PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FOXN1	3	CUX1	7	affinity chromatography technology	Li X (2015)	1
TP53	0	SMARCB1	1	pull down, affinity chromatography technology, pull down, biochemical	Lee D (2002), Lee D (2002), Lee D (2002), Lee D (2002)	4
SMARCB1	1	SMARCC2	9	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Wang W (1996), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Medjkane S (2004), Mak AB (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	9
RPA2	0	SMARCC2	9	affinity chromatography technology	Marechal A (2014)	1
FOXN1	3	SATB2	18	affinity chromatography technology	Li X (2015)	1
FOXN1	3	SATB1	1	affinity chromatography technology	Li X (2015)	1
RPA2	0	TXNDC5	5	biochemical	Wan C (2015)	1
CUX1	7	SATB1	1	pull down, affinity chromatography technology	Liu J (1999), Liu J (1999)	2
TP53	0	RPA2	0	affinity chromatography technology	Li X (2015)	1
FOXN1	3	KTN1	1	affinity chromatography technology	Li X (2015)	1
TP53	0	YY1	7	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Groenroos E (2004), Groenroos E (2004), Sui G (2004), Sui G (2004), Sui G (2004), Wu S (2007), Wan M (2012), Kotlyar M (2015)	8
SMARCE1	1	ACTL6A	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Zhao K (1998), Kaeser MD (2008), Mak AB (2010), Havugimana PC (2012)	4
FOXN1	3	TXNDC5	5	affinity chromatography technology	Li X (2015)	1
SMARCC2	9	ACTL6A	4	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Mak AB (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	4
FOXN1	3	SMARCC2	9	affinity chromatography technology	Li X (2015)	1
FOXN1	3	RPA2	0	affinity chromatography technology	Li X (2015)	1
TFCP2	1	UBP1	2	two hybrid, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2017)	2
FOXN1	3	LACTB	0	affinity chromatography technology	Li X (2015)	1
SIM2	2	ARNT	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down	Probst MR (1997), Ooe N (2004), Probst MR (1997), Woods SL (2002), Moffett P (1997), Moffett P (1997), Moffett P (1997), Sullivan AE (2016), Sullivan AE (2016), Sullivan AE (2016), Sullivan AE (2016)	11
FOXN1	3	TFCP2	1	affinity chromatography technology	Li X (2015)	1
FOXN1	3	YY1	7	affinity chromatography technology	Li X (2015)	1
FOXN1	3	SMARCB1	1	affinity chromatography technology	Li X (2015)	1
FOXN1	3	TP53	0	affinity chromatography technology	Li X (2015)	1
TP53	0	ACTL6A	4	affinity chromatography technology, affinity chromatography technology	Wang M (2007), Wang M (2007)	2
YY1	7	TFCP2	1	affinity chromatography technology, pull down	Coull JJ (2000), Coull JJ (2000)	2
SMARCE1	1	SMARCC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhao K (1998), Hu K (2006), Lai D (2009), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Chen J (2005), Mak AB (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	13
TP53	0	ARNT	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FOXN1	3	SMARCE1	1	affinity chromatography technology	Li X (2015)	1
FOXN1	3	NFIX	8	affinity chromatography technology	Li X (2015)	1
YY1	7	ACTL6A	4	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Wu S (2007), Wu S (2007), Wu S (2007), Cai Y (2007), Hauri S (2016)	5
FOXN1	3	VARS	5	affinity chromatography technology	Li X (2015)	1
FOXN1	3	TBP	0	affinity chromatography technology	Li X (2015)	1
TBP	0	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Seto E (1992), Cvekl A (1999), Wu Y (2001), Qadri I (2002), Qadri I (2002), Sommer MH (1994)	6
SMARCB1	1	SMARCE1	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Wang W (1996), Zhao K (1998), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Chen J (2005), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	12
FOXN1	3	SIM2	2	affinity chromatography technology	Li X (2015)	1
SMARCB1	1	ACTL6A	4	biochemical, biochemical	Wang W (1996), Wan C (2015)	2
FOXN1	3	HOXD13	0	affinity chromatography technology	Li X (2015)	1
FOXN1	3	HOXC13	0	affinity chromatography technology	Li X (2015)	1
FOXN1	3	ARNT	1	affinity chromatography technology	Li X (2015)	1
FOXN1	3	TTF2	4	affinity chromatography technology	Li X (2015)	1
FOXN1	3	ACTL6A	4	affinity chromatography technology	Li X (2015)	1
FOXN1	3	UBP1	2	affinity chromatography technology	Li X (2015)	1
FOXN1	3	NR2F6	1	affinity chromatography technology	Li X (2015)	1