PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RBPMS	0	C1orf94	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
VPS37C	3	MAPK1IP1L	0	two hybrid	Rolland T (2014)	1
ATXN1	2	RBPMS	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
ROR2	0	C1orf94	1	two hybrid	Rolland T (2014)	1
CARD9	3	C1orf94	1	two hybrid	Rolland T (2014)	1
DGCR6	0	C1orf94	1	two hybrid	Corominas R (2014)	1
VENTX	1	AES	2	affinity chromatography technology	Huttlin EL (2017)	1
FAM168A	0	DTX2	3	two hybrid	Rolland T (2014)	1
ATXN1	2	HSPA8	4	affinity chromatography technology	Choi JY (2007)	1
PITX1	2	PRR20A	0	two hybrid	Corominas R (2014)	1
RBFOX2	5	DMRTB1	1	two hybrid	Rual JF (2005)	1
BANP	1	C1orf94	1	two hybrid	Rolland T (2014)	1
AES	2	CFAP206	1	two hybrid	Rolland T (2014)	1
RBPMS	0	BANP	1	two hybrid	Rolland T (2014)	1
GRB2	2	C1orf94	1	two hybrid	Rolland T (2014)	1
LMO2	2	BANP	1	two hybrid	Rolland T (2014)	1
NR3C1	2	RBFOX2	5	bioid	Lempiaeinen JK (2017)	1
MAGED1	0	RBPMS	0	two hybrid	Rolland T (2014)	1
DAZAP2	1	PRR20A	0	two hybrid	Rolland T (2014)	1
DGCR6	0	MEIS2	7	two hybrid	Corominas R (2014)	1
AES	2	CCNJL	3	two hybrid	Rolland T (2014)	1
C1orf94	1	CARM1	0	affinity chromatography technology	Huttlin EL (2017)	1
NGB	0	C1orf94	1	two hybrid	Rolland T (2014)	1
MVP	1	BANP	1	two hybrid	Corominas R (2014)	1
RBPMS	0	VENTX	1	two hybrid	Rolland T (2014)	1
AKAP9	13	C1orf94	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
LMO2	2	C1orf94	1	two hybrid	Rolland T (2014)	1
C1orf94	1	NIF3L1	0	affinity chromatography technology	Huttlin EL (2017)	1
BANP	1	CFAP206	1	two hybrid	Rolland T (2014)	1
BOLA1	0	C1orf94	1	two hybrid	Rolland T (2014)	1
MAGED1	0	DAZAP2	1	two hybrid	Yu H (2011)	1
RBFOX1	1	DAB1	1	two hybrid	Corominas R (2014)	1
FAM168A	0	C1orf94	1	two hybrid	Rolland T (2014)	1
AES	2	RBPMS	0	two hybrid	Rolland T (2014)	1
UBQLN4	2	C1orf94	1	two hybrid	Lim J (2006)	1
MAPK9	3	C1orf94	1	two hybrid	Rolland T (2014)	1
AES	2	BYSL	3	two hybrid	Rolland T (2014)	1
TBX6	0	RBPMS	0	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
USO1	1	AKAP9	13	two hybrid	Rolland T (2014)	1
RFX2	5	C1orf94	1	two hybrid	Yu H (2011)	1
MVP	1	AES	2	two hybrid	Corominas R (2014)	1
RBPMS	0	GSE1	14	two hybrid	Rual JF (2005)	1
RBPMS	0	RBFOX2	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
C1orf94	1	PRR20A	0	two hybrid	Rolland T (2014)	1
C1orf94	1	ANKRD40	1	affinity chromatography technology	Huttlin EL (2017)	1
CCHCR1	2	CARD9	3	two hybrid	Rolland T (2014)	1
RBFOX2	5	ANKRD40	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBFOX1	1	FAM168A	0	two hybrid	Corominas R (2014)	1
C1orf94	1	HERC4	0	affinity chromatography technology	Huttlin EL (2017)	1
DGCR6	0	GSE1	14	two hybrid	Corominas R (2014)	1
C1orf94	1	RPAP1	5	affinity chromatography technology	Huttlin EL (2017)	1
MAGED1	0	SMAP2	4	two hybrid	Rolland T (2014)	1
DAB1	1	ROR2	0	two hybrid	Rolland T (2014)	1
DAB1	1	MAGED1	0	two hybrid	Rolland T (2014)	1
RAD51D	1	C1orf94	1	two hybrid	Rolland T (2014)	1
RBPMS	0	FAM168A	0	two hybrid	Rolland T (2014)	1
FAM168A	0	PRR20A	0	two hybrid	Rolland T (2014)	1
DAB1	1	RBFOX2	5	two hybrid	Rolland T (2014)	1
RBFOX1	1	ATXN1	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
TNPO2	10	C1orf94	1	two hybrid	Rolland T (2014)	1
DAB1	1	PRR20A	0	two hybrid	Rolland T (2014)	1
PRKAG1	1	C1orf94	1	two hybrid	Rolland T (2014)	1
RBFOX1	1	HNRNPF	5	two hybrid	Lim J (2006)	1
ATXN1	2	C1orf94	1	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
OAZ3	2	C1orf94	1	two hybrid	Rolland T (2014)	1
R3HDM2	2	C1orf94	1	two hybrid	Rolland T (2014)	1
RBFOX2	5	BOLL	0	two hybrid	Rolland T (2014)	1
CCHCR1	2	C1orf94	1	two hybrid	Rolland T (2014)	1
RBFOX1	1	MAGED1	0	two hybrid, two hybrid	Lim J (2006), Corominas R (2014)	2
RBFOX2	5	MAPK1IP1L	0	two hybrid	Rolland T (2014)	1
GSE1	14	CFAP206	1	two hybrid	Rolland T (2014)	1
BYSL	3	C1orf94	1	two hybrid	Rolland T (2014)	1
C1orf94	1	FAM46D	0	two hybrid	Rolland T (2014)	1
PLEKHB2	4	C1orf94	1	two hybrid	Rolland T (2014)	1
GRB2	2	LMO2	2	two hybrid	Rolland T (2014)	1
DAZAP2	1	RBPMS	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
CLK1	1	C1orf94	1	enzymatic study	Lipp JJ (2015)	1
RBFOX1	1	PRR20A	0	two hybrid	Corominas R (2014)	1
AES	2	LMO2	2	two hybrid	Rolland T (2014)	1
AES	2	HNRNPF	5	two hybrid	Rolland T (2014)	1
DAZAP2	1	C1orf94	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RBFOX1	1	DMRTB1	1	two hybrid	Lim J (2006)	1
BYSL	3	TNPO2	10	biochemical	Wan C (2015)	1
DMRTB1	1	C1orf94	1	two hybrid	Yu H (2011)	1
C1orf109	1	C1orf94	1	two hybrid	Rolland T (2014)	1
MVP	1	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
NR3C1	2	C1orf94	1	protein complementation assay	Lievens S (2016)	1
RBFOX1	1	RBFOX2	5	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
DAZAP2	1	RBFOX2	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
ROR2	0	MAGED1	0	affinity chromatography technology	Matsuda T (2003)	1
DGCR6	0	AES	2	two hybrid	Corominas R (2014)	1
DAZAP2	1	FAM168A	0	two hybrid	Rolland T (2014)	1
CCNJL	3	C1orf94	1	two hybrid	Rolland T (2014)	1
FAM168A	0	VPS37C	3	two hybrid	Rolland T (2014)	1
RBFOX1	1	RBPMS	0	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
ATXN1	2	R3HDM2	2	two hybrid	Lim J (2006)	1
DAZAP2	1	SMAP2	4	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
DAB1	1	SMAP2	4	two hybrid	Rolland T (2014)	1
ATXN1	2	DAZAP2	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBFOX1	1	C1orf94	1	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
C1orf94	1	GLUL	2	affinity chromatography technology	Huttlin EL (2017)	1
RBPMS	0	DOK6	2	two hybrid	Rolland T (2014)	1
AES	2	GRB2	2	two hybrid	Rolland T (2014)	1
DAB1	1	DAZAP2	1	two hybrid	Rolland T (2014)	1
ATRIP	1	C1orf94	1	two hybrid	Rolland T (2014)	1
ATXN1	2	RBFOX2	5	two hybrid, affinity chromatography technology, two hybrid, two hybrid	Lim J (2006), Lim J (2006), Suter B (2013), Rolland T (2014)	4
NR3C1	2	GSE1	14	bioid	Lempiaeinen JK (2017)	1
BOLL	0	C1orf94	1	two hybrid	Rolland T (2014)	1
DAB1	1	C1orf94	1	two hybrid	Rolland T (2014)	1
MAGED1	0	RBFOX2	5	two hybrid	Rolland T (2014)	1
RBPMS	0	VPS37C	3	two hybrid	Rolland T (2014)	1
HNRNPF	5	RBFOX2	5	two hybrid, two hybrid, two hybrid	Hegele A (2012), Hegele A (2012), Rolland T (2014)	3
GORASP2	1	C1orf94	1	two hybrid	Rolland T (2014)	1
RBPMS	0	R3HDM2	2	two hybrid	Rolland T (2014)	1
DAZAP2	1	VPS37C	3	two hybrid	Rolland T (2014)	1
RBFOX2	5	C1orf94	1	two hybrid	Rolland T (2014)	1
LMO2	2	DAZAP2	1	two hybrid	Rual JF (2005)	1
MVP	1	C1orf94	1	two hybrid	Corominas R (2014)	1
AES	2	C1orf94	1	two hybrid	Rolland T (2014)	1
UBQLN4	2	DTX2	3	two hybrid	Lim J (2006)	1
R3HDM2	2	FAM168A	0	two hybrid	Rolland T (2014)	1
C1orf94	1	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
OIP5	1	C1orf94	1	two hybrid	Rolland T (2014)	1
TXNDC9	0	C1orf94	1	two hybrid	Rolland T (2014)	1
MAGED1	0	AKAP9	13	two hybrid	Rolland T (2014)	1
C1orf94	1	DTX2	3	two hybrid	Rolland T (2014)	1
ROR2	0	PRR20A	0	two hybrid	Rolland T (2014)	1
LMO2	2	NIF3L1	0	two hybrid	Rolland T (2014)	1
AES	2	GORASP2	1	two hybrid	Rolland T (2014)	1
GCC1	1	C1orf94	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TBX6	0	C1orf94	1	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
NFKBID	1	C1orf94	1	two hybrid	Rolland T (2014)	1
MVP	1	RBPMS	0	two hybrid	Corominas R (2014)	1
AES	2	C1orf109	1	two hybrid	Rolland T (2014)	1
YES1	1	C1orf94	1	two hybrid	Rolland T (2014)	1
GRB2	2	HSPA8	4	affinity chromatography technology	Brehme M (2009)	1
RBM47	2	C1orf94	1	two hybrid	Rolland T (2014)	1
SMAP2	4	C1orf94	1	two hybrid	Rolland T (2014)	1
MEIS2	7	C1orf94	1	two hybrid	Rolland T (2014)	1
USO1	1	C1orf94	1	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
PITX1	2	MAGED1	0	two hybrid	Corominas R (2014)	1
VENTX	1	C1orf94	1	two hybrid	Rolland T (2014)	1
MAGED1	0	C1orf94	1	two hybrid	Rolland T (2014)	1
ROR2	0	RBPMS	0	two hybrid	Rolland T (2014)	1
OIP5	1	CCHCR1	2	affinity chromatography technology	Boldt K (2016)	1
VPS37C	3	C1orf94	1	two hybrid	Rolland T (2014)	1
ACTN3	2	C1orf94	1	two hybrid	Rolland T (2014)	1
DAZAP2	1	PLEKHB2	4	two hybrid	Rolland T (2014)	1
C1orf94	1	KLHL32	2	two hybrid	Rolland T (2014)	1
OIP5	1	GCC1	1	two hybrid	Rolland T (2014)	1
RBPMS	0	BOLL	0	two hybrid	Rolland T (2014)	1
GRB2	2	MAPK9	3	pull down, pull down	Saleem A (1995), Kharbanda S (1995)	2
C1orf94	1	MMADHC	0	affinity chromatography technology	Huttlin EL (2017)	1
RBPMS	0	PRR20A	0	two hybrid	Rolland T (2014)	1
YES1	1	NIF3L1	0	two hybrid	Rolland T (2014)	1
C1orf94	1	CFAP206	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
RPAP1	5	HSPA8	4	affinity chromatography technology	Jeronimo C (2007)	1
DAB1	1	VENTX	1	two hybrid	Rolland T (2014)	1
HNRNPF	5	C1orf94	1	two hybrid	Rolland T (2014)	1
AES	2	CARD9	3	two hybrid	Rolland T (2014)	1
PITX1	2	RBPMS	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Corominas R (2014), Rolland T (2014)	3
ROR2	0	DAZAP2	1	affinity chromatography technology, two hybrid	Winkel A (2008), Rolland T (2014)	2
FAM168A	0	SMAP2	4	two hybrid	Rolland T (2014)	1
DAB1	1	FAM168A	0	two hybrid	Rolland T (2014)	1
NIF3L1	0	DMRTB1	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
ATXN1	2	UBQLN4	2	two hybrid, two hybrid	Davidson JD (2000), Lim J (2006)	2
RBPMS	0	DTX2	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
CDKN2D	0	C1orf94	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
GRB2	2	NIF3L1	0	two hybrid	Rolland T (2014)	1
RBFOX1	1	DAZAP2	1	two hybrid	Corominas R (2014)	1
C1orf94	1	MAPK1IP1L	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
C1orf94	1	C1orf94	1	two hybrid	Rolland T (2014)	1
ATXN1	2	PRR20A	0	two hybrid	Rolland T (2014)	1
IPO11	0	C1orf94	1	two hybrid	Rolland T (2014)	1
GSE1	14	C1orf94	1	two hybrid	Rolland T (2014)	1
C1orf94	1	DOK6	2	two hybrid	Rolland T (2014)	1
AES	2	VPS37C	3	two hybrid	Rolland T (2014)	1
UBQLN4	2	DAZAP2	1	two hybrid	Lim J (2006)	1
PITX1	2	C1orf94	1	two hybrid	Corominas R (2014)	1