PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CHEK2	2	KPNA2	0	two hybrid, pull down, affinity chromatography technology	Zannini L (2003), Zannini L (2003), Zannini L (2003)	3
CHEK2	2	LYPD3	0	two hybrid	Arroyo R (2015)	1
PSMC2	2	RAD21	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PSMD4	1	PSMD2	2	biochemical, biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Hamazaki J (2007), Havugimana PC (2012), Su V (2013), Kristensen AR (2012), Wan C (2015), Sparks A (2014)	6
KPNB1	3	NUP153	1	pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakielny S (1999), Nakielny S (1999), Kehlenbach RH (2000), Ben-Efraim I (2001), Walther TC (2003), Ciciarello M (2010), Hein MY (2015), Hein MY (2015)	8
PSMD6	0	PSMC5	4	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
G3BP1	4	KPNA2	0	affinity chromatography technology	Jain S (2016)	1
PTGES3	0	RANBP2	9	biochemical	Wan C (2015)	1
MDM2	2	PSMD4	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, pull down	Kulikov R (2010), Kulikov R (2010), Uchiki T (2009), Dolezelova P (2012), Kim HT (2012), Sparks A (2014)	6
HIST1H3A	3	PPM1D	11	affinity chromatography technology, pull down	Zhang H (2013), Zhang H (2013)	2
CDC5L	2	KPNB1	3	affinity chromatography technology	Lleres D (2010)	1
PPM1D	11	TMOD3	0	affinity chromatography technology	Yadav L (2017)	1
G3BP1	4	PTGES3	0	affinity chromatography technology	Jain S (2016)	1
PPM1D	11	KPNB1	3	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Yadav L (2017)	2
DIRAS3	0	MDM2	2	affinity chromatography technology	Huttlin EL (2015)	1
PPM1D	11	NAT2	0	two hybrid	Arroyo R (2015)	1
PSMC2	2	TPM4	0	biochemical	Havugimana PC (2012)	1
KPNA2	0	KPNA3	0	biochemical	Wan C (2015)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
PPM1D	11	PSMC2	2	affinity chromatography technology	Yadav L (2017)	1
PPM1D	11	PSMD6	0	affinity chromatography technology	Yadav L (2017)	1
PSMD6	0	PSMC2	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	5
RANBP2	9	MDM2	2	enzymatic study	Miyauchi Y (2002)	1
PPM1D	11	TUBB2A	2	affinity chromatography technology	Yadav L (2017)	1
CDC5L	2	PPM1D	11	affinity chromatography technology, biochemical, affinity chromatography technology	Ajuh P (2000), Ajuh P (2000), Lleres D (2010)	3
PPM1D	11	DIRAS3	0	two hybrid	Arroyo R (2015)	1
MDM2	2	KPNA6	1	pull down, affinity chromatography technology	Nihira NT (2017), Nihira NT (2017)	2
MDM2	2	TUBB2A	2	affinity chromatography technology	Frum R (2007)	1
PPM1D	11	YWHAB	1	affinity chromatography technology	Yadav L (2017)	1
G3BP1	4	TUBA1C	1	affinity chromatography technology	Jain S (2016)	1
H2AFX	1	HIST1H3A	3	affinity chromatography technology, imaging technique	Lee HS (2010), Soldi M (2013)	2
PSMD2	2	PSMC2	2	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, biochemical, affinity chromatography technology	Gorbea C (2000), Um JW (2010), Lee SH (2012), Shim SM (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Sun S (2017)	8
PPM1D	11	PSMC5	4	affinity chromatography technology	Yadav L (2017)	1
MDM2	2	TUBA1C	1	affinity chromatography technology	Frum R (2007)	1
PPM1D	11	ACTN4	4	affinity chromatography technology	Yadav L (2017)	1
PPM1D	11	G3BP1	4	affinity chromatography technology	Yadav L (2017)	1
G3BP1	4	TPM4	0	biochemical	Havugimana PC (2012)	1
CHEK2	2	DIRAS3	0	two hybrid	Arroyo R (2015)	1
NUP153	1	KPNA2	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
KPNA2	0	RANBP2	9	two hybrid	Wang J (2011)	1
ACTN4	4	KPNA2	0	two hybrid	Wang J (2011)	1
UBC	7	PSMD6	0	pull down	Zhang X (2017)	1
PSMD4	1	PSMC5	4	biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Hamazaki J (2007), Hamazaki J (2007), Thompson D (2009), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	6
UBC	7	PSMC5	4	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhu Q (2004), Zhang X (2017)	3
RAD21	3	PSMD2	2	affinity chromatography technology	Panigrahi AK (2011)	1
PSMD2	2	MDM2	2	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Jin Y (2008), Jin Y (2008), Kulikov R (2010), Kulikov R (2010)	4
CHEK2	2	RHOBTB2	6	two hybrid	Arroyo R (2015)	1
PPM1D	11	RHOBTB2	6	two hybrid	Arroyo R (2015)	1
G3BP1	4	CDC5L	2	affinity chromatography technology	Jain S (2016)	1
PSMD6	0	PSMD4	1	affinity chromatography technology, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Wan C (2015)	3
TUBB2A	2	TUBA1C	1	biochemical	Kristensen AR (2012)	1
KPNA3	0	KPNA6	1	biochemical	Kristensen AR (2012)	1
CDC5L	2	PSMD2	2	affinity chromatography technology	Lleres D (2010)	1
UBC	7	G3BP1	4	affinity chromatography technology	Matsumoto M (2005)	1
CDC5L	2	TMOD3	0	affinity chromatography technology	Lleres D (2010)	1
RANBP2	9	KPNB1	3	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Yaseen NR (1999), Delphin C (1997), Ben-Efraim I (2001), Walther TC (2003), Chi NC (1996), Chi NC (1996), Hein MY (2015)	7
CHEK2	2	ITIH5	1	two hybrid	Arroyo R (2015)	1
TUBA1C	1	PSMC5	4	affinity chromatography technology	Hein MY (2015)	1
CDC5L	2	RANBP2	9	affinity chromatography technology	Lleres D (2010)	1
PARK7	0	YWHAB	1	affinity chromatography technology	Malty RH (2017)	1
MDM2	2	PSMC5	4	affinity chromatography technology, pull down, biochemical, pull down	Kulikov R (2010), Kulikov R (2010), Kulikov R (2010), Kulikov R (2010)	4
YWHAB	1	UBC	7	affinity chromatography technology	Jin J (2004)	1
KDM1A	2	HIST1H3A	3	enzymatic study, unspecified method, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Chen Y (2006), Forneris F (2005), Shi YJ (2005), Lee MG (2005), Metzger E (2010), Lin Y (2010)	6
G3BP1	4	PSMD2	2	affinity chromatography technology	Jain S (2016)	1
PSMC2	2	UBC	7	pull down, pull down	Jacobson AD (2014), Zhang X (2017)	2
RAD21	3	KPNB1	3	affinity chromatography technology	Panigrahi AK (2011)	1
CHEK2	2	MDM2	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Pereg Y (2006), Kass EM (2009), Kass EM (2009), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005)	7
PSMC2	2	PSMC5	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Tipler CP (1997), Kim YC (2011), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	7
PPM1D	11	GPI	0	affinity chromatography technology	Yadav L (2017)	1
PPM1D	11	NSD3	6	two hybrid	Arroyo R (2015)	1
PPM1D	11	TUBB6	2	affinity chromatography technology	Yadav L (2017)	1
PPM1D	11	OSGIN1	1	two hybrid	Arroyo R (2015)	1
ACTN4	4	TPM4	0	biochemical	Wan C (2015)	1
UBC	7	PSMD4	1	pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Fallon L (2006), Wang Q (2005), Leonchiks A (2002), Isasa M (2010), Wang Q (2005), Wang Q (2005), Haririnia A (2007), Fenner BJ (2009), Raasi S (2005), Nathan JA (2013), Beal R (1996), Uchiki T (2009), Young P (1998), Fujiwara K (2004), Dimitrov S (2005), Yoshimoto N (2009), Hawryluk MJ (2006), Nakayasu ES (2013), Nakayasu ES (2013), Tomaic V (2015), Aguileta MA (2015), Zhang X (2017), Kristariyanto YA (2017)	23
PPM1D	11	KPNA2	0	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Yadav L (2017)	2
RAD21	3	G3BP1	4	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Jain S (2016)	2
PPM1D	11	GLCE	0	two hybrid	Arroyo R (2015)	1
PPM1D	11	MRC2	3	two hybrid	Arroyo R (2015)	1
H2AFX	1	UBC	7	affinity chromatography technology	Sharma N (2013)	1
KPNB1	3	KPNA2	0	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Nagoshi E (2001), Koehler M (1999), Kutay U (1997), Hein MY (2015), Huttlin EL (2017)	5
PPM1D	11	TUBA1C	1	affinity chromatography technology	Yadav L (2017)	1
PPM1D	11	KDM1A	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Peng B (2015), Peng B (2015), Peng B (2015), Peng B (2015)	4
UBC	7	PSMD2	2	pull down	Zhang X (2017)	1
UBC	7	PPM1D	11	pull down	Nathan JA (2013)	1
NUP153	1	KPNA3	0	affinity chromatography technology	Hein MY (2015)	1
RAD21	3	PPM1D	11	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
G3BP1	4	KPNB1	3	affinity chromatography technology	Jain S (2016)	1
CDC5L	2	KDM1A	2	two hybrid	Camargo LM (2007)	1
RAD21	3	UBC	7	affinity chromatography technology	Panigrahi AK (2011)	1
PPM1D	11	NUP153	1	affinity chromatography technology	St-Denis N (2016)	1
G3BP1	4	TMOD3	0	affinity chromatography technology	Jain S (2016)	1
CDC5L	2	PSMC2	2	affinity chromatography technology	Lleres D (2010)	1
CHEK2	2	PPM1D	11	pull down, pull down, enzymatic study, affinity chromatography technology	Fujimoto H (2006), Fujimoto H (2006), Fujimoto H (2006), Fujimoto H (2006)	4
NUP153	1	KPNA6	1	affinity chromatography technology	Hein MY (2015)	1
PPM1D	11	PTGES3	0	affinity chromatography technology	Yadav L (2017)	1
KPNA6	1	PSMC2	2	biochemical	Wan C (2015)	1
G3BP1	4	YWHAB	1	affinity chromatography technology	Jain S (2016)	1
PPM1D	11	KPNA3	0	affinity chromatography technology	St-Denis N (2016)	1
PPM1D	11	PARK7	0	affinity chromatography technology	Yadav L (2017)	1
G3BP1	4	EIF3A	4	affinity chromatography technology	Jain S (2016)	1
PARK7	0	TMOD3	0	affinity chromatography technology	Malty RH (2017)	1
H2AFX	1	YWHAB	1	affinity chromatography technology	Yang X (2010)	1
PPM1D	11	DKK3	3	two hybrid	Arroyo R (2015)	1
PPM1D	11	MDM2	2	affinity chromatography technology, affinity chromatography technology	Lu X (2007), Lu X (2007)	2
PPM1D	11	EIF3A	4	affinity chromatography technology	Yadav L (2017)	1
KPNA6	1	KPNA2	0	biochemical, biochemical	Kristensen AR (2012), Wan C (2015)	2
PPM1D	11	ITIH5	1	two hybrid	Arroyo R (2015)	1
PPM1D	11	EPSTI1	0	two hybrid	Arroyo R (2015)	1
PPM1D	11	BEX2	0	two hybrid	Arroyo R (2015)	1
YWHAB	1	HIST1H3A	3	pull down	Macdonald N (2005)	1
CDC5L	2	PSMC5	4	affinity chromatography technology	Lleres D (2010)	1
KPNA3	0	KPNB1	3	pull down, pull down, affinity chromatography technology	Koehler M (1999), Nachury MV (1998), Hein MY (2015)	3
PPM1D	11	PSMD4	1	affinity chromatography technology	St-Denis N (2016)	1
PPM1D	11	SPAG9	5	affinity chromatography technology	St-Denis N (2016)	1
PPM1D	11	H2AFX	1	enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Macurek L (2010), Cha H (2010), Moon SH (2010), Moon SH (2010), Moon SH (2010)	5
ERRFI1	1	YWHAB	1	two hybrid	Ying H (2010)	1
H3F3A	1	PPM1D	11	affinity chromatography technology, pull down	Zhang H (2013), Zhang H (2013)	2
PSMC2	2	PSMD4	1	biochemical, biochemical, biochemical, biochemical, pull down, biochemical, affinity chromatography technology	Kim YC (2011), Shim SM (2012), Havugimana PC (2012), Kristensen AR (2012), Berko D (2014), Wan C (2015), Sun S (2017)	7
PPM1D	11	ERRFI1	1	two hybrid	Arroyo R (2015)	1
PPM1D	11	TUBB4A	3	affinity chromatography technology	Yadav L (2017)	1
ERRFI1	1	TUBA1C	1	affinity chromatography technology	Li J (2013)	1
EIF3A	4	TUBB6	2	biochemical	Havugimana PC (2012)	1
RAD21	3	EIF3A	4	affinity chromatography technology	Panigrahi AK (2011)	1
UBC	7	EIF3A	4	pull down	Zhang X (2017)	1
PPM1D	11	NTPCR	2	affinity chromatography technology	Yadav L (2017)	1
NSD3	6	HIST1H3A	3	enzymatic study, pull down	Morishita M (2014), Sankaran SM (2016)	2
TUBA1C	1	TUBB6	2	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
TUBB4A	3	TUBA1C	1	biochemical	Wan C (2015)	1
CDC5L	2	KPNA2	0	affinity chromatography technology	Lleres D (2010)	1
PSMC5	4	PSMD2	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Hamazaki J (2007), Lee SH (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	5
PPM1D	11	PSMD2	2	affinity chromatography technology	Yadav L (2017)	1
CDC5L	2	TUBA1C	1	affinity chromatography technology	Lleres D (2010)	1
PSMD2	2	TPM4	0	biochemical	Havugimana PC (2012)	1
PPM1D	11	TPM4	0	affinity chromatography technology	Yadav L (2017)	1
PSMD6	0	PSMD2	2	affinity chromatography technology, biochemical, biochemical, biochemical	Ewing RM (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
RANBP2	9	NUP153	1	affinity chromatography technology, affinity chromatography technology	Yokoyama N (1995), Hein MY (2015)	2
PPM1D	11	RANBP2	9	affinity chromatography technology	St-Denis N (2016)	1
PPM1D	11	LYPD3	0	two hybrid	Arroyo R (2015)	1
PPM1D	11	CASZ1	7	two hybrid	Arroyo R (2015)	1
CHEK2	2	NSD3	6	two hybrid	Arroyo R (2015)	1
KPNA6	1	KPNB1	3	pull down, biochemical, affinity chromatography technology	Koehler M (1999), Havugimana PC (2012), Hein MY (2015)	3
PPM1D	11	KPNA6	1	affinity chromatography technology	Yadav L (2017)	1
G3BP1	4	KPNA6	1	affinity chromatography technology	Jain S (2016)	1
UBC	7	KPNB1	3	affinity chromatography technology	Matsumoto M (2005)	1