PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SPINK7	0	FTL	0	two hybrid	Cui Y (2003)	1
SPINK7	0	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
SPINK7	0	ZER1	5	affinity chromatography technology	Huttlin EL (2017)	1
SPINK7	0	GID8	1	affinity chromatography technology	Huttlin EL (2017)	1
SPINK7	0	ARMC8	1	affinity chromatography technology	Huttlin EL (2017)	1
SPINK7	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
SPINK7	0	RABL6	3	two hybrid, two hybrid	Cui YP (2003), Cui Y (2003)	2
SPINK7	0	MT1H	0	two hybrid, two hybrid	Cui YP (2003), Cui Y (2003)	2
GID8	1	ARMC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Boldt K (2016), Lampert F (2018), Lampert F (2018)	3
SPINK7	0	MT2A	0	two hybrid, two hybrid, pull down, affinity chromatography technology	Cui YP (2003), Cui Y (2003), Cui Y (2003), Cui Y (2003)	4
SPINK7	0	EPB42	3	two hybrid, two hybrid	Cui YP (2003), Cui Y (2003)	2
SPINK7	0	MRPS12	0	two hybrid, two hybrid	Cui YP (2003), Cui Y (2003)	2
SPINK7	0	LYPD1	0	affinity chromatography technology	Huttlin EL (2017)	1
SPINK7	0	HBA1	0	two hybrid	Cui Y (2003)	1
SPINK7	0	SMPX	0	affinity chromatography technology	Huttlin EL (2017)	1
SPINK7	0	MT1G	0	two hybrid, two hybrid	Cui YP (2003), Cui Y (2003)	2
SPINK7	0	IDE	3	affinity chromatography technology	Huttlin EL (2017)	1