PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CASR	2	CASR	2	pull down	Bai M (1998)	1
CASR	2	STAMBP	2	two hybrid, affinity chromatography technology	Herrera-Vigenor F (2006), Herrera-Vigenor F (2006)	2
VCP	6	RNF19A	3	affinity chromatography technology, affinity chromatography technology, pull down	Huang Y (2006), Ishigaki S (2004), Ishigaki S (2004)	3
OS9	4	VCP	6	affinity chromatography technology	Tyler RE (2012)	1
PRKCA	7	CASR	2	enzymatic study	Bai M (1998)	1
PRKCA	7	PRKCG	3	affinity chromatography technology	Huttlin EL (2017)	1
OS9	4	CASR	2	affinity chromatography technology, affinity chromatography technology	Ward BK (2018), Ward BK (2018)	2
FLNA	10	CASR	2	two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Hjaelm G (2001), Hjaelm G (2001), Awata H (2001), Awata H (2001), Awata H (2001)	5
VCP	6	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dai RM (1998), Dai RM (1998), Gao Y (2000), Hotta K (2013), Yu CC (2013), Li JM (2013), Li JM (2013), Schweitzer K (2016)	8
PRKCA	7	NFKBIA	0	enzymatic study	Taylor JA (1999)	1
CASR	2	CHD8	44	affinity chromatography technology	Nishiyama M (2009)	1
PRKCA	7	PRKCB	4	affinity chromatography technology	Huttlin EL (2017)	1
HIF1A	1	OS9	4	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Baek JH (2005), Baek JH (2005), Baek JH (2005), Yanagisawa K (2010)	4
PRKCG	3	CASR	2	enzymatic study	Bai M (1998)	1
VCP	6	CASR	2	affinity chromatography technology	Huang Y (2006)	1
CASR	2	HIF1A	1	affinity chromatography technology, affinity chromatography technology	Shin DH (2009), Shin DH (2009)	2
CASR	2	NFKBIA	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Shin DH (2009), Shin DH (2009), Shin DH (2009)	3
CASR	2	RNF19A	3	affinity chromatography technology	Huang Y (2006)	1
PRKCB	4	CASR	2	enzymatic study	Bai M (1998)	1
VCP	6	HIF1A	1	affinity chromatography technology	Alexandru G (2008)	1