PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SMAD1	0	SKIL	3	affinity chromatography technology	Mizuide M (2003)	1
XPO1	8	CNTROB	6	affinity chromatography technology	Kirli K (2015)	1
DKK3	3	TTF2	4	affinity chromatography technology	Huttlin EL (2017)	1
CDKL3	1	TTF2	4	two hybrid	Wang J (2011)	1
UBC	7	PPP6R1	4	affinity chromatography technology	Matsumoto M (2005)	1
PCM1	5	TTF2	4	bioid	Gupta GD (2015)	1
NINL	1	TTF2	4	bioid	Gupta GD (2015)	1
CEP162	3	TTF2	4	bioid	Gupta GD (2015)	1
CETN2	0	TTF2	4	bioid	Gupta GD (2015)	1
TTF2	4	MYBL2	2	two hybrid	Leonard D (2003)	1
CNTROB	6	TTF2	4	bioid	Gupta GD (2015)	1
PSMC4	6	TTF2	4	affinity chromatography technology	Huttlin EL (2017)	1
TTF2	4	PDCD6IP	3	two hybrid	Leonard D (2003)	1
TTF2	4	TOP3A	0	biochemical	Wan C (2015)	1
TTF2	4	PRDX4	0	two hybrid	Leonard D (2003)	1
CEP120	5	CNTROB	6	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP152	2	TNIP1	1	bioid	Gupta GD (2015)	1
CEP128	1	NINL	1	bioid	Gupta GD (2015)	1
SMAD1	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
PCM1	5	CEP120	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	CEP120	5	bioid	Gupta GD (2015)	1
XPO1	8	PPP6R1	4	affinity chromatography technology	Kirli K (2015)	1
SMAD7	1	TTF2	4	two hybrid	Colland F (2004)	1
CEP120	5	CEP152	2	bioid	Gupta GD (2015)	1
CNTROB	6	PDCD6IP	3	affinity chromatography technology	Hein MY (2015)	1
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
XPO1	8	DCP1A	1	affinity chromatography technology	Kirli K (2015)	1
HAVCR2	0	TTF2	4	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	TNIP1	1	affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down	Wagner S (2008), Wagner S (2008), Fenner BJ (2009), Verhelst K (2012), Zhang X (2017), Kliza K (2017)	6
PCM1	5	TNIP1	1	bioid	Gupta GD (2015)	1
NIN	4	PCM1	5	bioid	Gupta GD (2015)	1
XPO1	8	SMAD1	0	affinity chromatography technology	Kirli K (2015)	1
FOXL2	1	TTF2	4	affinity chromatography technology	Li X (2015)	1
TTF2	4	CDC5L	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonard D (2003), Leonard D (2003), Leonard D (2003), Lleres D (2010)	4
DKK3	3	PCM1	5	affinity chromatography technology	Huttlin EL (2017)	1
CETN1	0	TTF2	4	affinity chromatography technology	Huttlin EL (2017)	1
CEP128	1	TTF2	4	bioid	Gupta GD (2015)	1
XPO1	8	TTF2	4	affinity chromatography technology	Kirli K (2015)	1
HDAC11	0	CLPB	3	affinity chromatography technology	Joshi P (2013)	1
CETN1	0	CETN2	0	affinity chromatography technology	Huttlin EL (2017)	1
CEP128	1	CEP162	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PPP6R1	4	TTF2	4	bioid	Couzens AL (2013)	1
NIN	4	TTF2	4	bioid	Gupta GD (2015)	1
CEP128	1	CNTROB	6	bioid	Gupta GD (2015)	1
HDAC7	4	TTF2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NIN	4	DCTN1	6	bioid	Gupta GD (2015)	1
SMAD1	0	TTF2	4	two hybrid	Colland F (2004)	1
SKIL	3	TTF2	4	two hybrid	Colland F (2004)	1
NINL	1	CEP162	3	bioid	Gupta GD (2015)	1
CEP162	3	CEP120	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
CNTRL	5	TTF2	4	bioid	Gupta GD (2015)	1
FAM131B	0	TTF2	4	affinity chromatography technology	Huttlin EL (2017)	1
TTF2	4	NVL	5	two hybrid	Leonard D (2003)	1
CEP152	2	CEP128	1	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
UBC	7	TTF2	4	pull down	Zhang X (2017)	1
RPGR	0	TTF2	4	bioid	Gupta GD (2015)	1
ACAT1	1	TTF2	4	biochemical	Havugimana PC (2012)	1
RAB2B	0	TTF2	4	affinity chromatography technology	Huttlin EL (2017)	1
SKAP1	0	TTF2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CNTRL	5	NIN	4	bioid	Gupta GD (2015)	1
SIRT3	1	TTF2	4	affinity chromatography technology	Law IK (2009)	1
CEP162	3	TOP3A	0	affinity chromatography technology	Gupta GD (2015)	1
NINL	1	PCM1	5	bioid	Gupta GD (2015)	1
NINL	1	TNIP1	1	bioid	Gupta GD (2015)	1
CNTRL	5	PCM1	5	bioid	Gupta GD (2015)	1
NINL	1	DCTN1	6	affinity chromatography technology	Boldt K (2016)	1
CREB1	1	TTF2	4	affinity chromatography technology	Li X (2015)	1
RABL2A	0	TTF2	4	affinity chromatography technology	Huttlin EL (2015)	1
CNTRL	5	CEP152	2	bioid	Gupta GD (2015)	1
TTF2	4	DCP1A	1	two hybrid	Leonard D (2003)	1
HDAC11	0	TTF2	4	affinity chromatography technology	Joshi P (2013)	1
TTF2	4	TNIP1	1	two hybrid	Leonard D (2003)	1
DCTN1	6	TTF2	4	bioid	Gupta GD (2015)	1
IQCF1	0	TTF2	4	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	PRDX4	0	pull down	Zhang X (2017)	1
COMMD1	1	TTF2	4	affinity chromatography technology	Huttlin EL (2017)	1
PEX19	2	TTF2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP152	2	PCM1	5	bioid	Gupta GD (2015)	1
TTF2	4	ZSCAN1	2	two hybrid	Ravasi T (2010)	1
TTF2	4	DRAP1	2	two hybrid	Leonard D (2003)	1
IQCF1	0	PEX19	2	affinity chromatography technology	Huttlin EL (2015)	1
CDC5L	2	ZSCAN1	2	two hybrid	Ravasi T (2010)	1
CEP128	1	CNTRL	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
HDAC11	0	PPP6R1	4	affinity chromatography technology	Joshi P (2013)	1
IL17RA	3	TTF2	4	affinity chromatography technology	Huttlin EL (2017)	1
TFAP4	3	TTF2	4	affinity chromatography technology	Ku WC (2009)	1
TTF2	4	TACC3	1	two hybrid	Leonard D (2003)	1
FOXP1	23	TTF2	4	affinity chromatography technology	Li X (2015)	1
CEP120	5	TTF2	4	bioid	Gupta GD (2015)	1
CEP152	2	TTF2	4	bioid	Gupta GD (2015)	1
UBC	7	PSMC4	6	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
XPO1	8	CLPB	3	affinity chromatography technology	Kirli K (2015)	1
TTF2	4	CLPB	3	two hybrid, affinity chromatography technology	Leonard D (2003), Huttlin EL (2015)	2
XPO1	8	PEX19	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	TNIP1	1	affinity chromatography technology	Kirli K (2015)	1
CEP128	1	NIN	4	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CDC5L	2	PSMC4	6	affinity chromatography technology	Lleres D (2010)	1
PCM1	5	CEP162	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
SMAD1	0	UBC	7	two hybrid	Guo X (2001)	1
UBC	7	PDCD6IP	3	pull down	Zhang X (2017)	1
HINFP	0	TTF2	4	two hybrid	Miele A (2007)	1
FOXN1	3	TTF2	4	affinity chromatography technology	Li X (2015)	1
IL17RA	3	CBWD1	1	affinity chromatography technology	Huttlin EL (2017)	1
CBWD1	1	TTF2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CNTRL	5	CEP162	3	bioid	Gupta GD (2015)	1