUDCD3	0	affinity chromatography technology	Sowa ME (2009)	1
SQSTM1	0	NOTCH1	25	affinity chromatography technology, affinity chromatography technology	Ahn JS (2016), Ahn JS (2016)	2
SQSTM1	0	CAV1	0	affinity chromatography technology, affinity chromatography technology	Liang X (2013), Luo X (2017)	2
DCUN1D5	0	CUL3	17	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Monda JK (2013), Bommelje CC (2013), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	7
IBTK	3	COPS3	1	affinity chromatography technology	Pisano A (2015)	1
GAN	4	KCTD5	0	affinity chromatography technology	Johnson-Kerner BL (2015)	1
DCUN1D1	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	WDR77	2	affinity chromatography technology	Matsumoto M (2005)	1
LRRC42	2	APP	1	pull down	Olah J (2011)	1
GAN	4	WDR77	2	affinity chromatography technology	Johnson-Kerner BL (2015)	1
PGAM5	4	RBX1	2	affinity chromatography technology	Lo SC (2006)	1
DAXX	5	SENP3	1	affinity chromatography technology	Hein MY (2015)	1
CUL3	17	ELOC	0	affinity chromatography technology, two hybrid	Bennett EJ (2010), Wang J (2011)	2
COPS6	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	6
CUL3	17	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Wimuttisuk W (2014), Maerki S (2009), Huttlin EL (2017)	6
CUL3	17	RHOA	0	affinity chromatography technology, affinity chromatography technology	Chen Y (2009), Dubiel D (2017)	2
DCUN1D1	0	KLHL26	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	KLHL36	11	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
UBC	7	KCTD7	0	pull down	Zhang X (2017)	1
CUL3	17	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Oshikawa K (2003), Bennett EJ (2010)	2
GABARAPL1	0	CUL3	17	affinity chromatography technology, pull down	Behrends C (2010), Genau HM (2015)	2
FAF1	1	KCTD10	1	affinity chromatography technology	Raman M (2015)	1
HSPA4	3	APP	1	affinity chromatography technology	Kumar P (2007)	1
KLHL13	0	COPS4	0	affinity chromatography technology	Sowa ME (2009)	1
HSP90AA1	7	ARMC5	3	affinity chromatography technology	Taipale M (2012)	1
COPS5	0	COPS9	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bennett EJ (2010), Ebina M (2013), Ebina M (2013), Rozen S (2015), Rozen S (2015)	5
COPS8	2	COPS5	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Sowa ME (2009), Fang L (2008), Bennett EJ (2010), Olma MH (2009), Asare Y (2013), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	9
KLHL12	4	DRD4	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rondou P (2010), Rondou P (2010), Rondou P (2008), Skieterska K (2015), Skieterska K (2016)	5
SQSTM1	0	CUL3	17	imaging technique, affinity chromatography technology	Lau A (2010), Mori Y (2015)	2
GPS1	1	COPS7A	0	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Wan C (2015), Hein MY (2015), Huang X (2016)	6
COPS4	0	ELOC	0	affinity chromatography technology	Olma MH (2009)	1
CAND1	2	UBE2M	0	pull down	Kim AY (2008)	1
CUL5	1	KHSRP	5	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	KCTD3	2	affinity chromatography technology	Bennett EJ (2010)	1
HSP90AA1	7	KBTBD7	3	affinity chromatography technology	Taipale M (2012)	1
DCUN1D1	0	CUL3	17	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Monda JK (2013), Wan C (2015), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Huttlin EL (2017)	19
COPS5	0	SHKBP1	4	affinity chromatography technology	Bennett EJ (2010)	1
MCM7	5	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
UBC	7	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
VCP	6	CUL5	1	affinity chromatography technology	Yu CC (2013)	1
COPS5	0	RHOBTB1	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	COPS3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Fang L (2008), Enchev RI (2010), Bennett EJ (2010), Oh W (2006), Olma MH (2009), Olma MH (2009), Asare Y (2013), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	13
CUL3	17	KHSRP	5	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Kung YA (2017)	2
PEF1	0	KLHL26	2	affinity chromatography technology	McGourty CA (2016)	1
COPS6	0	COPS7A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sharon M (2009), Bennett EJ (2010), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Olma MH (2009), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	15
KLHL12	4	PEF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Rolland T (2014), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016)	6
CUL3	17	KLHL24	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
UBXN1	0	RBX1	2	affinity chromatography technology	Hu Y (2017)	1
CAND1	2	KHSRP	5	affinity chromatography technology	Bennett EJ (2010)	1
KCTD13	1	KCTD10	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
BTBD1	2	FMOD	2	affinity chromatography technology	Wimuttisuk W (2014)	1
CUL3	17	COPS8	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Schumacher FR (2015)	2
UBC	7	KLHL13	0	pull down	Nathan JA (2013)	1
RBBP8	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016)	4
SQSTM1	0	HSPA4	3	pull down, affinity chromatography technology	Pridgeon JW (2004), Pridgeon JW (2004)	2
DCUN1D1	0	TNFAIP1	4	affinity chromatography technology	Bennett EJ (2010)	1
RFWD2	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Choi HH (2011), Choi HH (2011)	4
DCUN1D1	0	UBC	7	affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Huang G (2014), Huang G (2014)	3
DCUN1D4	0	RBX1	2	affinity chromatography technology	Keuss MJ (2016)	1
COPS8	2	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
WNK4	5	KLHL3	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wakabayashi M (2013), Wakabayashi M (2013), Shibata S (2013), Shibata S (2013), Takahashi D (2013), Mori Y (2013), Schumacher FR (2014), Schumacher FR (2014), Shibata S (2014), Shibata S (2014), Schumacher FR (2015), Yoshizaki Y (2015), Mori Y (2015), Wu G (2013)	14
GAN	4	HSPD1	0	affinity chromatography technology	Johnson-Kerner BL (2015)	1
SENP3	1	CUL3	17	affinity chromatography technology, affinity chromatography technology	Wang M (2016), Wang M (2016)	2
CUL3	17	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
VCP	6	COPS7A	0	affinity chromatography technology	Yu CC (2013)	1
CUL3	17	KBTBD4	4	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
COPS8	2	COPS6	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	10
CUL1	7	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Min KW (2005), Min KW (2005), Yang X (2002), Yang X (2002), Huang X (2005), Bennett EJ (2010), Scherer PC (2016), Scherer PC (2016), Reitsma JM (2017)	9
COPS5	0	KLHL15	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
COPS5	0	KLHL23	0	affinity chromatography technology	Bennett EJ (2010)	1
KLHL2	0	KEAP1	0	affinity chromatography technology, affinity chromatography technology	Mai A (2004), Huttlin EL (2017)	2
DCUN1D2	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Keuss MJ (2016), Keuss MJ (2016)	2
GPS1	1	COPS7B	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Stotland A (2012), Havugimana PC (2012), Huang X (2016), Huttlin EL (2017)	4
DCUN1D1	0	NEDD8	0	affinity chromatography technology	Bennett EJ (2010)	1
ACLY	3	KLHL25	6	affinity chromatography technology, affinity chromatography technology, pull down	Zhang C (2016), Zhang C (2016), Zhang C (2016)	3
COPS5	0	KBTBD6	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS4	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
GABARAPL2	0	APP	1	pull down	Olah J (2011)	1
DCUN1D1	0	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS4	0	KLHL18	2	affinity chromatography technology	Olma MH (2009)	1
COPS5	0	ABTB2	2	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	UBE2M	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li T (2006), Norman JA (2006), Huttlin EL (2017)	3
NOTCH1	25	CUL3	17	affinity chromatography technology, affinity chromatography technology	Ren K (2014), Ren K (2014)	2
COPS5	0	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Neuss H (2007), Fang L (2008), Orel L (2010), Uhle S (2003), Bennett EJ (2010), Luke-Glaser S (2007), Kapelari B (2000), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	17
CUL3	17	KLHL22	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Maerki S (2009), Huttlin EL (2017), Ferretti LP (2016)	6
CUL3	17	ANKFY1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Maekawa M (2017)	2
DCUN1D1	0	KLHL13	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	KLHL26	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
DCUN1D3	1	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Huang G (2014), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Zhang S (2016), Zhang S (2016)	6
GABARAPL1	0	KBTBD6	0	affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, x-ray crystallography	Behrends C (2010), Genau HM (2015), Genau HM (2015), Genau HM (2015), Genau HM (2015)	5
RBX1	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Norman JA (2006)	2
UBXN1	0	KBTBD7	3	affinity chromatography technology	Alexandru G (2008)	1
COPS6	0	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009)	5
COPS5	0	KLHL21	3	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	GPS1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Stotland A (2012), Sharon M (2009), Bennett EJ (2010), Lingaraju GM (2014), Huttlin EL (2015), Huttlin EL (2017)	7
CUL3	17	NUDCD3	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
CUL3	17	BTBD10	4	affinity chromatography technology, two hybrid, affinity chromatography technology	Bennett EJ (2010), Wang J (2011), Huttlin EL (2017)	3
FAF1	1	UBC	7	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Song EJ (2005), Lee JJ (2012), Song J (2009), Song J (2009), Song J (2009), Lee JJ (2013), Lee JJ (2013), Nathan JA (2013), Baron Y (2014), Alexandru G (2008), Lee JJ (2012)	11
COPS6	0	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
GABARAPL1	0	KBTBD7	3	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, unspecified method	Behrends C (2010), Rolland T (2014), Genau HM (2015), Genau HM (2015), Genau HM (2015)	5
FAF1	1	KBTBD7	3	affinity chromatography technology	Alexandru G (2008)	1
COPS4	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	3
COPS3	1	KLHL15	1	affinity chromatography technology	Huttlin EL (2015)	1
COPS6	0	ELOC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009)	3
AURKB	2	KLHL9	1	affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Maerki S (2009), Maerki S (2009), Maerki S (2009), Sumara I (2007), Sumara I (2007), Sumara I (2007)	6
CUL3	17	DRD4	3	affinity chromatography technology, affinity chromatography technology	Rondou P (2008), Skieterska K (2015)	2
DCUN1D2	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	5
RBM45	1	NFE2L2	1	affinity chromatography technology	Bakkar N (2015)	1
UBXN1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
COPS2	5	BTBD2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS7B	0	COPS7A	0	biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2017)	2
RHOBTB3	1	RBX1	2	affinity chromatography technology, pull down	Lu A (2013), Lu A (2013)	2
UBC	7	KLHL11	3	pull down	Nathan JA (2013)	1
KCTD3	2	SHKBP1	4	affinity chromatography technology	Huttlin EL (2017)	1
COPS4	0	KLHL42	1	affinity chromatography technology	Olma MH (2009)	1
CUL3	17	ARHGEF12	2	two hybrid, affinity chromatography technology, pull down	Lin MY (2011), Lin MY (2011), Lin MY (2011)	3
UBE2M	0	COPS4	0	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
UBXN7	3	KLHL13	0	affinity chromatography technology	Alexandru G (2008)	1
COPS6	0	KLHL22	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
COPS5	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Fang L (2008), Sharon M (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Choi HH (2011), Kristensen AR (2012), Birol M (2014), Birol M (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	18
DCUN1D1	0	UBE2M	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, unspecified method, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Scott DC (2011), Huang G (2014), Huang G (2014), Keuss MJ (2016), Huttlin EL (2017), Zhou H (2017), Zhou H (2017), Zhou H (2017)	13
HSP90AA1	7	KLHL36	11	affinity chromatography technology	Taipale M (2012)	1
UBE2M	0	KBTBD7	3	affinity chromatography technology	Huttlin EL (2017)	1
NOTCH1	25	GPS1	1	affinity chromatography technology	Yatim A (2012)	1
KLHL13	0	KLHL9	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sumara I (2007), Sumara I (2007), Maerki S (2009), Maerki S (2009)	5
CUL5	1	BTBD1	2	affinity chromatography technology	Bennett EJ (2010)	1
BTBD1	2	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
KLHL9	1	KLHL22	3	affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Huttlin EL (2017)	2
USP21	2	CUL3	17	affinity chromatography technology, affinity chromatography technology	Heride C (2016), Heride C (2016)	2
KBTBD7	3	RBX1	2	affinity chromatography technology	Genau HM (2015)	1
APP	1	KEAP1	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	KCTD13	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Bennett EJ (2010), Chen Y (2009), Rolland T (2014), Ibeawuchi SR (2015), Huttlin EL (2017), Pinkas DM (2017)	6
UBE2M	0	GPS1	1	affinity chromatography technology	Huttlin EL (2017)	1
DCUN1D2	0	CUL3	17	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016)	7
CUL5	1	RCBTB1	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	KLHL13	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Bennett EJ (2010)	3
RFWD2	0	COPS5	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
KEAP1	0	NFE2L2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, unspecified method, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cullinan SB (2003), Shibata T (2008), Wang XJ (2008), Nioi P (2007), Tanigawa S (2007), Tanigawa S (2007), Hong F (2005), Furukawa M (2005), Furukawa M (2005), Zhang DD (2003), McMahon M (2006), Ichikawa T (2009), Niture SK (2009), Niture SK (2009), Wu JH (2010), Wong DP (2010), Wong DP (2010), Yu M (2011), Lau A (2010), Lau A (2010), Kay HY (2010), Sun Z (2011), Sun Z (2011), Li X (2004), Li X (2004), Lo SC (2008), Plafker KS (2010), Plafker KS (2010), Yao JW (2012), Li Y (2012), Lo SC (2006), Lo SC (2006), Lo SC (2006), Eggler AL (2005), Zipper LM (2002), Sekhar KR (2002), Seng S (2009), Hast BE (2013), Hoerer S (2013), Baba K (2013), Wang J (2011), Ichimura Y (2013), Baird L (2013), Baird L (2013), Gorrini C (2013), Schaap M (2013), Jiang ZY (2014), Hast BE (2014), Hast BE (2014), Hast BE (2014), Qin S (2014), Buommino E (2012), Kaspar JW (2012), Kaspar JW (2012), Camp ND (2012), Zhang DD (2004), Furukawa M (2005), Khan H (2015), Huo L (2015), Foygel K (2015), Liu K (2015), Lo SC (2006), Kim WD (2012), Kim WD (2012), Kim WD (2012), Zhang Y (2016), Zhang Y (2016), Wu G (2017), Villeneuve NF (2013), Ma J (2012), Ma J (2012), Ma J (2012), Ge W (2017), Ge W (2017), Yoshizaki Y (2017), Yoshizaki Y (2017), Quinti L (2017), Wang Q (2017), Ha Kim K (2017), Yang C (2016), Mulvaney KM (2016), Lu K (2017)	82
SEC31A	7	PEF1	0	affinity chromatography technology, affinity chromatography technology, pull down	McGourty CA (2016), McGourty CA (2016), McGourty CA (2016)	3
COPS4	0	COPS7A	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Sharon M (2009), Luke-Glaser S (2007), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huang X (2016)	13
COPS6	0	KLHL8	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
NUDCD3	0	SF3B3	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
RHOBTB2	6	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, two hybrid	Manjarrez JR (2014), Prince TL (2015), Prince TL (2015)	3
COPS6	0	KLHL42	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
COPS3	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	5
GPS1	1	COPS4	0	affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical	Stotland A (2012), Tsuge T (2001), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Lingaraju GM (2014), Wan C (2015)	7
GAN	4	RBX1	2	affinity chromatography technology	Zhang DD (2005)	1
VCP	6	COPS3	1	affinity chromatography technology	Yu CC (2013)	1
USP21	2	KCTD6	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Heride C (2016), Heride C (2016), Heride C (2016)	3
COPS6	0	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huang X (2016), Huttlin EL (2017), Boldt K (2016)	9
CAND1	2	RBM45	1	affinity chromatography technology	Bennett EJ (2010)	1
UBXN1	0	FAF1	1	affinity chromatography technology	Raman M (2015)	1
NEDD8	0	KLHL22	3	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	RCBTB1	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Bennett EJ (2010), Plafker KS (2009), Plafker KS (2009), Plafker KS (2009)	4
KATNA1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, biochemical	Cummings CM (2009), Cummings CM (2009), Wan C (2015)	3
COPS2	5	COPS9	1	affinity chromatography technology	Rozen S (2015)	1
CCNE1	1	CUL3	17	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Singer JD (1999), Singer JD (1999), Singer JD (1999), Wimuttisuk W (2007), Jin X (2016), Jin X (2016), Jin X (2016)	7
CUL5	1	COMMD1	1	pull down, pull down	Mao X (2011), Mao X (2011)	2
SEC31A	7	UBC	7	affinity chromatography technology	McGourty CA (2016)	1
KLHL28	1	KLHL26	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2M	0	DCUN1D2	0	pull down, x-ray crystallography, affinity chromatography technology, pull down	Monda JK (2013), Monda JK (2013), Meyer-Schaller N (2009), Keuss MJ (2016)	4
DCUN1D1	0	DCUN1D2	0	affinity chromatography technology	Bennett EJ (2010)	1
UBE2M	0	KLHL24	1	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	KLHL12	4	affinity chromatography technology	Bennett EJ (2010)	1
DVL2	5	SQSTM1	0	affinity chromatography technology, imaging technique, affinity chromatography technology	Zhang Y (2011), Zhang Y (2011), Geng Y (2014)	3
UBE2M	0	KCTD6	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2M	0	DCUN1D4	0	pull down, pull down	Monda JK (2013), Keuss MJ (2016)	2
ABTB2	2	RBX1	2	affinity chromatography technology	Maezawa S (2008)	1
RBBP8	1	UBC	7	far western blotting, affinity chromatography technology	Murina O (2014), Unno J (2014)	2
CUL5	1	COPS3	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
HSP90AA1	7	RHOBTB1	0	affinity chromatography technology	Taipale M (2012)	1
DCUN1D1	0	KLHL12	4	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	KLHL42	1	affinity chromatography technology	Bennett EJ (2010)	1
ENC1	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Lee H (2015), Lee H (2015)	2
USP25	0	KLHL9	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu D (2017)	2
UBC	7	UBXN7	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Kelsall IR (2013), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
COPS3	1	ELOC	0	affinity chromatography technology	Olma MH (2009)	1
RHOBTB1	0	CUL5	1	two hybrid	Berthold J (2008)	1
ENC1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang DD (2005), Bennett EJ (2010), Huttlin EL (2017)	3
NEDD8	0	GPS1	1	affinity chromatography technology	Bennett EJ (2010)	1
HSP90AA1	7	ENC1	0	affinity chromatography technology	Taipale M (2012)	1
RHOBTB1	0	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2M	0	DCUN1D5	0	pull down, affinity chromatography technology, pull down, pull down	Monda JK (2013), Bommelje CC (2013), Monda JK (2013), Keuss MJ (2016)	4
IBTK	3	CAND1	2	affinity chromatography technology	Pisano A (2015)	1
TNFAIP1	4	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Hu X (2012), Bennett EJ (2010), Chen Y (2009), Rolland T (2014), Huttlin EL (2017)	5
UBC	7	KHSRP	5	affinity chromatography technology	Bish RA (2007)	1
UBE2M	0	COPS7A	0	affinity chromatography technology	Huttlin EL (2017)	1
USP21	2	KCTD11	0	affinity chromatography technology	Heride C (2016)	1
CUL3	17	RHOBTB3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Berthold J (2008), Berthold J (2008), Lu A (2013), Lu A (2013), Lu A (2013), Huttlin EL (2017)	7
VCP	6	UBXN1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), McNeill H (2004), LaLonde DP (2011), LaLonde DP (2011), LaLonde DP (2011), LaLonde DP (2011), Rolland T (2014), McNeill H (2004), Raman M (2015), Park ES (2017)	11
RHOBTB3	1	HSP90AA1	7	affinity chromatography technology	Zhang CS (2015)	1
COPS5	0	KCTD3	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	DNTT	1	affinity chromatography technology, affinity chromatography technology	Maezawa S (2008), Maezawa S (2008)	2
DDIT3	1	COPS8	2	affinity chromatography technology, biochemical	Huang X (2012), Huang X (2012)	2
CUL3	17	KLHL28	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
CUL3	17	ACBD3	1	affinity chromatography technology, biochemical	Bennett EJ (2010), Kristensen AR (2012)	2
APP	1	KATNA1	0	pull down	Virok DP (2011)	1
CAND1	2	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Kim AY (2008), Zheng J (2002), Zheng J (2002), Liu J (2002), Liu J (2002)	7
COPS5	0	HSPA4	3	affinity chromatography technology	Bennett EJ (2010)	1
CUL5	1	RBX1	2	x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Duda DM (2008), Ohta T (1999), Furukawa M (2002), Tron AE (2012), Tron AE (2012), Yu Y (2004), Huang DT (2009), Wang X (2015), Wang X (2015), Wang X (2015)	10
CUL5	1	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	CUL3	17	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wimuttisuk W (2007), Wimuttisuk W (2007), Bennett EJ (2010), Choo YY (2012), Choo YY (2012), Schenkova K (2012), Ibeawuchi SR (2015), Schumacher FR (2015), Chew EH (2007)	9
NUP50	0	SPOP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD8	0	KLHL9	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	KLHL15	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Oberg EA (2012), Huttlin EL (2017), Ferretti LP (2016)	4
KCTD3	2	USP21	2	affinity chromatography technology	Boldt K (2016)	1
COPS7A	0	DDIT3	1	affinity chromatography technology	Huang X (2012)	1
KLHL21	3	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Maerki S (2009), Bennett EJ (2010), Mei ZZ (2016), Huttlin EL (2017)	5
DNTT	1	ABTB2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Maezawa S (2008), Maezawa S (2008), Maezawa S (2008), Maezawa S (2008), Maezawa S (2008), Maezawa S (2008)	6
NOTCH1	25	CAND1	2	affinity chromatography technology	Yatim A (2012)	1
COPS3	1	KLHL18	2	affinity chromatography technology	Olma MH (2009)	1
COPS6	0	KLHL15	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
CUL3	17	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Oshikawa K (2003), Bennett EJ (2010)	2
UBXN1	0	UBXN7	3	affinity chromatography technology	Raman M (2015)	1
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
RCBTB1	1	APP	1	pull down	Olah J (2011)	1
DDIT3	1	COPS3	1	biochemical	Huang X (2012)	1
NEDD8	0	COPS9	1	affinity chromatography technology	Bennett EJ (2010)	1
KLHL12	4	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Rondou P (2008), Rondou P (2008), Angers S (2006), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Rolland T (2014), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016)	10
UBXN1	0	KLHL12	4	affinity chromatography technology	Alexandru G (2008)	1
DCUN1D1	0	ELOC	0	affinity chromatography technology	Bennett EJ (2010)	1
SPOP	1	NUDCD3	0	two hybrid	Zhang P (2017)	1
CUL5	1	COPS7A	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Olma MH (2009)	2
GAN	4	NUDCD3	0	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	CAV1	0	affinity chromatography technology	Ji Y (2007)	1
COPS3	1	BTBD2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	3
HSP90AA1	7	AURKB	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012), Fogeron ML (2013), Huttlin EL (2015), Huttlin EL (2017)	5
KLHL28	1	KLHL13	0	affinity chromatography technology	Huttlin EL (2017)	1
DCUN1D1	0	KLHL42	1	affinity chromatography technology	Bennett EJ (2010)	1
NOTCH1	25	APP	1	genetic interference, affinity chromatography technology	Kim SY (2007), Kim SY (2007)	2
ANKRD39	0	APP	1	pull down	Olah J (2011)	1
CCNE1	1	RHOBTB3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lu A (2013), Lu A (2013), Lu A (2013)	3
CUL3	17	COPS9	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Ebina M (2013)	2
KLHL28	1	NUDCD3	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	ACLY	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Bennett EJ (2010), Zhang C (2016), Zhang C (2016), Zhang C (2016), Zhang C (2016)	5
UBXN7	3	TNFAIP1	4	affinity chromatography technology	Raman M (2015)	1
RHOA	0	ARHGEF12	2	pull down, affinity chromatography technology, affinity chromatography technology	Reuther GW (2001), Yang Y (2013), Huttlin EL (2017)	3
APP	1	CAV1	0	biochemical, unspecified method	Ikezu T (1998), Ikezu T (1998)	2
SQSTM1	0	NFE2L2	1	imaging technique	Lau A (2010)	1
COPS7A	0	BTBD1	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
COPS5	0	KHSRP	5	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huang X (2005), Bennett EJ (2010), Kapelari B (2000), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	11
KLHL20	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Lee YR (2010), Bennett EJ (2010), Yuan WC (2014), Chen HY (2015), Chen HY (2015), Huttlin EL (2017)	6
COPS3	1	COPS7A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2005), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huang X (2016), Huttlin EL (2017)	10
CUL1	7	HSPD1	0	affinity chromatography technology	Oshikawa K (2003)	1
DDIT3	1	SPOP	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Zhang P (2014), Zhang P (2014)	3
DCUN1D4	0	CAND1	2	affinity chromatography technology, pull down	Keuss MJ (2016), Keuss MJ (2016)	2
NEDD8	0	SHKBP1	4	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	KLHL12	4	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), McGourty CA (2016)	2
AURKB	2	APP	1	pull down	Olah J (2011)	1
KBTBD7	3	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Bennett EJ (2010), Genau HM (2015), Genau HM (2015), Huttlin EL (2017)	5
VCP	6	COMMD1	1	affinity chromatography technology	Yu CC (2013)	1
KLHL42	1	KATNA1	0	affinity chromatography technology	Cummings CM (2009)	1
DCUN1D1	0	KLHL22	3	affinity chromatography technology	Bennett EJ (2010)	1
UBE2M	0	BTBD1	2	affinity chromatography technology	Huttlin EL (2017)	1
RAB18	1	CUL3	17	affinity chromatography technology, affinity chromatography technology	Dubiel D (2017), Dubiel D (2017)	2
NEDD8	0	KCTD10	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	KBTBD4	4	affinity chromatography technology	Bennett EJ (2010)	1
GABARAPL2	0	KEAP1	0	affinity chromatography technology	Behrends C (2010)	1
GABARAPL1	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
UBXN7	3	NEDD8	0	affinity chromatography technology, affinity chromatography technology, pull down	Bandau S (2012), Besten Wd (2012), Kelsall IR (2013)	3
CUL3	17	KBTBD2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Zhang Z (2016), Huttlin EL (2017)	3
UBXN7	3	KLHL22	3	affinity chromatography technology	Alexandru G (2008)	1
CUL3	17	KLHL2	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Bennett EJ (2010), Takahashi D (2013), Rolland T (2014), Huttlin EL (2017)	4
COPS7A	0	KLHL13	0	affinity chromatography technology	Hein MY (2015)	1
CASP8	1	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
NFE2L2	1	UBC	7	affinity chromatography technology	Su C (2015)	1
CUL1	7	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Menon S (2008), Chew EH (2007), Min KW (2005), Min KW (2005), Min KW (2005), Hwang JW (2003), Hwang JW (2003), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012), Zheng J (2002), Zheng J (2002), Bornstein G (2006), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), He YJ (2006), Emberley ED (2012), Choo YY (2011), Jonason JH (2007), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Liu J (2002), Liu J (2002), Korzeniewski N (2012), Pierce NW (2013), Kim AY (2008), Zhang S (2016), Tikhmyanova N (2017), Tikhmyanova N (2017), Reitsma JM (2017), Reitsma JM (2017)	41
DCUN1D2	0	APP	1	pull down	Olah J (2011)	1
NUDCD3	0	KBTBD6	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
DCUN1D1	0	RBX1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Kim AY (2008), Bommelje CC (2013), Meyer-Schaller N (2009), Huang G (2014), Huang G (2014), Keuss MJ (2016), Keuss MJ (2016)	9
CAND1	2	ACLY	3	affinity chromatography technology	Bennett EJ (2010)	1
KLHL3	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Ohta A (2013), Ohta A (2013), Wakabayashi M (2013), Ji AX (2013), Shibata S (2013), Shibata S (2013), Takahashi D (2013), McCormick JA (2014), Rolland T (2014), Ibeawuchi SR (2015), Schumacher FR (2015), Schumacher FR (2015), Wu G (2013)	13
CUL5	1	COPS8	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS3	1	KLHL42	1	affinity chromatography technology	Olma MH (2009)	1
CUL3	17	GMCL1	0	affinity chromatography technology, two hybrid	Bennett EJ (2010), Rolland T (2014)	2
NEDD8	0	KLHL12	4	affinity chromatography technology	Bennett EJ (2010)	1
COMMD1	1	CUL1	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Mao X (2011), Mao X (2011), Mao X (2011), Malek E (2017)	4
DCUN1D1	0	KLHL18	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	RHOBTB1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	3
COPS5	0	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
COPS3	1	COPS9	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology	Huttlin EL (2015), Rozen S (2015), Rozen S (2015), Rozen S (2015), Rozen S (2015), Huttlin EL (2017)	6
CUL3	17	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Chua YS (2011), Chua YS (2011), Tron AE (2012), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Schumacher FR (2015), Schumacher FR (2015), Lo SC (2006), Lo SC (2006)	12
COPS5	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
SQSTM1	0	GABARAPL1	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, two hybrid	Rual JF (2005), Behrends C (2010), Wild P (2011), Kirkin V (2009), Zhang Y (2011), Zhang Y (2011), Rolland T (2014)	7
CUL1	7	PWP2	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	COPS7B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huang X (2016), Reitsma JM (2017)	3
UBXN7	3	KCTD13	1	affinity chromatography technology	Raman M (2015)	1
SPOP	1	CUL3	17	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li C (2011), Cummings CM (2009), Choo YY (2011), Choo YY (2012), Plafker KS (2009), Kwon JE (2006), Kwon JE (2006), Wang J (2011), Wimuttisuk W (2014), Theurillat JP (2014), Sakaue T (2017)	11
COPS5	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
UBXN7	3	ELOC	0	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Bandau S (2012)	2
COPS5	0	KLHL26	2	affinity chromatography technology	Bennett EJ (2010)	1
HSP90AA1	7	KLHL13	0	affinity chromatography technology	Taipale M (2012)	1
NACC1	9	CUL3	17	affinity chromatography technology, affinity chromatography technology	Shen H (2007), Shen H (2007)	2
COPS8	2	COPS4	0	biochemical, affinity chromatography technology, biochemical, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wei N (1998), Olma MH (2009), Havugimana PC (2012), Kotiguda GG (2012), Kotiguda GG (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	9
KLHL12	4	CUL1	7	affinity chromatography technology	McGourty CA (2016)	1
NEDD8	0	KBTBD7	3	affinity chromatography technology	Bennett EJ (2010)	1
UBE2M	0	KCTD3	2	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	KCTD10	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Huttlin EL (2017), Ren K (2014), Pinkas DM (2017), Dubiel D (2017)	6
UBXN1	0	SHKBP1	4	affinity chromatography technology	Huttlin EL (2015)	1
COPS5	0	APP	1	pull down, affinity chromatography technology	Olah J (2011), Wang H (2013)	2
USP21	2	UBC	7	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study	Bremm A (2010), Faesen AC (2011), Ye Y (2011), Urbe S (2012), Loch CM (2012), Ernst A (2013), Ye Y (2011), Wauer T (2015), Leung I (2016), Michel MA (2017)	10
UBXN1	0	KCTD10	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
RFWD2	0	SPOP	1	affinity chromatography technology	Huttlin EL (2017)	1
IBTK	3	RBX1	2	affinity chromatography technology	Pisano A (2015)	1
RFWD2	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Wertz IE (2004), Olma MH (2009)	2
COPS9	1	GPS1	1	affinity chromatography technology, biochemical	Rozen S (2015), Rozen S (2015)	2
KCTD5	0	CUL3	17	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down	Bayon Y (2008), Bayon Y (2008), Bennett EJ (2010), Balasco N (2014), Ji AX (2016), Pinkas DM (2017)	6
DCUN1D1	0	SHKBP1	4	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	SEC31A	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), McGourty CA (2016), McGourty CA (2016)	3
COPS6	0	KCTD7	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	KLHL9	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2