PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SEPHS1	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
HSPB1	2	IGSF21	1	two hybrid	Stelzl U (2005)	1
NACA	1	IGSF21	1	two hybrid	Stelzl U (2005)	1
DGKD	6	IGSF21	1	two hybrid	Stelzl U (2005)	1
ETHE1	3	IGSF21	1	two hybrid	Stelzl U (2005)	1
PSMD11	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
CRCT1	1	IGSF21	1	two hybrid	Stelzl U (2005)	1
GSK3B	1	ATF3	0	affinity chromatography technology	Lee SH (2010)	1
S100A8	0	PRMT1	3	two hybrid	Stelzl U (2005)	1
GSTM4	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
PAFAH1B3	1	IGSF21	1	two hybrid	Stelzl U (2005)	1
PCDHA4	1	IGSF21	1	two hybrid	Stelzl U (2005)	1
KRAS	1	ERH	0	genetic interference	Luo J (2009)	1
BTBD2	4	IGSF21	1	two hybrid	Stelzl U (2005)	1
ATF3	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
SERPINB9	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
SEPHS1	0	HSPB1	2	biochemical	Wan C (2015)	1
GIPC2	2	IGSF21	1	two hybrid	Stelzl U (2005)	1
SULT1E1	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
ANXA3	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
ALDH2	2	IGSF21	1	two hybrid	Stelzl U (2005)	1
BCR	3	IGSF21	1	two hybrid	Stelzl U (2005)	1
ERH	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
PAEP	1	IGSF21	1	two hybrid	Stelzl U (2005)	1
KRAS	1	IGSF21	1	two hybrid	Vinayagam A (2011)	1
GSK3B	1	IGSF21	1	two hybrid	Vinayagam A (2011)	1
NREP	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
UBE2V2	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
RPP14	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
GADD45A	1	IGSF21	1	two hybrid	Vinayagam A (2011)	1
S100A8	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
MAD2L1BP	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
28620	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
PRMT1	3	IGSF21	1	two hybrid	Stelzl U (2005)	1