PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGLN3	0	YAP1	0	affinity chromatography technology	Rodriguez J (2016)	1
AJUBA	2	RARA	5	affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Hou Z (2010), Hou Z (2010), Hou Z (2010), Hou Z (2010)	4
ZNF576	2	AJUBA	2	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	BUB1B	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	TRIP6	2	affinity chromatography technology	Rodriguez J (2016)	1
AJUBA	2	AURKB	2	affinity chromatography technology, enzymatic study	Ferrand A (2009), Ferrand A (2009)	2
AJUBA	2	EGLN3	0	affinity chromatography technology	Foxler DE (2012)	1
LATS1	3	YAP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang J (2008), Zhang J (2008), Ho KC (2011), Vigneron AM (2010), Vigneron AM (2010), Huntoon CJ (2010), Hao Y (2008), Hao Y (2008), Hao Y (2008), Hao Y (2008), Matallanas D (2007), Matallanas D (2007), Oka T (2008), Oka T (2008), Oka T (2008), Yu FX (2012), Yu FX (2012), Chiyoda T (2012), Couzens AL (2013), Ho KC (2011), Salah Z (2013), Hauri S (2013), Schuchardt BJ (2014), Mei L (2017), Enzo E (2015), Si Y (2017), Guo PD (2016)	27
AURKB	2	BUB1B	0	affinity chromatography technology	Ferrand A (2009)	1
PTPN21	10	TRIP6	2	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
RARG	2	ZNF576	2	two hybrid	Wang J (2011)	1
AJUBA	2	LCK	0	two hybrid	Feng Y (2005)	1
YAP1	0	PTPN21	10	pull down, affinity chromatography technology	Li X (2016), Li X (2016)	2
AJUBA	2	BUB1B	0	affinity chromatography technology	Ferrand A (2009)	1
YAP1	0	RARG	2	affinity chromatography technology, affinity chromatography technology	Guo PD (2016), Guo PD (2016)	2
YWHAZ	1	PRKCZ	5	pull down, enzymatic study	Zemlickova E (2003), Van Der Hoeven PC (2000)	2
AJUBA	2	RARG	2	affinity chromatography technology	Hou Z (2010)	1
GFI1B	1	TRIP6	2	two hybrid	Lim J (2006)	1
LATS2	1	LATS1	3	affinity chromatography technology, bioid	Xiao L (2011), Couzens AL (2013)	2
LATS2	1	AURKB	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Yabuta N (2011), Yabuta N (2011), Yabuta N (2011)	3
AJUBA	2	PRKCZ	5	affinity chromatography technology	Feng Y (2005)	1
TRIP6	2	EGLN2	4	affinity chromatography technology	Foxler DE (2012)	1
VHL	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Chen K (2016), Chen K (2016)	2
IQCN	0	AJUBA	2	affinity chromatography technology	Huttlin EL (2017)	1
YAP1	0	AJUBA	2	affinity chromatography technology	Enzo E (2015)	1
YWHAZ	1	PRMT5	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
LCK	0	SQSTM1	0	pull down	Joung I (1996)	1
YWHAZ	1	SFN	1	biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	3
RARA	5	RXRG	1	two hybrid, two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Albers M (2005), Wang J (2011), Rolland T (2014), Yu H (2011)	5
RARG	2	RARA	5	affinity chromatography technology	Huttlin EL (2017)	1
EGLN3	0	YWHAZ	1	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	AURKB	2	affinity chromatography technology	Rodriguez J (2016)	1
LATS2	1	AJUBA	2	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Abe Y (2006), Abe Y (2006), Abe Y (2006), Abe Y (2006), Das Thakur M (2010)	5
AJUBA	2	EGLN2	4	affinity chromatography technology	Foxler DE (2012)	1
AJUBA	2	TRAF6	0	affinity chromatography technology	Feng Y (2005)	1
TRIP6	2	IQCN	0	two hybrid	Rual JF (2005)	1
YWHAZ	1	LATS2	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
EGLN3	0	EGLN2	4	affinity chromatography technology, affinity chromatography technology	Nakayama K (2007), Nakayama K (2007)	2
XPO1	8	SQSTM1	0	affinity chromatography technology	Kirli K (2015)	1
AJUBA	2	SNAI1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hou Z (2008), Hou Z (2008), Hsu DS (2014)	3
PRMT5	3	AJUBA	2	affinity chromatography technology, affinity chromatography technology	Hou Z (2008), Hou Z (2008)	2
SAV1	0	LATS2	1	bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Rashidian J (2015), Bae SJ (2015)	3
LATS2	1	SNAI1	1	enzymatic study, affinity chromatography technology	Zhang K (2012), Vinas-Castells R (2013)	2
SQSTM1	0	PRKCZ	5	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, imaging technique, affinity chromatography technology	Sanz L (2000), Hirano Y (2004), Chang S (2002), Wilson MI (2003), Feng Y (2005), Kim GY (2012), Urbanczyk A (2011), Linares JF (2011), So J (2015), Tsai LC (2015), Huttlin EL (2017), Tobias IS (2016), Tobias IS (2016)	13
LATS1	3	AURKB	2	enzymatic study	Yabuta N (2011)	1
XPO1	8	YAP1	0	affinity chromatography technology	Kirli K (2015)	1
SQSTM1	0	YWHAZ	1	pull down	Pridgeon JW (2004)	1
XPO1	8	AJUBA	2	affinity chromatography technology	Kirli K (2015)	1
SAV1	0	LATS1	3	affinity chromatography technology	Guo C (2007)	1
XPO1	8	TRIP6	2	affinity chromatography technology	Kirli K (2015)	1
TRAF6	0	PRKCZ	5	affinity chromatography technology	Sanz L (2000)	1
YAP1	0	YWHAZ	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Couzens AL (2013), Mo XL (2015), Zhang B (2017), Ivanov AA (2017)	4
IQCN	0	SAV1	0	affinity chromatography technology	Huttlin EL (2017)	1
SQSTM1	0	RARA	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Z (2011), Wang Z (2011), Yang L (2015), Yang L (2015)	4
YAP1	0	TRIP6	2	affinity chromatography technology	Enzo E (2015)	1
XPO1	8	AURKB	2	affinity chromatography technology	Kirli K (2015)	1
SAV1	0	YWHAZ	1	affinity chromatography technology	Couzens AL (2013)	1
SAV1	0	AJUBA	2	affinity chromatography technology	Das Thakur M (2010)	1
SFN	1	AJUBA	2	affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Benzinger A (2005)	2
LATS1	3	AJUBA	2	affinity chromatography technology	Das Thakur M (2010)	1
YAP1	0	SFN	1	affinity chromatography technology	Enzo E (2015)	1
AJUBA	2	SQSTM1	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Feng Y (2005), Feng Y (2005), Feng Y (2005)	3
EGLN3	0	SQSTM1	0	affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology	Rantanen K (2013), Rantanen K (2013), Rantanen K (2013), Rodriguez J (2016)	4
YWHAZ	1	AJUBA	2	affinity chromatography technology	Benzinger A (2005)	1
TRIP6	2	AJUBA	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAZ	1	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
GFI1B	1	AJUBA	2	two hybrid	Lim J (2006)	1
EGLN3	0	SAV1	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	PRMT5	3	affinity chromatography technology	Rodriguez J (2016)	1
AJUBA	2	RXRG	1	affinity chromatography technology	Hou Z (2010)	1
LATS2	1	YAP1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study	Ikeda M (2009), Zhang J (2008), Zhang J (2008), Vigneron AM (2010), Vigneron AM (2010), Bao Y (2009), Kawahara M (2008), Paramasivam M (2011), Aylon Y (2010), Oka T (2008), Yu FX (2012), Mo XL (2015), Rashidian J (2015), Kim M (2016), Enzo E (2015), Si Y (2017), Ivanov AA (2017), Zhu C (2018)	18
AJUBA	2	VHL	0	affinity chromatography technology	Foxler DE (2012)	1
PTPN21	10	AJUBA	2	affinity chromatography technology	St-Denis N (2016)	1
SLC1A2	4	AJUBA	2	two hybrid, pull down, affinity chromatography technology	Marie H (2002), Marie H (2002), Marie H (2002)	3
XPO1	8	BUB1B	0	affinity chromatography technology	Kirli K (2015)	1
VHL	0	PRKCZ	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okuda H (1999), Okuda H (1999), Schermer B (2006)	3
SFN	1	SAV1	0	affinity chromatography technology	Benzinger A (2005)	1
RARG	2	RXRG	1	two hybrid	Albers M (2005)	1