PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2V2	0	UBC	7	x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	McKenna S (2003), McKenna S (2003), McKenna S (2003), Lewis MJ (2006), McKenna S (2001)	5
ZNRF2	0	ATP1A2	4	affinity chromatography technology, affinity chromatography technology, biochemical	Hoxhaj G (2012), Hoxhaj G (2012), Hoxhaj G (2012)	3
YWHAQ	0	AARS2	3	pull down	Meek SE (2004)	1
UBE2D3	1	ZNRF2	0	two hybrid	van Wijk SJ (2009)	1
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
ZNRF1	1	NCEH1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2E3	0	ZNRF1	1	two hybrid	Markson G (2009)	1
UBE2V1	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
ZNRF1	1	TSEN2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D3	1	ZNRF1	1	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
UBE2N	1	ZNRF2	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	van Wijk SJ (2009), Plans V (2006), Hoxhaj G (2012), Hoxhaj G (2012), Scheper J (2009), Hoxhaj G (2012), Boldt K (2016)	7
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
UBE2D4	0	ZNRF1	1	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
ZNRF1	1	NMT1	4	affinity chromatography technology	Huttlin EL (2015)	1
UBE2E1	1	ZNRF1	1	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Markson G (2009)	3
ZNRF1	1	ATP1A1	9	enzymatic study	Hoxhaj G (2012)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
ZNRF1	1	BHMT	0	affinity chromatography technology	Huttlin EL (2015)	1
UBE2V1	0	ZNRF1	1	two hybrid	Markson G (2009)	1
ZNRF2	0	UBE2E1	1	two hybrid	Scheper J (2009)	1
UBE2D1	0	ZNRF2	0	two hybrid	van Wijk SJ (2009)	1
CDC34	3	UBE2D3	1	affinity chromatography technology, affinity chromatography technology	Kuang P (2016), Kuang P (2016)	2
UBE2V1	0	YWHAQ	0	biochemical	Kristensen AR (2012)	1
ZNRF2	0	ZNRF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hoxhaj G (2012), Hoxhaj G (2012), Hoxhaj G (2012), Hoxhaj G (2012)	4
UBC	7	GLUL	2	affinity chromatography technology	Matsumoto M (2005)	1
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
ZNRF1	1	NMT2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSEN2	5	TSEN54	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Rolland T (2014), Huttlin EL (2017)	4
UBE2N	1	ZNRF1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Hoxhaj G (2012), Hoxhaj G (2012), Markson G (2009), Hoxhaj G (2012), Boldt K (2016)	7
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
ZNRF1	1	FBXW5	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
UBE2D2	0	ZNRF1	1	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Markson G (2009)	3
UBE2D2	0	ZNRF2	0	two hybrid	van Wijk SJ (2009)	1
GLUL	2	ZNRF1	1	affinity chromatography technology, affinity chromatography technology	Saitoh F (2010), Saitoh F (2010)	2
ZNRF1	1	UBC	7	enzymatic study	Hoxhaj G (2012)	1
UBE2W	0	ZNRF1	1	two hybrid	Markson G (2009)	1
UBE2N	1	UBE2V1	0	biochemical, pull down, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deng L (2000), Deng L (2000), Zhang M (2005), Andersen PL (2005), Andersen PL (2005), Scheper J (2010), Scheper J (2010), Scheper J (2010), Wooff J (2004), Plans V (2006), Huen MS (2008), Huen MS (2008), Havugimana PC (2012), Bohgaki M (2008), Petroski MD (2007), Sawasaki T (2008), Wan C (2015), Chen J (2015), Boldt K (2016), Zhang Y (2018)	20
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBC	7	ATP1A1	9	affinity chromatography technology	Bish RA (2007)	1
ZNRF1	1	ZNRF1	1	enzymatic study	Markson G (2009)	1
UBE2V2	0	ZNRF1	1	two hybrid	Markson G (2009)	1
UBE2D1	0	ZNRF1	1	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Markson G (2009), Hoxhaj G (2012)	4
ZNRF1	1	AARS2	3	affinity chromatography technology	Huttlin EL (2015)	1
UBE2D4	0	ZNRF2	0	two hybrid	van Wijk SJ (2009)	1
ZNRF2	0	ATP1A1	9	enzymatic study	Hoxhaj G (2012)	1
CDC34	3	UBC	7	pull down, x-ray crystallography, enzymatic study, enzymatic study, x-ray crystallography, pull down, fluorescent resonance energy transfe, affinity chromatography technology, enzymatic study, enzymatic study	Choi YS (2010), Choi YS (2010), Sheng Y (2012), Enchev RI (2012), Huang H (2014), Huang H (2014), Huang H (2014), Bish RA (2007), Chong RA (2014), Phillips AH (2013)	10
ZNRF1	1	ATP1A2	4	affinity chromatography technology, affinity chromatography technology	Hoxhaj G (2012), Hoxhaj G (2012)	2
ZNRF1	1	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Hoxhaj G (2012), Hoxhaj G (2012)	2
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE2E2	1	ZNRF1	1	two hybrid	Markson G (2009)	1
ZNRF1	1	TSEN54	1	affinity chromatography technology	Huttlin EL (2015)	1
ZNRF1	1	CDC34	3	pull down	Markson G (2009)	1
UBE2V2	0	UBE2N	1	pull down, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, pull down, biochemical, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, biochemical, x-ray crystallography, affinity chromatography technology	Andersen PL (2005), Andersen PL (2005), Markin CJ (2010), Wooff J (2004), Wooff J (2004), Plans V (2006), Wu PY (2003), McKenna S (2003), McKenna S (2003), Zou W (2005), Takeuchi T (2005), Pastushok L (2005), Pastushok L (2005), Pastushok L (2005), Huen MS (2008), Huen MS (2008), Ye Y (2003), Havugimana PC (2012), Moraes TF (2001), Pastushok L (2007), Zou W (2005), McKenna S (2001), Hodge CD (2015), Wan C (2015), Branigan E (2015), Boldt K (2016)	26
ZNRF2	0	UBC	7	enzymatic study	Hoxhaj G (2012)	1
ZNRF2	0	YWHAQ	0	far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hoxhaj G (2012), Hoxhaj G (2012), Hoxhaj G (2012), Ichimura T (2013)	4